[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"environmental-exposure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:environmental-exposure":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,83,113,141,171,197,224,257,290,337,363,387,418,441,476,506,579,605,641,665,692,722],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":45,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100641995","human-observatory-study-100641995",false,"NCT07646782","Human Observatory Study","The Human Observatory: A Prospective Individual and Population-Level Study of Aging, Health, and Longevity","HOS","Inclusion Criteria:\n\n* Enrolled in the 100-Year Human Aging Study at any fixed or mobile clinical site; OR completion of online health screener with provision of geographic anchor data and consent.\n\nExclusion Criteria:\n\n* Age under 18 years (current protocol; pediatric amendment planned).",true,"ALL","18 Years",{"count":21,"type":22},1000000,"ESTIMATED","OBSERVATIONAL","The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a continuously-ingested ecological data infrastructure spanning environmental exposures, social determinants, genealogical and family history records, mortality data, and population health databases at geographic resolutions from home address to global scale and beyond. The resulting model generates individual screening recommendations informed by population-level causal estimates, and population-level causal forecasts anchored by present-timepoint individual clinical biology. Thus creating a feedback architecture designed to improve both simultaneously.",[26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44],"Aging","Mortality","All-cause Mortality","Life Expectancy","Cardiovascular Diseases","Neoplasms","Cognitive Dysfunction","Metabolic Syndrome","Frailty","Musculoskeletal Disease","Neurodegenerative Disease","Dementia","Activities of Daily Living","Health Related Quality of Life","Disability Physical","Environmental Exposure","Occupational Diseases","Health Equity","Social Determinants of Health",[46,47,48,49,50,51,52,53,54,55,56,57,58,43,59,60,61,62,63,64,65,66,67,68,69],"longevity","biological aging","causal inference","life expectancy","exposome","Environmental Health","Social Determinants","Genealogy","Family History","Human Family Tree","Population Health","Neighborhood Health","Geographic Health Disparities","Mortality Prediction","Biomarker Validation","Cardiopulmonary Exercise Testing","Body Composition","Preventive Medicine","Healthspan","Functional Decline","Centenarian","Space Medicine","Aerospace Medicine","World Model","RECRUITING","2026-06-09",{"date":73,"type":74},"2026-06-15","ACTUAL",{"date":76,"type":74},"2026-04-25",{"date":78,"type":22},"2099-12-31",{"name":80,"class":81},"Longevity Metrics, Inc.","INDUSTRY",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":17,"sex":91,"minAge":19,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":82},"100524377","developmental-impacts-of-microplastics-exposure-in-early-life-100524377","NCT06107933","Developmental Impacts of Microplastics Exposure in Early Life","Developmental Impacts of MicroPLastics Exposure in Early Life","DIMPLE","Inclusion Criteria:\n\n* All gender expressions\n* Mothers at 1 or 3 months postpartum (± 2 weeks)\n* Intent to exclusively breastfeed for ≥ 6 months\n* Nulliparous and singleton births\n* Receiving only breast milk from the mother, with no formula supplementation\n\nExclusion Criteria:\n\n* Physical, mental, or cognitive disability that prevents participation; current incarceration\n* Chronic conditions in mother and\u002For infant (e.g., heart disease, cancer, autoimmune disease, diabetes, intestinal bowel syndrome\u002Fdisease), conditions diagnosed for the first time during pregnancy (e.g. gestational diabetes), neurological conditions in mother and\u002For infant (e.g. epilepsy, seizures), psychological conditions in mother and\u002For infant (e.g. bipolar disorder), or neurological\u002Fpsychological conditions diagnosed in mother during or immediately after pregnancy (e.g. postpartum depression)\n* Previously diagnosed with any major illness (e.g., intrauterine growth restriction, birth asphyxia, cancer) or eating disorder or previous gastric band surgery\n* Maternal antibiotic use during pregnancy or the postpartum period. Infant antibiotic use at any time during life or taking medications that could affect plastic exposure or the microbiome, such as medications administered via a plastic syringe.\n* Use of any breast pump except the Silicon Breast Pump for the 14 days prior to the clinical visit.\n* PHQ9 score greater than or equal to 10 indicating clinically relevant symptoms of moderate or worse depression\n* Infants who are intersex\n* Smoking, drug use (including marijuana use), or alcohol abuse","FEMALE",{"count":93,"type":22},40,"The goal of this observational study is to characterize and evaluate micro- and nano-plastic (MNP) exposures among mothers and infants in mother-infant dyads 1 or 3 months postpartum living in Baltimore, Maryland. The main questions it aims to answer are:\n\n* What MNPs are present in breastmilk and maternal blood samples and in their infants stool sample?\n* Are there associations between amount of maternal MNPs in breast milk and mass of MNP particles in infant stool?\n* Which environmental and lifestyle factors are most predictive of maternal MNP burden?\n* Is infant exposure to MNPs associated with birth weight and postnatal growth trajectories?\n\nParticipants will:\n\n* Complete several questionnaires assessing medical histories, lifestyle factors, environmental exposures, eating behaviors, etc.\n* Provide biological specimens including: maternal blood, stool, and breastmilk; infant stool\n* Clinical visit to have anthropometric measures documented including maternal height and weight, infant weight, length, and skin-fold thickness",[96,97,41],"Infant Development","Breast Feeding",[99,100,101,102,103],"microplastic","breastmilk","infant microplastic exposure","gut microbiome","fecal metabolome","2026-06-05",{"date":71,"type":74},{"date":107,"type":74},"2023-10-01",{"date":109,"type":22},"2027-01-01",{"name":111,"class":112},"Johns Hopkins Bloomberg School of Public Health","OTHER",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":122,"phases":123,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":82},"100643393","a-study-to-assess-the-efficacy-of-public-health-campaigns-in-reducing-lead-exposure-100643393","NCT07632937","A Study to Assess the Efficacy of Public Health Campaigns in Reducing Lead Exposure","Inclusion Criteria:\n\n* Resident of selected urban neighborhoods with documented environmental lead risk\n* Household includes at least one adult aged 18-75 years willing to participate\n* Willing to provide informed consent\n* Willing to allow home visits and blood sampling\n* Able to understand study procedures and interventions\n\nExclusion Criteria:\n\n* Planning to relocate from the area within the next 12 months\n* Household member with a known diagnosis of severe anemia or bleeding disorder\n* Participation in another intervention study targeting lead exposure in the past 12 months\n* Inability or unwillingness to comply with study procedures\n* Household with known ongoing lead remediation efforts during the study period\n* Pregnant women (due to additional ethical considerations for blood sampling)","75 Years",{"count":121,"type":22},400,"INTERVENTIONAL",[124],"NA","This clinical trial aims to evaluate the effectiveness of targeted public health campaigns in reducing lead exposure among adults living in urban communities with known environmental lead hazards. Lead exposure remains a significant public health concern, particularly in older urban neighborhoods with aging infrastructure and legacy contamination. Despite existing regulations and remediation efforts, many communities continue to experience elevated blood lead levels, especially among vulnerable populations.\n\nThe study will compare the impact of an intensive, multi-modal public health campaign-featuring community workshops, educational materials, and home intervention resources-against standard municipal information dissemination. By assessing changes in blood lead levels and lead-related knowledge, attitudes, and behaviors over a 12-month period, the trial seeks to determine whether enhanced public health outreach can more effectively reduce lead exposure and promote safer practices. The findings will inform future strategies for community-based environmental health interventions.",[127,41],"Lead Poisoning",[129,130],"lead poisoning","lead","NOT_YET_RECRUITING","2026-06-02",{"date":134,"type":74},"2026-06-08",{"date":136,"type":22},"2026-10-31",{"date":138,"type":22},"2028-11-01",{"name":140,"class":81},"International Health Strategies LLC",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":18,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":152,"conditions":153,"keywords":157,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":82},"100616444","climate-anxiety-in-a-young-population-at-risk-of-suicide-100616444","NCT07305688","Climate Anxiety in a Young Population at Risk of Suicide","Anx-RS","Inclusion Criteria:\n\n* Men and women, boys and girls ;\n* Aged between 16 and 24;\n* Participants seen in adult or pediatric emergency departments, hospitalised in adult psychiatry or in child and adolescent psychiatry, or seen in outpatient consultation at Esquirol Hospital Center ;\n* Affiliated with a social security scheme or entitled to coverage under one ;\n* Having received full information about the study and having co-signed, together with the investigator, an informed consent form to participate in the study.