[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"evaluate-pk-profile\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:evaluate-pk-profile":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100619597","phase-1-a-study-testing-the-effects-of-different-thc-doses-on-psychological-and-biological-function-100619597",false,"NCT07346690","A Study Testing the Effects of Different THC Doses on Psychological and Biological Function","Acute Dose-Dependent Effects of Oral THC on Physiological and Subjective Responses in Healthy Cannabis-Experienced Adults","DRATT","Inclusion Criteria:\n\n* Adults aged 18-55\n* No major medical or psychiatric conditions\n* At least one previous, well-tolerated experience with cannabis\n* Not currently pregnant or breastfeeding\n\nExclusion Criteria:\n\n* Family history (first- or second-degree relatives) of bipolar disorder, psychosis, or schizophrenia\n* Significant negative reaction to cannabis in the past or known allergy to cannabis products\n* Currently using recreational drugs",true,"ALL","18 Years","55 Years",{"count":22,"type":23},24,"ESTIMATED","INTERVENTIONAL",[26],"PHASE1","The goal of this clinical trial is to learn how a investigational medicinal product (THC) affects psychological and physical responses in healthy adults with prior cannabis use experience. The main questions it aims to answer are:\n\n\\- How do different dose levels of the investigational medicinal product (THC) influence short-term subjective and physiological responses?\n\nResearchers will compare three dose levels of the study drug to a placebo (a look-alike substance with no active ingredient) to see how responses vary across sessions.\n\nParticipants will:\n\n* Attend four in-person study visits, each involving a single dose of either the study drug or placebo\n* Complete questionnaires about their moment-to-moment experiences\n* Have their heart rate, blood pressure, and other physical measures monitored\n* Undergo serial blood sampling to measure circulating biomarkers",[29,30,31,32],"Evaluate PK Profile","Evaluate PD Profile","Healthy Adults","Safety and Tolerability in Healthy Volunteers",[34,35],"Cannabinoid","Cannabis","NOT_YET_RECRUITING","2026-01-07",{"date":39,"type":40},"2026-01-16","ACTUAL",{"date":42,"type":23},"2026-02-01",{"date":44,"type":23},"2028-02-01",{"name":46,"class":47},"University of Calgary","OTHER"]