[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"esmolol\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:esmolol":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100563809","pre-operative-phentolamine-vs-intraoperative-esmolol-efficacy-for-hypotensive-anesthesia-in-functional-endoscopic-sinus-surgery-100563809",false,"NCT06620991","Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery","Inclusion Criteria:\n\n* Age from 21 to 50 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n\nExclusion Criteria:\n\n* Patients with a medical condition that contraindicated hypotensive anesthesia, such as peripheral vascular disease, cerebrovascular stroke, carotid artery stenosis, previous myocardial infarction, ischemic heart disease, congestive heart failure, limb ischemia, uncontrolled hypertension and raised intracranial tension\n* Renal disease, liver dysfunction, pregnancy.\n* Patients on hypnotic or narcotic analgesic.\n* History of alcohol or drug abuse.\n* History of allergic reaction to any drug used in this study.\n* Bleeding diathesis.\n* Previous nasal surgery.\n* Patients on Non-steroidal anti-inflammatory drugs (NSAIDs).\n* Patients with peripheral vascular disease.","ALL","21 Years","50 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","The aim of this study is to evaluate the efficacy of intra-operative phentolamine vs intraoperative esmolol for hypotensive anesthesia in functional endoscopic sinus surgery.",[26,27,28,29,30,31],"Preoperative","Phentolamine","Intraoperative","Esmolol","Hypotensive Anesthesia","Functional Endoscopic Sinus Surgery","NOT_YET_RECRUITING","2024-09-29",{"date":35,"type":36},"2024-10-01","ACTUAL",{"date":38,"type":20},"2024-10-10",{"date":40,"type":20},"2025-04-01",{"name":42,"class":43},"Ain Shams University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":15,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":44},"100488112","phase-4-effects-of-low-dose-esmolol-on-myocardial-injury-after-non-cardiac-surgery-in-elderly-frail-patients-100488112","NCT05635877","Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients","Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients:A Multicenter, Prospective, Double-blind, Randomized Controlled Study","Inclusion Criteria:\n\n1. Age ≥ 65 years;\n2. ASA: ⅰ-ⅳ;\n3. Modified frailty index (mFI) ≥ 0.21;\n4. Patients undergoing non-cardiac surgery.\n\nExclusion Criteria:\n\n1. Refuse to participate;\n2. Expected hospital stay \\\u003C3 days;\n3. Preoperative β-blocker therapy;\n4. History of myocardial infarction or coronary artery disease;\n5. Preoperative bradycardia (heart rate \\[HR\\] \\\u003C 50 bpm) or arrhythmia;\n6. Significant cardiac insufficiency (i.e., pulmonary artery pressure \\>18 mm Hg, cardiac index ≤ 2.2 L\u002Fmin\u002Fm 2);\n7. Severe valvular heart disease;\n8. Severe lung disease (e.g. asthma or chronic obstructive pulmonary disease);\n9. Patients with perioperative troponin elevation due to nonischemic causes (e.g., sepsis, pulmonary embolism, arrhythmia);\n10. The same patient can only be included once, regardless of whether the reason for the second operation is related to the first cause.\n\n    \\-","65 Years","90 Years",{"count":55,"type":20},2000,[57],"PHASE4","This topic will focus on the following questions:\n\n1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the predictive factors of myocardial injury after non-cardiac surgery （MINS） in elderly frail patients before operation.\n2. Part Two: To explore the effect of low-dose esmolol on myocardial injury after non-cardiac surgery in frail elderly patients.",[60,29,61],"Frailty","Myocardial Injury",[63],"myocardial injury after non-cardiac surgery, MINS","RECRUITING","2023-03-27",{"date":67,"type":36},"2023-03-29",{"date":69,"type":36},"2023-02-07",{"date":71,"type":20},"2026-12-30",{"name":73,"class":43},"Yongtao Sun"]