\n* For minor participants: the consent to participate in the study must be signed by the holder(s) of parental authority, and the minor's assent will also be required.\n\nExclusion Criteria:\n\n* Participants will not be included in the study if their health condition is incompatible with understanding or completing the questionnaires used. This includes, in particular ;\n* Any chronic somatic pathology or major sensory impairment (for example : deafness or blindness) preventing reading, comprehension or communication with healthcare professionals ;\n* Any severe psychiatric pathology that significantly impairs cognitive or communication abilities, such as acute psychotic disorders, pervasive developmental disorders or confusional states ;\n* Participants hospitalised in units specialising in severe psychiatric disorders with major impairment of cognitive functions.\n* Adults under legal protection, in accordance with article L 1121-8 of the Public Health Code ;\n* Insufficient command of the French language","16 Years","24 Years",{"count":151,"type":22},108,"Climate change has become a major source of concern, particularly among younger generations who are facing the progressive degradation of ecosystems, loss of biodiversity, and alarming environmental information disseminated through the media. The direct perception of climate-related disruptions has been shown to engender a profound sense of helplessness and loss. This distress, termed eco-anxiety, is characterised by feelings of fear, sadness and guilt regarding the planet's future.\n\nIn a context where there has been a marked increase in suicidal thoughts and attempts among young people over the past decade, it is essential to explore the psychological manifestations of eco-anxiety within this vulnerable population. The paucity of studies investigating this association underscores the significance of the present research.\n\nThe aims of this study is to examine the relationship between climate anxiety and suicidal risk among young people aged 16 to 24 years.\n\nThe study will encompass 108 young participants aged between 16 and 24 years, who are either hospitalised or receiving outpatient psychiatric care.\n\nEach participant will be required to complete one clinician-administered assessment, namely the Columbia Suicide Severity Rating Scale (C-SSRS), and two self-report questionnaires: the Climate Change Anxiety Scale - French version (CCAS-FR) and the State-Trait Anxiety Inventory (STAI-Y).\n\nFurthermore, a sociodemographic questionnaire will be administered in order to collect information regarding the subjects' age, sex, education level, living conditions, and psychiatric history.\n\nIt is hypothesised that there is a positive association between climate anxiety and suicidal risk, with the most eco-anxious participants showing higher C-SSRS scores. It is further predicted that eco-anxiety will correlate with elevated levels of state and trait anxiety, with the potential for modulating this relationship by sociodemographic factors, including gender.\n\nThis study will contribute to a better understanding of the psychological impacts of climate change on young people and help identify the most vulnerable profiles.",[154,155,156,41],"Anxiety","Suicidal Ideation","Mental Health Issue",[158,159,160,161,162],"Eco-anxiety","Anxiety disorders","Suicide risk","Mental health","Young adults",{"date":164,"type":74},"2026-06-04",{"date":166,"type":74},"2025-12-15",{"date":168,"type":22},"2027-03-15",{"name":170,"class":112},"Centre Hospitalier Esquirol",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":179,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":4},"100640455","clinical-utility-of-libs-multi-element-imaging-and-the-iff-algorithm-in-chronic-lung-diseases-100640455","NCT07597187","Clinical Utility of LIBS Multi-Element Imaging and the IFF Algorithm in Chronic Lung Diseases","Evaluation of the Clinical Utility of LIBS Multi-Element Imaging and the IFF Algorithm for the Etiological and Medico-Legal Management of Chronic Lung Diseases","PNEUMO-LIBS","Inclusion Criteria:\n\n* Adult patient aged 18 years or older.\n* Diagnosis or documented clinical suspicion of chronic lung disease, including interstitial lung disease, pulmonary granulomatosis such as sarcoidosis, or pulmonary emphysema.\n* Availability of a lung tissue biopsy sample obtained during routine medical care and stored as a formalin-fixed paraffin-embedded sample.\n* Sufficient medical record information to document the clinical context, occupational or environmental exposure history, smoking status, imaging, pathology reports, and other relevant routine-care data.\n* No documented objection to the secondary use of health data and biological samples for this research.\n\nExclusion Criteria:\n\n* Documented objection to participation in the study or to the secondary use of health data or biological samples for research.\n* Missing, unavailable, degraded, or technically unusable biopsy sample.\n* Insufficient medical record information to document the clinical context or exposure history.\n* Lung condition outside the scope of the study, such as isolated acute infection, isolated cardiac disease, or primary lung cancer.\n* Patient under legal protection when the applicable legal conditions for non-opposition cannot be fulfilled.",{"count":180,"type":22},70,"PNEUMO-LIBS is a multicenter, non-interventional observational study designed to evaluate whether multi-element tissue imaging by Laser-Induced Breakdown Spectroscopy (LIBS), combined with an artificial intelligence-based analysis tool called Interesting Features Finder (IFF), may help physicians better understand the possible causes of chronic lung diseases.\n\nThe study focuses on adult patients with chronic lung diseases for which a lung biopsy has already been performed as part of routine medical care. These diseases include diffuse interstitial lung diseases, pulmonary granulomatoses such as sarcoidosis, and emphysema, especially when an environmental or occupational exposure is suspected but not clearly demonstrated.\n\nSome chronic lung diseases may be influenced by inhaled mineral or metallic particles, such as silica, aluminum, titanium, or other metals. However, these exposures are often difficult to document at the individual patient level. Standard clinical, radiological, and pathological investigations do not usually provide direct information on the presence and distribution of such elements within lung tissue.\n\nLIBS is an imaging technique that can detect and map chemical elements directly in tissue samples, including archived formalin-fixed paraffin-embedded biopsy blocks. In this study, lung biopsy samples will be analyzed with LIBS to search for elemental signatures that may be compatible with occupational or environmental exposures. The IFF algorithm will then be used to help interpret the LIBS data and identify rare or unexpected elemental signals.\n\nThe study does not require any additional biopsy, blood test, imaging examination, treatment, or hospital visit for participants. It uses tissue samples and medical data already collected during routine care. The results of LIBS and IFF analyses will be presented to the treating physician or investigator, who will complete standardized online questionnaires at three time points: before receiving the LIBS results, after receiving the LIBS report, and after receiving the IFF-assisted interpretation.\n\nThe main objective is to assess the perceived clinical utility of LIBS imaging for physicians, particularly regarding etiological understanding, possible occupational disease recognition, and prevention-oriented reasoning. Secondary objectives include assessing the added value of the IFF algorithm and evaluating the feasibility of a centralized multicenter workflow for sample transfer, LIBS analysis, IFF processing, result reporting, and questionnaire completion.