[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"event-related-potentials\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:event-related-potentials":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100599190","physical-fitness-and-hot-executive-function-in-alzheimers-risk-100599190",false,"NCT07081269","Physical Fitness and Hot Executive Function in Alzheimer's Risk","Inclusion Criteria:\n\n* Age 50-70.\n* Able to engage in fitness testing.\n* Normal vision or corrected-to-normal vision.\n\nExclusion Criteria:\n\n* Suffering from cardiopulmonary-related diseases.\n* Suffering from cognitive, neurological or psychiatric disorders (e.g., dementia, Parkinson's disease, epilepsy, depression, schizophrenia, etc.).\n* Suffering from infectious diseases (e.g., hepatitis, human immunodeficiency virus or Creutzfeldt-Jakob disease).\n* Having a history of drug or alcohol abuse.\n* Having colour vision deficiency (e.g., colour blindness).\n* Having a family history of aneurysm.\n* Taking medications that affect brain function.",true,"ALL","50 Years","70 Years",{"count":20,"type":21},240,"ESTIMATED","OBSERVATIONAL","This 18-month study tracks how physical fitness relates to executive function in older adults, aiming to determine if fitness improvements predict better cognitive performance. Participants complete assessments at baseline and 18 months, including cardiorespiratory fitness (YMCA bike test), muscle strength (chest and leg press tests), and executive function (computer tasks with brain activity recording via EEG). Additional measures include physical activity questionnaires, cognitive screening (MMSE), memory tests (digit span), demographics (age, sex, education), and blood tests for APOE ε4 gene status. No exercise program will be provided, allowing observation of natural fitness-cognition relationships in daily life.",[25,26,27],"Executive Function (Cognition)","Event-Related Potentials","Physical Fitness","RECRUITING","2025-07-15",{"date":31,"type":32},"2025-07-23","ACTUAL",{"date":34,"type":32},"2025-01-10",{"date":36,"type":21},"2027-07-31",{"name":38,"class":39},"National Taiwan Normal University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":15,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":40},"100596676","health-related-physical-fitness-and-executive-function-in-older-adults-a-prospective-study-100596676","NCT07048561","Health-related Physical Fitness and Executive Function in Older Adults: A Prospective Study","Changes in Health-related Physical Fitness on the Behavioural and Electrophysiological Aspects of Cool and Hot Executive Function in Older Adults: A Prospective Study","Inclusion Criteria:\n\n* Age 65 or above.\n* Able to engage in fitness testing.\n* Normal vision or corrected-to-normal vision.\n\nExclusion Criteria:\n\n* Suffering from cardiopulmonary-related diseases.\n* Suffering from cognitive, neurological or psychiatric disorders (e.g., dementia, Parkinson's disease, epilepsy, depression, schizophrenia, etc.).\n* Suffering from infectious diseases (e.g., hepatitis, human immunodeficiency virus or Creutzfeldt-Jakob disease).\n* Having a history of drug or alcohol abuse.\n* Having colour vision deficiency (e.g., colour blindness).\n* Having a family history of aneurysm.\n* Taking medications that affect brain function.","65 Years",{"count":50,"type":21},200,"This study aims to explore the relationship between health-related physical fitness and behavioural and electrophysiological aspects of cool and hot executive function in older adults through a year prospective study design. The main questions it aims to answer whether changes in health-related physical fitness will positively predict changes in behavioural and electrophysiological aspects of cool and hot executive functions in older adults. The participants will be asked to complete pre-test, a one-year observation period, and post-test. Both pre- and post-tests will measure health-related physical fitness, executive function, and various demographic variables and covariates. Health-related physical fitness assessments include cardiorespiratory endurance (YMCA submaximal cycle test), muscular strength (grip strength, chest press, and leg press), muscular endurance (30-second chair stand, 30-second bicep curl), flexibility (range of motion), and balance (Balance Error Scoring System). Executive function will be measured using the Stroop test and emotional Stroop test, with concurrent EEG recording of brain activity. Demographic variables and covariates include sex, age, years of education, annual income, Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire (IPAQ) Taiwan short form, World Health Organisation Quality of Life Brief Assessment (WHOQOL-BREF) Taiwan version, Geriatric Depression Scale, Mini-Mental State Examination (MMSE), digit span tests, and step count recorded by mobile phones or watches over the previous month, resting heart rate, and resting blood pressure. No interventions will be conducted during the one-year observation period, maintaining participants' normal daily living conditions.",[53,54,25,55,26],"Older Adults (65 Years and Older)","Fitness Testing","Prospective Study","2025-06-29",{"date":58,"type":32},"2025-07-02",{"date":60,"type":32},"2025-06-01",{"date":62,"type":21},"2027-03-31",{"name":38,"class":39}]