[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"energy-balance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:energy-balance":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,50,80,104,131,160],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100640449","the-role-of-estradiol-and-progesterone-on-appetite-regulation-and-energy-balance-100640449",false,"NCT07620587","The Role of Estradiol and Progesterone on Appetite Regulation and Energy Balance","E2 & P4 in EB","Inclusion Criteria:\n\n* ages 18-30 years\n* deemed healthy using Canadian Society for Exercise Physiology Get Active Questionnaire (CSEP-GAQ)\n* non-smoking\n\nExclusion Criteria:\n\n* failure to meet inclusion criteria\n* contraindications to exercise as indicated by the (CSEP-GAQ)\n\n  * hypersensitivity or allergy to estradiol, progesterone, cellulose, or capsule components\n  * having been diagnosed with any metabolic disease (ie. diabetes, metabolic syndrome) or current diagnosis of overweight\u002Fobesity (BMI \\> 30.0)\n  * personal of family history of stroke or thrombotic (blood clot) disease, blood clot disorder, venous or arterial thromboembolic disease, or any possible blood clotting disease\n  * currently taking anticoagulants, antidiabetic medications, cyclosporine, antihypertensives, and CYP3A4 inducers or inhibitors (e.g., rifampin, ketoconazole, St. John's Wort)\n  * known liver dysfunction or liver disease\n  * history of ophthalmic vascular disease\n  * hormone-dependent malignancies or previous diagnosis of cancer\n  * recent major surgery (within \\~6 months)\n  * prolonged use of a cast or presence of immobility deeming inability to exercise, diagnosis of inflammatory disorders (ie. rheumatoid arthritis, celiac disease, inflammatory bowel disease)\n  * history of sensitivity to or extreme nausea\u002Fvomiting or any gastrointestinal disorder\n  * diagnosis of mental health or mood disorder\n  * presence of abnormal eating behaviours as assessed by the Food Cravings State Questionnaire and the Three Factor Eating Questionnaire\n  * diagnosed or presence of porphyria or classical migraines",true,"MALE","18 Years","30 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to determine if estradiol and progesterone are involved in appetite regulation and energy balance. The study aims to complete a 13 day randomized controlled trial (RCT) where oral supplementation of estradiol only, progesterone only, a combination of each, or a placebo in young males will be provided. During the supplementation period, participants will complete two in-lab sessions where they will complete an acute bout of high-intensity interval training or a period of seated rest (completed on separate days by each participant) and have blood samples and perceptions of appetite measured taken over the course of the in-lab sessions. At the end of each session participants will consume an ad-libitum meal and participants will also track free-living energy intake and wear a thigh-worn accelerometer to measure energy expenditure for three days (day before, day of, and day after) each in-lab session.",[28,29],"Energy Balance","Physiology - Regulation of Appetite and Food Intake",[31,32,33,34,35,36],"ovarian hormones","energy intake","appetite regulation","appetite-regulating hormones","energy balance","regulation of food intake","RECRUITING","2026-05-26",{"date":40,"type":41},"2026-06-02","ACTUAL",{"date":43,"type":22},"2026-06-01",{"date":45,"type":22},"2028-08-31",{"name":47,"class":48},"Wilfrid Laurier University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":49},"100640788","lifestyle-intervention-to-improve-muscle-function-in-older-adults-100640788","NCT07597980","Lifestyle Intervention to Improve Muscle Function in Older Adults","Inclusion Criteria:\n\n1. Age \\> 50 years.\n2. Body mass index (BMI) ≥ 30 kg\u002Fm2.\n3. Homeostatic model assessment of insulin resistance ≥ 3.\n4. Mini-Mental State Examination (MMSE) \\> 25.\n5. Geriatric Depression Scale-15 (GDS-15) \\\u003C 9.\n6. Sedentary (less than 90 minutes\u002Fweek of moderate to vigorous activity).\n7. Ability to provide written informed consent.\n\nExclusion Criteria:\n\n1. Diagnosis of cancer (received within five years) or diabetes (type 1 and 2), or significant musculoskeletal, or cardiovascular, or hepatic, or renal, disease or dysfunction.