[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endothelial-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endothelial-function":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100645419","effect-of-platelet-concentrate-transfusion-on-microcirculatory-endothelial-function-in-intensive-care-unit-100645419",false,"NCT07682246","EFFECT OF PLATELET CONCENTRATE TRANSFUSION ON MICROCIRCULATORY ENDOTHELIAL FUNCTION IN INTENSIVE CARE UNIT","EFFECT OF PLATELET CONCENTRATE TRANSFUSION ON MICROCIRCULATORY ENDOTHELIAL FUNCTION IN INTENSIVE CARE UNIT.","PLATOMIR","Inclusion Criteria:\n\n* Adult patient ≥ 18 years of age\n* Admitted to intensive care\n* Requires prophylactic platelet transfusion for thrombocytopenia\n* Enrolled in a social security program\n* No objection to participating in the study\n\nExclusion Criteria:\n\n* Recent platelet or red blood cell transfusion (\\\u003C 24 hours)\n* Need for urgent red blood cell transfusion due to active bleeding\n* Patient under guardianship or conservatorship\n* Significant peripheral edema","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the impact of platelet concentrate (PC) transfusions on endothelial function and the systemic inflammatory response in thrombopenic patients admitted to intensive care who require prophylactic platelet transfusions.\n\nEndothelial function will be measured using a laser Doppler device coupled with an acetylcholine iontophoresis system that is applied to the skin.",[25,26,27,28],"Thrombocytopenia","Prophylactic Platelet Transfusion","Platelet Transfusion","Endothelial Function",[30,31,27,28,32,33,34,35],"ICU","intensive care","endothelial biomarkers","systemic inflammation","oxidative stress","peripheral tissue perfusion","NOT_YET_RECRUITING","2026-06-26",{"date":39,"type":40},"2026-07-02","ACTUAL",{"date":42,"type":21},"2026-07",{"date":44,"type":21},"2027-07",{"name":46,"class":47},"Assistance Publique - Hôpitaux de Paris","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":48},"100554496","early-phase-1-comparing-approaches-to-assess-nitric-oxide-dependent-cutaneous-vasodilation-100554496","NCT06499844","Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation","CAP NOVA","Inclusion Criteria:\n\n* men and women\n* 18-30 years of age\n\nExclusion Criteria:\n\n* Current or recent (within 8 wks) use of medication that could conceivably alter microvascular function \\[including (but not limited to) stimulants, antihypertensives, HMG-CoA reductase inhibitors\\]\n* Changes or alterations in medication status (starting a new, additional, or different medication or changing the dose of a current medication)\n* Unstable or diagnosed chronic clinical disease, including cardiovascular, metabolic, renal, hepatic, autonomic, autoimmune, or dermatological disease (e.g., hypertension, heart disease, diabetes, hyperlipidemia, psoriasis)\n* Body mass index \\\u003C18.5 or \\>35 kg\u002Fm2\n* Pregnancy (including a positive urine pregnancy test) or breast-feeding\n* Known allergies to pharmacological agents or study drugs\n* Non-English-speaking. Participants need to understand English to follow instructions and comply with procedures conducted during the screening and experimental visits.",true,"30 Years",{"count":59,"type":21},56,"INTERVENTIONAL",[62],"EARLY_PHASE1","The increase in skin blood flow in response to rapid local heating of the skin (i.e., cutaneous vasodilation) is commonly used to assess nitric oxide (NO)-dependent dilation and overall microvascular function. Historically, rapid local heating to 42°C was considered the standard approach for these assessments. More recently, many investigators have adopted rapid local to 39°C instead, based on its larger dependency on NO and therefore improved ability to quantify NO-dependent dilation without the use of pharmacological techniques. However, to date, only one direct methodological comparison between these protocols has been performed.\n\nIn this study, the investigators use the blood vessels in the skin as a representative vascular bed for examining mechanisms of microvascular dysfunction in humans. Using a minimally invasive technique (intradermal microdialysis for the local delivery of pharmaceutical agents) they examine the blood vessels in a nickel-sized area of the skin in young adults ages 18 - 30 years old. Local heating of the skin at the microdialysis sites is used to explore differences in mechanisms governing microvascular control. As a compliment to these measurements, the investigators also have participants fill out a variety of surveys to assess things such as sleep quality, physical activity, daily stressors, etc.",[28],"RECRUITING","2025-08-19",{"date":68,"type":40},"2025-08-24",{"date":70,"type":40},"2024-08-01",{"date":72,"type":21},"2026-09",{"name":74,"class":47},"University of Iowa"]