[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"epidural-dosage-of-lidocaine-bupivacaine-in-lower-limb-surgeries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:epidural-dosage-of-lidocaine-bupivacaine-in-lower-limb-surgeries":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":39,"locationsCount":5},"100642985","comparison-of-different-epidural-lidocaine-bupivacaine-mixtures-for-lower-limb-surgeries-100642985",false,"NCT07648784","Comparison of Different Epidural Lidocaine-Bupivacaine Mixtures for Lower Limb Surgeries","Comparison of the Outcomes of Epidural Injection of Different Lidocaine-Bupivacaine Mixtures for Lower Limb Surgeries at a Tertiary Care Hospital, Karachi","LBM-LLS","Inclusion Criteria:\n\nPatients undergoing lower limb surgeries under epidural block Age between 20-60 years Either gender American Society of Anesthesiologists (ASA) physical status I and II Patients willing to provide informed consent\n\nExclusion Criteria:\n\nContraindications to regional anesthesia including patient refusal and bleeding diathesis History of allergy to local anesthetics Patients undergoing emergency surgeries Deformities of the spine History of hypothyroidism or hyperthyroidism Pregnant patients","ALL","20 Years","60 Years",{"count":21,"type":22},96,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled trial will evaluate different epidural lidocaine-bupivacaine mixtures in patients undergoing lower limb surgery at a tertiary care hospital in Karachi, Pakistan. Ninety-six participants will be randomly assigned to one of three study groups receiving different combinations of lidocaine and bupivacaine for epidural anesthesia.\n\nThe purpose of this study is to determine which anesthetic mixture provides the most effective anesthesia for lower limb surgery. The study will compare the speed of onset and duration of anesthesia, as well as the effects of the anesthetic mixtures on cardiovascular stability during surgery.\n\nThe results of this study may help identify an epidural anesthetic regimen that provides optimal surgical conditions, effective pain control, and stable hemodynamic parameters for patients undergoing lower limb procedures.",[28],"Epidural Dosage of Lidocaine Bupivacaine in Lower Limb Surgeries",[30],"Epidural, Lidocaine, Bupivacaine, lower limb surgeries","RECRUITING","2026-06-12",{"date":34,"type":35},"2026-06-15","ACTUAL",{"date":37,"type":35},"2025-12-18",{"date":34,"type":22},{"name":40,"class":41},"Shaheed Mohtarma Benazir Bhutto Institue of Trauma","OTHER"]