[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"enteral-nutrition-intolerance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:enteral-nutrition-intolerance":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100633009","predictive-value-of-gastrointestinal-blood-flow-for-enteral-nutrition-intolerance-in-critically-ill-patients-100633009",false,"NCT07521111","Predictive Value of Gastrointestinal Blood Flow for Enteral Nutrition Intolerance in Critically Ill Patients","Study on the Predictive Value of Gastrointestinal Blood Flow for Enteral Nutrition Intolerance in Critically Ill Patients","Inclusion Criteria:\n\n* Age \\> 18 years old.\n* Expected duration of enteral nutrition support \\> 7 days.\n* Patients or their legal representatives sign the informed consent form.\n\nExclusion Criteria:\n\n* History of major gastrointestinal surgery such as subtotal gastrectomy and gastrointestinal anastomosis.\n* Contraindications to abdominal point-of-care ultrasound (POCUS) examination (e.g., recent large-area abdominal burns, dressings blocking movement, open abdomen).\n* Presence of severe gastrointestinal diseases such as gastroparesis, intestinal obstruction, digestive tract perforation, and gastrointestinal bleeding upon admission.\n* Presence of severe peripheral vascular disease or valvular heart disease.\n* Pregnant or lactating women.","ALL","18 Years",{"count":19,"type":20},500,"ESTIMATED","28 Days","OBSERVATIONAL","This study aims to explore the correlation between gastrointestinal blood flow and the incidence of enteral nutrition intolerance (ENI) and its symptoms in critically ill patients, construct and compare predictive models including blood flow parameters, and evaluate their incremental predictive value.",[25,26,27,28,29],"Critical Illness","Enteral Nutrition Intolerance","Enteral Nutrition Feeding","Prediction Models","Machine Learning","RECRUITING","2026-04-02",{"date":33,"type":34},"2026-04-09","ACTUAL",{"date":36,"type":34},"2026-01-25",{"date":38,"type":20},"2027-06-30",{"name":40,"class":41},"Ruijin Hospital","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100618913","implementation-of-clinical-nutrition-practice-guidelines-in-surgical-icus-100618913","NCT07337798","Implementation of Clinical Nutrition Practice Guidelines in Surgical ICUs","Effects of Implementing Evidence-Based Clinical Nutrition Practice Guidelines in Surgical Intensive Care Units: A Cohort Study","Inclusion Criteria:\n\nFor ICU healthcare professionals:\n\nEmployed at one of the participating study sites (tertiary general hospitals)\n\nHolds a valid Registered Nurse license issued in the People's Republic of China\n\nCurrently working in frontline clinical nursing care in a surgical intensive care unit (ICU) during the study period\n\nAt least 1 year of clinical working experience\n\nAble to understand the study objectives and procedures\n\nWilling to participate and able to provide written informed consent\n\nFor surgical critically ill patients (outcome assessment population):\n\nAged 18 years or older\n\nAdmitted to a surgical ICU due to surgical-related conditions, including trauma, infection, malignancy, or postoperative complications\n\nExpected length of stay in the surgical ICU of at least 48 hours\n\nNo restriction on sex\n\nPatient or legally authorized representative able to provide written informed consent\n\nExclusion Criteria:\n\nFor ICU healthcare professionals:\n\nCurrently pregnant, breastfeeding, or planning pregnancy during the study period\n\nTemporarily assigned, rotating, externally dispatched, on long-term training, or on leave during the study period, making continuous participation impossible\n\nParticipation in other interventional studies that may interfere with the implementation of this study\n\nDetermined by the research team to have cognitive, communication, or other conditions that would make participation inappropriate\n\nFor surgical critically ill patients:\n\nDiagnosed with brain death or awaiting organ donation\n\nPregnant or breastfeeding women\n\nConcurrent participation in other nutrition-related clinical trials",{"count":51,"type":20},200,"INTERVENTIONAL",[54],"NA","The goal of this interventional clinical trial is to evaluate whether the implementation of an evidence-based, context-adapted clinical nutrition practice guideline can improve clinical nutrition management in surgical intensive care units (ICUs) in China. The guideline is selected based on the best available evidence from existing surgical and critical care nutrition guidelines, adapted to the Chinese healthcare context, and implemented using an i-PARIHS-guided translation strategy. The trial involves ICU healthcare professionals working in surgical ICUs of tertiary general hospitals, while assessing nutrition-related clinical outcomes among surgical critically ill patients.