\n2. Clinically significant gastrointestinal malabsorption syndromes such as chronic diarrhea, celiac disease, or clinically significant abnormal laboratory markers.\n3. Fluctuation in body weight \\> 3 kg in the preceding two months\n4. Condition that impedes testing of the study hypothesis or makes it unsafe to exercise or consume the study foods.","ALL","50 Years",{"count":59,"type":22},80,[25],"The goal of this randomized controlled two-arm trial is to determine the effect of a diet and exercise intervention for 12 weeks on body composition, muscle function, and energy balance in 80 adults aged 50 years and over with obesity and insulin resistance. The main questions the trial aims to answer are: Will 12 weeks of a structured nutrition plan + exercise reduce fat mass, improve muscle function, and increase energy deficit compared to the usual diet + exercise. The hypothesis is that 12 weeks of a structured nutrition plan + exercise will reduce fat mass, improve muscle function, and produce greater energy deficit than the usual diet + exercise. Participants will be provided with all meals for 12 weeks and will exercise at the Center under supervision three times each week. Pre and post-intervention, body composition, physical function, and energy deficit will be measured.",[63,64,28],"Body Composition","Physical Function",[66,67,68,69],"Fat mass","muscle mass","physical function","energy deficit","NOT_YET_RECRUITING","2026-05-19",{"date":73,"type":41},"2026-05-22",{"date":75,"type":22},"2026-06",{"date":77,"type":22},"2030-12",{"name":79,"class":48},"Pennington Biomedical Research Center",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":16,"sex":56,"minAge":86,"maxAge":19,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":49},"100627083","effect-of-resistance-exercise-on-energy-balance-and-appetite-regulation-in-males-and-females-100627083","NCT07444021","Effect of Resistance Exercise on Energy Balance and Appetite Regulation in Males and Females","Inclusion Criteria:\n\n* Healthy males and females aged 20-30 years\n* Females with a regular menstrual cycle\n* Stable body weight, defined as no significant change in body weight during the past 6 months\n* Willingness to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Obesity, defined as:\n* Body mass index (BMI) \\> 30 kg\u002Fm²\n* Body fat percentage \\> 25% in males\n* Body fat percentage \\> 30% in females\n* Hypertension, defined as resting blood pressure \\> 140\u002F90 mmHg\n* History of cardiovascular disease\n* History of cancer\n* History of liver disease\n* History of kidney disease\n* Presence of any medical condition that may interfere with study outcomes","20 Years",{"count":88,"type":22},30,[25],"There is growing evidence that males and females may exhibit different acute responses and long-term adaptations to exercise training. Accordingly, contemporary exercise physiology research increasingly recognizes sex as an important biological variable that may influence appetite regulation and energy balance.\n\nThis year's project aims to investigate: (1) appetite regulation and energy balance following acute resistance exercise, and (2) potential sex-based differences in appetite regulation and energy balance in response to resistance exercise.\n\nUnderstanding both the overall effects of resistance exercise and sex-related variability in these responses is important for improving the physiological interpretation of exercise-induced changes in appetite and energy balance. Such knowledge may help to reduce heterogeneity in exercise research findings and support the development of more precise, evidence-based exercise prescriptions that are applicable to both males and females.",[28,92,93,94],"Energy Expenditure","Males and Females","Resistance Exercise","2026-02-25",{"date":97,"type":41},"2026-03-02",{"date":99,"type":41},"2025-12-01",{"date":101,"type":22},"2026-12-30",{"name":103,"class":48},"National Taiwan Normal University",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":16,"sex":112,"minAge":18,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":49},"100501310","healthy-mom-zone-gestational-weight-gain-management-intervention-20-100501310","NCT05807594","Healthy Mom Zone Gestational Weight Gain Management Intervention 2.0","Efficacy of a Novel Digital