\n\nThe study aims to include approximately 70 patients across several French hospital centers. Its results may support the development of future diagnostic, occupational health, and environmental medicine approaches, without modifying the medical care of participants during the study.",[183,184,185,186,41,187],"Interstitial Lung Diseases (ILD)","Pulmonary Emphysema","Chronic Lung Diseases","Occupational Lung Diseases","Occupational Exposure","2026-05-12",{"date":190,"type":74},"2026-05-19",{"date":192,"type":22},"2026-07-01",{"date":194,"type":22},"2027-07-01",{"name":196,"class":112},"University Hospital, Grenoble",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":122,"phases":206,"briefSummary":207,"conditions":208,"keywords":211,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":82},"100600889","table-top-water-pitcher-to-reduce-arsenic-exposure-among-well-users-in-new-hampshire-100600889","NCT07103356","Table-Top Water Pitcher to Reduce Arsenic Exposure Among Well Users in New Hampshire","Developing a Hybrid Type 1 Effectiveness-Implementation Randomized Controlled Trial to Test a Table-Top Water Pitcher to Reduce Arsenic Exposure in Northern New England","Inclusion Criteria:\n\n* Age 18 years or older\n* NH resident living in Merrimack or Belknap county\n* Use a private water system as primary drinking water source\n* Water arsenic \\>5 micrograms\u002FL upon testing\n* Confirm would be primary person in home maintaining the provided pitcher filter\n\nExclusion Criteria:\n\n* Use or plan to use a mitigation strategy to reduce exposure to arsenic-contaminated drinking water in the next 12 weeks",{"count":205,"type":22},20,[124],"The goals of this clinical trial are to:\n\n1. gather preliminary data on the effectiveness of a table-top water pitcher filtration system in reducing arsenic exposure among individuals using private wells with elevated (\\>5 μg\u002FL) arsenic concentrations, and\n2. identify the factors influencing implementation of the filter intervention (uptake and sustainability) and barriers and facilitators to its use.\n\nThe main questions it aims to answer are:\n\nDo water and urinary arsenic concentrations change from baseline to Week 4 of the water pitcher intervention?\n\nAre changes in arsenic concentrations maintained during the eight-week sustainability period?\n\n* Which factors facilitate or impede uptake, use, and sustainability of the intervention?\n* Are household income and\u002For home ownership associated with sustained filter use?\n\nParticipants will:\n\n* Receive a free 12-cup water filter pitcher and cartridge replacements\n* Use the pitcher filtration system, including replacement of filter cartridges, per manufacturer recommendations\n* Collect and mail water and urine samples at baseline, 4 weeks, and 12 weeks\n* Complete online questionnaires at baseline, 4 weeks, and 12 weeks",[209,41,210],"Arsenic Poisoning","Water-Related Diseases",[212,213,51,214],"Arsenic","Private Well","Filter","2026-03-20",{"date":217,"type":74},"2026-03-24",{"date":219,"type":74},"2026-02-24",{"date":221,"type":22},"2027-08-31",{"name":223,"class":112},"Trustees of Dartmouth College",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":91,"minAge":232,"maxAge":233,"enrollmentInfo":234,"targetDuration":4,"studyType":122,"phases":236,"briefSummary":237,"conditions":238,"keywords":241,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":256},"100522499","early-breast-growth-in-girls-aged-6-to-8-years-in-the-current-environmental-context-100522499","NCT06083415","Early Breast Growth in Girls Aged 6 to 8 Years in the Current Environmental Context","Early Breast Growth in Girls Aged 6 to 8 Years in the Current Environmental Context: Clinical and Biological Parameters, Level of Impregnation With Endocrine Disruptors and Evaluation of the Impact of Environmental Health Measures","PENELOPE","For patients:\n\nInclusion Criteria:\n\n* Girls aged 6 to 8 years\n* Presenting a breast development (isolated or not)\n* Undergoing scheduled pediatric day hospital care (HDJ)\n* Who agree to participate in the study\n* Whose parents agree to their child's participation in the study\n* French speaking\n* Whose parents speak French\n* Affiliated to social security\n\nExclusion Criteria:\n\n* Organic brain causes of precocious puberty: History of neurocerebral disease (malformations, developmental abnormalities)\n* Organic causes of precocious puberty: Mac Cune Albright syndrome, ovarian cyst or tumor and adrenal hyperplasia\n* History of chemotherapy or radiation therapy\n* Presenting with a communication disorder\n* Pregnancy\n* Persons under protective measures\n* Persons deprived of liberty for judicial or administrative reasons\n\nFor controls:\n\nInclusion Criteria:\n\n* Girls aged 6 to 8\n* Tanner stage 1: Absence of breasts and hairiness\n* Coming for routine consultation in the pediatric HDJ at Saint-Vincent-de-Paul hospital, or at the BLM practice in Lambersart, or to radiology for an MRI for another medical other medical reason\n* Agree to participate in the study\n* Whose parents agree to their child's participation in the the study\n* French-speaking\n* Whose parents speak French\n* Affiliated with social security\n\nExclusion Criteria:\n\n* Signs of puberty (Tanner stages 2, 3, 4 and 5 for breast development) breast development)\n* Previous chemotherapy or radiotherapy\n* Presenting a communication disorder\n* Pregnant women\n* Persons under protective supervision\n* Persons deprived of their liberty for judicial or administrative reasons","6 Years","8 Years",{"count":235,"type":22},62,[124],"Various studies show an increase in the number of cases of early puberty in girls with breast development with a variable clinical presentation and evolution. This increasing phenomenon concerns girls between 6 and 8 years old. In a large number of cases, from 70 to 95% depending on the series, no medical cause is found and environmental factors are suspected to be involved.\n\nDescriptive studies of these patients are scarce and not always provide an overview of all the parameters in line with the concept of the exposome.\n\nThe PENELOPE clinical trial will allow to analyze a large number of parameters, including the adipose tissue, its metabolism, the endocrine disruptors, and the epigenetic modifications, and to study the impact of environmental health measures in the evolution of these parameters.\n\nThe data from the analyses of the endocrine disruptors of the patients will be explored in parallel in experimental models (amphibians, murine, cellular) in order to test potential mechanistic hypotheses.",[239,240,41],"Puberty, Precocious","Breast",[242,243,244,245,246],"Early puberty","Endocrine disruptors","Girls","Breast growth","Environmental Health Measure","2026-03-16",{"date":249,"type":74},"2026-03-17",{"date":251,"type":74},"2023-05-15",{"date":253,"type":22},"2027-05-15",{"name":255,"class":112},"Lille Catholic University",2,{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":17,"sex":18,"minAge":265,"maxAge":266,"enrollmentInfo":267,"targetDuration":4,"studyType":122,"phases":269,"briefSummary":272,"conditions":273,"keywords":274,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":289},"100628720","phase-2-behavioural-intervention-to-decrease-exposure-to-emerging-chemical-pollutants-100628720","NCT07465315","Behavioural Intervention to Decrease Exposure to Emerging Chemical Pollutants","Effectiveness of a Behavioural Intervention to Decrease Exposure to Emerging Chemical Pollutants Compared to Standard Lifestyle Recommendations Among Adults in Spain (INPOL): a 3-month Multicentre, Parallel-group, Superiority Randomized Controlled Trial","INPOL","Inclusion Criteria for the Screening phase:\n\n* Not planning to change residence within one year after recruitment\n* Spanish fluency\n* Living independently in the community\n* WhatsApp user\n* Age 30-60 years\n* Providing signed informed consent\n\nExclusion Criteria for the Screening phase:\n\n* Unable to provide any of the required biological samples\n* Suffering any chronic condition that substantially hinders adherence to the trial protocol and\u002For affects pollutant analyses\n* Inability to understand the informed consent, questionnaires, or intervention\n* Already participating in another intervention trial at the time of recruitment\n* Pregnancy or lactation\n* Inability to communicate with the research team and\u002For to attend the follow-up visits\n\nInclusion Criteria for the Intervention Phase:\n\n* Not planning to change residence within one year after recruitment\n* Spanish fluency\n* Living independently in the community\n* WhatsApp user\n* Age 30-60 years\n* Providing signed informed consent\n* Participant of the Screening phase\n\nExclusion Criteria for the Intervention Phase:\n\n* Unable to provide any of the required biological samples\n* Suffering from any chronic condition that substantially hinders adherence to the trial protocol and\u002For affects pollutant analyses\n* Inability to understand the informed consent, questionnaires, or intervention\n* Already participating in another intervention trial at the time of