[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"eveningness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:eveningness":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100645046","digital-insomnia-and-circadian-therapy-for-reducing-depression-symptoms-in-college-students-100645046",false,"NCT07677930","Digital Insomnia and Circadian Therapy for Reducing Depression Symptoms in College Students","Prevent Worsening of Depressive Symptoms Using Digital Cognitive Behavioral Therapy for Insomnia and Circadian Intervention in College Students","Inclusion Criteria:\n\n* Youths aged between 18-24 years old.\n* Insomnia disorders as determined by DSM-5 criteria with a predominant complaint of difficulty initiating sleep.\n* Presence of an evening chronotype according to the score on the Horne-Östberg Morning-Eveningness Questionnaire (MEQ) and having a late bedtime of 12:00 am\u002Fmidnight or later for at least 3 nights per week in the last 3 months.\n* Presented with at least subclinical depressive symptoms as determined by Patient Health Questionnaire-9 ≥ 10.\n* Accessibility to a smartphone.\n\nExclusion Criteria:\n\n* Having a diagnosed sleep disorder that may potentially contribute to the disruption of sleep quantity and quality other than insomnia and delayed sleep phase syndrome, as ascertained by Structured Diagnostic Interview for Sleep patterns and Disorders (DISP), such as restless leg syndrome and OSA, and narcolepsy.\n* Diagnosed with neuropsychiatric disorders such as major depressive disorder, anxiety disorders, bipolar affective disorders, schizophrenia, moderate or above suicidality.\n* Concurrent, regular use of medications known to affect sleep continuity and quality, including both Western medications (e.g. hypnotics, steroids, antidepressants, antihistamines) and over-the-counter medications (e.g. melatonin).\n* Participate in other psychotherapy (e.g., CBT, mindfulness) currently or in the past three months.","ALL","18 Years","24 Years",{"count":20,"type":21},195,"ESTIMATED","INTERVENTIONAL",[24],"NA","Depression is a leading cause of global disease burden, poor quality of life, disability and suicide, and commonly occurs in adolescence and early adulthood. Insomnia and circadian factors were regarded as potential targets for preventing worsening of depressive symptoms. Additionally, digital insomnia treatment reduces depressive symptoms but is insufficient for individuals with an evening chronotype. Circadian intervention is an adjunctive treatment for sleep disturbance and depression, but is often overlooked. In this study, we aim to evaluate the effect of guided digital insomnia and circadian intervention (dCBT-I + dCI) in reducing depressive symptoms in college students with insomnia and an evening chronotype compared with digital insomnia intervention alone (dCBT-I) and a health education group (dHE). We also aim to develop and evaluate multimodal prediction models to identify individuals who are more or less likely to respond to the interventions, using clinical, behavioral, circadian, and digital engagement data.",[27,28,29,30],"Eveningness","Insomnia","Circadian Rhythm","Depressed Mood",[27,28,30,29],"NOT_YET_RECRUITING","2026-06-29",{"date":35,"type":36},"2026-07-01","ACTUAL",{"date":35,"type":21},{"date":39,"type":21},"2029-06-30",{"name":41,"class":42},"Chinese University of Hong Kong","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100625597","effect-of-bright-light-therapy-on-idiopathic-scoliosis-100625597","NCT07424703","Effect of Bright Light Therapy on Idiopathic Scoliosis","Effect of Morning Bright Light Therapy on the Onset and Progression of Idiopathic Scoliosis: A Prospective, Single-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age between 10 and 15 years.\n2. Classified as evening chronotype based on the reduced Horne-Östberg Morningness-Eveningness Questionnaire (rMEQ), defined as a score \\\u003C 12.\n3. Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit.\n4. Skeletally immature (Risser sign 0-3) with a major Cobb angle \\\u003C 40 degrees at baseline.\n5. Written informed consent\u002Fassent provided by the participant and legal guardian.\n6. Willing and able to comply with the study protocol, including device use and scheduled follow-ups.\n\nExclusion Criteria:\n\n1. Plans to relocate outside the study area within the next 24 months.\n2. Use of medications that may interfere with circadian rhythm within the past 3 months (e.g., lithium, exogenous melatonin, melatonergic antidepressants).\n3. Trans-meridian travel across at least two time zones within the past 3 months or anticipated during the study period.\n4. Presence of any eye disease (e.g., glaucoma, retinal disease, macular degeneration) that could be exacerbated by or interfere with light therapy.