[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"epistaxis-nosebleed\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:epistaxis-nosebleed":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,70,94,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100625360","management-of-epistaxis-comparing-nasal-packing-versus-greater-palatine-foramen-block-100625360",false,"NCT07421622","Management of Epistaxis Comparing Nasal Packing Versus Greater Palatine Foramen Block","A Pilot Randomized Controlled Trial in Management of Epistaxis Comparing Nasal Packing Versus Greater Palatine Foramen Block","ANPvsGPF block","Inclusion Criteria:\n\n* Presentation with active anterior epistaxis\n* Failure of initial conservative measures (e.g., nasal compression and topical vasoconstrictors)\n* Ability to provide informed consent and those who consent for the study.\n\nExclusion Criteria:\n\n* Suspected or confirmed posterior epistaxis\n* Known bleeding disorders or platelet count \\\u003C50,000\u002Fmm³\n* Use of anticoagulants with supratherapeutic INR\n* Known allergy to local anaesthetic agents","ALL","18 Years","70 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this pilot randomized controlled trial is to compare pain relief efficacy while using nasal packing versus greater palatine foramen block (GPFB) in the management of acute episodes of epistaxis. The main questions it aims to answer are: Does GPFB have less potential to inflict pain when dealing with hemostasis with epistaxis, utilizing a pre-validated 10-point visual analog scale (VAS)? Was hemostasis management more effective in either technique? Researchers will compare anterior nasal packing to greater palatine foramen block using 2% xylocaine with adrenaline.\n\nPatients will receive any of the hemostatic interventions at the time of the acute epistaxis episode.\n\nThe questionnaire will be administered 24 hours post-intervention.",[28,29],"Epistaxis Nosebleed","Greater Palatine Foramen",[31],"epistaxis","NOT_YET_RECRUITING","2026-02-20",{"date":35,"type":36},"2026-02-24","ACTUAL",{"date":38,"type":22},"2026-03-01",{"date":40,"type":22},"2027-02-28",{"name":42,"class":43},"Sheikh Zayed Federal Postgraduate Medical Institute","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100592773","phase-1-treatment-of-nosebleeds-in-the-emergency-department-with-powder-tranexamic-acid-100592773","NCT06997796","Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid","Sprayed-In Medicated Powder for Less-Invasive Epistaxis Treatment Using Tranexamic Acid: The Bloody SIMPLE Treatment Pilot Study","Bloody SIMPLE","Inclusion Criteria:\n\n* Capable of giving informed consent form\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Adults 18 years or older\n* Male or female\n* Presenting to the ED with active, spontaneous epistaxis. Anterior versus posterior epistaxis will be identified a priori. Anterior epistaxis is operationally defined as active nasal bleeding that occurs anterior to the anterior limit of the middle turbinate, visible by anterior rhinoscopy.\n\nExclusion Criteria:\n\n* Prior sinonasal surgery within the preceding 1 month.\n* Patients who required medical treatment for epistaxis in the preceding 30 days.\n* Septum perforation.\n* Known history of bleeding disorders, including thrombocytopenia, hemophilia, hereditary hemorrhagic telangiectasia, or von Willebrand disease.\n* History of known thromboembolic disease, including subarachnoid hemorrhage, stroke, or TIA.\n* Known history of disease of the central nervous system, including seizures, convulsions, or intra-cerebral disease processes\u002Flesions.\n* Known or suspected history of significant skull base trauma, including skull base fracture or cerebrospinal fluid leak.\n* Known history of acquired disturbances of colour vision.\n* Known hematuria or any bleeding related to the kidney.\n* Pregnant and\u002For lactating women.\n* History of known allergy or sensitivity to the study medication.\n* Presence of signs or symptoms of concomitant emergent conditions, including myocardial infarction, stroke, major trauma, shock, or hemodynamic instability.\n* Patients with other medical conditions including cognitive limitations or impairment due to substance abuse.\n* Patients with any other condition that, in the opinion of the investigator, may present an unreasonable risk to the patient, may make the patient unreliable, or may interfere with the study assessments.\n* Current participation in another interventional clinical trial.",{"count":53,"type":22},24,[55,56],"PHASE1","PHASE2","Nosebleeds are very common, occurring in 60% of the population; in some patients, nosebleeds are a life-threatening emergency. To stop a nosebleed in the emergency department, doctors usually have to burn the nose (called cauterization) or insert pledgets (called nasal packing) into the nose to apply direct pressure to the bleeding site. Nasal packing can cause pain and discomfort at the time it is inserted in the nose and again when it is removed. In rare cases it can cause a range of complications: minor complications include scar bands in the nose, but serious complications of nasal packing have also occurred, including death. Nasal packing can also present risks to doctors, such as the risk of contracting airborne and bloodborne infections, like COVID-19 and HIV.