[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"enteral-nutrition-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:enteral-nutrition-therapy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100571566","continuous-vs-bolus-protein-protein-regimen-outcomes-in-critically-ill-children-kids-in-distress-100571566",false,"NCT06721923","Continuous vs Bolus Protein (Protein Regimen Outcomes) in Critically Ill Children (Kids In Distress)","Continuous Versus Bolus Dietary Protein and Nutrition Status in the Pediatric Intensive Care Unit: Pilot Study","PRO-KID","Inclusion Criteria:\n\n* Children admitted to PICU over 1 year of age and younger than 11 years of life\n* Expected to remain in the pediatric intensive care unit for longer than 72 hours\n* Receiving standard pediatric formula via NGT\u002FOGT\u002FGT\n\nExclusion Criteria:\n\n* Neuromuscular condition such as muscular dystrophy\n* Admitted with home prescription for high dose steroids, receives growth hormone or insulin\n* Enteral nutrition is contraindicated or if nutrition requirements are partially\u002Ffully met by parenteral nutrition\n* Formula delivered into the small bowel (duodenum\u002Fjejunum, NJT\u002FGJ)\n* Those who require a highly specialized diet (E.g., large burns or metabolic diseases)\n* Patients with a cow's milk protein allergy cannot safely receive a whey-based protein supplement","ALL","1 Year","11 Years",{"count":21,"type":22},96,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this intervention study is to evaluate the difference in nutrition status markers (weight and muscle mass) when giving dietary protein by continuous or bolus delivery in critically ill children ages 1-11y.\n\nThe main questions it aims to answer are:\n\nPrimary: Bolus protein delivery will lessen the decline in mid-upper arm circumference (MUAC) z-score by 0.5 standard deviation in critically ill children aged 1-11y after 1wk. Ultrasound will correlate to MUAC.\n\nSecondary: Bolus protein delivery will provide more (grams per day) than when provided continuously, therefore it is more likely to meet the minimum estimated needs.\n\nParticipants will have daily nutrition intake data collected, and undergo body composition measures (weight, MUAC and ultrasound of the upper thigh muscle) at day of enrollment, and MUAC\u002FUltrasound on follow up days 3, 5, 7 and 14 after the intervention started.",[28,29,30,31],"Critical Illness","Pediatric Intensive Care","Enteral Nutrition Therapy","Dietary Protein",[33,34,35,36,37,38],"enteral nutrition","pediatric critical care","bolus protein delivery","continuous protein delivery","ultrasound","mid-upper arm circumference","RECRUITING","2026-02-09",{"date":42,"type":43},"2026-02-12","ACTUAL",{"date":45,"type":43},"2024-02-13",{"date":47,"type":22},"2027-12-12",{"name":49,"class":50},"University of British Columbia","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100595906","evidence-based-practice-in-the-management-of-gastric-tube-placement-in-children-100595906","NCT07038538","Evidence-based Practice in the Management of Gastric Tube Placement in Children","Evidence-based Practice in the Management of Gastric Tube Placement in Children: A Multicenter Quality Improvement Project","Nurse Inclusion and Exclusion Criteria:\n\nInclusion:\n\n* Nurses who hold a valid and legal nursing license.\n* Nurses who have at least 1 year of clinical nursing experience in pediatric care.\n\nExclusion:\n\n* Nurses who are on leave or not on duty.\n* Nurses working in departments such as the operating room or intravenous compounding center, where nasogastric tube placement is not routinely performed.\n* Nurses who are in training or on internships.\n\nPediatric Patient Inclusion and Exclusion Criteria:\n\nInclusion:\n\n* Hospitalized children Aged 0-18 years.\n* Scheduled for nasogastric tube placement.\n* Parents or legal guardians have signed the informed consent form, agreeing to the child's participation in the study.\n\nExclusion:\n\n* Presence of severe complications or unstable medical conditions.