[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"enteral-nutrition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:enteral-nutrition":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,47,75,105,136,163,190,220,242],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100616592","phase-1-high-energy-human-milk-diets-in-the-first-two-weeks-after-birth-to-reduce-bpd-in-extremely-preterm-infants-100616592",false,"NCT07307612","High-energy Human Milk Diets in the First Two Weeks After Birth to Reduce BPD in Extremely Preterm Infants","Improving Lung Health in Premature Babies Through Early Nutrition: The More & Early Nutritional Delivery for Bronchopulmonary Dysplasia (MEND-BPD) Trial","MEND-BPD","Inclusion Criteria:\n\n* Gestational age ≤ 28 weeks of gestation\n* Postnatal age \\\u003C 72 hours\n\nExclusion Criteria:\n\n* Congenital malformations\n* Chromosomal anomalies\n* Terminal illness needing to limit or withhold support","ALL","1 Day","3 Days",{"count":21,"type":22},150,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","This Phase II, parallel-group, masked, randomized clinical trial aims to evaluate whether a DHA\u002FARA-enriched, fortified human milk diet administered during the first 14 days of life reduces respiratory morbidity and improves lung function in extremely preterm (EPT) infants (born at ≤28 weeks gestation).",[29,30,31],"Extreme Prematurity","Enteral Nutrition","Bronchopulmonary Dysplasia",[33],"Prematurity; Extreme","NOT_YET_RECRUITING","2026-06-11",{"date":37,"type":38},"2026-06-12","ACTUAL",{"date":40,"type":22},"2026-08-15",{"date":42,"type":22},"2029-07-31",{"name":44,"class":45},"University of Alabama at Birmingham","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100636811","tubeclear-system-evaluation-in-pediatric-patients-100636811","NCT07570537","TubeClear System Evaluation in Pediatric Patients","Inclusion Criteria:\n\n* Males or females under the age of 18 for the entire duration of the study procedure and follow up with an occluded (partial\u002Fsluggish or fully blocked) EAD\n* Indwelling EAD must be NE, NG, NJ tube composed of PVC or polyurethane and is 6-18 FR, 38-140 cm\n* NG tube being used as a J tube inserted through a G tube and is 6-18 Fr; 38-140 cm\n* G and J tubes 10-18 Fr; 20-36cm\n* Specific GJ tubes: G-Jet, MIC, and MIC-KEY Tubes that are size 14-22Fr and have a jejunal length of 15-45cm\n\nExclusion Criteria:\n\n* Wards of the State\n* Positive urine pregnancy test\u002Fpregnant females or inability to take a pregnancy test\n* Any active gastrointestinal abnormalities, including but not limited to infections, inflammation, and\u002For recent abdominal surgery (except for recent gastrostomy placement) or trauma\n* Constant dependency on the EAD for glucose source\n* Unable to tolerate water volume needed for EAD flush\n* Unknown length of EAD\n* Attending physician declines enrollment based on clinical judgment\n* Subject turns 18 years of age during study duration\n* Very low birth weight (\\\u003C1.5kg)","0 Years","17 Years",{"count":56,"type":22},20,[58],"NA","Enteral access devices (EADs) provide necessary hydration, nutrition, and medications to numerous patients in hospitals across the United States. When patient's EAD becomes clogged it can delay administration of important nutrition and medications which can cause adverse effects such as malnutrition, and dehydration, especially in pediatric patients. Traditional methods of unclogging EADs can require the use of special enzymes or chemicals but these produce a variable rate of success. The TubeClear system has been developed to help alleviate the need for use of special enzymes or chemicals and to provide a quick, safe alternative for those with a clogged or sluggish EAD all while at the patient's bedside. This system prevents the need for subsequent exposure to radiation and contrast media for confirmation of EAD location after replacement.",[61,62,30,63,64,65],"Clogged Enteral Access Devices","Occluded Enteral Access Devices","Enteral Access Device","Tube Feeding","Gastric Feeding Tubes","2026-06-04",{"date":68,"type":38},"2026-06-05",{"date":70,"type":22},"2026-07-01",{"date":72,"type":22},"2028-06-01",{"name":74,"class":45},"Children's Mercy Hospital Kansas City",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":46},"100601793","effectiveness-of-high-energy-density-enteral-nutrition-for-enhancing-physical-growth-and-cognitive-brain-development-in-infants-with-congenital-heart-disease-100601793","NCT07115108","Effectiveness of High-Energy Density Enteral Nutrition for Enhancing Physical Growth and Cognitive Brain Development in Infants With Congenital Heart Disease","Effectiveness of High-Energy Density Enteral Nutrition for Enhancing Physical Growth and Cognitive Brain Development in Infants With Congenital Heart Disease: A Randomized Controlled Study","RCT","Inclusion Criteria:\n\n* Diagnosed with congenital heart disease through symptoms, physical signs, imaging, and ultrasound examinations.