[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"episodic-memory\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:episodic-memory":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,62],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100626948","the-dynamics-of-representational-change-underlying-recall-100626948",false,"NCT07442266","The Dynamics of Representational Change Underlying Recall","Exclusion Criteria:\n\n* Under the age of 18 or over the age of 40\n* Does not live in the United States or is not a native speaker of English\n* Diagnosis of a neurological disorders, a history of head trauma, or diagnosis of psychiatric disorder\n* Imperfect and uncorrected visual acuity, color blindness, or imperfect hearing\n* Magnetically or mechanically activated implants or other untested metal implants\n* Claustrophobia",true,"ALL","18 Years","40 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to examine how repeated memory retrieval changes visual representations in the brain in healthy adult participants. Specifically, the study aims to determine whether repeated recall strengthens or transforms neural representations in visual cortex compared to a time-matched control condition. The main questions it aims to answer are: 1) Does repeated retrieval produce cumulative changes in visual cortical representations compared to a control condition matched for elapsed time? 2) Do these representational changes differ for simple spatial stimuli and complex natural images?\n\nResearchers will compare neural activity patterns during repeated retrieval to those during a control retrieval condition to determine whether repeated recall leads to systematic changes in representational structure beyond those attributable to the passage of time. Participants will: 1) complete two fMRI sessions. 2) Undergo a localizer session including anatomical imaging, population receptive field (pRF) mapping, and a visual category localizer task. 3) Study cue-stimulus pairs consisting of either simple spatial patterns or natural images. 4) Recall previously studied stimuli multiple times during repeated and control retrieval conditions while undergoing fMRI scanning. Brain activity patterns during study and recall will be compared to assess how repeated retrieval influences the structure and tuning of visual representations.",[27],"Episodic Memory","RECRUITING","2026-02-27",{"date":31,"type":32},"2026-03-02","ACTUAL",{"date":34,"type":32},"2026-02-03",{"date":36,"type":21},"2026-08",{"name":38,"class":39},"Brown University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":40},"100557658","posterior-cingulate-cortex-and-executive-control-of-episodic-memory-100557658","NCT06540976","Posterior Cingulate Cortex and Executive Control of Episodic Memory","Inclusion Criteria:\n\n* All participants are patients undergoing invasive brain monitoring for epilepsy and will be asked to consent to participation in this basic science protocol (which is focused on the patient group but is not focused on the study of epilepsy).\n\nExclusion Criteria:\n\n* Individuals not undergoing invasive brain monitoring for epilepsy.\n* Individuals outside of the age range (18-50 yrs).\n* Individuals with cognitive impairment or intellectual difficulty.","50 Years",{"count":49,"type":21},130,[24],"This project will use intracranial recordings and stimulation of the human brain to understand the unique contributions of the posterior cingulate cortex (PCC) to episodic memory behavior. The goal is to test how distinct subregions of the PCC differentially contribute to memory-based decisions (e.g., have I seen this picture before?). The ability to perform invasive studies of the human brain is through routine clinical monitoring of brain activity which occurs during the neurosurgical treatment of epilepsy. However, this project only focuses on the basic science of PCC and memory behavior. Specifically, the investigators will use single-0cell and population measures of brain activity to test a new theory of PCC function which focuses on the executive processes needed to support memory retrieval and memory-based decisions. By studying the PCC, a convergence zone of memory and executive brain systems, progress can be made in elucidating how the failure to successfully leverage past experiences in daily behavior can occur as a common symptom of both neurodegenerative disease (e.g., Alzheimer's disease) and multiple psychiatric conditions (e.g., schizophrenia) implicating PCC dysfunction.",[27],"2025-09-05",{"date":55,"type":32},"2025-09-12",{"date":57,"type":32},"2023-01-18",{"date":59,"type":21},"2027-04-30",{"name":61,"class":39},"University of Pennsylvania",{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":22,"phases":72,"briefSummary":73,"conditions":74,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":40},"100514121","episodic-memory-integration-and-interference-100514121","NCT05974371","Episodic Memory Integration and Interference","A Basic Science Study on Episodic Memory Integration and Interference in Healthy Adults","Inclusion Criteria:\n\n1. All participants: willing and able to follow the protocol\n2. All participants: fluent in English\n3. Online participants: online account in the crowdsourcing platform that will be used (e.g., Prolific)\n\nExclusion Criteria:\n\n1. All participants: history of a psychiatric or neurological condition, and\u002For current psychotropic drug use (indicated by the participant)\n2. fMRI participants: pregnant, metal in body (incl piercings or metallic makeup if unwilling to remove), unable to lie still for duration of scan (e.g., due to pain), Meniere's disease, claustrophobic, or other contraindication for MRI as determined my MRI technician, left-handed","39 Years",{"count":71,"type":21},150,[24],"The purpose of this study is to assess how emotional memories integrate and interfere with one another over time. We will be using a multi-session experimental paradigm consisting of two encoding sessions and one retrieval session. Participants will either complete these sessions online or in-person, with the latter collecting functional magnetic resonance imaging during the two encoding sessions.",[27],"NOT_YET_RECRUITING","2023-07-26",{"date":78,"type":32},"2023-08-03",{"date":80,"type":21},"2024-08",{"date":82,"type":21},"2027-08",{"name":84,"class":39},"Boston College"]