[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"esophageal-motility-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:esophageal-motility-disorders":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,65,92],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100631143","clinical-outcomes-safety-and-effectiveness-of-speedboat-ultraslim-in-per-oral-endoscopic-myotomy-poem-100631143",false,"NCT07496840","Clinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM)","Clinical Outcome, Safety, and Effectiveness Assessment of Speedboat Ultraslim™ Surgical Device in the Performance of Per-Oral Endoscopic Myotomy (POEM)","SU-POEM","Inclusion Criteria:\n\n* Adult patients (≥18 years of age)\n* Diagnosed with achalasia or other esophageal motility disorders\n* Scheduled to undergo clinically indicated per-oral endoscopic myotomy (POEM) using the Speedboat UltraSlim™ device\n* Able and willing to provide informed consent\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* Patients not considered appropriate candidates for POEM by the principal investigator or treating physician","ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","This study is a prospective registry designed to evaluate the clinical outcomes, safety, and effectiveness of per-oral endoscopic myotomy (POEM) performed using the Speedboat UltraSlim™ device in patients with achalasia or other esophageal motility disorders.\n\nParticipants included in this registry are those undergoing clinically indicated POEM as part of standard of care. No experimental interventions will be performed as part of this study. Patients will be approached for participation after the clinical decision to perform POEM has already been made.\n\nData will be collected through review of electronic medical records and procedural documentation, including patient demographics, procedural details, and clinical outcomes. Follow-up data will be collected at predefined time points (e.g., 30 days, 3 months, 6 months, and up to 1 year) to assess symptom improvement, procedural success, and adverse events.\n\nThe primary objective of the study is to assess technical success, clinical success, and safety outcomes associated with the use of the Speedboat UltraSlim™ device during POEM procedures.\n\nThis registry poses minimal risk to participants, as all procedures are performed as part of routine clinical care. No additional interventions beyond standard care are required for participation.",[25,26],"Esophageal Motility Disorders","Achalasia","RECRUITING","2026-06-16",{"date":30,"type":31},"2026-06-17","ACTUAL",{"date":33,"type":31},"2026-01-15",{"date":35,"type":21},"2027-09-30",{"name":37,"class":38},"Baylor College of Medicine","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":39},"100449464","high-resolution-manometry-after-partial-fundoplication-for-gastro-oesophageal-reflux-100449464","NCT05132816","High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux","High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux: Does the Ineffective Preoperative Oesophageal Motility Change Postoperatively?","Inclusion Criteria:\n\n* Age older than 18 years\n* Ineffective esophageal motility disorder according the Chicago classification (7), defined as ≥ 7\u002F10 (70%) of swallows with weak contraction (distal contraction interval (DCI) between 100mmHg\u002Fs\u002Fcm and less than 450 mmHg\u002Fs\u002Fcm) or ≥ 5\u002F10 (50%) of swallows with failed peristalsis (DCI \\\u003C100mgHg\u002Fs\u002Fcm)Performance of partial fundoplication (180° anterior or 270° posterior) at Spital Limmattal\n* Informed Consent as documented by signature\n\nExclusion Criteria:\n\n* Age under 18 years\n* Pregnancy\n* Normal preoperative esophageal motility\n* Other specifically defined esophageal motility disorders such as Nutcracker or Jackhammer esophagus\n* Preoperative presence of a hiatal hernia with migration of \\>20% of stomach in the chest\n* Revisional surgery (after other procedures for reflux or at the hiatus)",{"count":48,"type":21},100,"INTERVENTIONAL",[51],"NA","This is a combined retro- and prospective, monocentric study. All patients who underwent or are planned for laparoscopic partial fundoplication (180° anterior or 270° posterior) between 2020-2023 are assessed for preoperative ineffective esophageal motility (IEM).\n\nThe main hypothesis is, that preoperative oesophageal motility disorders, especially hypo-contractility or failed peristalsis, are caused by gastro-oesophageal reflux. Therefore, postoperative manometry after partial wrap fundoplication (270° posterior, 180° anterior) shows a decrease in comparison to preoperative motility disorders.\n\nThe primary objective of this study is to examine the postoperative esophageal motility in patients with known preoperative motility disorders.\n\nSecondary endpoints are the presence of other oesophageal motility disorders pre- vs. postoperatively (including new onset disorders), the assessment of the Gastrointestinal Symptom Rating Scale (GSRS) pre- vs. postoperatively, and more.