Platform to Scale-Up a Personalized Prenatal Weight Gain Intervention Using Control Systems Methodology","HMZ Two","Inclusion Criteria:\n\n* Pregnant women\n* ≥ 8 and \\\u003C 18 weeks gestation at time of screening. This range of gestational age is chosen to: a) reduce chances of false pregnancy or miscarriage under 8 weeks gestation and b) recruit women in the 1st trimester for greatest impact of the intervention on gestational weight gain. In the feasibility and initial impact study, the investigators had less than 10% (n=3) miscarriages prior to randomization using these criteria\n* Singleton gestation\n* Not currently heavily smoking (\\>20 cigarettes\u002Fday)\n* Any parity (i.e., first-time pregnancy, second pregnancy, etc.)\n* Any race\u002Fethnicity\n* Ages 18-45 years\n* Body mass index (BMI) range 20.0 to 45.0. If BMI is over 40, consultation with woman's health care provider will be made to determine eligibility and ensure she does not have any contraindications to physical activity or other concerns with intervention participation.\n* Haven't exceeded 25% or more of their total GWG (based on BMI and IOM guidelines) from pre-pregnancy to date of enrollment.\n* Participant has physician consent to confirm subject participation\n* Able to read, understand, and speak English\n* Access to a computer\u002Fphone\n* Willingness and ability to complete study materials and intervention sessions electronically (e.g., email, Facetime, Zoom), at home (e.g., Zoom sessions delivered synchronous and asynchronous) or if requested by the participant, on-site at Penn State University Park or Hershey campuses.\n* No current use of weight loss medications\n* No current participation in another interventional study or program that influences weight control\n* No planned bariatric surgery during this current pregnancy\n* No absolute contraindications to exercise in pregnancy and relative contraindications with provider consent (see below)\n\nExclusion Criteria:\n\n* Not pregnant women\n* Men (unable to become pregnant)\n* Multiple gestation\n* \\\u003C 8 weeks gestation or \\> 18 weeks gestation at time of pre-intervention assessment\n* Currently smoking \\> 20 cigarettes\u002Fday\n* Outside of the age range of 18-45 years\n* Outside of the BMI range of 20.0-45.0\n* Exceeded 25% of their total GWG (based on BMI and IOM guidelines) from pre-pregnancy to date of enrollment\n* Not able to read and\u002For understand English\n* Unable to access materials by computer or phone (even with data plan assistance if necessary)\n* Current use of weight loss medications\n* Current participation in another interventional study or program that influences weight control\n* Planned bariatric surgery during this current pregnancy\n* Contraindications to aerobic exercise in pregnancy:\n\nAbsolute contraindications to exercise:\n\n* Hemodynamically significant heart disease\n* Restrictive lung disease (pulmonary fibrosis, sarcoidosis, pleural effusion, neuromuscular disease). This DOES NOT include ASTHMA\n* Incompetent cervix\u002Fcerclage\n* Severe anemia\n* Multiple gestation at risk for premature labor\n* Persistent 2nd or 3rd trimester bleeding\n* Placenta previa after 26 weeks gestation\n* Premature labor during the current pregnancy\n* Ruptured membranes\n* Poorly controlled chronic hypertension\n* Preeclampsia diagnosis during current pregnancy\n* Poorly controlled Type 1 diabetes\n\nRelative contraindications to exercise (if permission is not given by provider):\n\n* Unevaluated maternal cardiac arrhythmia\n* Chronic bronchitis\n* Extreme morbid obesity (BMI \\> 40.0; needs provider consent to participate)\n* Extreme underweight (BMI \\\u003C 12.0)\n* History of extremely sedentary lifestyle\n* Current eating disorder(s) diagnosis\n* Severe food allergies and\u002For dietary restrictions that may preclude study participation.\n* Intrauterine growth restriction in current pregnancy\n* Poorly controlled respiratory disorder (severe asthma) that precludes study participation\n* Orthopedic limitations\n* Poorly controlled seizure disorder\n* Poorly controlled thyroid disease\n* Uncontrolled sleep disorder (insomnia, sleep-disordered breathing)","FEMALE","45 Years",{"count":115,"type":22},144,[25],"The goal of this clinical trial is to see if the enhanced HMZ 2.0 intervention with new control system\u002Fdigital platform to regulate gestational weight gain (GWG) and impact maternal-infant outcomes while collecting implementation data works and can be given to other pregnant women in various settings. The question this study aims to answer are:\n\n1. Does the new intervention manage GWG?