[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"energy-deficit\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:energy-deficit":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100602382","impact-of-diet-induced-change-in-energy-balance-on-metabolism-in-endurance-athletes-100602382",false,"NCT07122778","Impact of Diet-induced Change in Energy Balance on Metabolism in Endurance Athletes","Impact of Diet-induced Change in Energy Balance on Metabolism in Endurance Athletes: the Carpe DIEM Study","Carpe DIEM","Inclusion Criteria:\n\n* Self-identified endurance-trained sport participants\n* Training volume: \\>7 hours per week endurance training\n* Training frequency: at least 5 days per week\n\nExclusion Criteria:\n\n* Diagnosis of Relative Energy Deficiency in Sport (REDs)\n* Active eating disorder (EDE-Q)\n* Active flare of a chronic disease (e.g. inflammatory bowel disease)\n* Type 1 or 2 diabetes mellitus\n* Untreated or undergoing active treatment of anaemia (any cause)\n* Current injury which precludes undertaking high volume endurance training\n* Individuals following a habitual low-carbohydrate, high-fat diet\n* Any medical diagnosis which precludes intense exercise (e.g. untreated cardiac arrhythmia)\n* Allergy or intolerance to study foods\n* Blood donation within preceding 8 weeks of study start date\n* Use of medications that affect substrate utilisation (e.g. statins, corticosteroids, thyroxine, HRT)\n* For females: current pregnancy, breastfeeding within past 6 months or post-menopausal\n* Unable to undertake a treadmill running test\n* Participation in any research study in the past 8 weeks\n* Participation in a research study within the past year involving more than one DEXA scan\n* Unable to provide informed consent due to impaired cognitive capacity or decision-making ability",true,"ALL","18 Years","49 Years",{"count":22,"type":23},20,"ESTIMATED","INTERVENTIONAL",[26],"NA","Recent research has suggested that increasing levels of physical activity are associated with a reduction in the independent components that contribute to total energy expenditure (such as resting metabolic rate and non-exercise movement) - this occurs to conserve energy required for physical activity where energy provision becomes scarce. There are potential deleterious health and performance consequences of a reduced energy supply to fundamental metabolic processes, putting individuals regularly undertaking high levels of physical activity, such as endurance athletes, at risk. However, this association is largely based on observational data in only moderately active populations, and it is currently unclear what role energy balance status and biological sex has on this relationship.\n\nThis research intends to address these unknowns by assessing the impact of diet-induced manipulation of energy balance (conditions of energy deficit and energy surplus) in individuals undertaking habitually high levels of physical activity on independent components of total energy expenditure (resting metabolism, exercise and non-exercise movement).\n\nMale and female athletes conducting regular moderate-to-high training volumes will undertake a randomised crossover study with a 7-day state of energy deficit and a 7-day state of energy surplus. Participants will continue to live and train as normal, but their diet will be controlled by specific food provision over the intervention periods in order to facilitate both conditions. Independent components of energy expenditure, markers of health, metabolism and performance will be measured to allow for comparison of conditions.",[29,30,31,32],"Energy Balance","Energy Deficit","Low Energy Availability","Relative Energy Deficiency in Sport",[34,35,36,37],"energy deficit","energy balance","energy availability","physical activity","NOT_YET_RECRUITING","2025-08-11",{"date":41,"type":42},"2025-08-14","ACTUAL",{"date":44,"type":23},"2025-08",{"date":46,"type":23},"2027-05",{"name":48,"class":49},"University of Bath","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":17,"sex":18,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":50},"100576380","the-effects-of-repeated-operational-stress-and-limited-recovery-on-resilience-capacity-100576380","NCT06784544","The Effects of Repeated Operational Stress and Limited Recovery on Resilience Capacity","REP DEF","Inclusion Criteria:\n\n* Men and women aged 18 - 39 years (17 - 39 years if military personnel)\n* Weight stable in the past 2 months (± approximately 5 kg)\n* Healthy without evidence of chronic illness or musculoskeletal injury as determined by the USARIEM Office of Medical Support and Oversight (OMSO) or home duty station medical support (HMS)\n* Functional exercise (i.e., step ups, box jumps, body mass movements) and\u002For aerobic exercise trained defined by self-report as performing ≥ 2 sessions\u002Fwk for previous 6 months\n* Willing to refrain from alcohol, smoking any nicotine product (includes e-cigarettes); vaping, chewing tobacco, caffeine not provided in the study, and dietary supplement use throughout the dietary interventions\n* Biological females must be on sustained (i.e., approximately \\>3 months) oral\u002Fhormonal contraceptive use which acts to maintain continuous hormonal levels (i.e., contains low-dose estrogen\u002Fprogesterone with no oral placebos, hormonal IUD)\n* Supervisor approval for federal civilian employees and non-HRV active duty military personnel)\n\nExclusion Criteria:\n\n* Musculoskeletal injuries that compromise exercise capability as determined by OMSO or HMS\n* Metabolic or cardiovascular abnormalities, sleep disorders (i.e., sleep apnea) gastrointestinal disorders (e.g., kidney disease, diabetes, cardiovascular disease, etc.) as determined by OMSO or HMS\n* Abnormal or problems with blood clotting as determined by OMSO or HMS\n* History of complications with lidocaine or similar local anesthetic analogue\n* Present condition of alcoholism, anabolic steroids, or other substance abuse issues\n* Blood donation within 8-wk of beginning or completing study blood draws\n* Current diagnosis of Anemia (hemoglobin \\\u003C 13 g\u002FdL for males, hemoglobin \\\u003C 12 g\u002FdL for females) and Sickle Cell Anemia\u002FTrait as determined by OMSO or HMS\n* Pregnant, trying to become pregnant, and\u002For breastfeeding (results of urine pregnancy test or self-report for breastfeeding will be obtained before body composition testing)\n* Claustrophobia or discomfort related to having enclosed equipment around the head\n* Unwillingness or inability to consume study diets or foods provided due to personal preference or food allergies\u002Fsensitivities\n* Unwillingness or inability to adhere to study exercise restrictions and prescriptions","17 Years","39 Years",{"count":61,"type":23},24,[26],"This longitudinal study will examine the effects of repeated bouts of operational stress and limited recovery on integrated MPS, whole-body protein balance, iron absorption, and aerobic performance. Following baseline characterization measures, active adults (n=24) representative of normal weight phenotype (NW; n=12) and overweight phenotype (OW; n=12) will complete a 48h balance phase preceding two rounds of repeated 72h energy deficit exposure each immediately followed by a 48h recovery phase. NW cutoff will be defined ≤ 22% body fat for males and ≤ 32% body fat for females. OW cutoff will be defined as \\>22% body fat for males and \\>32% body fat for females. These body composition cutoffs are informed by the maximum allowable percent body fat standards outlined in current Army Regulation 600-9. Additional details for determining % body fat are outlined in the experimental procedures section of the protocol.",[65,30,66,67],"Sleep, Inadequate","Iron Absorption","High Physical Activity","2025-01-14",{"date":70,"type":42},"2025-01-20",{"date":72,"type":23},"2025-05",{"date":74,"type":23},"2025-11",{"name":76,"class":77},"United States Army Research Institute of Environmental Medicine","FED"]