\n* Age 0-6 months\n* Children with nutritional risks (defined by STRONGkids: Nutritional risk screening tool for children )\n* Artificial or mixed feeding\n* Open heart surgery under cardiopulmonary bypass\n* The guardians of the children voluntarily participate in this study and sign a written informed consent form before the surgery.\n\nExclusion Criteria:\n\n* Diagnosed with major non cardiac diseases leading to nutritional intake disorders, such as congenital gastrointestinal malformations, preoperative diagnosis of gastroesophageal reflux, genetic diseases related to growth restriction, and various syndromes with chromosomal abnormalities (trisomy 21 syndrome, trisomy 18 syndrome)\n* Abnormal immune system function due to congenital or acquired factors, unable to effectively resist pathogens or eliminate abnormal cells, which can be divided into primary and secondary immunodeficiencies.\n* Any pre - operative history of neurological diseases (e.g., encephalitis, epilepsy).\n* Secondary or primary gastrointestinal infection symptoms such as abdominal distension and diarrhea after surgery.\n* Estimated stay time in the postoperative intensive care unit ≤ 2 days","0 Months","6 Months",{"count":86,"type":22},160,[58],"The purpose of this study is to compare the effect of high and ordinary energy density enteral nutrition for improving physical growth and brain cognitive development in infants with congenital heart disease after operation, as well as evaluate the safety of interventions.",[90,30,91],"Congenital Heart Disease","Pediatrics",[93,94,91],"Congenital heart disease","Enteral nutrition","RECRUITING","2026-05-12",{"date":98,"type":38},"2026-05-13",{"date":100,"type":38},"2025-10-13",{"date":102,"type":22},"2026-12-31",{"name":104,"class":45},"Children's Hospital of Fudan University",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":46},"100636890","adherence-to-enteral-nutrition-100636890","NCT07571564","Adherence to Enteral Nutrition","ADHENUTE","Inclusion Criteria:\n\n* Patients hospitalized (including those in the day hospital) in a medical oncology unit;\n* Adults;\n* Men or women;\n* Patients for whom enteral nutrition is indicated according to SFNCM recommendations;\n\nExclusion Criteria:\n\n* Minors (under 18 years of age)\n* Patients receiving end-of-life palliative care\n* Individuals deprived of their liberty or under legal guardianship (including conservatorship);\n* Adults under judicial protection;\n* Inability to participate in the study for geographical, social, or psychological reasons.\n* Persons referred to in Articles L. 1121-5 through L. 1121-8 and L. 1122-1-2 of the Public Health Code (e.g., minors, adults under guardianship, etc.).\n* Patients who do not speak or understand French.","18 Years","100 Years",{"count":115,"type":22},80,"OBSERVATIONAL","Malnutrition is a major challenge in cancer nutrition, affecting approximately 40% of cancer patients and having negative consequences on treatment efficacy, quality of life, and prognosis. It must be detected and managed early, based on clinical and laboratory criteria defined by the HAS recommendations.\n\nTo address this, several nutritional strategies are available, ranging from fortified oral feeding to artificial nutrition. Enteral nutrition, which is more physiological and carries fewer risks than parenteral nutrition, is recommended as the first-line treatment. Tools such as personalized care plans and guidelines help tailor patient care.\n\nHowever, enteral nutrition remains underutilized in clinical practice, despite the recommendations. The ADHENUTE study, conducted at the Institut Curie, showed low compliance with recommendations (31%) and a tendency to favor oral nutritional supplements, even in severely malnourished patients. The lack of traceability of decisions makes it difficult to identify barriers, although patient refusal is sometimes mentioned.\n\nTo improve this situation, corrective measures have been implemented:\n\n* for patients, through educational workshops to help them better understand and accept enteral nutrition;\n* for healthcare providers, through training sessions to address reservations and enhance knowledge.