\n* Nasogastric tube is intended for gastrointestinal decompression, drainage, or venting.","18 Years",{"count":61,"type":22},2750,[25],"This multi-center quality improvement project aims to enhance gastric tube placement practices for children by systematically reviewing the latest evidence. The project team will identify gaps between current practices and best evidence, analyze barriers to implementing evidence-based guidelines, and develop strategies to facilitate their integration into clinical settings. The focus will also be on improving the knowledge and skills of pediatric nurses through targeted education and support. Ultimately, this initiative seeks to ensure the safety and effectiveness of gastric tube placement in the pediatric population, leading to better patient outcomes and higher standards of care.",[65,66,30],"Hospitalized Children","Nursing",[68,69,70],"Quality Improvement","Before-and-After Comparison","Cognitive and behavior","2025-09-09",{"date":73,"type":43},"2025-09-10",{"date":75,"type":43},"2025-06-26",{"date":77,"type":22},"2025-12-31",{"name":79,"class":50},"Children's Hospital of Fudan University",22,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":51},"100562903","oral-intake-of-enteral-nutrition-formula-preceding-placement-and-feeding-via-gtube-and-its-impact-on-formula-intolerance-in-pals-100562903","NCT06609213","Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS","Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via G-Tube and Its Impact on Formula Intolerance in pALS","Inclusion Criteria:\n\n* Diagnosis of possible, probable, or definite ALS or motor neuron disease by the treating neurologist (El-Escorial Revisited).\n* Planned tube feeding placement within the following 4 to 6 weeks.\n\nExclusion Criteria:\n\n* History of Crohns disease, inflammatory bowel disease, irritable bowel syndrome, celiac disease, food allergies and\u002For sensitivities to any of the formula ingredients, neurodegenerative disease diagnosis outside of ALS, or other concomitant disorder that might contribute to GI symptoms.\n* Diagnosis of frontotemporal dementia.\n* Nil per oral status.\n* Any reason causing the immediate need for a feeding tube placement, including but not limited to severe malnutrition diagnosis.",{"count":80,"type":22},[25],"The main objective of the proposed study is to evaluate if oral intake of EN formula preceding Gtube placement will impact tolerance upon placement and feeding via Gtube in pALS. This single arm intervention study all participants will receive the intervention and researchers will utilize validated indicators combined with clinical expertise to assess gastrointestinal symptoms of feeding intolerance before and after the intervention.\n\nThe main questions this study aims to answer are:\n\n1. Wil participants meeting a greater percentage of their estimated nutritional needs at baseline present a slower disease progression rate and a lower incidence of GI symptoms of feeding intolerance when feeding via Gtube?\n2. Will there be significant change in feeding intolerance when oral intake of enteral nutrition formula precedes feeding via Gtube?\n\nThis proposed study consists of three stages, as follows:\n\n1. Pre-Intervention: The lead in period of one-week preceding intervention phase I will be timed to initiate 3 weeks before the scheduled Gtube placement procedure. Patients will be advised to maintain their usual food and beverage intake. Dietary intake and GI symptoms data will be collected by research personnel.\n2. Phase I: Dietary intake data collected from the pre-intervention stage will be averaged and used to determine the number of cartons of enteral nutrition formula needed to meet the participants estimated nutritional needs. For two weeks +- 2 days participants will be directed to drink the number of cartons of a pre-selected enteral nutrition formula to meet their estimated nutritional needs when combined to their current oral dietary intake. A plant based EN formula (Kate Farms 1.4 Standard) commonly prescribed for pALS was selected to be provided to all patients in the study to keep this variable constant. Weekly data collection of dietary intake and GI symptoms will be ongoing.\n3. Phase II: At the end of phase I, patients will undergo a Gtube placement at their selected medical facility. For the following two weeks +- 2 days participants will be directed to feed via Gtube the same number of cartons of the enteral nutrition formula used orally on phase I and make no changes to their current oral intake.",[92,93,30],"Amyotrophic Lateral Sclerosis","Gastrointestinal Intolerance",[95,96,97,33,98,99,100,101,102,103],"amyotrophic lateral sclerosis","ALS","Gtube","feeding intolerance","EN intolerance","enteral nutrition intolerance","gastrointestinal symptoms","percutaneous endoscopic gastrostomy","PEG","2025-08-14",{"date":106,"type":43},"2025-08-19",{"date":108,"type":43},"2025-01-10",{"date":110,"type":22},"2026-06",{"name":112,"class":50},"Andrea Charvet"]