\n5. Clinically diagnosed sleep disorder (e.g., narcolepsy, restless legs syndrome) or prominent medical condition known to interfere with sleep continuity and quality (e.g., moderate-to-severe eczema).\n6. Severe chronic health conditions that could confound study outcomes, including but not limited to:\n\n   * Known syndromic, neuromuscular, or congenital musculoskeletal causes of scoliosis.\n   * History of spine surgery or significant spinal trauma.\n   * Spinal tumor.\n   * Leg length discrepancy \\> 20 mm.\n   * Other severe chronic diseases (e.g., poorly controlled diabetes, chronic liver or renal disease, malabsorption syndromes).\n   * Severe obesity (body mass index z-score ≥ 3).","10 Years","15 Years",{"count":53,"type":21},120,[24],"This trial aims to investigate whether morning bright light therapy can reduce the progression rate of idiopathic scoliosis in children and potentially prevent its de novo development.",[57,27,58],"Idiopathic Scoliosis","Delayed Sleep Phase","RECRUITING","2026-05-14",{"date":62,"type":36},"2026-05-19",{"date":64,"type":36},"2025-09-01",{"date":66,"type":21},"2028-09-01",{"name":68,"class":42},"Second Affiliated Hospital of Wenzhou Medical University",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":69},"100523191","effects-of-cbt-and-blt-in-youth-with-unipolar-depression-and-evening-chronotype-100523191","NCT06092411","Effects of CBT and BLT in Youth With Unipolar Depression and Evening Chronotype","Effects of Cognitive Behavioural Therapy and Bright Light Therapy in Youth With Unipolar Depression and Evening Chronotype: An Assessor-blind Parallel-group Randomised Controlled Trial","DELAY","Inclusion Criteria:\n\n1. Chinese aged 12-20 years old.\n2. Written informed consent of participation into the study is given by the participant and his\u002Fher parent or guardian (for those aged under 18).\n3. Being able to comply with the study protocol.\n4. Having a DSM-5 diagnosis of depressive disorders.\n5. Having a score of ≥ 40 on Children's Depression Rating Scale (CDRS-R).\n6. Having a score of ≤ 41 on Horne-Östberg Morning-Eveningness Questionnaire (MEQ; classified as evening chronotype).\n7. Having a sleep onset time of 11:15pm or later for 12 year olds, 11:30pm or later for 13-14 year olds, and 12:00pm or later for 15-20 years at least 3 nights per week in the past 3 months.\n\nExclusion Criteria:\n\n1. A current diagnosis of substance abuse or dependence; a current or past history of manic or hypomanic episode, schizophrenia spectrum disorders, neurodevelopmental disorders, organic mental disorders, or intellectual disabilities.\n2. Initiation of and change of medication that may interfere with circadian rhythm within past 3 months (e.g., lithium, exogenous melatonin, melatonergic antidepressants).\n3. In the opinion of the research clinician, having a clinically significant suicidality (presence of suicidal ideation with a plan or an attempt).\n4. Having been enrolled in any other clinical trial investigational products within one month at the entry of the study.\n5. Initiation of or change in antidepressant medication within past 3 months.\n6. Having been or is currently receiving any structured psychotherapy.\n7. With hearing or speech deficit.\n8. Night shift worker.\n9. Trans-meridian flight in the past 1 month and during intervention.\n10. Presence of an eye disease (e.g., retinal blindness, severe cataract, glaucoma).","12 Years","20 Years",{"count":81,"type":21},162,[24],"The goal of this prospective randomised controlled trial is to examine the effects of cognitive behavioural therapy and bright light therapy in youths with unipolar depression and evening chronotype. The main questions it aims to answer are:\n\n1. What is the efficacy of CBT-D and CBT-D plus bright light therapy in reducing depression severity in adolescents with depression and eveningness?\n2. What are the effects of CBT-D and CBT-D plus bright light therapy on the subjective and objective sleep and circadian measures, as well as the quality of life, daytime symptoms, and functioning (e.g., sleepiness, fatigue)?\n\nParticipants will participate in 8 weekly group sessions of CBT-D intervention based on the well-established CBT elements for treating depression. Concurrently participants will also be asked to wear a portable light device at home for 30 minutes daily for seven weeks, starting from the second week of the group intervention. Participants in the CBT-D only group will receive a placebo light via the device, whereas participants in the CBT-D plus light therapy group will receive the active bright light via the device.",[85,27],"Depression, Unipolar",[87,27,88,89,90],"Depression","Adolescents","Bright Light Therapy","Cognitive Behavioural Therapy","2024-04-17",{"date":93,"type":36},"2024-04-22",{"date":95,"type":36},"2023-10-31",{"date":97,"type":21},"2026-10-20",{"name":99,"class":42},"The University of Hong Kong"]