\n\nA third phase of the study aims to evaluate the impact of these actions, with the goal of increasing adherence to recommendations and the use of enteral nutrition.",[30],[120,121,122,123,124,125,126],"enteral nutrition","adherence to enteral nutrition","compliance with enteral nutrition guidelines","malnutrition","nutritional supplements","patient education workshops","training for healthcare staff","2026-04-30",{"date":129,"type":38},"2026-05-06",{"date":131,"type":38},"2026-03-05",{"date":133,"type":22},"2027-09-04",{"name":135,"class":45},"Institut Curie",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":143,"maxAge":112,"enrollmentInfo":144,"targetDuration":4,"studyType":23,"phases":146,"briefSummary":147,"conditions":148,"keywords":151,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":46},"100626908","clinical-implementation-of-the-group-standard-for-enteral-feeding-care-in-critically-ill-children-100626908","NCT07441746","Clinical Implementation of the Group Standard for Enteral Feeding Care in Critically Ill Children","Clinical Implementation of the Group Standard for Enteral Feeding Care in Critically Ill Children: A Multi-center, Stratified Cluster Randomized Controlled Trial","1. Nurses：\n\n   Inclusion Criteria:\n   * Nurses who have worked in the Pediatric Intensive Care Unit (PICU) for ≥ 3 months, completed the departmental training, and are capable of independently performing feeding tube procedures.\n   * Nurses who hold a valid and legal nursing license.\n   * Nurses who voluntarily participate in the study and sign the informed consent form.\n\n   Exclusion Criteria:\n   * Nurses who are trainees or interns.\n   * Nurses who are on leave or not on duty.\n2. Pediatric Patients：\n\nInclusion:\n\n* Critically ill children aged \\> 28 days and ≤ 18 years.\n* Length of hospital stay ≥ 24 hours.\n* Children receiving nutritional support via feeding tube during hospitalization.\n* Parents or legal guardians of the child have signed the informed consent form, agreeing to the child's participation in the study.\n\nExclusion:\n\n* Children who are fed via gastrostomy or jejunostomy.\n* Children who are in the transition phase from tube feeding to oral feeding and can partially consume food orally.","28 Days",{"count":145,"type":22},500,[58],"This study aims to evaluate the feasibility and effectiveness of the \" Standard for Enteral Feeding Care in Critically Ill Pediatric Patients \" (T\u002FCNAS 45-2024) in a multicenter setting. Tube feeding is a critical intervention for maintaining the nutritional status of critically ill children, particularly when oral intake of sufficient nutrition is not possible. While there are established guidelines for enteral nutrition in adults, the specific needs of critically ill children have not been sufficiently addressed. This study, based on the \"Grol and Wensing Implementation of Change Model\" in implementation science, will guide the clinical implementation of the \" Standard for Enteral Feeding Care in Critically Ill Pediatric Patients \" across multiple centers. The goal is to provide practical evidence for the nationwide application of this standard, enhance the quality of tube feeding care for critically ill children, and ultimately improve clinical outcomes for these patients.",[149,150,30],"Clinical Implementation","Standardized Tube Feeding Care",[152,153,154],"Tube feeding","Pediatric Intensive Care Unit","Grol and Wensing model","2026-02-27",{"date":157,"type":38},"2026-03-02",{"date":159,"type":22},"2026-03",{"date":161,"type":22},"2027-06",{"name":104,"class":45},{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":170,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":23,"phases":173,"briefSummary":174,"conditions":175,"keywords":178,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":46},"100616547","stepwise-enteral-nutritional-algorithm-and-patient-outcomes-in-pediatric-intensive-care-units-100616547","NCT07307027","Stepwise Enteral Nutritional Algorithm and Patient Outcomes in Pediatric Intensive Care Units","Could a Stepwise Enteral Nutritional Algorithm Affect Patient's Outcome in Pediatric Intensive Care Units? An Interventional Study","Inclusion Criteria:\n\n* Critically ill infants and children admitted to the Pediatric Intensive Care Units.\n* Age range from 1 month to 16 years (specifically males up to 14 years and females up to 16 years).\n\nExclusion Criteria:\n\n* Patients who are discharged or died within 24 hours of admission.\n* Patients with acute pancreatitis.\n* Patients with esophageal perforation.\n* Patients with a known metabolic disorder.\n* Patients requiring a ketogenic diet.