recruitment\n* Pregnancy or lactation\n* Inability to communicate with the research team and\u002For attend follow-up visits","30 Years","60 Years",{"count":268,"type":22},740,[270,271],"PHASE2","PHASE3","The purpose of this study is to evaluate the effectiveness of a behavioural intervention designed to reduce exposure to environmental chemical pollutants among adults in Spain.",[41],[41,275,276,277,278,279,280],"Biological Monitoring","Biomarkers","Urine","Hair","Environmental Pollutants","Healthy Lifestyle","2026-03-12",{"date":247,"type":74},{"date":284,"type":22},"2026-05",{"date":286,"type":22},"2027-02",{"name":288,"class":112},"Universidad de Granada",5,{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":296,"eligibilityCriteria":297,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":298,"targetDuration":4,"studyType":122,"phases":300,"briefSummary":301,"conditions":302,"keywords":318,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":256},"100556807","environmental-exposure-to-heavy-metals-nanoparticles-and-emergent-contaminants-and-risk-of-allergic-diseases-100556807","NCT06529913","Environmental Exposure to Heavy Metals, Nanoparticles, and Emergent Contaminants and Risk of Allergic Diseases","Model of diseAses Related to Environmental Exposure to Heavy meTals, nanopaRticles and Emergent Contaminants, Using a dIgital platfOrm of Clinical and Bio-humoral Data: the Way to Susceptibility\u002FRisK BiomArker [MATRIOSKA Study] - The Seed.","MATRIOSKA","Inclusion Criteria:\n\n* adult subjects (over 18 years of age).\n* Subjects suffering from allergic contact dermatitis due to metals.\n* Subjects with systemic allergic syndrome due to metals.\n* Adult healthy subjects.\n* Subjects able to give written informed consent.\n\nExclusion Criteria:\n\n* Subjects under the age of 18years.\n* Pregnant\u002Fbreastfeeding women.\n* Subjects suffering from chronic renal failure requiring replacement treatment.\n* Subjects suffering from other systemic pathologies related to exposure to metals.\n* Subjects suffering from gastrointestinal diseases such as celiac disease, chronic inflammatory intestinal diseases, tumors, other skin diseases.\n* Subjects unable to express written informed consent.",{"count":299,"type":22},280,[124],"The goal of this clinical trial is to collect environmental, bio-humoral, and clinical data derived from patients with allergic contact dermatitis (ACD) and systemic metal allergic syndromes related to the exposure to heavy metals, nanoparticles, and emergent contaminants and from healthy subjects.\n\nThe main question it aims to answer is: are environmental, bio-humoral, and clinical data derived from patients with ACD and systemic metal allergic syndromes, related to the exposure to heavy metals, nanoparticles, and emergent contaminants, different from ones obtained by healthy subjects? Researchers will compare serum and urine concentration of heavy metals and nanoparticles, patch test to metals, within-breath analysis of oscillometry parameters, serum zonulin, and serum levels of protein oxidation products among patients with systemic allergic syndrome (1st study group), patients with ACD (2nd study group) and healthy subjects (3rd study group).\n\nParticipants will undergo:\n\n* measurement of exposure to heavy metals and nanoparticles including nickel, cobalt, chromium, palladium, molybdenum, aluminium, and copper, through serum and urine measurement of concentration.\n* Patch test to before mentioned metals.\n* Within-breath analysis of oscillometry parameters.\n* Measurement of serum zonulin (related to gastro-intestinal exposure).\n* Measurement of serum levels of protein oxidation products (as markers of systemic oxidative stress).",[303,304,305,306,307,308,309,310,311,312,313,41,314,315,316,317],"Allergic Contact Dermatitis","Metal Allergy","Food Allergy","Nickel Sensitivity","Nickel; Eczema","Aluminum Allergy","Chromium; Eczema","Functional Gastrointestinal Disorders","Respiratory Injury","Pollution; Exposure","Pollution Related Respiratory Disorder","Environment Related Disease","Environmental Illness","Oxidative Stress","Risk Reduction",[304,319,320,321,322,323,324,325,326,327,303,305,310,311,41,328,276],"Nanoparticles","Emergent contaminants","Nickel","Aluminium","Copper","Chromium","Cobalt","Palladium","Titanium","Patch test","2026-02-23",{"date":219,"type":74},{"date":332,"type":74},"2025-01-13",{"date":334,"type":22},"2026-12-31",{"name":336,"class":112},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":338,"slug":339,"hasResults":11,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":344,"enrollmentInfo":345,"targetDuration":4,"studyType":122,"phases":346,"briefSummary":347,"conditions":348,"keywords":349,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":82},"100540307","assessing-and-addressing-community-exposures-to-environmental-contaminants-100540307","NCT06315140","Assessing and Addressing Community Exposures to Environmental Contaminants","Building Food Sovereignty, Sustainability and Better Health in Environmentally-impacted Native Americans","Inclusion Criteria:\n\n* Male or female between the age of 18 - 80 years old at the time of enrollment\n* Living on the streets of Halifax Road, Orange Turnpike, Ramapo Ave, 1st-7th Streets, Mountain Avenue and Fox Hollow Road in Hillburn, NY; Peter's Mine Road, Canon Mine Road, Pipeline Road, Milligan Drive, Cable House Road and Van Dunk Lane in Ringwood, NJ; Stag Hill Road, and Ramapo Brae Lane in Mahwah, NJ\n* Willing and able to provide consent\n\nExclusion Criteria:\n\n* Pregnant women and individuals under 18 or over 80 years old\n* Do not live in the identified streets above and\u002For have lived there for less than 2 years will be excluded from the study","80 Years",{"count":121,"type":22},[124],"The purpose of this study is to build on our equitable, eight-year Tribal-academic partnership with the Ramapough Nation of northern NJ to advance tradition-centered farming practices and management strategies supporting sustainable food systems to relieve local food insecurity and nutritional deficiency, prevent disease and promote health. Furthermore, assessing the extent of environmental contamination, individual toxicant burdens and micronutrient levels and health disorders in Ramapough Tribal members of both sexes as outlined in the following:\n\n* Collect in-person\u002Fonline survey information on demographics, health and food intake, nutrition, food security, and psychosocial stressors, and perform core anthropometric measurements (i.e., height, weight, body mass index, body circumference and blood pressure) at enrollment on Tribal members to inform health promotion strategies and community actions.\n* Determine individual-level contaminant burdens and micronutrient concentrations (e.g., iron, calcium, folate, vitamins) in urine and blood from surveyed (sub-aim 1a) Ramapough Turtle Clan volunteers.\n* Test soil, plants and surface water where Turtle Clan residents live, recreate and attend church in Ringwood, NJ using a community-based, citizen scientist approach.",[41],[350,351,352,353],"Ramapough Nation","metals","food","nutrition","2026-01-27",{"date":356,"type":74},"2026-01-29",{"date":358,"type":74},"2023-02-16",{"date":360,"type":22},"2027-04",{"name":362,"class":112},"NYU Langone Health",{"id":364,"slug":365,"hasResults":11,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":4,"eligibilityCriteria":369,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":370,"enrollmentInfo":371,"targetDuration":373,"studyType":23,"phases":4,"briefSummary":374,"conditions":375,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":82},"100622519","environmental-and-behavioral-factors-in-infertility-and-art-outcomes-100622519","NCT07384676","Environmental and Behavioral Factors in Infertility and ART Outcomes","A Large-Scale Prospective Cohort Study on the Association of Environmental Exposures and Behavioral Factors With Infertility and Assisted Reproductive Technology (ART) Success Rates","Inclusion Criteria:\n\n* A. Women aged 18 to 46 who use their own eggs; Men aged 18 to 55 who use their own sperm; B. Patients meeting the diagnostic criteria for infertility; C. Medical history clearly indicating the duration of persistent infertility; D. Voluntarily participating in the project and signing the informed consent form;\n\nExclusion Criteria:\n\n* A. The groups of artificial insemination patients with any of the following ARTs contraindications: a. The female has a sperm-egg combination disorder caused by tubal factors. b. The female has acute infections of the reproductive and urinary systems or sexually transmitted diseases. c. The female has genetic diseases, severe physical illnesses, or mental and psychological disorders. d. There is a history of giving birth to infants with congenital defects and it has been confirmed that the defect was caused by the female. e. The female has been exposed to teratogenic