[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"executive-function-cognition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:executive-function-cognition":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,48,86,124,153,187,235,269,293,316,339,369,405],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100643989","probiotics-for-depressive-symptomatology-and-neural-activity-100643989",false,"NCT07667530","Probiotics for Depressive Symptomatology and Neural Activity.","The Acute and Chronic Effects of Ecologic® Barrier on Depressive Symptoms and Neural Activation.","PRODAN","Inclusion Criteria:\n\n* Mild to moderate depression symptoms (BDI-II 12-28)\n* Males and females\n* Age range will be 25-40 years\n* Right-handed participants only (required for EEG)\n\nExclusion Criteria:\n\n* Taking antidepressants (up to 2 months prior to inclusion)\n* Undergoing psychological treatment in the form of counselling, therapy or similar (up to 1 month prior to inclusion)\n* Any diagnosed chronic medical condition (e.g. diabetes) or psychiatric illness.\n* Use of antibiotics or laxatives (up to 3 months prior to inclusion)\n* Use of probiotics and\u002For prebiotics (up to 1 month prior to inclusion)\n* Enrolled in any other clinical trial (up to 1 month prior to inclusion)\n* Following restrictive and\u002For unbalanced diets\n* Smoking\n* Continuous use of a weight-loss medication for more than one month prior to screening\n* Significant gastrointestinal conditions affecting absorption, including but not limited to: inflammatory bowel disease; total colectomy or bariatric surgery; irritable bowel disease; end-stage renal disease; active cancer or cancer treatment within the past three years","ALL","25 Years","40 Years",{"count":21,"type":22},76,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to investigate the acute and chronic effects of 16-week probiotic supplementation (Ecologic® Barrier) on depressive symptoms and neural activity in those with mild-to-moderate depression.",[28,29,30],"Mild-to-moderate Depression","Neural Activity","Executive Function (Cognition)",[28,32,33,34],"Probiotic Supplementation","Neural Activation","Executive Function","NOT_YET_RECRUITING","2026-06-19",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":22},"2026-07-01",{"date":43,"type":22},"2027-03-01",{"name":45,"class":46},"University of Reading","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":47},"100634343","active-breaks-and-executive-function-in-scholars-100634343","NCT07538453","Active Breaks and Executive Function in Scholars","Active-breaks, Learning, Creativity and Emotional Health in Preadolescent Students (ACTISTOP)","ACTISTOP","Inclusion Criteria:\n\n* Students enrolled in the 5th and 6th grades of primary education in the city of Castellón, with continuous academic progression and no history of grade retention.\n* Students without diagnosed physical, neurological, or cognitive disorders.\n\nExclusion Criteria:\n\n* Students with a history of grade retention.\n* Students with diagnosed learning difficulties or neurodevelopmental disorders.\n* Students presenting any medical or psychiatric disease.\n* Students undergoing chronic pharmacological treatment.",true,"11 Years","12 Years",{"count":60,"type":22},114,[25],"This study aims to examine whether short bouts of exercise (10 minutes) performed during the school day can improve thinking skills, creativity and emotional wellbeing in primary school children. Specifically, children aged 11-12 years will be randomly assigned to perform either a short aerobic exercise break, a strength-based exercise break, or a seated control activity. The study will evaluate how these 10 minutes activity breaks influence attention, working memory, creativity, and emotional wellbeing state after completing cognitively demanding tasks. The findings will help to identify effective strategies to integrate physical activity into the classroom to enhance learning and overall well-being in school settings.",[64,30,65],"Creativity","Psychological Wellbeing",[67,68,69,70,71,72,73,74,75],"cognition","attention","creativity","exercise","memory","sedentarism","physical activity","Inhibition","emotions","RECRUITING","2026-04-15",{"date":79,"type":39},"2026-04-20",{"date":81,"type":39},"2026-03-26",{"date":83,"type":22},"2026-06",{"name":85,"class":46},"Universitat Jaume I",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":56,"sex":17,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":23,"phases":97,"briefSummary":98,"conditions":99,"keywords":104,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":47},"100631047","the-acute-effects-of-onnit-alpha-brain-on-cognition-and-mood-states-100631047","NCT07495592","The Acute Effects of Onnit Alpha Brain on Cognition and Mood States","The Acute Effects of Onnit Alpha Brain on Cognition and Mood States: A Randomized, Crossover, Double Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Healthy males and females aged 20-59\n* Free of chronic diseases.