\n2. Does the new intervention have any influence on sleep and eating behaviors and infant outcomes.\n3. Does the new platform and other data collected help inform how well the research and information can be used in health care settings?\n\n144 pregnant women with overweight\u002Fobesity will be randomized to either the HMZ 2.0 intervention or attention control groups from \\~8-36 weeks gestation. All participants will be asked to:\n\n1. Weight themselves and wear an activity monitor each day over the study.\n2. Complete online surveys at either a weekly or monthly level about their thoughts, attitudes, and behaviors on GWG, physical activity, eating behaviors, sleep, their anxiety, depression, and stress.\n3. Attend weekly sessions with a registered dietician.\n\nThe weekly sessions will differ based on intervention group. The HMZ 2.0 intervention group will receive education, create and follow goal-setting and action plans, self-monitor their behaviors, and receive feature evidence and fetal growth facts. Education, goals, and self-monitoring will focus on GWG, physical activity, eating behaviors, sleep, self-regulating behaviors and emotions, and preparing for labor\u002Fdelivery and postpartum.\n\nThe attention control group will receive weekly sessions on preparing for labor\u002Fdelivery and benefits of behavioral pain management strategies (e.g., mindfulness-based relaxation, imagery, music, massage, deep-breathing) to help with pain after childbirth without medicine.",[119,120,121,28],"Gestational Weight Gain","Overweight and Obesity","Pregnancy","2026-01-14",{"date":124,"type":41},"2026-01-16",{"date":126,"type":41},"2023-11-27",{"date":128,"type":22},"2028-01-31",{"name":130,"class":48},"Penn State University",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":16,"sex":56,"minAge":18,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":142,"briefSummary":143,"conditions":144,"keywords":148,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":49},"100602382","impact-of-diet-induced-change-in-energy-balance-on-metabolism-in-endurance-athletes-100602382","NCT07122778","Impact of Diet-induced Change in Energy Balance on Metabolism in Endurance Athletes","Impact of Diet-induced Change in Energy Balance on Metabolism in Endurance Athletes: the Carpe DIEM Study","Carpe DIEM","Inclusion Criteria:\n\n* Self-identified endurance-trained sport participants\n* Training volume: \\>7 hours per week endurance training\n* Training frequency: at least 5 days per week\n\nExclusion Criteria:\n\n* Diagnosis of Relative Energy Deficiency in Sport (REDs)\n* Active eating disorder (EDE-Q)\n* Active flare of a chronic disease (e.g. inflammatory bowel disease)\n* Type 1 or 2 diabetes mellitus\n* Untreated or undergoing active treatment of anaemia (any cause)\n* Current injury which precludes undertaking high volume endurance training\n* Individuals following a habitual low-carbohydrate, high-fat diet\n* Any medical diagnosis which precludes intense exercise (e.g. untreated cardiac arrhythmia)\n* Allergy or intolerance to study foods\n* Blood donation within preceding 8 weeks of study start date\n* Use of medications that affect substrate utilisation (e.g. statins, corticosteroids, thyroxine, HRT)\n* For females: current pregnancy, breastfeeding within past 6 months or post-menopausal\n* Unable to undertake a treadmill running test\n* Participation in any research study in the past 8 weeks\n* Participation in a research study within the past year involving more than one DEXA scan\n* Unable to provide informed consent due to impaired cognitive capacity or decision-making ability","49 Years",{"count":141,"type":22},20,[25],"Recent research has suggested that increasing levels of physical activity are associated with a reduction in the independent components that contribute to total energy expenditure (such as resting metabolic rate and non-exercise movement) - this occurs to conserve energy required for physical activity where energy provision becomes scarce. There are potential deleterious health and performance consequences of a reduced energy supply to fundamental metabolic processes, putting individuals regularly undertaking high levels of physical activity, such as endurance athletes, at risk. However, this association is largely based on observational data in only moderately active populations, and it is currently unclear what role energy balance status and biological sex has on this relationship.