doses of radiation, toxins, or drugs and is in the active period. f. The female has bad habits such as alcoholism or drug abuse. B. The groups of first-generation and second-generation IVF patients with any of the following ARTs contraindications: a. Either of the parties providing gametes has acute infections of the reproductive and urinary systems and sexually transmitted diseases or has bad habits such as alcoholism or drug abuse. b. Either of the parties providing gametes has been exposed to teratogenic doses of radiation, toxins, or drugs and is in the active period. c. The female partner of the recipient who provides eggs or embryos has acute infections of the reproductive and urinary systems and sexually transmitted diseases, or has bad habits such as alcoholism or drug abuse. d. The female has an unviable uterus or severe physical illnesses that cannot withstand pregnancy. C. No embryo transfer was performed after egg retrieval; D. More than 180 days have passed since egg retrieval and frozen embryo transfer was performed.","46 Years",{"count":372,"type":22},5000,"18 Months","This large-scale study aims to understand how everyday environment and lifestyle may affect the success of fertility treatments like IVF. The main idea is that exposure to certain environmental chemicals (e.g., from plastics or air pollution) and personal habits (e.g., diet, stress) could be linked to whether these treatments result in a successful pregnancy and live birth.\n\nThe study will follow approximately 5,000 couples undergoing fertility treatment in Hunan, China. Participants will answer questionnaires about their health, lifestyle, and environment and provide small biological samples (like blood and urine) during their standard treatment process. Their treatment outcomes will be tracked anonymously.The goal is to identify factors that might lower the chances of treatment success. This knowledge could help future patients and doctors make informed decisions and could guide public health advice on reducing potential risks. The study has received ethical approval, and all participant information will be kept strictly confidential.",[41,376,377],"Assisted Reproductive Technology","Prospective Study","2026-01-26",{"date":380,"type":74},"2026-02-03",{"date":382,"type":74},"2024-12-01",{"date":384,"type":22},"2034-12-31",{"name":386,"class":112},"The Third Xiangya Hospital of Central South University",{"id":388,"slug":389,"hasResults":11,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":393,"eligibilityCriteria":394,"healthyVolunteers":17,"sex":18,"minAge":395,"maxAge":19,"enrollmentInfo":396,"targetDuration":4,"studyType":122,"phases":397,"briefSummary":398,"conditions":399,"keywords":403,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":82},"100617230","planetary-health-and-environmental-justice-in-construction-career-education-100617230","NCT07315919","Planetary Health and Environmental Justice in Construction Career Education","Integrating Planetary Health and Environmental Justice Into High School Construction Career Education: A Randomized Controlled Trial of the Ecosystem Justice Translator","EJT-CTE","Inclusion Criteria:\n\n* Age 14-18 years at enrollment\n* Current enrollment in a participating construction career pathway program (minimum 2nd semester)\n* Ability to participate in 6-month curriculum during regular CTE class periods\n* Written informed consent from parent\u002Fguardian for participants under 18 years\n* Written assent from student participant\n* Ability to complete assessments in English (with accommodations as needed)\n\nExclusion Criteria:\n\n* Prior participation in a formal environmental justice or planetary health curriculum within the past 12 months\n* Expected inability to complete study assessments due to planned relocation or program withdrawal\n* Concurrent enrollment in another research study involving educational interventions","14 Years",{"count":93,"type":22},[124],"This study tests whether a new educational curriculum can help high school students in construction career programs better understand how building design affects community health and environmental justice. The study compares two approaches: (1) a new \"Community-Centered Design\" curriculum that uses the Ecosystem Justice Translator (EJT) software tool, which helps students see connections between construction decisions, energy efficiency, nature exposure, and health outcomes in different neighborhoods; versus (2) the traditional construction career curriculum that focuses on technical skills. Students aged 14-18 enrolled in construction career programs will be randomly assigned to one of these two groups. Over 6 months, the intervention group will learn to use the EJT tool and apply environmental justice concepts to construction projects. Researchers will measure how well students understand connections between construction, environment, and health at the start, middle, and end of the program, and again 6 months later. The goal is to determine if integrating environmental justice and health concepts into construction education improves students' awareness of how their future work can help or harm community health, particularly in disadvantaged neighborhoods.",[400,41,401,402],"Health Knowledge","Attitude","Practice",[404,405,406,407,408],"Environmental justice","Planetary health","Construction education","Workforce development","Health equity","2026-01-02",{"date":411,"type":74},"2026-01-07",{"date":413,"type":22},"2026-08-05",{"date":415,"type":22},"2027-12-12",{"name":417,"class":112},"Stanford University",{"id":419,"slug":420,"hasResults":11,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":4,"eligibilityCriteria":424,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":344,"enrollmentInfo":425,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":427,"conditions":428,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":82},"100617075","effects-of-environmental-fungal-exposure-on-bronchial-asthma-abpa-and-bronchiectasis-100617075","NCT07313904","Effects of Environmental Fungal Exposure on Bronchial Asthma, ABPA and Bronchiectasis","Effects of Environmental Fungal Exposure on Bronchial Asthma, Allergic Bronchopulmonary Aspergillosis (ABPA), and Bronchiectasis","Inclusion Criteria:\n\n1. Age range of 18-80 years old (including 18 and 80 years old), gender and race are not limited;\n2. No history of asthma, ABPA, or other chronic respiratory diseases.\n3. No history of allergic diseases, such as allergic rhinitis, eczema, or food allergies.\n4. Pulmonary function is normal or close to the normal range.\n5. Laboratory testing:\n\n1\\. Blood routine: High sensitivity C-reactive protein, white blood cells, neutrophils, lymphocytes, and monocytes are all within the normal range.\n\nAllergen testing: IgE levels for common allergens such as dust mites, cat hair, dog hair, cockroaches, mold, and pollen are normal or close to the normal range.\n\nExclusion Criteria:\n\n1. Suffering from bronchial asthma ABPA、 Bronchiectasis or other respiratory diseases: chronic obstructive pulmonary disease, active pulmonary tuberculosis, pulmonary embolism, lung cancer, pneumothorax, hemoptysis, pulmonary arterial hypertension, interstitial lung disease, etc;\n2. Cancer patients who suffer from serious other systemic diseases, such as myocardial infarction, stroke, hypertensive crisis or refractory hypertension, severe arrhythmia, heart failure, aortic aneurysm, liver failure, renal failure, hematological disorders, etc., and have recently been discovered or are currently receiving treatment;\n3. Four weeks prior to enrollment, systemic use of antibiotics, antifungal drugs, immunosuppressants, cytotoxic agents, hormones, etc;\n4. Other individuals with contraindications for induced sputum testing:",{"count":426,"type":22},125,"This study is a prospective, observational study of patients aged 18-80 years with clinical diagnosis of bronchial asthma, allergic bronchopulmonary aspergillosis (ABPA), bronchiectasis and healthy subjects. Among them, the bronchial asthma group will be divided into asthma control group, asthma partial control group and asthma uncontrolled group according to the GINA asthma control classification. Record the baseline information of the subjects in detail, including basic information, disease course, smoking, previous acute attacks and hospitalizations, long-term medication, etc. (including the frequency, dose and duration of ICS use, antifungal drug type, dose, duration of use, and course of treatment), and evaluate and record environmental factors (such as indoor).Humidity, temperature, ventilation, pet keeping, plant planting, etc.) and other lifestyle factors that may affect disease control and fungal exposure. The patient's disease status was assessed using questionnaire scores.