[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"epiphora\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:epiphora":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100645019","phase-2-atropine-eye-drops-for-watery-eyes-excessive-tearing-100645019",false,"NCT07676981","Atropine Eye Drops for Watery Eyes (Excessive Tearing)","A Randomized, Double-Masked, Dose-Ranging Study of Atropine Sulfate Ophthalmic Solution for the Treatment of Symptoms of Epiphora","You may be able to join if you:\n\n* Are 18 years or older\n* Have vision of 20\u002F200 or better in at least one eye\n* Have watery eyes (epiphora) bad enough to need wiping or dabbing at least twice a day\n* Have watering caused by a functional\u002Fidiopathic, gustatory (\"crocodile tears\"), environmentally triggered (reflex), or obstructive cause - in one or both eyes\n* Have a healthy eye surface, with no significant dry eye, active eye infection, or active eye inflammation\n* Have adequate eyelid position and tone, where surgery is not the main treatment needed and reducing tear production is likely to help\n* Are willing and able to put drops in your eye(s) once each night for 7 days and attend the study visits\n* Can understand and follow the study procedures and communicate with study staff (an interpreter is allowed)\n\nYou will not be able to join if you:\n\n* Have significant dry eye disease\n* Have had an active eye infection within the past 30 days\n* Have an active tear-sac infection, or a blocked tear duct that needs urgent surgery (a blocked tear duct that does not need surgery is allowed)\n* Currently use eye drops that affect tear production or eye-surface testing, unless you are willing to stop them for the study\n* Are allergic to, or should not take, atropine, similar (anticholinergic) medicines, or any ingredient in the study drops\n* Have narrow-angle or angle-closure glaucoma, where dilating the pupil would not be safe for you\n* Are pregnant or breastfeeding\n* Are taking part in another interventional study, or took part in one within 30 days before screening\n* Have any condition that, in the doctor's judgment, would make it unsafe for you to join or hard to follow the study","ALL","18 Years",{"count":19,"type":20},18,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","The goal of this clinical trial is to learn if low-dose atropine eye drops work to reduce excessive watery eyes (epiphora) in adults. It will also learn about the safety of the eye drops.\n\nThe main questions it aims to answer are:\n\nDo the eye drops reduce how often participants have watery eyes? What medical problems do participants have when taking the eye drops?\n\nResearchers will compare two strengths of the eye drops (0.005% and 0.01%) to see whether one works better than the other and whether the lower strength works as well as the higher one.\n\nParticipants will:\n\n* Use the assigned eye drops in the affected eye(s) for one week\n* Visit the clinic twice for checkups and eye tests\n* Receive a follow-up phone call about two weeks after starting, to check on any symptoms",[26],"Epiphora","RECRUITING","2026-06-24",{"date":30,"type":31},"2026-06-30","ACTUAL",{"date":33,"type":20},"2026-06",{"date":35,"type":20},"2026-07",{"name":37,"class":38},"Rehan Ahmed","OTHER",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":21,"phases":48,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":66},"100490250","phase-4-does-topical-ophthalmic-proparacaine-05-prior-to-probing-and-irrigation-decrease-pain-100490250","NCT05663684","Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain?","Does Administration of Proparacaine Hydrochloride 0.5% Ophthalmic Solution Prior to Canalicular Probing and Irrigation Decrease Patient Discomfort?","Inclusion Criteria:\n\n* Participants of any sex aged 18 years or older\n* Signs and symptoms of epiphora which necessitate performance of a diagnostic probing and irrigation of the bilateral lower eyelid lacrimal drainage system at Louisiana State University Health Sciences Center or any of the listed physician offices who present with a complaint of epiphora from either eye\n\nExclusion Criteria:\n\n* A known allergy to topical proparacaine hydrochloride\n* Known pre-existing scarring, surgery, radiation to the nasolacrimal system\n* Presence of blockage and or reflux on probing and irrigation of either side\n* Cognitive Impairment",{"count":47,"type":20},145,[49],"PHASE4","Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves participant comfort during the procedure. To date, there have been no formal studies evaluating the possible benefit of this pretreatment.\n\nMethods: Participants 18 years and older who present to the Louisiana State University or associated outpatient ophthalmology clinic(s) with a complaint of epiphora (excessive tearing) who necessitate bilateral lower lid probing and irrigation of the lacrimal drainage system will be enrolled in the study. One eye will be randomized to receive a drop of the anesthetic Proparacaine hydrochloride 0.5% and the other eye will receive a control drop of Balanced Salt Solution (BSS). Probing and irrigation will then be performed in the usual fashion. The participant will then be questioned via survey on a pain scale of 1-5 as to the amount of subjective pain experienced on each side during the procedure.\n\nExpected Results: Investigators expect participants will experience statistically significantly less pain in eyes that have received a drop of Proparacaine hydrochloride 0.5% prior to performance of probing and irrigation compared to the eyes which have received the control drop.",[26,52,53],"Dacryostenosis","Dacryocystitis",[55,56],"Nasolacrimal duct obstruction","Probe and irrigation","2022-12-15",{"date":59,"type":31},"2022-12-23",{"date":61,"type":31},"2020-06-30",{"date":63,"type":20},"2023-01-31",{"name":65,"class":38},"Louisiana State University Health Sciences Center in New Orleans",1]