[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"epilepsy-intractable\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:epilepsy-intractable":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,44,78,138,160,182,203],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100558017","sleep-sensitive-seizure-risk-assessment-with-wearable-eegs-100558017",false,"NCT06545643","Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs","Personalized Risk Assessment of Seizures Sensitive to Poor Sleep: a Longitudinal Study Using Wearable Electroencephalography Devices","Inclusion Criteria:\n\n* Age \\> 18 years\n* At least 2 seizures per week based on clinical notes\n* Patients where medications will stay stable over the study period\n* 40% of both spikes and spindles are identifiable on the dreem headband based on the screening night\n\nExclusion Criteria:\n\n* Cognitive impairment\n* Psychiatric comorbidities which may influence sleep\n* No bedpartner\u002Fcaregiver to observe seizures\n* Low agreement (below 60%) between Dreem's sleep scoring and manual scoring will be excluded from the study\n* Apnea-hypopnea index of \\> 10\u002Fh","ALL","18 Years",{"count":19,"type":20},35,"ESTIMATED","INTERVENTIONAL",[23],"NA","Epilepsy, a prevalent neurological disorder, affects 40% of patients with uncontrolled seizures despite medications. Sleep disturbance exacerbates epilepsy, and vice versa, but existing literature suffers from limitations. Studies conducted in hospital settings provide only brief observation periods and fail to capture the natural sleep environment. Wearable technology offers a promising solution, providing a nuanced understanding of the relationship between seizures and sleep. The Dreem headband, an EEG-based wearable, is well-suited for such studies, offering ease of use and validated accuracy. This technology enables extended observation periods under stable medication conditions, essential for assessing the complex interplay between sleep and epilepsy. By elucidating the impact of sleep on seizures, the researchers seek to identify patient populations where sleep significantly influences seizure susceptibility, ultimately informing personalized epilepsy treatments.",[26],"Epilepsy Intractable",[28,29,30],"epilepsy","sleep","wearable EEG","RECRUITING","2026-06-04",{"date":34,"type":35},"2026-06-05","ACTUAL",{"date":37,"type":35},"2025-05-01",{"date":39,"type":20},"2028-06-01",{"name":41,"class":42},"Duke University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":43},"100619894","pediatric-epilepsy-100619894","NCT07350551","Pediatric Epilepsy","Inclusion Criteria:\n\n* Candidates will be those who are admitted to the Epilepsy Monitoring Unit and are able to participate in a pre-operative evaluation using depth intracranial electrodes. The candidacy is determined independently by the patient's treating physician as part of the patient's routine medical care.\n* Patients have drug-intractable epilepsy undergoing invasive monitoring in the EMU.\n\nExclusion Criteria:\n\n* Determination by clinicians and investigators that a patient is unable to complete the behavioral tasks required for the protocol due to either cognitive limits, psychological limits, or pain.","3 Years","25 Years",{"count":53,"type":20},200,[23],"The purpose of the research is to better understand how the human brain accomplishes the basic cognitive tasks of learning new information, recalling stored information, making decisions or choices about presented information and self-control. These investigations are critical to better understand human cognition and to design treatments for disorders of learning, memory, decision making and cognitive control.",[26],[58,59,60,61,62,63,64,65,66,67],"Epilepsy","Decision-making","Cognitive control","Memory","Depth Electrode","Brain Diseases","Central Nervous System Diseases","Nervous System Diseases","ADHD (Attention-Deficit\u002FHyperactivity Disorder)","Cognitive development","NOT_YET_RECRUITING","2026-05-28",{"date":71,"type":35},"2026-06-01",{"date":73,"type":20},"2026-07",{"date":75,"type":20},"2032-12",{"name":77,"class":42},"University of Texas Southwestern Medical Center",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":16,"minAge":17,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":21,"phases":89,"briefSummary":90,"conditions":91,"keywords":103,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":137},"100640275","spatial-scene-recognition-memory-in-epilepsy-surgery-100640275","NCT07580183","Spatial Scene Recognition Memory in Epilepsy Surgery","Investigations of Spatial Recognition Memory to Improve Cognitive Outcomes in Epilepsy Surgery","Inclusion Criteria:\n\n* Age 18 years or older\n* For Aims I and III: Diagnosis of focal epilepsy or temporal lobe lesion; patients undergoing evaluation for or having undergone epilepsy surgery\n* For Aim II: Healthy adult participants\n* Full-Scale IQ ≥ 70\n* English proficiency sufficient to understand and complete the task\n* For Aim I: Enrolled in or eligible for Emory University epilepsy surgery research registry\n* For Aim III: Undergoing clinically indicated stereoelectroencephalography (SEEG) at UC Davis Medical Center\n* Able to provide informed consent (or for Aim I retrospective component, prior consent in Emory registry)\n\nExclusion Criteria:\n\n* Full-Scale