\n\nSputum samples were taken at the time of enrollment.Set (asthma ABPA group uses sputum induction), pulmonary function test and bronchodilator test, FeNO measurement (asthma ABPA group only), blood routine test, Aspergillus-specific IgE and IgG detection, total immunoglobulin IgE, allergen detection, etc. Dust was collected indoors (bedrooms), outdoor (balconies) and on the surface of air conditioners or fans (if applicable) in the subject's living environment, and environmental data such as ambient temperature, humidity, and particulate matter concentration were recorded. 18S rRNA technology was used for sputum and dust fungus detection, and ELISA was used for asthmatitis symptomatic markers, which assess the impact of fungal infections on the disease. Follow-up for each subject 6 months, 6 months after enrollment, the patient's symptom changes, acute exacerbations\u002Fexacerbations, and prognosis were recorded, and relevant questionnaire scores were completed.",[41,429,430,431],"Asthma","Bronchiectasis","ABPA","2025-12-17",{"date":409,"type":74},{"date":435,"type":74},"2025-07-23",{"date":437,"type":22},"2026-06-30",{"name":439,"class":440},"First Affiliated Hospital of Ningbo University","NETWORK",{"id":442,"slug":443,"hasResults":11,"nctId":444,"briefTitle":445,"officialTitle":446,"acronym":447,"eligibilityCriteria":448,"healthyVolunteers":11,"sex":18,"minAge":449,"maxAge":450,"enrollmentInfo":451,"targetDuration":4,"studyType":122,"phases":453,"briefSummary":454,"conditions":455,"keywords":459,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":467,"lastUpdatePostDateStruct":468,"startDateStruct":470,"completionDateStruct":472,"leadSponsor":474,"locationsCount":256},"100601493","ambient-air-and-noise-effect-on-cardiovascular-health-risk-and-lifestyle-intervention-to-attenuate-it-metsgreen-100601493","NCT07111208","Ambient Air and Noise Effect on Cardiovascular Health Risk and Lifestyle Intervention to Attenuate It (METSGREEN)","Noise and\u002For Ultrafine Particulate Matter Induced Cerebral and Cardiovascular Damage: Experimental and Epidemiological Studies (MARKOPOLO) and Lifestyle Intervention to Attenuate Cardiovascular Health Risk (METSGREEN)","METSGREEN","Inclusion Criteria:\n\n* Age 45-64 years\n* Residence in Kaunas City\n* Presence of metabolic disorder indicators (e.g., increased waist circumference and\u002For elevated blood pressure)\n* Willingness to participate and provide written informed consent\n* Agreement to wear a wristband sensor continuously for 7 days\n\nExclusion Criteria:\n\n* Unstable angina or cardiomyopathy\n* Blood pressure \\>160\u002F110 mmHg\n* Neurological diseases or limited mobility\n* Presence of a cardiac pacemaker\n* Pregnancy\n* Alcohol dependence","45 Years","64 Years",{"count":452,"type":22},180,[124],"This study, combining both an observational study and an interventional clinical trial, aims to assess how exposure to ultrafine particulate matter (PM0.1) and noise pollution affects the risk of cardiovascular diseases and metabolic disorders in 45-64-year-old residents of Kaunas City, and whether lifestyle interventions-specifically physical activity in green spaces and the Mediterranean diet-can help reduce these risks.\n\nIn the observational part, approximately 1,000 randomly selected 45-64 years men and women living in private households will complete an anonymous online health and lifestyle questionnaire. The clinical interventional trial will include 180 participants, who agreed to participate in the clinical study and, who meet specific health criteria. The main questions the study seeks to answer are: whether increased exposure to PM0.1 and noise is linked to higher cardiovascular and metabolic risk; and whether short-term healthy lifestyle changes can improve biological markers associated with these conditions.\n\nParticipants in the clinical trial will be randomly assigned to one of three groups: (1) control group continuing usual habits, (2) physical activity group at least 30-minute daily walks in green spaces, or (3) group adherence to a Mediterranean diet. They will have two visits to the clinic for health surveys:\n\n* Wear a wristband sensor for 7 days to monitor physical activity, heart rate, and sleep quality\n* Visit a clinic on Day 1 and Day 8 for measurements (blood pressure, waist circumference, body composition) and give blood samples for biomarker analysis.\n\nThis research will provide new evidence on environmental health risks and practical recommendations for reducing the burden of metabolic and cardiovascular diseases.",[456,33,457,41,458],"Cardiovascular Diseases (CVD)","Air Pollution Exposure","Health Behavior Change",[460,461,462,463,464,465,466],"ultrafine particles","noise pollution","cardiovascular risk","metabolic syndrome","physical activity","Mediterranean diet","environmental exposure","2025-11-21",{"date":469,"type":74},"2025-11-28",{"date":471,"type":74},"2025-10-24",{"date":473,"type":22},"2028-12",{"name":475,"class":112},"Regina Grazuleviciene",{"id":477,"slug":478,"hasResults":11,"nctId":479,"briefTitle":480,"officialTitle":480,"acronym":481,"eligibilityCriteria":482,"healthyVolunteers":17,"sex":18,"minAge":483,"maxAge":484,"enrollmentInfo":485,"targetDuration":4,"studyType":122,"phases":487,"briefSummary":488,"conditions":489,"keywords":492,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":256},"100550507","the-barts-charity-childrens-environmental-health-clinic-100550507","NCT06447974","The Barts Charity Children's Environmental Health Clinic","BCCEHC","Inclusion Criteria:\n\n* Parent\u002FGuardian able to provide written informed consent\n\nReferral made by paediatric asthma team\n\nChild aged 4-17 years at the time of consent to study\n\nA diagnosis of a chronic respiratory condition (diagnosis by a medical professional)\n\nContactable for regular follow up by the research team\n\nReasonable level of English language\n\nAbility to engage with technology and devices used in the study\n\nExclusion Criteria:\n\n* Inability to use the tools and devices in the research study\n\nInability to visit the hospital for the initial hospital visit\n\nInability to allow home environmental assessment","4 Years","17 Years",{"count":486,"type":22},200,[124],"The study will be based from a newly formed NHS service, the children's environmental health service. Participants will be children with a known chronic respiratory condition. Participants will undergo personal environmental exposure monitoring as well as home environmental assessments, before personalised exposure reports will be provided including a summary of their exposure and advising mitigation strategies based on exposure patterns and behaviours. The monitoring will be repeated after introduction of mitigation strategies. This will allow a comparison of the effectiveness of each method of mitigation.",[41,490,491,315],"Health Behavior","Asthma in Children",[493,494,495,496],"asthma","Air pollution","environmental","Environmental health clinic","2025-08-07",{"date":499,"type":74},"2025-08-12",{"date":501,"type":74},"2025-07-24",{"date":503,"type":22},"2027-06",{"name":505,"class":112},"Queen Mary University of London",{"id":507,"slug":508,"hasResults":11,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":512,"eligibilityCriteria":513,"healthyVolunteers":17,"sex":18,"minAge":514,"maxAge":4,"enrollmentInfo":515,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":517,"conditions":518,"keywords":541,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":570,"lastUpdatePostDateStruct":571,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":577,"locationsCount":82},"100469557","generation-victoria-cohort-2020s-a-statewide-longitudinal-cohort-study-of-victorian-children-and-their-parents-100469557","NCT05394363","Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents","Generation Victoria Cohort 2020s. A Statewide Longitudinal Cohort of Victorian Children and Their Parents","GenV","Inclusion Criteria (Children):\n\n* Birth date between 4th October 2021 and 3rd October 2023\n* Live at the time of recruitment\n* Residing in Victoria at the time of recruitment\n* Has a legally acceptable representative capable of understanding the informed consent document and providing consent on the child's behalf, who provides a signed and dated informed consent form (e.g. a parent\u002Fguardian)\n\nInclusion Criteria (Adults):\n\n* Be a parent or guardian of a child who meets the eligibility criteria above\n* Provide a signed and dated informed consent form or have a legally acceptable representative capable of understanding the informed consent document and providing consent on the participant's behalf.