\n\nIf IEM is present preoperatively, patients are contacted at least 1 year after surgery and will be informed about the study and asked to participate. In case of agreement, they are invited to the study site. They undergo high-resolution manometry 18-24 months postoperatively (study intervention).",[54,25,55],"Gastroesophageal Reflux","Upper Gastrointestinal Disorder","2026-06-08",{"date":58,"type":31},"2026-06-09",{"date":60,"type":31},"2022-01-24",{"date":62,"type":21},"2027-12-31",{"name":64,"class":38},"Prof Urs Zingg",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":17,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":49,"phases":76,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":39},"100474242","phase-4-gastrointestinal-dysmotility-on-aspiration-risk-100474242","NCT05455359","Gastrointestinal Dysmotility on Aspiration Risk","The Impact of Upper Gastrointestinal Dysmotility on Aspiration-associated Symptoms","Inclusion Criteria:\n\n1. are 5-21 years of age;\n2. receive \\>90% of their calories by enteral tube (i.e., patients take no food or drink by mouth);\n3. are determined to be at high risk for aspiration pneumonia based on evidence of impaired airway protective mechanisms, documented by aspiration on video fluoroscopic swallow study;\n4. have static neurologic impairment, defined as functional and\u002For intellectual impairment that results from a chronic neurologic or related diagnosis (e.g., cerebral palsy) with no prospect of progression for at least one year;\n5. have chronic respiratory symptoms, defined as coughing, choking, or need for oral suctioning a minimum of three times per week during the prior four weeks.\n\n   \\-\n\nExclusion Criteria:\n\n1. have progressive neurologic impairment;\n2. have a history of prior intact Nissen fundoplication;\n3. are currently taking oral or inhaled antibiotics, including prophylactic antibiotics;\n4. are currently taking or have taken in the last four weeks acid suppression (H2 antagonist or PPI); or\n5. are fed by gastrojejunostomy rather than by gastrostomy. -","5 Years","21 Years",{"count":75,"type":21},120,[77],"PHASE4","The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment. The investigators are conducting a ten week cross over study comparing prucalopride to famotidine for the treatment of aspiration-associated symptoms.",[25,80,81,82],"Gastric Motor Dysfunction","Aspiration Pneumonia","Gastro Esophageal Reflux","2025-12-23",{"date":85,"type":31},"2025-12-26",{"date":87,"type":31},"2025-02-13",{"date":89,"type":21},"2027-05-31",{"name":91,"class":38},"Boston Children's Hospital",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100583612","diagnostic-evaluation-of-esophageal-motility-disorders-using-the-chicago-iv-protocol-in-egypt-100583612","NCT06878586","Diagnostic Evaluation of Esophageal Motility Disorders Using the Chicago IV Protocol in Egypt","Inclusion Criteria:\n\n* Adult patients (age ≥ 18 years) at Ain Shams University presenting symptoms such as dysphagia, chest pain, regurgitation, or heartburn.\n\nExclusion Criteria:\n\n* Patients with prior esophageal surgeries, significant structural abnormalities, or those unable to provide informed consent will be excluded.","60 Years",{"count":100,"type":21},157,"Esophageal motility disorders (EMDs) encompass a spectrum of conditions characterized by abnormal movement and coordination of the esophagus, leading to symptoms such as dysphagia, chest pain, regurgitation, and heartburn . These symptoms can severely impact quality of life, often requiring detailed diagnostic evaluations for appropriate management . High-resolution esophageal manometry (HRM) has emerged as a critical diagnostic tool, providing comprehensive assessments of esophageal motility and improving our understanding of the pathophysiology behind EMDs . The advancements in HRM technology have significantly enhanced diagnostic accuracy, leading to more effective treatment strategies.\n\nThe Chicago Classification (CC) was introduced to standardize the interpretation of HRM findings and facilitate communication among clinicians. Since its inception in 2009, the classification has undergone several updates to reflect ongoing advancements. The most recent update, Chicago Classification version 4.0 (CC v4.0), resulted from two years of collaboration by an international working group of motility experts . This version places a greater emphasis on clinical relevance, refining diagnostic criteria to include standardized assessments in both the supine and upright positions, as well as the use of provocative maneuvers to provide a more thorough evaluation of esophageal function\n\n. These enhancements aim to improve the understanding and diagnosis of complex motility disorders Although CC version 3.0 (CC v3.0) has been widely utilized, it has limitations that CC v4.0 effectively addresses to enhance esophageal motility testing. By requiring assessments in both supine and upright positions, CC v4.0 captures motility abnormalities in more physiologically relevant conditions, The inclusion of provocative testing methods, such as multiple rapid swallows (MRS) and solid swallows, further increases sensitivity for detecting disorders under stress. Moreover, CC v4.0 offers a comprehensive analysis of esophagogastric junction (EGJ) function, introducing criteria for EGJ outflow obstruction and EGJ typing, which clarify interactions with the lower esophageal sphincter . This updated framework also emphasizes bolus transit and metrics for fragmented peristalsis, facilitating the identification of subtle motility issues that may impact bolus clearance In Egypt, the majority of manometric devices are configured to automatically interpret results using CC v3.0, limiting the integration of newer diagnostic criteria. By manually applying CC v4.0 in this study, we seek to determine whether its updated metrics offer enhanced diagnostic precision and a better correlation with clinical symptoms.",[25],"NOT_YET_RECRUITING","2025-03-14",{"date":106,"type":31},"2025-03-17",{"date":108,"type":21},"2025-04-01",{"date":110,"type":21},"2027-06-01",{"name":112,"class":38},"Assiut University"]