\n* Able to read and write in English\n* Willing to maintain a habitual diet, supplement routine, and avoid other lifestyle changes during the study period\n* Willingness to meet all study requirements and restrictions. Including willing to arrive in lab in a sleep deprived state (\\\u003C or =5 hours), willing to avoid alcohol consumption 72 hours prior to testing days, and willing to avoid caffeine within 12 hours prior to testing days.\n\nExclusion Criteria:\n\n* Habitual high caffeine consumers (\\> 400 mg\u002Fday) assessed through caffeine assessment tool (Caffeine Consumption Questionnaire, CCQ)\n* Unwilling to wear sleep monitor at night\n* Known diagnosis of any cognitive impairment, cardiovascular, metabolic, endocrine, or renal disease\n* Has fever, or cold like symptoms\n* History of anxiety disorders\n* History of sleep disorders (i.e., insomnia), and habitually short sleepers (\\\u003C5 hours of sleep nightly)\n* History or current malignancy\n* Previous gastrointestinal surgery within the past 12 months\n* No alcohol consumption 72 hours prior to the start of the study\u002Fconsumption of the study product and during the testing days\n* No caffeine consumption within 12 hours prior to the start of the study and during the testing days\n* Sleep medicines, melatonin, or marijuana within 1 week of the start of the study\n* Regular smoker\n* Regular drinker (\\>14 drinks per week)\n* Current use (within the past 4 weeks) of dietary supplements or prescription medicines that may enhance cognitive performance (including, but not limited to L-Theanine, Cat's claw bark extract, Alpha GPC, Toothed clubmoss extract (Huperzine A), Bacopa, Phosphatidylserine, Paraxanthine, Pterostilbene, and Sceletium tortuosum).\n* Current use of prescription medications that may influence cognition (hormone therapies, peptides, etc.)\n* Travel involving time zone change, shift work, or other life events that alter sleep schedule \\>3 hours from the norm one week before the start of the study\n* Any subject with a condition deemed by the investigator or sponsor to potentially interfere with study participation\n* Women who have been pregnant within the past 6-months, are breastfeeding, lactating, or presently planning to become pregnant during the duration of the study","20 Years","59 Years",{"count":96,"type":22},34,[25],"The purpose of this randomized, double-blind, placebo-controlled crossover study is to evaluate the efficacy of the acute effects of an investigational supplement (Alpha Brain or Alpha Brain 2.0) on improving cognitive performance, vigilance, and subjective mood in healthy adults compared to placebo during a period of acute sleep deprivation under conditions of controlled sleep deprivation.",[100,101,102,30,103],"Cognitive","Mood and Cognitive Performance","Sleep Deprivation","Fatigue",[105,106,107,108,109,110,111,112,113,34],"Alpha Brain","Dietary Supplement","Reaction Time","Attention","Vigilance","Mood States","Psychomotor Vigilance Test","Stroop Test","alertness","2026-03-30",{"date":116,"type":39},"2026-04-03",{"date":118,"type":22},"2026-04-16",{"date":120,"type":22},"2026-08-15",{"name":122,"class":123},"Applied Science & Performance Institute","INDUSTRY",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":56,"sex":131,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":136,"phases":4,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":4},"100623685","investigating-the-effects-of-time-of-day-and-menstrual-cycle-phase-low-and-high-progesterone-on-females-cognitive-and-strength-performance-100623685","NCT07399847","Investigating the Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance","Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance","Inclusion Criteria:\n\n* Female (assigned at birth)\n* Aged 18-30 years\n* Tier 2 athlete which requires the participants to identify with a specific sport, train with a purpose to compete, regularly train \\~3 times per week and compete at a local level (for example being a member of a BUCS sport and competing regularly with that sport)\n* Regular menstrual cycle - considered between 21-35-day cycles with at least 9 periods a year.\n\nExclusion Criteria:\n\n* The current\u002Fprevious (in the last 3 months) use of any contraceptive method that alter the menstrual cycle\n* The use of the emergency contraceptive pill either 3 months prior to the study or during the study\n* Diagnosis of menstrual disorders including (but not exclusively) endometriosis and Polycystic Ovary Syndrome (PCOS)\n* A formal diagnosis of sleep disorders such as insomnia\n* Consume \\>400mg\u002Fday of caffeine\n* A musculoskeletal injury in the past 3 months\n* A formal diagnosis of neurological or psychiatric disorders such as Attention-Deficit\u002FHyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Dyslexia or schizophrenia\n* Taking prescribed medication that may affect sleep for example stimulants such as Methylphenidate\n* No regular night shift work\n* No trans-meridian travel within 10 days of their expected participation dates (travel that will cause jetlag)\n* Have given blood in the last 12 weeks - this is not strictly an exclusion; participants will just need to wait until after 12 weeks before taking part in the study","FEMALE","18 Years","30 Years",{"count":135,"type":22},30,"OBSERVATIONAL","This study is designed to determine whether time-of-day and menstrual cycle phase influence athletic performance and is expected to contribute valuable insight into how both time-of-day, and hormonal factors can influence performance and expand existing research. This study aims to support more inclusive, effective and personalised approaches to training and competition schedules for female athletes.