[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"epigenetic-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:epigenetic-disorder":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":5},"100498100","self-harm-behaviour-among-the-most-at-risk-adolescents-100498100",false,"NCT05765864","Self-harm Behaviour Among the Most At-risk Adolescents","Influences on and Prevention of Self-harm Behaviour Among the Most At-risk Adolescents","SH-MARA","CLINICAL GROUP:\n\nInclusion Criteria:\n\n* Suicidality\n* Self-harming with no intention to die\n\nExclusion Criteria:\n\n* Confirmed acute psychotic disorder\n* Intellectual disability\n* Severe physical illness (e.g. cardiovascular or renal disease)\n* Disease of the central nervous system (e.g. encephalitis, brain injury or haemorrhage, epilepsy)\n* Acute poisoning (including with psychoactive substances)\n\nCONTROL GROUP:\n\nInclusion Criteria:\n\n\\- Age 13-19\n\nExclusion criteria:\n\n* Suicidality\n* Self-harming with no intention to die\n* Known mental disorder (e.g. depression, bipolar disorder, schizophrenia, intellectual disability)\n* Severe physical illness (e.g. cardiovascular or renal disease)\n* Disease of the central nervous system (e.g. encephalitis, brain injury or haemorrhage, epilepsy)\n* Acute poisoning (including with psychoactive substances)\n* Mental disorder, history of suicidality or self-injurious behaviour in a first-degree relative (a parent or a sibling).",true,"ALL","13 Years","18 Years",{"count":22,"type":23},400,"ESTIMATED","OBSERVATIONAL","In the proposed study, three objectives will be pursued:\n\n1. To develop a method to identify more effectively the acute and long-term risk of adolescents with the most threatening self-harm behaviours.\n2. To identify the factors that influence the risk of self-harm behaviours and the success of treatment\u002Ftreatment of these behaviours in the most at-risk adolescents (changes in these factors).\n3. Develop guidelines for more effective treatment of the most at-risk adolescents.\n\nFor this purpose, a sample of approximately 200 young people who will be hospitalised for suicide risk (the most at risk in Slovenia) and an approximately equal number of healthy adolescents will be included. At inclusion, the presence of several factors will be assessed by reviewing demographic data, clinical diagnosis, self-assessment questionnaires and clinical psychological tests (CSSRS, B-NSSI-AT, ISAS, LPFS-BF2.0, BPFSC-11, TSCC, PAI, ECR-RS, DASA-YV, ASHRS), social assessment, and blood sampling for genetic analyses (DNA isolation, sequencing, nucleotide sequence recognition, quantification and evaluation of short tandem repeats, identification of methylation sites). Longitudinal tracking of autoaggressive events and heteroaggressive events during hospitalisation will be performed and recorded on an ongoing basis. The risk and protective factors of the adolescents most at risk will be compared with a control group of adolescents. The same factors will be reassessed in the most at-risk adolescents after 6 and 18 months of treatment as usual. The data will be collected in a data entry and storage system that will ensure the privacy of the data entered in accordance with the GDPR.\n\nThis will allow the investigators to identify young people at particular risk of severe self-harm behaviour more reliably, to target them for more intensive and effective treatment, and thus to improve their safety, quality of life and prognosis in the short and long term.",[27,28,29,30,31,32],"Self-harm","Personality Disorder, Borderline","Epigenetic Disorder","Non-Suicidal Self Injury","Change; Mental","Difference, Individual",[34,35,36,37,38,39,40,41,42],"adolescent","deliberate self-harm","risk and protective factors","suicidal behavior","non-suicidal self-injury","risk assessment","attachment","genetics","epigenetics","RECRUITING","2025-03-26",{"date":46,"type":47},"2025-03-28","ACTUAL",{"date":49,"type":47},"2023-03-23",{"date":51,"type":23},"2025-10",{"name":53,"class":54},"University of Ljubljana, Faculty of Medicine","OTHER",{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100557767","phase-2-pbm-as-strategy-to-cabg-anemic-patients-bypass-graft-cabg-100557767","NCT06542393","PBM as Strategy to CABG Anemic Patients Bypass Graft (CABG)","Patient Blood Manegement (PBM) as Perioperative Strategy to Anemic Patients Who Will be Submitted to Coronary Artery Bypass Graft (CABG).","Inclusion Criteria:\n\n* Eletive surgery;\n* Only CABG as procedure;\n* Off pump CABG candidate.\n\nExclusion Criteria:\n\n* Age \\> 80 years;\n* Chronic dialytic kidney disease;\n* Chronic rheumatologic disease;\n* Men with Hb levels \\> 13 g\u002Fdl and \\\u003C 8g\u002Fdl;\n* Women with Hb levels \\> 12 g\u002Fdl and \\\u003C 8g\u002Fdl;\n* Presence of another heart disease requiring surgical intervention;\n* Presence of hepatic insufficiency;\n* Presence of any implantable electronic cardiac device in any cardiac chambers;\n* Pregnancy;\n* Diagnosis of malignant neoplasia;\n* Thrombophilias;\n* Need for Erythropoietin treatment due to any other disease.\n* Recent ischemic event (\\\u003C 3 months).\n* Ejection fraction \\\u003C30%.","80 Years",{"count":64,"type":23},120,"INTERVENTIONAL",[67],"PHASE2","Anemia poses risks during coronary artery bypass grafting (CABG), increasing complications and mortality rates. Blood transfusions in cardiac surgery have negative outcomes, prompting the use of erythropoietin in Patient Blood Management (PBM) to limit transfusion needs and enhance postoperative recovery. EPO can reduce blood component requirements, adverse events, and inflammation in anemic CABG patients. A study aims to minimize transfusions through a PBM anemia treatment protocol for CABG patients, comparing outcomes in three groups: a Control Group (CG), a Non-PBM Group (NPBMG) treated with blood components, and a PBM Group (GPBM) treated with EPO. Parameters include post-op stay, mortality, cardiovascular events, non-cardiovascular events, ICU time, mechanical ventilation duration, vasoactive drug use, inflammatory responses, and cardiac cell death. Analysis will consider demographic and clinical factors, with expectations that GPBM will yield superior results compared to NPBMG and similar or better outcomes than CG.",[70,71,72,73,74,75,76,29],"Anemia","Coronary Disease","Coronary Artery Disease","Coronary Stenosis","Coronary Occlusion","Systemic Inflammatory Response","Bleeding","2024-08-04",{"date":79,"type":47},"2024-08-07",{"date":81,"type":47},"2024-06-01",{"date":83,"type":23},"2026-06-01",{"name":85,"class":54},"Federal University of São Paulo",1]