[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"erectile-disfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:erectile-disfunction":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100628386","phase-2-trial-of-statin-therapy-effect-on-androgen-status-and-erectile-function-in-men-100628386",false,"NCT07460960","TRIal of STatin Therapy Effect on Androgen Status and Erectile functioN in Men","A Randomized Controlled Trial of Statin Therapy Effect on Androgen Status and Erectile Function in Men With High and Very High Cardiovascular Risk","Inclusion Criteria:\n\n* male patients aged 40-65 years, sexually active\n* high and very high risk of cardiovascular events (The Systematic Coronary Risk Evaluation 2 (SCORE2))\n* absence of previous statin therapy for 3 months\n* there are no known cardiovascular diseases requiring the appointment of statins in high doses from the start of treatment\n* the invariance of concomitant therapy for 3 months, if the patient needs it.\n\nExclusion Criteria:\n\n* known statin intolerance\n* known hypogonadism\n* persistent forms of atrial fibrillation\n* active malignant neoplasm requiring treatment at the time of screening\n* known chronic inflammatory diseases (rheumatoid arthritis, systemic connective tissue diseases, metabolically associated fatty liver disease, etc.)\n* impaired renal function (estimated glomerular filtration rate \\\u003C30 ml\u002Fmin\u002F1.73 m2) and liver (transaminase levels more than 3 times reference values, bilirubin levels more than 2 times reference values)\n* chronic heart failure\n* a well-known diagnosis of mental illness\n* alcoholism and drug addiction\n* glucocorticoid therapy and regular therapy with nonsteroidal anti-inflammatory drugs (80% of the time for 3 months before switching on)\n* participation in any other clinical trial during this trial, including participation in the trial for 30 days prior to providing informed consent\n* the patient's inability to understand the essence of the study and consent to participate in it","MALE","40 Years","65 Years",{"count":20,"type":21},150,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Aim. To study the effect of different intensities of statin therapy on androgen status and erectile function in men aged 40-65 years with high and very high cardiovascular risk. Additionally, to assess the association between sex hormone levels, erectile function parameters, and traditional cardiovascular risk factors, arterial stiffness, and endothelial function in this patient category.\n\nMaterial and methods. It is planned to conduct a prospective randomized controlled trial, including 150 male patients aged 40-65 years, undergoing routine preventive examinations in the clinic of Moscow State University, having a high and very high risk of cardiovascular diseases and meeting the inclusion criteria. Group Pit (n=75) will receive pitavastatin at a starting dose of 1 mg\u002Fday. Group Ros (n=75) will receive rosuvastatin 20 mg\u002Fday. After 3 months, the biochemical parameters will be monitored, and dose titration of pitavastatin to 2-4 mg\u002Fday and\u002For rosuvastatin to 40 mg\u002Fday will be performed if necessary. Patient recruitment to the study will occur over 9 months at a single research center. Patients will be monitored with an objective assessment of erectile function parameters, blood analysis (including androgen status), central arteries stiffness, and endothelial function for 6 months from the moment of activation. Follow-up visits are scheduled at 1, 3 and 6 months.\n\nResults. The expected result of testing the research hypothesis is that statin therapy will not have a negative effect on androgen status and erectile function in men. Intensive statin therapy will have a greater positive effect on endothelial function, which may lead to an improvement in men's erectile function.\n\nConclusion. The study was planned under the assumption that statin therapy would not have a negative effect on androgen status and erectile function in men aged 40-65 years. It is also suggested that the positive effect of statins on endothelial function and vascular stiffness may lead to an improvement in erectile function among men with high and very high cardiovascular risk. If the hypothesis is confirmed, the results obtained will help improve statin treatment adherence in male patients and, as a result, increase the effectiveness of prevention of cardiovascular events.",[27,28,29,30,31,32],"Erectile Dysfunction Due to Arterial Disease","Atheroscleroses","Erectile Disfunction","Endothelial Dysfunction","Androgen Profile","Testosterone",[34,35,36,37,38,39,40,41,42],"cardiovascular diseases","erectile dysfunction","androgen status","atherosclerosis","statins","statin therapy","coronary artery disease","endothelial dysfunction","testosterone","RECRUITING","2026-03-12",{"date":46,"type":47},"2026-03-16","ACTUAL",{"date":49,"type":47},"2026-03-05",{"date":51,"type":21},"2027-12",{"name":53,"class":54},"Lomonosov Moscow State University Medical Research and Educational Center","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":16,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":69,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":55},"100627135","erectile-function-after-pci-in-mi-and-non-mi-patients-100627135","NCT07444697","\"Erectile Function After PCI in MI and Non-MI Patients\"","Erectile Function After Percutaneous Coronary Intervention in Myocardial Infarction and Non-Infarction Patients: A Prospective Comparative Study.","ERECT-PCI","Inclusion Criteria\n\n* Male patients aged 30-75 years\n* Undergoing successful percutaneous coronary intervention (PCI) for one of the following:\n\n  * Acute myocardial infarction (Group 1)\n  * Stable angina (Group 2)\n* Hemodynamically stable after the PCI procedure\n* Survival of the index hospitalization\n* Ability to provide written informed consent\n* Sexually active within the 3 months prior to enrollment\n* Willingness and ability to complete follow-up visits and questionnaires at:\n\n  * Baseline (post-PCI recovery)\n  * 3 months\n  * 6 months Exclusion Criteria\n* Known malignancy (active or recently treated)\n* Neurological disorders affecting erectile function, including:\n\n  * Spinal cord injury\n  * Multiple sclerosis\n  * Parkinson's disease\n* Uncontrolled diabetes mellitus (HbA1c \\> 9%)\n* Presence of more than two chronic systemic diseases, such as:\n\n  * Severe renal disease\n  * Severe hepatic disease\n  * Severe pulmonary disease\n* Polypharmacy, defined as chronic use of more than three daily medications\n* Absence of sexual activity or lack of a sexual partner\n* Refusal or inability to provide informed consent or complete study questionnaires\n* Severe psychiatric illness interfering with study participation\n* Endocrine disorders, including:\n\n  * Untreated hypogonadism\n  * Thyroid disease\n* Major post-PCI complications preventing participation, including:\n\n  * Reinfarction\n  * Stroke\n  * Heart failure",true,"30 Years","75 Years",{"count":68,"type":21},100,"6 Months","OBSERVATIONAL","The goal of this observational study is to assess changes in patients' erectile function after percutaneous coronary intervention (PCI) using a standard IIEF (International Index of Erectile Function) questionnaire at 1, 3, and 6 months post-PCI. By doing this, we try to compare patients' responses to PCI after having a heart attack and stable angina to see the real effect of myocardial infarction on erectile function status in the long term by comparing it with a very similar group.",[29,73,74,75,76],"Coronary Artery Disease (CAD)","Diabete Mellitus","Anxiety","Depression and Quality of Life",[78,40,79,80,81,82,83],"erectile disfunction","Syntax score","percutaneous coronary intervention","anxiety","Fear","angina","2026-02-24",{"date":86,"type":47},"2026-03-03",{"date":88,"type":47},"2026-01-15",{"date":90,"type":21},"2026-11",{"name":92,"class":54},"Kırıkkale University"]