\n\nThe study will involve two testing days that require a participant to complete a compilation of tests at 07:00, 12:00 and 18:00 hours. The testing days will be arranged for when a participant is in phase 1 (lowest levels of progesterone in the menstrual cycle) and phase 4 (highest level of progesterone in the menstrual cycle). The tests will examine a participant's executive function and physical strength.\n\nThis study will aim to recruit thirty 18-30-year-old females from Lancaster University who identify with a sport that they train \\~3 times a week for with a purpose to compete. The females recruited must have a regular menstrual cycle and no history of sleep disorders.\n\nAim: To investigate the effects of time-of-day and menstrual cycle phase (low and high progesterone levels) on executive function and strength in females.\n\nObjectives:\n\n1. To determine the effects of time-of-day on executive function and strength tests.\n2. To determine the effects of menstrual cycle phase on executive function and strength tests.\n3. To examine if there is an interaction between time-of-day and menstrual cycle phase on executive function and strength tests.",[139,140,141,30,142,143],"Circadian Rhythm","Menstrual Cycle Phase","Female Athletes","Eumenorrhea","Strength","2026-02-05",{"date":146,"type":39},"2026-02-10",{"date":148,"type":22},"2026-02",{"date":150,"type":22},"2026-09",{"name":152,"class":46},"Lancaster University",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":56,"sex":17,"minAge":161,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":23,"phases":165,"briefSummary":166,"conditions":167,"keywords":172,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":185,"locationsCount":4},"100616602","motor-focused-exercise-and-brain-development-in-preschool-children-100616602","NCT07307742","Motor-Focused Exercise and Brain Development in Preschool Children","Effects of Motor-Focused Exercise Training on Brain Function and Gross Motor Skills in Preschool Children","MoBraD","Inclusion Criteria:\n\n* Children aged 4 to 6 years enrolled in participating kindergartens in Changsha, China\n* Physically healthy and able to safely participate in structured physical education activities\n* Written informed consent provided by a parent or legal guardian\n\nExclusion Criteria:\n\n* Diagnosed neurological, developmental, or musculoskeletal disorders that may interfere with motor performance or EEG measurement\n* Currently enrolled in specialized sports or motor-training programs outside of the kindergarten curriculum\n* Unable to comply with EEG assessment procedures due to behavioral or sensory intolerance","4 Years","6 Years",{"count":164,"type":22},110,[25],"This study will test whether a structured motor-focused exercise program can improve both brain function and gross motor skills in preschool children. About 110 children aged 4 to 6 years will be recruited from kindergartens in Changsha, China. Classes will be randomly assigned to receive either (1) motor-focused physical education three times per week for 16 weeks, or (2) ordinary physical education of the same frequency and duration.\n\nThe motor-focused program includes playful, game-based activities designed to strengthen locomotor skills (such as running and hopping) and object-control skills (such as throwing and catching). The main outcome will be changes in children's gross motor skills, measured with a standardized motor test (TGMD-3). Brain activity will also be assessed using portable electroencephalography (EEG) during rest and simple tasks related to attention and memory. Parents and teachers will complete short questionnaires about children's behavior and executive function.\n\nThe results of this study may provide new insights into how physical education influences both movement skills and brain development in early childhood.",[168,169,170,171,30],"Child Development","Motor Skills","Neurodevelopment","Brain Function",[173,174,175,176,177,178],"Preschool children","Physical education","Gross motor skills","Motor development","Neurocognitive development","Early childhood education","2025-12-25",{"date":181,"type":39},"2025-12-29",{"date":183,"type":22},"2026-03-01",{"date":41,"type":22},{"name":186,"class":46},"Hunan Normal University",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":56,"sex":131,"minAge":19,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":23,"phases":197,"briefSummary":198,"conditions":199,"keywords":216,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":47},"100617476","evaluation-of-the-impact-of-a-nutritional-formulation-on-cognitive-performance-following-stress-exposure-100617476","NCT07319117","Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.","A Double-blind, Placebo-controlled, Randomised, Acute, Repeated Measures Cross-over Study to Evaluate the Impact of Skoshify 'Think Tank' Nutritional Formulation on Cognitive Performance Following Stress Exposure.","Inclusion Criteria:\n\n1. Willing and able to provide written informed consent (in English)\n2. Aged 40-60\n3. Female\n4. Daily caffeine drinkers\n5. Healthy and free from significant physical and psychiatric disorders\n\nExclusion Criteria:\n\n1. Current cigarette smokers\u002Fvapers.