[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"enteral-nutrition-intolerance-efi\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:enteral-nutrition-intolerance-efi":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":5},"100632777","serum-bicarbonate-and-enteral-feeding-intolerance-in-adult-icu-a-prospective-clinical-trial-100632777",false,"NCT07518095","Serum Bicarbonate and Enteral Feeding Intolerance in Adult ICU: A Prospective Clinical Trial","Serum Bicarbonate and Enteral Feeding Intolerance in Adult ICU Patients: A Prospective Clinical Trial","Inclusion Criteria:\n\n* Adult patients aged 18 and older.\n* Patients started on enteral nutrition (EN) within the first 48 hours of their intensive care unit admission.\n* Patients predicted to remain in the intensive care unit for at least 72 hours.\n* Patients (or their legal representatives) who have provided consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients under the age of 18.Individuals who are currently pregnant or breastfeeding.\n* Patients with gastrointestinal (GI) perforation, active GI bleeding, or mechanical bowel obstruction.\n* Patients who have undergone major abdominal surgery (e.g., esophagectomy, gastrectomy) within the last month.\n* Patients receiving total parenteral nutrition (TPN) or those who are only fed orally.\n* Patients requiring specialized enteral formulas (e.g., diabetic, renal, immunomodulatory, elemental, or semi-elemental) due to clinical necessity.\n* Patients with a known diagnosis of diabetes or those with HbA1c \\>6.5 requiring a diabetic enteral formula.\n* Patients with terminal-stage malignancy or those requiring specific enteral nutrition protocols.\n* Patients with advanced (Child-Pugh C) liver failure.\n* Patients with chronic kidney failure requiring dialysis.\n* Patients with diabetic ketoacidosis, severe metabolic asidozis, or those requiring initial bicarbonate replacement.\n* Patients who are brain dead or in the palliative care stage.","ALL","18 Years",{"count":19,"type":20},70,"ESTIMATED","OBSERVATIONAL","This prospective, observational study evaluates whether serum bicarbonate HCO3 levels can predict enteral nutrition intolerance (EFI) in adult ICU patients.Objective: To determine if lower HCO3 levels correlate with the development of EFI.Design: A 12-month study involving 70 participants at Sultangazi Haseki Training and Research Hospital.Methodology: Patients starting enteral nutrition within 48 hours of admission will be monitored for 72 hours. Daily HCo3 pH, and lactate levels will be recorded from routine morning blood draws.Hypothesis: Lower bicarbonate levels are an independent predictor of EFI development in critically ill patients.",[24],"Enteral Nutrition Intolerance (EFI)","NOT_YET_RECRUITING","2026-04-01",{"date":28,"type":29},"2026-04-08","ACTUAL",{"date":31,"type":20},"2026-04-15",{"date":33,"type":20},"2027-01-15",{"name":35,"class":36},"Istinye University","OTHER"]