\n\nThis research intends to address these unknowns by assessing the impact of diet-induced manipulation of energy balance (conditions of energy deficit and energy surplus) in individuals undertaking habitually high levels of physical activity on independent components of total energy expenditure (resting metabolism, exercise and non-exercise movement).\n\nMale and female athletes conducting regular moderate-to-high training volumes will undertake a randomised crossover study with a 7-day state of energy deficit and a 7-day state of energy surplus. Participants will continue to live and train as normal, but their diet will be controlled by specific food provision over the intervention periods in order to facilitate both conditions. Independent components of energy expenditure, markers of health, metabolism and performance will be measured to allow for comparison of conditions.",[28,145,146,147],"Energy Deficit","Low Energy Availability","Relative Energy Deficiency in Sport",[69,35,149,150],"energy availability","physical activity","2025-08-11",{"date":153,"type":41},"2025-08-14",{"date":155,"type":22},"2025-08",{"date":157,"type":22},"2027-05",{"name":159,"class":48},"University of Bath",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":16,"sex":17,"minAge":86,"maxAge":19,"enrollmentInfo":167,"targetDuration":4,"studyType":23,"phases":169,"briefSummary":170,"conditions":171,"keywords":175,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":49},"100558300","timing-and-resistance-exercise-impact-on-eating-and-metabolism-100558300","NCT06549322","Timing and Resistance Exercise: Impact on Eating and Metabolism","The Efficacy of Exercise Timing - Effects of Resistance Exercise on Eating Behavior and Energy Metabolism","Inclusion Criteria:\n\n* Age: 20-30\n* weight stable for at least 6 months\n\nExclusion Criteria:\n\n* Obesity (BMI \\> 30 kg\u002Fm² or body fat percentage \\> 25%)\n* Hypertension (blood pressure over 140\u002F90 mmHg)\n* Heart disease\n* Cancer\n* Liver or kidney diseases\n* Any other conditions that could potentially influence the study's outcomes",{"count":168,"type":22},18,[25],"Exercise timing (morning or evening) for optimal weight control is a research topic urgently addressed by scholars in the relevant field. Due to the better control of energy metabolism and physical activity levels in the morning, existing research on resistance exercise and eating behavior primarily focuses on experiments conducted in the morning, with only one study in the afternoon. No research has yet compared the potential differences between morning and evening resistance exercise. A one-year study aims to investigate the impact of morning and evening resistance exercise on physiological metabolism and eating behavior. Eighteen healthy male participants will be randomly assigned to a crossover design study, including AM exercise, PM exercise, and control (rest condition) trials. Variables including subjective appetite, appetite hormones (ghrelin, peptide YY), food preferences, ad libitum eating, dietary records, energy expenditure, and PBMCs circadian rhythm genes will be measured. This preliminary study through a multidimensional observation, the results will contribute to understanding the potential differences and mechanisms of morning and evening resistance exercise on physiological metabolism and eating behavior. In practical applications, conducting resistance exercise in the evening or at night aligns better with current lifestyles. The findings of this study can support the optimization of exercise benefits by validating the choice of exercise timing.",[172,28,173,174],"Circadian Rhythm","Appetitive Behavior","Food Reward",[176,177],"resistance exercise","energy expenditure","2024-08-08",{"date":180,"type":41},"2024-08-12",{"date":182,"type":22},"2024-09-01",{"date":184,"type":22},"2025-12-30",{"name":103,"class":48}]