\n2. Known food allergy or intolerance to the investigational products or control products.\n3. Not willing to consume coffee.\n4. Individuals diagnosed with psychiatric\u002Fmental health conditions.\n5. Individuals engaging in recreational drug use.\n6. Individuals with diagnosed cardiovascular conditions (e.g. heart disease, high blood pressure)\n7. Individuals taking prescribed medication except contraceptives\u002Fhormone replacement therapy\n8. Individuals suffering from Raynaud's or circulatory issues\n9. Individuals who have suffered an injury or infection in their hand\u002Farm in the last month\n10. Individuals who have suffered from chronic pain conditions or experience extreme numbness or pain in response to cold temperatures.\n11. Previous brain injury\u002Fbrain surgery\n12. Individuals who work night shifts.\n13. Currently pregnant or breastfeeding.\n14. Previous participants in a laboratory stress protocol.","60 Years",{"count":196,"type":22},40,[25],"The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor. Adopting a double-blind repeated measures cross-over design, middle-aged females (40-60 years) will be recruited to take part in a two-stage research study that will examine whether the formulation enhances cognitive performance and subjective well-being following the challenge of a stressor, compared to placebo. Cognitive assessments will examine the impact of the nutritional formulation on working memory, sustained attention, cognitive flexibility and inhibitory control. The study will also assess physiological (heart rate, blood pressure and cortisol) and subjective (well-being, anxiety, positive and negative mood, stress) markers of stress reactivity. The study will also explore levels sleep quality, mental and physical fatigue, effort, productivity, and perceived impact of the intervention.",[200,201,30,202,203,204,205,206,207,208,209,210,211,212,213,214,215],"Cognitive Assessment","Working Memory","Sustained Attention","Inhibitory Control","Cognitive Flexibility","Cortisol","Stress","Anxiety","Depression","Sleep Quality","Blood Pressure","Heart Rate","Mental Fatigue","Physical Fatigue","Productivity","Effort",[217,218,219,220,221,222,223,224,225],"Cognitive Performance","Stress Response","Creatine","Magnesium","L-Tyrosine","L-Theanine","Rhodiola","Phosphatidylserine","Citicoline","2025-12-19",{"date":228,"type":39},"2026-01-06",{"date":230,"type":22},"2025-12-15",{"date":232,"type":22},"2026-08-31",{"name":234,"class":46},"Leeds Beckett University",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":17,"minAge":194,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":23,"phases":245,"briefSummary":246,"conditions":247,"keywords":250,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":268},"100614326","effects-of-resistance-and-dual-task-training-on-physical-oculomotor-and-executive-functions-in-older-adults-with-mci-100614326","NCT07278141","Effects of Resistance and Dual-Task Training on Physical, Oculomotor, and Executive Functions in Older Adults With MCI","Study Protocol: Effects of Combined Resistance Training and Dual-Task Interventions on Physical, Oculomotor, and Executive Functions in Older Adults With Mild Cognitive Impairment. A Randomized Controlled Trial","Inclusion Criteria:\n\n* Men and women aged 60 years or older\n* Score between 10 and 25 points on the Montreal Cognitive Assessment (MoCA) scale\n* Provide informed consent\n\nExclusion Criteria:\n\n* Visual or auditory disability that impedes communication\n* Previous diagnosis of dementia\n* Wheelchair use\n* Epilepsy\n* Progressive or terminal illness\n* Depression\n* History of alcoholism\n* Musculoskeletal or cardiovascular contraindications for strength exercises\n* Color blindness\n* Dyslexia\n* Severe mental or cognitive problems supported by medical reports","90 Years",{"count":244,"type":22},66,[25],"The goal of this clinical trial is to determine the effect of a combined therapeutic intervention program with anaerobic exercises (resistance exercises) and dual tasks on the physical, oculomotor, and executive functions of older adults with mild cognitive impairment.