\n* Patients with Short Bowel Syndrome.","1 Month","16 Years",{"count":115,"type":22},[58],"The aim of the study to evaluate the effectiveness and patient's outcome after implementing enteral nutrition algorithm designed to achieve optimal enteral nutrition delivery in the pediatric intensive care unit and to evaluate the effect of implementing this protocol on critically ill patient's individual's outcome.",[30,176,177],"Enteral Nutrition Feeding","Enteral Nutrition Intolerance in Critically Ill Patients",[179,180],"enteral nutrition in critically ill","EN","2026-01-14",{"date":183,"type":38},"2026-01-16",{"date":185,"type":38},"2024-12-01",{"date":187,"type":22},"2026-03-03",{"name":189,"class":45},"Ain Shams University",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":197,"targetDuration":4,"studyType":23,"phases":199,"briefSummary":200,"conditions":201,"keywords":206,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":218,"locationsCount":4},"100618913","implementation-of-clinical-nutrition-practice-guidelines-in-surgical-icus-100618913","NCT07337798","Implementation of Clinical Nutrition Practice Guidelines in Surgical ICUs","Effects of Implementing Evidence-Based Clinical Nutrition Practice Guidelines in Surgical Intensive Care Units: A Cohort Study","Inclusion Criteria:\n\nFor ICU healthcare professionals:\n\nEmployed at one of the participating study sites (tertiary general hospitals)\n\nHolds a valid Registered Nurse license issued in the People's Republic of China\n\nCurrently working in frontline clinical nursing care in a surgical intensive care unit (ICU) during the study period\n\nAt least 1 year of clinical working experience\n\nAble to understand the study objectives and procedures\n\nWilling to participate and able to provide written informed consent\n\nFor surgical critically ill patients (outcome assessment population):\n\nAged 18 years or older\n\nAdmitted to a surgical ICU due to surgical-related conditions, including trauma, infection, malignancy, or postoperative complications\n\nExpected length of stay in the surgical ICU of at least 48 hours\n\nNo restriction on sex\n\nPatient or legally authorized representative able to provide written informed consent\n\nExclusion Criteria:\n\nFor ICU healthcare professionals:\n\nCurrently pregnant, breastfeeding, or planning pregnancy during the study period\n\nTemporarily assigned, rotating, externally dispatched, on long-term training, or on leave during the study period, making continuous participation impossible\n\nParticipation in other interventional studies that may interfere with the implementation of this study\n\nDetermined by the research team to have cognitive, communication, or other conditions that would make participation inappropriate\n\nFor surgical critically ill patients:\n\nDiagnosed with brain death or awaiting organ donation\n\nPregnant or breastfeeding women\n\nConcurrent participation in other nutrition-related clinical trials",{"count":198,"type":22},200,[58],"The goal of this interventional clinical trial is to evaluate whether the implementation of an evidence-based, context-adapted clinical nutrition practice guideline can improve clinical nutrition management in surgical intensive care units (ICUs) in China. The guideline is selected based on the best available evidence from existing surgical and critical care nutrition guidelines, adapted to the Chinese healthcare context, and implemented using an i-PARIHS-guided translation strategy. The trial involves ICU healthcare professionals working in surgical ICUs of tertiary general hospitals, while assessing nutrition-related clinical outcomes among surgical critically ill patients.\n\nThe main questions it aims to answer are:\n\nDoes guideline implementation improve ICU healthcare professionals' adherence to recommended clinical nutrition practice guidelines?\n\nDoes the implementation of the clinical nutrition practice guideline improve the proportion of surgical critically ill patients who achieve recommended energy and protein intake targets during ICU stay?\n\nResearchers will compare outcomes before and after guideline implementation to determine whether the i-PARIHS-guided guideline translation improves nutrition management processes, healthcare professional performance, and patient-related clinical outcomes.\n\nParticipants will:\n\nComplete baseline and post-implementation assessments related to clinical nutrition knowledge, attitudes, and practices.\n\nParticipate in guideline-based education, training, and implementation activities guided by the i-PARIHS framework.\n\nApply the adapted clinical nutrition practice guideline during routine clinical care in surgical ICUs.\n\nBe evaluated through on-site audits, questionnaires, and clinical data collection during the implementation process.",[202,203,204,30,205],"ICU Patients","Surgical","Nutrition Intervention","Enteral Nutrition Intolerance",[207,208,209,210,211],"Clinical Nutrition","Surgical Intensive Care Units","i-PARIHS Framework","Implementation Science","Clinical practice guideline","2026-01-11",{"date":214,"type":38},"2026-01-13",{"date":216,"type":22},"2025-12-20",{"date":102,"type":22},{"name":219,"class":45},"Xuanwu Hospital, Beijing",{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":23,"phases":229,"briefSummary":230,"conditions":231,"keywords":233,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":240,"locationsCount":4},"100620133","effect-of-intermittent-enteral-feeding-in-severe-stroke-100620133","NCT07353658","Effect of Intermittent Enteral Feeding in Severe Stroke","The Effect of Intermittent Versus Continuous Enteral Feeding on Outcomes in Severe Stroke: An Exploratory Study","Inclusion Criteria:\n\n1. Age ≥18 years old\n2. It was definitely diagnosed as acute stroke by clinical imaging.