[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endothelial-function-reactive-hyperemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endothelial-function-reactive-hyperemia":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,64,103,135],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":63},"100582737","peanuts-for-cardiometabolic-brain-and-intestinal-health-100582737",false,"NCT06867198","Peanuts for Cardiometabolic, Brain, and Intestinal Health","Impact of Peanuts on Cardiometabolic, Cognitive, and Intestinal Health in Prediabetes Among Racially Diverse Populations","Inclusion Criteria:\n\n* men and women\n* 20-59 years of age\n* BMI: 24.5 - 35.5 kg\u002Fm\\^2\n* Prediabetes (fasting blood glucose levels 100-125 mg\u002FdL and\u002For HbA1c between 5.7-6.4%)\n* Ability to give consent\n\nExclusion Criteria:\n\n* Allergies to peanuts and peanut products\n* Use of insulin, antidiabetic, antibiotics, and anti-inflammatory drugs\n* Active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological diseases or severe head injury\n* Smoking\n* Consumes greater than 2 alcoholic beverages per day\n* Consumes antioxidant, probiotic, and prebiotic supplements\n* Pregnant or Lactating\n* Actively participating in a weight loss program\n\nMRI Exclusion Criteria:\n\n* Certain neurological disorders (e.g., uncontrolled seizure disorders)\n* Braces on their teeth, a cardiac pacemaker; hearing aid; other metal in the body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects","ALL","20 Years","59 Years",{"count":20,"type":21},72,"ESTIMATED","INTERVENTIONAL",[24],"NA","The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially diverse prediabetes population.",[27,28,29,30,31,32,33,34],"Prediabetes","Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)","Cognition","Microvascular Function","Gut Microbiota","Endothelial Function (Reactive Hyperemia)","Arterial Stiffness, Blood Pressure","Adult",[36,37,38,39,40,41,42,43,44,45,46,47,48,49,50],"prediabetes","peanuts","functional foods","nuts","metabolic health","insulin resistance","type II diabetes","microvascular function","dietary intervention","cognitive function","vascular function","neuroimaging","endothelial function","cardiovascular health","gut microbiota","RECRUITING","2026-03-23",{"date":54,"type":55},"2026-03-27","ACTUAL",{"date":57,"type":55},"2025-03-06",{"date":59,"type":21},"2027-09",{"name":61,"class":62},"Georgia State University","OTHER",1,{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":90,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":63},"100572617","wild-blueberries-for-gut-brain-and-heart-health-in-adults-with-high-blood-pressure-100572617","NCT06735599","Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure","Effects of Wild Blueberry Consumption on Gut, Brain, and Cardiovascular Health in Non-Hispanic Black and White Adults With High Blood Pressure","Inclusion Criteria:\n\n* Individuals 45-65 years of age\n* Diagnosis of elevated blood pressure or stage 1 hypertension (systolic blood pressure = 120-139 mmHg and\u002For diastolic blood pressure = 80-89 mmHg) for at least 6 months\n* BMI 25-35 kg\u002Fm2 via anthropometric measurements.\n* Ability to give consent\n\nExclusion Criteria:\n\n* Allergies to berries\n* Use of one hypertensive drug for less than three months\n* Use of more than one anti-hypertensive or statin drug, insulin, antibiotics, and anti-inflammatory drugs, active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological disorders or severe head injury\n* Smoking\n* Alcohol consumption (\\>2 drinks\u002Fday)\n* Consuming antioxidant, probiotic, and prebiotic supplements\n* Pregnant or lactating\n* Participating in a weight loss program","45 Years","65 Years",{"count":74,"type":21},40,[24],"The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.",[78,79,80,81,34,29,32,82,83,84,85,86,87,88,89,30],"Hypertension (Without Type 2 Diabetes Mellitus)","High Blood Pressure","Male","Female","Oxidative Stress","Diet","Overweight","Body Composition Measurement","Gut Microbiome","Arterial Stiffness","Caucasian Whites","Inflammation",[91,92,84,79,93,94,95,38,50,96,43],"Blueberries","Hypertension","Endothelial Function","Cognitive Function","Dietary intervention","arterial stiffness",{"date":54,"type":55},{"date":99,"type":55},"2024-09-17",{"date":101,"type":21},"2027-01-01",{"name":61,"class":62},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":110,"minAge":17,"maxAge":72,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":63},"100572621","wild-blueberries-for-gut-brain-and-cardiometabolic-health-in-prediabetes-100572621","NCT06735651","Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes","Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Female Adults With Prediabetes.","Inclusion Criteria:\n\n* Women aged 20-65 years old\n* Prediabetes (fasting blood glucose 