IQ \\\u003C 70\n* Inability to provide informed consent\n* For Aim III: Age \\> 55 years\n* For Aim II: History of neurological or psychiatric disorder (as applicable per study protocol)",true,"55 Years",{"count":88,"type":20},620,[23],"This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions. Standard neuropsychological tests are insensitive to important memory deficits experienced by patients, particularly in spatial\u002Fscene memory, recollective experience, and familiarity processing. Using a validated virtual tour paradigm, the study examines how familiarity-based recognition and recall of spatial scenes relate to specific brain structures. In Aim I, a large cohort of patients with varied temporal lobe lesions at Emory University undergoes the virtual tour task with voxel-based lesion-symptom mapping to localize necessary brain regions. In Aim II, scalp event-related potentials and eye tracking in healthy participants at UC Davis characterize the temporal dynamics and lateralization of scene recognition. In Aim III, intracranial EEG recordings (including local field potentials and single-unit activity) in epilepsy surgery patients at UC Davis determine the precise network dynamics underlying spatial scene familiarity and recall. The long-term goal is to improve the prediction and prevention of cognitive morbidity from epilepsy surgery by providing a more complete model of spatial recognition memory circuits.",[92,93,94,95,96,26,97,98,99,100,101,102],"Focal Epilepsy","Temporal Lobe Epilepsy","Medically Refractory Epilepsy","Memory Disorders","Epilepsy Comorbidities","Epilepsy Surgery","Epilepsy, Temporal Lobe","Memory Deficits","Memory Disorder, Spatial","Memory Dysfunction","Spatial Perception",[104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127],"spatial memory","recognition memory","familiarity","recollection","neural circuits of memory","phenomenology of memory","scene memory","virtual tour","epilepsy surgery","SEEG","stereo-electroencephalography","lesion-symptom mapping","network-symptom mapping","cognitive electrophysiology","event-related potentials","intracranial EEG","iEEG","parahippocampal gyrus","perirhinal cortex","hippocampus","tetrodes","deja vu","neuropsychology","consciousness","2026-05-06",{"date":130,"type":35},"2026-05-12",{"date":132,"type":35},"2024-07-01",{"date":134,"type":20},"2030-06-30",{"name":136,"class":42},"University of California, Davis",2,{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":85,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":21,"phases":147,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":43},"100412319","early-phase-1-localizing-epileptic-networks-using-mri-and-ieeg-100412319","NCT04649008","Localizing Epileptic Networks Using MRI and iEEG","Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics","Inclusion Criteria:\n\n* Patients with medication-refractory epilepsy\n* Planned intracranial EEG (IEEG) placement\n* Hypothesized to have temporal lobe epilepsy\n\nExclusion Criteria:\n\n* Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified)",{"count":146,"type":20},290,[148],"EARLY_PHASE1","Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.",[58,26,98],"2026-02-11",{"date":153,"type":35},"2026-02-13",{"date":155,"type":35},"2021-03-01",{"date":157,"type":20},"2027-02-28",{"name":159,"class":42},"University of Pennsylvania",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":16,"minAge":167,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":21,"phases":171,"briefSummary":172,"conditions":173,"keywords":174,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":178,"completionDateStruct":179,"leadSponsor":181,"locationsCount":4},"100560744","sleep-disruption-pattern---epilepsy-monitoring-unit-100560744","NCT06581133","Sleep Disruption Pattern - Epilepsy Monitoring Unit","Introducing a Structured Sleep Disruption Pattern to Provoke Earlier Seizures During Epilepsy Monitoring Unit Admissions","Inclusion Criteria:\n\n* Age 14 to 60 years\n* EMU monitoring for presurgical evaluations\n* Average 2-3 seizures per week based on pre-admission seizure diary\n* Sleep as a known seizure trigger\n\nExclusion Criteria:\n\n\\- Multiple seizures a day based on pre-admission seizure diary","14 Years","60 Years",{"count":170,"type":20},75,[23],"Epilepsy affects millions worldwide, with 40% of patients experiencing uncontrolled seizures despite medication. Comprehensive epilepsy centers recommend continuous video-electroencephalography monitoring to define seizure type and distinguish mimickers. This process, however, is resource-intensive, with lengthy hospital stays. The investigators' recent study identified a heightened association between arousals and epileptic activity in drug-resistant focal epilepsy patients. Building on these findings, the investigators aim to explore whether disrupting sleep with an alarm system triggers earlier occurrence of seizures, potentially offering insights to reduce hospital stay durations in epilepsy monitoring units.",[26],[175],"epilepsy monitoring unit","2026-02-09",{"date":151,"type":35},{"date":71,"type":20},{"date":180,"type":20},"2027-12-01",{"name":41,"class":42},{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":21,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":43},"100470476","neural-mechanisms-of-spatial-representations-beyond-the-self-100470476","NCT05406349","Neural