\n\nExclusion criteria:\n\n* Children who are deceased at the time of recruitment (i.e. still born or died after birth) and their parents\u002Fguardians\n* Families unable to provide informed consent in any of the languages available","1 Day",{"count":516,"type":22},150000,"Generation Victoria (GenV) is a longitudinal, population-based study of Victorian children and their parents that will bring together data on a wide range of conditions ,exposures and outcomes. GenV blends study-collected, study-enhanced and linked data. It will be multi-purpose, supporting observational, interventional, health services and policy research within the same cohort. It is designed to address physical, mental and social issues experienced during childhood, as well as the antecedents of a wide range of diseases of ageing. It seeks to generate translatable evidence (prediction, prevention, treatments, services) to improve future wellbeing and reduce the future disease burden of children and adults.\n\nThe GenV Cohort 2020s is open to all children born over a two-year period, and their parents, residing in the state of Victoria Australia. The GenV Cohort 2020s is preceded by an Advance Cohort of children born between 5 Dec 2020 and 3 October 2021, and their parents. This comprises all families recruited at GenV's Vanguard hospital (Joan Kirner Women's and Children's) and at birthing hospitals throughout Victoria as GenV scaled up to commence recruiting for the GenV Cohort 2020s. The Advance Cohort have ongoing and full participation in GenV for their lifetime unless they withdraw but may have less complete data and biosamples.",[519,520,521,522,523,524,43,525,44,41,526,527,528,529,530,531,532,533,534,535,536,537,538,539,540],"Mental Health","Child Wellbeing","Infant Health","Child Health","Reproductive Health","Healthy Aging","Quality of Life","Genetics","Cognition","Learning","Child Development","Congenital Abnormalities","Disability","Injuries","Communicable Diseases","Noncommunicable Diseases","Physical Fitness","Diet","Obesity","Allergy and Immunology","Inflammation","Intergenerational Relations",[542,512,543,544,545,522,546,547,548,549,550,551,552,553,56,554,555,556,557,558,559,560,43,561,562,563,564,565,566,567,44,568,569],"Generation Victoria","Cohort Studies","Data Collection","Data Linkage","Midlife Health","Children","Infants","Family","Parents","Mothers","Fathers","Life course perspective","Longitudinal Studies","Genetics, population","Demography","Epidemiology","Health Disparity","Minority Health","Vulnerable Populations","Clinical Trial","Randomized Controlled Trial","Pragmatic Clinical Trial","Health Services Research","Economic Models","Value of Life","Geographic Information Systems","Climate Change","Built Environment","2025-07-30",{"date":572,"type":74},"2025-08-03",{"date":574,"type":74},"2021-10-04",{"date":576,"type":22},"2033-10",{"name":578,"class":112},"Murdoch Childrens Research Institute",{"id":580,"slug":581,"hasResults":11,"nctId":582,"briefTitle":583,"officialTitle":584,"acronym":585,"eligibilityCriteria":586,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":587,"targetDuration":4,"studyType":122,"phases":589,"briefSummary":590,"conditions":591,"keywords":594,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":4},"100565487","evaluation-of-the-effectiveness-of-prevenir-prevention-environnement-reproduction-platforms-100565487","NCT06642818","Evaluation of the Effectiveness of PREVENIR (PREVention ENvIronnement Reproduction) Platforms","Evaluation of the Effectiveness of PREVENIR (PREVention ENvIronnement Reproduction) Platforms on Urinary Markers of Chemical Exposures - Unblinded Randomized Clinical Trial. PREVENIR-G","PREVENIR-G","Inclusion Criteria:\n\n* All pregnant women less than 24 SA of age referred to the PREVENIR platforms participating in the study for management.\n* Only women less than 24 SA months pregnant will be included to limit the number of women who gave birth during the study.\n* More than 18 years old\n\nFor qualitative study:\n\n* Professionnal working within PREVENIR platforms\n* Women included in the intervention group and who agreed with participating\n\nExclusion Criteria:\n\n* Women under court protection, under guardianship or curatorship, severely altered physical and\u002For psychological health, which, in the opinion of the investigator, may affect the participant's compliance to the study.\n* Women with an altered medical condition related to prgnancy that may required a therapeutic abortion according to the environmental expert\n* Non-French speakers",{"count":588,"type":22},300,[124],"Unblinded randomized clinical superiority trial in two parallel groups (intervention vs. no intervention) national multicentre to evaluate the effectiveness of the platforms on the evolution of phenoxyacetic acid levels measured in the urine at inclusion and 3 months after the intervention for patients who received the intervention compared to patients who did not receive the intervention.",[592,41,593],"Pregnancy","Prevention",[592,595,593],"Environmental exposure","2025-07-21",{"date":598,"type":74},"2025-07-25",{"date":600,"type":22},"2025-09-01",{"date":602,"type":22},"2027-02-01",{"name":604,"class":112},"University Hospital, Bordeaux",{"id":606,"slug":607,"hasResults":11,"nctId":608,"briefTitle":609,"officialTitle":610,"acronym":611,"eligibilityCriteria":612,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":613,"targetDuration":4,"studyType":122,"phases":615,"briefSummary":616,"conditions":617,"keywords":625,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":639,"locationsCount":82},"100594836","assessing-the-effectiveness-of-heat-adaptation-digital-messages-from-primary-care-providers-to-their-patients-on-the-change-in-behaviour-for-heatwave-related-preparedness-100594836","NCT07024628","Assessing the Effectiveness of Heat Adaptation Digital Messages From Primary Care Providers to Their Patients on the Change in Behaviour for Heatwave-related Preparedness","Heat Smart: Empowering Primary Care Providers to Safeguard Vulnerable Populations Against Extreme Heat","HeatSmart","Inclusion Criteria:\n\nThe Heat Smart randomized controlled trial study will recruit patients and primary care providers (PCPs) from Eastern Ontario. The inclusion criteria ensure that the intervention reaches at-risk individuals while being scalable across different patient populations:\n\nPrimary Care Patients:\n\n* Adults (18 years and older)\n* Patients must be registered with a participating PCP.\n* They must have had at least one visit with their PCP in the past two years to ensure active engagement.\n* Participants must have an active email, cell phone or messaging service (SMS) to receive Heat Smart digital messages.\n* Patients must be able to understand and consent to participate in the study.\n* Patients must be able to communicate in at least one of the official languages (English, French).\n* Participants will be recruited from PCP located in two Eastern Ontario public health districts: the Eastern Ontario Health Unit and Ottawa Public Health (including urban, rural, and Indigenous communities such as Akwesasne).\n\nPrimary Care Providers:\n\n* Must be a licensed Family Physician (FP) or Nurse Practitioner (NP) in a practice of at least 2 PCPS.\n* The providers must be offering comprehensive primary care to a panel of patients (not solely urgent care or walk-in services).\n* Must work in a computerized primary care clinic with an electronic medical record system.\n* Must expect to remain in practice for at least 24 months.\n* Must be located in Eastern Ontario.\n* Must be willing to use the Canadian Primary Care Information Network (CPIN) to deliver Heat Smart messages and surveys.\n* Must be using Cliniconex or Qualtrics as a practice tool for communication enabling outreach before the patients are invited to consent to participate in the study.\n\nExclusion Criteria:\n\nPatients who do not read French or English will be excluded from the study as they will not be able to give informed consent or to fill out the surveys. Patients who do not have an email address or text messaging service will be excluded for the same reason. Minors, patients with dementia and people who cannot read and write in English or French will not be eligible because the automated approach to surveying patients makes it impractical to properly obtain their consent.",{"count":614,"type":22},20000,[124],"Extreme heat events pose a significant health threat in Canada, as demonstrated by the 2021 heat wave that claimed over 600 lives in Western Canada. Most heat-related deaths occur indoors and are preventable. Primary care providers (PCPs), who serve 88% of Canadians, are uniquely positioned to identify and support at-risk individuals. Heat Smart, in alignment with Heat Alert and Response Systems (HARS), aims to bridge the gap between primary care and public health to enhance community resilience and reduce health inequities related to extreme heat events.\n\nThis randomized control trial in Eastern Ontario will examine whether patients receiving tailored digital health messages from their family physician or nurse practitioner change their behaviour to protect themselves from extreme heat-related illness. The Heat Smart study will:\n\n* Assess risk: Analyze electronic medical records and patient surveys to identify vulnerable individuals.