100-125 mg\u002FdL and\u002For HbA1c percentage between 5.7-6.4)\n* Body Mass Index between 25-30 kg\u002Fm\\^2\n\nExclusion Criteria:\n\n* Allergies to berries\n* Use of insulin, antidiabetic, antibiotics, and anti-inflammatory drugs\n* Active cancer, gastrointestinal, renal, thyroid, stage 1 \\& 2 hypertension and other cardiovascular diseases, neurological diseases, or severe head injury\n* Smoking\n* Consumes greater than 2 alcoholic beverages per day\n* Consumes antioxidant, probiotic, and prebiotic supplements\n* Pregnant or Lactating\n* Actively participating in a weight loss program\n* Currently taking berry supplements or recently participated in another study taking berry supplements","FEMALE",{"count":112,"type":21},30,[24],"The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.",[28,81,34,32,87,29,82,31,84,89,30,116],"Body Composition",[91,27,118,119,95,120,121,122,123,124,125,126,30,127],"Insulin Resistance","Functional foods","Endothelial function","Vascular function","Cardiovascular health","Metabolic health","Gut microbiota","Cognitive function","Type II diabetes","Wild Blueberries",{"date":129,"type":55},"2026-03-25",{"date":131,"type":55},"2024-09-20",{"date":133,"type":21},"2026-06-01",{"name":61,"class":62},{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":142,"sex":16,"minAge":143,"maxAge":72,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":148,"conditions":149,"keywords":155,"overallStatus":160,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":63},"100579503","early-phase-1-therapeutic-strategies-to-reduce-endothelial-ischemia-reperfusion-injury-100579503","NCT06825143","Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury","Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury with Metabolic Syndrome: a Combination Approach with Lactate Administration and Ischemic Preconditioning","Inclusion Criteria:\n\n* Sedentary men and women between the ages of 18-65 years of all races and ethnicity\n* Diet and weight stable for the past 3 months\n* Non-smoking and not using tobacco or electronic cigarettes\n\nExclusion Criteria:\n\n* Use of medications known to affect cardiovascular function\n* Hyperlactemia\n* Type A lactic acidosis\n* Type B lactic acidosis\n* Extracellular hyperhydration or hypervolemia\n* Hyperkaliemia\n* Hypercalcemia\n* Metabolic alkalosis\n* Metabolic acidosis\n* McArdle's Disease\n* Diabetes Type 1 and 2\n* Taking oral contraceptives or hormone replacement therapy\n* Body mass index greater than or equal to 35\n* Smoking or using smokeless tobacco and electronic cigarettes\n* Cardiovascular, cerebrovascular, liver, respiratory, and renal disease\n* Atrial fibrillation or other sustained supraventricular\u002Fventricular arrhythmia\n* Familial hypercholesterolemia\n* Rheumatoid arthritis\n* Sleep apnea\n* Currently pregnant, recent pregnancy, or breast-feeding\n* Autonomic nervous system dysfunction\n* Raynaud's disease\n* Active malignancy excluding basal cell carcinoma of the skin\n* Three or more days of at least 30 minutes of aerobic exercise in the past 3 months\n* Inability to provide consent",true,"18 Years",{"count":145,"type":21},68,[147],"EARLY_PHASE1","The objective of this clinical trial is to better understand how lactate, a naturally occurring energy substance, can be used to lessen damage to the vascular system in adults with a high cardiovascular disease risk.\n\nThe main questions it aims to answer are:\n\n1. Does giving lactate intravenously reduce injury to the vascular system?\n2. Does giving lactate intravenously together with blood flow occlusion - known as ischemic preconditioning, reduce vascular injury better than blood flow occlusion by itself?\n3. How does lactate help the vascular system?\n\nResearchers will compare lactate to a placebo (a look-alike substance that contains no lactate) to see if lactate works to lessen vascular injury.\n\nResearchers will also compare lactate to blood flow occlusion to see which one is better at preventing vascular injury.\n\nResearchers will also compare lactate and blood flow occlusion together to see if combining them works better than either one alone.\n\nIn one visit to the laboratory, participants will:\n\nObtain a measurement of vascular health in an arm Be given liquid lactate, a liquid placebo, and\u002For arm blood flow occlusion Obtain a second measurement of vascular health in an arm.",[150,151,152,153,154],"Metabolic Syndrome","Vascular Injury","Ischemic Preconditioning","Endothelial Function (reactive Hyperemia)","Endothelial Dysfunction",[156,157,158,159],"endothelial ischemia\u002Freperfusion injury","remote ischemic preconditioning","lactate","metabolic syndrome","NOT_YET_RECRUITING","2025-02-07",{"date":163,"type":55},"2025-02-13",{"date":165,"type":21},"2026-10-01",{"date":167,"type":21},"2030-06-30",{"name":169,"class":62},"Gary Van Guilder"]