\n\nThe main questions it aims to answer are:\n\nDoes guideline implementation improve ICU healthcare professionals' adherence to recommended clinical nutrition practice guidelines?\n\nDoes the implementation of the clinical nutrition practice guideline improve the proportion of surgical critically ill patients who achieve recommended energy and protein intake targets during ICU stay?\n\nResearchers will compare outcomes before and after guideline implementation to determine whether the i-PARIHS-guided guideline translation improves nutrition management processes, healthcare professional performance, and patient-related clinical outcomes.\n\nParticipants will:\n\nComplete baseline and post-implementation assessments related to clinical nutrition knowledge, attitudes, and practices.\n\nParticipate in guideline-based education, training, and implementation activities guided by the i-PARIHS framework.\n\nApply the adapted clinical nutrition practice guideline during routine clinical care in surgical ICUs.\n\nBe evaluated through on-site audits, questionnaires, and clinical data collection during the implementation process.",[57,58,59,60,26],"ICU Patients","Surgical","Nutrition Intervention","Enteral Nutrition",[62,63,64,65,66],"Clinical Nutrition","Surgical Intensive Care Units","i-PARIHS Framework","Implementation Science","Clinical practice guideline","NOT_YET_RECRUITING","2026-01-11",{"date":70,"type":34},"2026-01-13",{"date":72,"type":20},"2025-12-20",{"date":74,"type":20},"2026-12-31",{"name":76,"class":41},"Xuanwu Hospital, Beijing",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":52,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100599512","the-effect-of-the-timing-of-supplemental-parenteral-nutrition-on-the-prognosis-of-critically-ill-patients-t-spn-100599512","NCT07085455","The Effect of the Timing of Supplemental Parenteral Nutrition on the Prognosis of Critically Ill Patients (T-SPN)","The Effect of the Timing of Supplemental Parenteral Nutrition on the Prognosis of Critically Ill Patients (T-SPN): A Multicenter Randomized Controlled Trial","Inclusion Criteria：\n\n1. Age ≥ 18 years\n2. Failure of one or more organ systems within 24 hours of ICU admission, defined as Sequential Organ Failure Assessment (SOFA) score ≥ 2 in any single organ system\n3. Expected ICU stay \\> 72 hours\n4. Able to initiate early enteral nutrition (EN) within 48 hours of ICU admission\n5. Enteral nutrition providing \\\u003C50% of target caloric requirements within 72 hour Exclusion Criteria\n\n1.Full oral intake or tolerance of full-dose EN; no need for SPN 2.Receiving palliative care or expected to die within 72 hours 3.Pregnant or lactating women 4.Long-term use of systemic corticosteroids or other immunosuppressive agents 5.Known malignancy currently receiving radiotherapy or chemotherapy 6.Contraindications to parenteral nutrition (PN) 7.Participation in another interventional clinical trial",{"count":85,"type":20},946,[54],"This multicenter, randomized controlled trial aims to evaluate whether early initiation of supplemental parenteral nutrition (SPN) (on day 4 of ICU admission) compared to late initiation (on day 8) can reduce 28-day all-cause mortality in critically ill patients. Secondary objectives include assessing the effects of early SPN on long-term functional outcomes (2-year EQ-5D-5L scores), mortality at various timepoints (ICU, 28-day, 90-day, 180-day, and 2-year), ICU length of stay, serum prealbumin levels (days 8 and 28), skeletal muscle measurements (diaphragm thickness, biceps, quadriceps, and rectus femoris cross-sectional area), incidence of ICU-acquired infections, adverse events (e.g., hyperglycemia, hypoglycemia, dyslipidemia, liver dysfunction), and ventilator-free days within 28 days.\n\nEligible patients are adults (≥18 years) with at least one organ failure (SOFA score ≥2) within 24 hours of ICU admission, expected to remain in the ICU for \\>72 hours, and unable to reach 50% of caloric target via enteral nutrition (EN) within the first 72 hours. A total of 946 patients will be enrolled and randomized to receive either early SPN (day 4) or late SPN (day 8) in addition to standard EN. Follow-up will include in-hospital assessments and telephone follow-ups at 28, 90, 180 days, and 2 years. The study hypothesizes that early SPN may improve short-term survival and nutritional\u002Fmuscle status, though its impact on long-term quality of life remains to be determined.",[25,89,26,90],"Organ Dysfunction","Inadequate Nutritional Intake",[92,93,94,95,96,97],"Nutritional support","Supplementary parenteral nutrition","Early enteral nutrition","Severe patients","critical care","intensive care","2025-09-09",{"date":100,"type":34},"2025-09-15",{"date":98,"type":34},{"date":103,"type":20},"2029-07-20",{"name":105,"class":41},"Dong Zhang",2]