\n* Deliver tailored messages: Send personalized digital guidance via e-mail or text, offering heat safety advice and local resource information in English and French.\n* Issue early warning alerts: Notify at-risk patients of upcoming heat events, prompting action.\n* Evaluate impact: Use surveys and health data to measure effectiveness in reducing heat-related health impacts.\n\nShort-term outcomes include increased awareness and preparedness among patients about heat-related health risks. Long-term goals involve scaling the intervention across Canada to reduce heat-related illnesses, enhance social connectedness, and decrease healthcare utilization.",[618,619,568,620,621,41,622,623,624],"Heathly Subjects","Primary Health Care","Public Health","Preventive Health Services (PREV HEALTH SERV)","Risk Reduction Behavior","Heat Stress Disorders","Heat Exposure",[626,627,628,629,630,631],"primary care","digital messaging","heatwave","climate change","public health","CPIN","2025-06-09",{"date":634,"type":74},"2025-06-17",{"date":636,"type":74},"2025-04-01",{"date":638,"type":22},"2028-03-31",{"name":640,"class":112},"Hopital Montfort",{"id":642,"slug":643,"hasResults":11,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":4,"eligibilityCriteria":647,"healthyVolunteers":17,"sex":18,"minAge":233,"maxAge":648,"enrollmentInfo":649,"targetDuration":4,"studyType":122,"phases":651,"briefSummary":652,"conditions":653,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":656,"lastUpdatePostDateStruct":657,"startDateStruct":659,"completionDateStruct":661,"leadSponsor":663,"locationsCount":82},"100505776","reconstructing-schoolyards-with-greenery-to-increase-schoolchildrens-physical-activity-and-mitigate-climate-changes-100505776","NCT05865782","Reconstructing Schoolyards With Greenery to Increase Schoolchildren's Physical Activity and Mitigate Climate Changes","Skolgårdsprojketet: Bygga om skolgårdar i Stockholm Med grönska för Att öka Skolbarns Fysisk Aktivitet Och hälsa Samt Mildra klimatförändringarna i städer","Inclusion Criteria:\n\nOn school level:\n\n-School selected for schoolyard reconstruction by the City of Stockholm\n\nOn individual level (schoolchildren):\n\n* Enrolled in participating school\n* 8-13 years old at the time of study start\n* In 2nd or 5th grade\n* Parents signed informed consent\n\nExclusion Criteria:\n\nOn school level:\n\n-School not selected for schoolyard reconstruction by the City of Stockholm\n\nOn individual level (schoolchildren):\n\n* Not enrolled in participating school\n* Outside 8-13 years old age range and\u002For not in 2nd or 5th grade\n* Parents declined informed consent","13 Years",{"count":650,"type":22},3600,[124],"By reconstructing schoolyards with greenery, physical activity levels among children can be increased at the population level and also mitigate health and environmental risks resulting from rising climate changes in urban areas.\n\nThe overarching purpose of the proposed project is to:\n\ni. increase physical activity levels among school-aged children, independent of socioeconomic factors, and thus affect short- and long-term health outcomes on a population level ii. establish an evidence-based bottom-up approach for schoolyard reconstructions iii. evaluate the cost-effectiveness of schoolyard reconstructions with greening on health outcomes and its environmental impact",[654,41,655],"Physical Inactivity","Mental Health Wellness 1","2024-06-17",{"date":658,"type":74},"2024-06-20",{"date":660,"type":74},"2024-05-22",{"date":662,"type":22},"2027-11-30",{"name":664,"class":112},"Karolinska Institutet",{"id":666,"slug":667,"hasResults":11,"nctId":668,"briefTitle":669,"officialTitle":670,"acronym":671,"eligibilityCriteria":672,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":673,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":675,"conditions":676,"keywords":680,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":683,"lastUpdatePostDateStruct":684,"startDateStruct":686,"completionDateStruct":688,"leadSponsor":690,"locationsCount":205},"100547471","impact-of-environmental-exposures-on-tumor-risk-in-sdhx-mutation-carriers-100547471","NCT06408402","Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers","Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx-related Paragangliomas - National Study","PGLEXPO2","Inclusion Criteria:\n\n* Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor\n* Controls: SDHx mutation carriers with no SDHx-related tumor\n\nExclusion Criteria:\n\n* Incapacity to exercise free and informed consent for the study\n* Patient under tutorship or guardianship or legal safeguard",{"count":674,"type":22},1300,"The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and\u002For domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects carrying a germline mutation in one of the SDHx genes.The primary endpoint will be the proportion of subjects (cases or controls) exposed to SDHi and the association with paraganglioma risk.\n\nIn addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study",[677,678,679,41],"SDH-Related Familial Paraganglioma","SDHx-Related Syndromes","SDH Gene Mutation",[681,682,466],"hereditary paraganglioma","SDHx gene mutation","2024-05-06",{"date":685,"type":74},"2024-05-10",{"date":687,"type":22},"2024-05-01",{"date":689,"type":22},"2028-05-01",{"name":691,"class":112},"Assistance Publique - Hôpitaux de Paris",{"id":693,"slug":694,"hasResults":11,"nctId":695,"briefTitle":696,"officialTitle":696,"acronym":697,"eligibilityCriteria":698,"healthyVolunteers":11,"sex":18,"minAge":699,"maxAge":700,"enrollmentInfo":701,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":703,"conditions":704,"keywords":710,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":712,"lastUpdatePostDateStruct":713,"startDateStruct":715,"completionDateStruct":717,"leadSponsor":719,"locationsCount":721},"100303086","prospective-urban-rural-epidemiology-study-100303086","NCT03225586","Prospective Urban Rural Epidemiology Study","PURE","Inclusion Criteria:\n\n* consenting adults between 35-70 years of age\n\nExclusion Criteria:\n\n* none","35 Years","70 Years",{"count":702,"type":22},200000,"To examine the impact of health determinants at the individual (e.g. health related behaviors) and societal level (e.g. environmental factors, health related policy, quality of health systems) on health outcomes (e.g. death, non-communicable disease development) across a range of socioeconomic and health resource settings. Additional components of this study will examine genetic factors for non-communicable diseases. This will be examined both through a cross sectional component, and prospectively (cohort component).",[30,705,490,41,706,707,532,708,709],"Risk Factor, Cardiovascular","Lung Diseases","Cancer","Renal Disease","Communicable Disease",[711],"Non-communicable Diseases, Risk Factors","2024-01-29",{"date":714,"type":74},"2024-01-31",{"date":716,"type":74},"2002-01-01",{"date":718,"type":22},"2030-12-31",{"name":720,"class":112},"Population Health Research Institute",34,{"id":723,"slug":724,"hasResults":11,"nctId":725,"briefTitle":726,"officialTitle":726,"acronym":727,"eligibilityCriteria":728,"healthyVolunteers":11,"sex":18,"minAge":233,"maxAge":729,"enrollmentInfo":730,"targetDuration":732,"studyType":23,"phases":4,"briefSummary":733,"conditions":734,"keywords":4,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":737,"lastUpdatePostDateStruct":738,"startDateStruct":740,"completionDateStruct":742,"leadSponsor":744,"locationsCount":4},"100447357","the-impact-of-synergies-of-indoor-air-pollutants-on-childhood-health-and-wellbeing-100447357","NCT05105386","The Impact of Synergies of Indoor Air Pollutants on Childhood Health and Wellbeing","SynAir-Child","Inclusion Criteria:\n\n1. Students of primary schools aged 8-9 years.\n2. The subject and\u002For legal custodian have the verbal, writing and mental ability to understand the intent and character of the study.\n3. Written informed consent from the child's parents\u002Fguardian's\n\nExclusion Criteria:\n\nUnwilling to use the application and follow the procedures of the protocol","9 Years",{"count":731,"type":22},3000,"1 Year","To quantify health effects of synergizing chemical and biological pollutants in a targeted population setting, i.e., school-aged children. Indoor air pollutants will be monitored within the classrooms with high end sensors. Exposure data from additional sources (outdoor, home, transports) will be obtained. Health outcomes will be assessed prospectively using validated medical procedures and real-time tracking with mobile health (mHealth) equipment and a gamified computer app.",[312,41,735,736],"Childhood Asthma","Childhood","2021-10-22",{"date":739,"type":74},"2021-11-03",{"date":741,"type":22},"2023-09",{"date":743,"type":22},"2027-09",{"name":745,"class":112},"National and Kapodistrian University of Athens"]