\n\nTranexamic acid in pill form or given directly into a vein is a medication that is currently used for nosebleeds. This study looks to evaluate if tranexamic acid in powder form sprayed directly in the nose can be used as an alternative to cauterization or nasal packing for the treatment of nosebleeds.",[28],"RECRUITING","2025-05-22",{"date":62,"type":36},"2025-05-30",{"date":64,"type":22},"2025-05",{"date":66,"type":22},"2025-12",{"name":68,"class":43},"Dr. Anne Conlin",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":17,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":4},"100566181","coblation-versus-bipolar-diathermy-in-management-of-refractory-idiopathic-recurrent-anterior-epistaxis-in-children-100566181","NCT06651840","Coblation Versus Bipolar Diathermy in Management of Refractory Idiopathic Recurrent Anterior Epistaxis in Children.","Comparison Between Coblation Versus Bipolar Diathermy in Management of Refractory Idiopathic Recurrent Anterior Epistaxis in Children.","Inclusion Criteria:\n\n1. A history of repeated unilateral epistaxis with at least four episodes, at least one episode per week during the preceding 4 weeks.\n2. Age \\> 5 years of age and \\\u003C 18 years of age.\n3. Failure of topical treatment with an antiseptic ointment, with or without silver nitrate cautery.\n4. A Katsanis epistaxis scoring system (ESS) score of 7-10.\n5. Bleeding originating from Kiesselbach's plexus, located in the anteroinferior portion of the nasal septum.\n\nExclusion Criteria:\n\n1. Patients \\\u003C 5 years of age and \\>= 18 years of age.\n2. Patients with bilateral epistaxis.\n3. Patients with bleeding tendencies like: Hemophilia, Leukemia, Idiopathic thrombocytopenic purpura, Von Willebrand disease and Thrombasthenia.\n4. Patients with previous nasal surgeries.\n5. Patients with hereditary hemorrhagic telangiectasia.\n6. Patients with vascular lesions like: angiofibroma, pyogenic granuloma and bleeding polypus.\n7. Patients who are unfit for surgery.",true,"6 Years","17 Years",{"count":81,"type":22},64,[25],"The aim of this study is to compare the outcomes of coblation technique versus bipolar technique in management of RAE in children regarding the following:\n\n1. Efficacy of each method to stop bleeding.\n2. Technical feasibility.\n3. Mucosal healing and crust formation.\n4. Post operative complications like: synechia formation and septal perforation.\n5. Nostril stenosis\u002F atresia.",[28],"2025-02-15",{"date":87,"type":36},"2025-02-19",{"date":89,"type":22},"2025-03-01",{"date":91,"type":22},"2026-01",{"name":93,"class":43},"Assiut University",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":101,"targetDuration":103,"studyType":104,"phases":4,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":69},"100556935","atmospheric-pressure-and-epistaxis-relationship-100556935","NCT06531577","Atmospheric Pressure and Epistaxis Relationship","Influence of Atmospheric Pressure on Patients Presenting to the Emergency Department With Epistaxis","Inclusion Criteria:\n\nPatients aged 18 and above Presenting to the emergency department with complaints of epistaxis, whether active or resolved.\n\nWilling volunteers consenting to participate in the study. Residing in central districts of Ankara\n\nExclusion Criteria:\n\nPatients under the age of 18. Pregnant individuals. Those with a history of maxillofacial surgery. Patients reporting a history of trauma at the time of admission. Patients stating they are from a city other than Ankara.",{"count":102,"type":22},600,"6 Months","OBSERVATIONAL","In this study, investigators aim to understand the relationship between changes in atmospheric pressure and blood pressure, and to investigate whether these changes have an impact on the etiology of epistaxis.",[107,28],"Atmospheric Pressure; Adverse Effect",[109,31,110],"atmospheric pressure","blood pressure","2024-07-29",{"date":113,"type":36},"2024-08-01",{"date":115,"type":36},"2024-04-01",{"date":117,"type":22},"2025-04-01",{"name":119,"class":43},"Saglik Bilimleri Universitesi",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":23,"phases":129,"briefSummary":131,"conditions":132,"keywords":133,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":144,"locationsCount":4},"100553789","phase-4-tranexamic-acid-versus-blood-stopper-treatments-in-epistaxis-management-100553789","NCT06490653","Tranexamic Acid Versus Blood Stopper Treatments in Epistaxis Management","Comparison of the Efficacy of Tranexamic Acid and Blood Stopper Treatments in Bleeding Control in Patients With Epistaxis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients over 18 years of age with epistaxis will present to the emergency department with non-traumatic epistaxis and whose bleeding do not stop with simple external compression for 10 minutes.\n\nExclusion Criteria:\n\n* Patients demonstrating hemodynamic instability\n* Patients with documented allergy to tranexamic acid or Ankaferd\n* patients with known bleeding disorders,\n* patients using anticoagulants,\n* pregnant patients",{"count":128,"type":22},186,[130],"PHASE4","In this randonmized controlled trial, aim to compare the effectiveness of local administration of tranexamic acid and blood stopper (Ankaferd®) on cessation of bleeding in epistaxis patients.",[28],[134,135,136,137],"Epistaxis","Nosebleed","Ankaferd","Tranexamic acid","2024-06-29",{"date":140,"type":36},"2024-07-08",{"date":142,"type":22},"2024-10",{"date":66,"type":22},{"name":145,"class":146},"Ankara Ataturk Sanatorium Training and Research Hospital","OTHER_GOV"]