[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endothelial-glycocalyx\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endothelial-glycocalyx":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100615466","endothelial-glycocalyx-and-inflammatory-response-changes-in-patients-with-acute-stroke-undergoing-mechanical-thrombectomy-100615466",false,"NCT07292974","ENDOTHELIAL GLYCOCALYX AND INFLAMMATORY RESPONSE CHANGES IN PATIENTS WITH ACUTE STROKE UNDERGOING MECHANICAL THROMBECTOMY","DYNAMIC CHANGES OF ENDOTHELIAL GLYCOCALYX AND INFLAMMATORY RESPONSE IN PATIENTS WITH ACUTE STROKE TREATED WITH MECHANICAL THROMBECTOMY","DEGIMT","Inclusion Criteria: all patients older than 18 years with a diagnosis of acute IS confirmed by brain CT or MRI, and to whom MT will be performed, regardless of whether they are previously received thrombolysis.\n\nExclusion Criteria: patients under the age of 18, patients with diagnosed with hemorrhagic stroke, patients with acute infection, autoimmune illness, malignant disease, trauma, pregnant women or patients who will refuse to participate in research.",true,"ALL","18 Years",{"count":21,"type":22},150,"ESTIMATED","2 Days","OBSERVATIONAL","Ischemic stroke (IS) is one of the leading causes of mortality and disability. Treatment of IS is based on reperfusion methods, thrombolysis and mechanical thrombectomy (MT). However, there are significant limitations in their implementation and success. Also, there is a mismatch between successful recanalization of the blood vessel, recovery of the neurological status as well as treatment outcome. Precisely for these reasons, there is a need for a better understanding of pathophysiology events in the acute IS and for the development of new therapeutic procedures that would include neuroprotection, modification of the inflammatory response and preservation of the integrity of the blood-brain barrier. Acute IS occurs as a result of a blood vessel blockage, which leads to ischemic damage to the brain parenchyma. It causes an early inflammatory response that is extremely complex, involving a large number of inflammatory cytokines whose dynamics and role in the pathophysiology of IS are insufficiently investigated. It is known that inflammatory processes damage the endothelial glycocalyx (EG), a thin luminal layer of the endothelium that has numerous functions such as maintaining the integrity of blood vessels and regulating tone, and itself participates in the inflammatory response. In the brain, EG is a key regulator of the integrity of the blood-brain barrier, and its damage makes the barrier more permeable, which can lead to edema and the passage of potentially harmful substances. Clinical studies have shown that there is a possible relationship between the prognosis of patients with IS and the concentration of EG breakdown products in the peripheral blood. However, the relationship between changes in EG and the inflammatory process in the context of IS, and especially in relation to available treatment methods, remains unclear. The aim of the proposed study is to determine and analyze the dynamics of concentrations of EG degradation products and inflammatory cytokines in patients with acute IS during and after MT. This study would include all adult patients with acute IS who will undergo MT, and the concentrations of EG degradation products and inflammatory cytokines would be determined by the enzyme immunoassay method from peripheral blood and blood samples from the cerebral circulation after reperfusion. The obtained results will be correlated with the collected data on the neurological condition of the patient before and after the intervention, the type and course of the intervention performed, the course and duration of hospital treatment, the occurrence of complications and the outcome of treatment.",[27,28,29],"Stroke","Thrombectomy","Endothelial Glycocalyx","NOT_YET_RECRUITING","2025-12-05",{"date":33,"type":34},"2025-12-18","ACTUAL",{"date":36,"type":22},"2026-01",{"date":38,"type":22},"2030-10",{"name":40,"class":41},"Clinical Hospital Centre Zagreb","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":52,"conditions":53,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100567596","evaluation-of-endothelial-glycocalyx-in-the-surgical-resuscitation-of-major-burn-patients-100567596","NCT06670248","Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients","GlycoBURN Study: Determination of Endothelial Glycocalyx Status in the Surgical Resuscitation of Severe Burn Patients","GlycoBURN","Inclusion Criteria:\n\n* Patients over 18 years old with burned TBSA greater than or equal to 20%.\n* Patients who will undergo debridement of at least 20% of the burned TBSA (including the debrided area and the donor site).\n\nExclusion Criteria:\n\n* Under 18 years old.\n* Pregnant women.\n* Patient refusal.\n* Polytraumatized patients.\n* Electrical or chemical burns.\n* Patients with any of the following pre-burn conditions: complicated heart disease\\*, renal disease on hemodialysis\u002Fhemofiltration or with Glomerular Filtration Rate (GFR) \\\u003C 30 ml\u002Fmin\u002F1.73m², and liver cirrhosis (Child A, B, and C).\n\n(\\* Definition of complicated heart disease: decompensated heart failure (NYHA class IV), Left Ventricular Ejection Fractio \\\u003C 40%, or severe valvular disease).\n\n* Patients with a history of chronic inflammatory diseases (autoimmune disease).\n* Patients on chronic treatment with corticosteroids or immunosuppressants.\n* Patients requiring reintervention for debridement surgery who have already been included in the study during their first surgery.",{"count":51,"type":22},40,"The purpose of this observational study is to examine whether Endotheliopathy of Trauma (EoT) is present in severely burned patients and how it is affected by burn debridement surgery.\n\nThe main questions it aims to answer are:\n\n* Do severely burned patients present with EoT before undergoing burn debridement surgery?\n* Does the surgical intervention worsen EoT, leading to increased postoperative syndecan 1 (sdc 1) levels compared to preoperative levels?\n\nParticipants will:\n\n* Undergo debridement surgery where the total area of debrided and donor sites covers 20% or more of the Total Body Surface Area (TBSA).\n* Have their sdc 1 levels measured before and after surgery.\n* Have perioperative factors analyzed to assess their impact on endothelial damage and glycocalyx functionality.\n\nThis study aims to provide insight into how surgical resuscitation affects the endothelial glycocalyx in severely burned patients.",[54,55,56,29,57,58],"Syndecan 1","Severe Burn","Endotheliopathy of Trauma","Hemorrhagic Shock","Postoperative Complications",[54,60,61,62,63],"Endotheliopathy","Glycocalyx","Proteoglycan","Severe burn","RECRUITING","2024-10-30",{"date":67,"type":34},"2024-11-01",{"date":69,"type":34},"2024-03-05",{"date":71,"type":22},"2026-09",{"name":73,"class":41},"Hospital Universitari Vall d'Hebron Research Institute",1]