Mechanisms of Spatial Representations Beyond the Self","Inclusion Criteria:\n\n* Between 18 and 70 years of age\n* Adequate visual and auditory acuity to allow neuropsychological testing\n* Have undergone depth electrode placement for the purpose of epilepsy evaluation\u002Ftreatment OR have NeuroPace RNS System implanted for epilepsy treatment\n\nExclusion Criteria:\n\n* All DSM-V Axis I and II disorders other than nicotine-dependence\n* History of brain damage","70 Years",{"count":190,"type":20},60,[23],"Spatial navigation is a fundamental human behavior, and deficits in navigational functions are among the hallmark symptoms of severe neurological disorders such as Alzheimer's disease. Understanding how the human brain processes and encodes spatial information is thus of critical importance for the development of therapies for affected patients. Previous studies have shown that the brain forms neural representations of spatial information, via spatially-tuned activity of single neurons (e.g., place cells, grid cells, or head direction cells), and by the coordinated oscillatory activity of cell populations. The vast majority of these studies have focused on the encoding of self-related spatial information, such as one's own location, orientation, and movements. However, everyday tasks in social settings require the encoding of spatial information not only for oneself, but also for other people in the environment. At present, it is largely unknown how the human brain accomplishes this important function, and how aspects of human cognition may affect these spatial encoding mechanisms. This project therefore aims to elucidate the neural mechanisms that underlie the encoding of spatial information and awareness of others. Specifically, the proposed research plan will determine how human deep brain oscillations and single-neuron activity allow us to keep track of other individuals as they move through our environment. Next, the project will determine whether these spatial encoding mechanisms are specific to the encoding of another person, or whether they can be used more flexibly to support the encoding of moving inanimate objects and even more abstract cognitive functions such as imagined navigation. Finally, the project will determine how spatial information is encoded in more complex real-world scenarios, when multiple information sources (e.g., multiple people) are present. To address these questions, intracranial medial temporal lobe activity will be recorded from two rare participant groups: (1) Participants with permanently implanted depth electrodes for the treatment of focal epilepsy through responsive neurostimulation (RNS), who provide a unique opportunity to record deep brain oscillations during free movement and naturalistic behavior; and (2) hospitalized epilepsy patients with temporarily implanted intracranial electrodes in the epilepsy monitoring unit (EMU), from whom joint oscillatory and single-neuron activity can be recorded.",[26],"2025-03-12",{"date":196,"type":35},"2025-03-14",{"date":198,"type":35},"2022-08-06",{"date":200,"type":20},"2027-04-30",{"name":202,"class":42},"Boston University Charles River Campus",{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":16,"minAge":209,"maxAge":17,"enrollmentInfo":210,"targetDuration":4,"studyType":212,"phases":4,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":4},"100562392","the-mosaic-brain-a-new-diagnostic-approach-in-focal-epilepsies-100562392","NCT06602570","The Mosaic Brain: a New Diagnostic Approach in Focal Epilepsies","Inclusion Criteria:\n\n* Children in the epilepsy surgery pathway at Great Ormond Street Hospital (GOSH) with a clear or suspected MRI lesion.\n* All children undergoing SEEG at GOSH. Children for which consent was obtained from themselves or, if appropriate, from their legal representatives.\n* Children in whom there are no clinical contraindication to having a lumbar puncture procedure pre-surgery.\n* Both sexes.\n* Under the age of 18.\n\nExclusion Criteria:\n\n* Children that although undergoing epilepsy treatment or testing for an ischaemic lesion.\n* Children with malignant brain tumours.\n* Children in whom there are contraindications to performing a lumbar puncture procedure.","6 Months",{"count":211,"type":20},40,"OBSERVATIONAL","Overall, this observational cohort study aims to:\n\n1. Improve our understanding of the genetic architecture of childhood focal epilepsies.\n2. Develop a liquid biopsy of cerebrospinal fluid (CSF) and assess feasibility to detect cerebral mosaicism using cell-free DNA (cfDNA) analysis and evaluate its performance against brain tissue on the panel testing.\n3. Develop a methodology to use trace tissue from Stereoelectroencephalography (SEEG) DNA and assess feasibility to detect cerebral mosaicism and evaluate its performance against brain tissue on the panel testing.\n\n3\\. Validate the use of the liquid biopsy and SEEG trace tissue for use in the English National Health Service clinical services and share with other Genomic Laboratory Hubs.",[26,215],"Epilepsy in Children","2024-09-17",{"date":218,"type":35},"2024-09-19",{"date":220,"type":20},"2024-10-01",{"date":222,"type":20},"2026-09-01",{"name":224,"class":42},"Institute of Child Health"]