\n3. Enteral nutrition program can be started within 72 hours of onset.\n4. Baseline GCS≤12 or NIHSS≥11\n5. There is nutritional risk (NRS 2002≥3), Wadian drinking water test≥ 3 or there is consciousnessdisorder,it is estimated that you need to receive nutritional support treatment for ≥7 days\n6. Obtain informed consent\n\nExclusion Criteria:\n\n1. Before joining the group, he had received total parenteral nutrition treatment.\n2. There are contraindications to enteral nutrition.\n3. Unstable vital signs\n4. Dementia or severe disability before onset (mRS≥3)\n5. There are concomitant diseases that will interfere with outcome evaluation and\u002For follow-up.\n6. Participating in other interventional clinical trials.\n7. Other circumstances in which the study cannot be completed.",{"count":228,"type":22},60,[58],"This is a single-center, randomized, exploratory clinical trial investigating whether intermittent enteral feeding improves outcomes compared to continuous feeding in patients with severe stroke. The study will enroll 60 patients to evaluate the impact on 90-day all-cause mortality, neurological function, nutritional status, and safety. It will also explore underlying mechanisms through analysis of metabolic profiles, circadian gene expression, and gut microbiota.",[232,30],"Severe Stroke",[234,30],"Stroke",{"date":236,"type":38},"2026-01-20",{"date":238,"type":22},"2026-01-05",{"date":102,"type":22},{"name":241,"class":45},"Xijing Hospital",{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":23,"phases":250,"briefSummary":251,"conditions":252,"keywords":257,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":4},"100613772","optimizing-enteral-nutrition-regimen-for-critically-ill-patients-100613772","NCT07270939","Optimizing Enteral Nutrition Regimen for Critically Ill Patients","Optimizing Enteral Nutrition: A Comparative Study of 18-Hour, 20-Hour, and 24-Hour","Inclusion Criteria\n\nParticipants must meet ALL of the following criteria to be eligible for the study:\n\n1. Patients aged ≥ 18 years.\n2. Patients expected to require enteral nutrition (EN) for ≥ 7 days.\n3. Critically ill, mechanically ventilated patients in the ICU.\n4. New patients initiating EN in the critical care unit.\n5. Patients receiving EN via:\n\n   * a nasogastric (NG) tube.\n   * orogastric (OG) feeding tube.\n\nExclusion Criteria:\n\n1. Patients with contraindications to enteral feeding or pre-existing gastrointestinal disorders, including:\n\n   * Active GI bleeding.\n   * Progressive GI disease.\n   * Recent GI tract resection.\n2. Indication for a special diet formula.\n3. Need for a large volume of feeding (as determined by the clinical team).\n4. Pre-existing hepatic failure.\n5. Use of a nasojejunal tube, gastrostomy, or jejunostomy.\n6. Pregnancy confirmed via β-hCG testing for women of childbearing potential.\n7. Insulin-dependent diabetes mellitus.",{"count":21,"type":22},[58],"Clinical Trial The goal of this clinical trial is to learn whether different enteral feeding cycles (18-hour, 20-hour, or standard 24-hour continuous feeding) improve outcomes for critically ill ICU patients who need tube feeding. It will also look at tolerance, nutrition delivery, and safety.\n\nThe main questions it aims to answer are:\n\nDo shorter feeding cycles (with fasting windows) reduce ICU length of stay?\n\nDo they lower the risk of infections like ventilator-associated pneumonia?\n\nHow do they affect calorie delivery, blood sugar control, and gastrointestinal tolerance?\n\nResearchers will compare:\n\nContinuous 24-hour feeding (standard care)\n\n20-hour feeding with a 4-hour fasting window\n\n18-hour feeding with a 6-hour fasting window\n\nParticipants will:\n\nBe critically ill adults in the ICU who require at least 7 days of enteral feeding\n\nBe randomized to one of the three feeding schedules\n\nReceive daily monitoring of calories, protein, blood sugar, and GI tolerance\n\nHave outcomes measured, including ICU length of stay, infections, metabolic control, and feeding tolerance",[253,30,254,255,256],"Critical Illness","Ventilator Associated Pneumonia","Hyperglycemia","Feeding Intolerance",[258,259,260,261,262],"Cyclic feeding","Feeding window","Critical care nutrition","Gastrointestinal tolerance","Nutritional adequacy","2025-11-26",{"date":265,"type":38},"2025-12-08",{"date":267,"type":22},"2025-12-30",{"date":269,"type":22},"2026-11-30",{"name":271,"class":272},"Hamad Medical Corporation","INDUSTRY"]