\n\nThe main questions it aims to answer are:\n\n• How effective will a therapeutic intervention program combining resistance exercises with dual tasks be in improving the physical, oculomotor, and executive functions of older adults with mild cognitive impairment living in the community? Researchers will compare the effectiveness of a resistance exercise training program combined with dual tasks versus a resistance-only exercise training program to see if it improves the physical, oculomotor, and executive functions of older adults with mild cognitive impairment\n\nParticipants Will:\n\n* Receive resistance exercises, resistance exercises combined with dual tasks. or the standard health care. The intervention programs will consist of 3 weekly sessions over 8 weeks.\n* Before the start and after the completion of the programs, they will be evaluated using a battery of tests. This includes sociodemographic and general health background, physical fitness tests, as well as assessments of executive functions and oculomotor Saccadic movements and anti-saccadic error.\n* be required to sign a consent form.",[248,30,249],"Physical Function","Saccadic Eye Movements",[251,252,253,254,255,256,257,258],"combination training","Dual-Task","Physical-Cognitive Training","aging","older adult","Timed Up & Go","executive function","Resistance Training","2025-11-28",{"date":261,"type":39},"2025-12-11",{"date":263,"type":22},"2026-01-17",{"date":265,"type":22},"2026-12-17",{"name":267,"class":46},"Universidad Santo Tomas, Chile",2,{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":56,"sex":276,"minAge":132,"maxAge":277,"enrollmentInfo":278,"targetDuration":4,"studyType":23,"phases":280,"briefSummary":281,"conditions":282,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":47},"100605770","exploring-the-cognitive-benefits-of-a-blackcurrant-based-supplement-in-normobaric-hypoxia-100605770","NCT07166835","Exploring the Cognitive Benefits of a Blackcurrant-Based Supplement in Normobaric Hypoxia","The Efficacy of a Blackcurrant-based Nootropic Drink to Support Cognitive Functioning Under Normobaric Simulated High Altitude","Inclusion Criteria:\n\n* Willing and able to provide written informed consent (in English)\n* Aged 18-35\n* Male\n* Residing at a low altitude (\\\u003C500m)\n\nExclusion Criteria:\n\n* Diagnosed food allergy or intolerance to the investigational products or control products. (Blackcurrant, food allergen\u002F pine, tree-derived allergen\u002F l-theanine tree allergen (camellia sinensis))\n* Significant past medical and psychiatric history and ongoing chronic conditions such as, cardiovascular disease, respiratory disease, endocrine disorder (e.g. Diabetes mellites) and neurological and psychiatric conditions including brain injury or are colourblind.\n* Significant medication history or current prescription of medication or supplements known to affect cognition such as. Sedatives, stimulants, or herbal supplements high in anthocyanin and polyphenol content.\n* A positive result from the pre-screening sickle cell trait blood test.\n* An abnormal ECG reading.\n* A resting heart rate above 100bmp.\n* A blood pressure reading above 140\u002F90mmHg.\n* Subjects not willing and\u002F or not able to comply with the scheduled visits required for the study.\n* Not willing to provide blood samples.\n* Not classified as low risk based on the ACSM guidelines.","MALE","35 Years",{"count":279,"type":22},27,[25],"This study investigates the cognitive effects of Ārepa, a blackcurrant-based drink, under simulated high-altitude conditions (4,500m normobaric hypoxia for \\~180 minutes). Using a double-blind, randomised, placebo-controlled crossover design, participants will consume either the nootropic blackcurrant-based drink or a taste-matched placebo. Cognitive testing (\\~80 minutes) includes Trail-making, Stroop, N-back, Serial 7s\u002F3s, and RVIP tasks. Physiological measures (heart rate, SpO₂, blood) and biomarkers (MAO-B, BDNF, hsCRP, S100B, Prolactin, C3G, Sarmentosin) will be assessed. Scales will evaluate mood, wellbeing, and perceived effects. The aim is to determine if the nootropic drink can support cognitive function in hypoxic environments.",[217,30,201,283,284],"Hypoxia Induced Cognitive Impairment","Mood","2025-09-03",{"date":287,"type":39},"2025-09-10",{"date":289,"type":22},"2025-09-01",{"date":291,"type":22},"2027-10-01",{"name":234,"class":46},{"id":294,"slug":295,"hasResults":11,"nctId":296,"briefTitle":297,"officialTitle":297,"acronym":4,"eligibilityCriteria":298,"healthyVolunteers":56,"sex":17,"minAge":299,"maxAge":300,"enrollmentInfo":301,"targetDuration":4,"studyType":136,"phases":4,"briefSummary":303,"conditions":304,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":47},"100599190","physical-fitness-and-hot-executive-function-in-alzheimers-risk-100599190","NCT07081269","Physical Fitness and Hot Executive Function in Alzheimer's Risk","Inclusion Criteria:\n\n* Age 50-70.\n* Able to engage in fitness testing.\n* Normal vision or corrected-to-normal vision.\n\nExclusion Criteria:\n\n* Suffering from cardiopulmonary-related diseases.\n* Suffering from cognitive, neurological or psychiatric disorders (e.g., dementia, Parkinson's disease, epilepsy, depression, schizophrenia, etc.).\n* Suffering from infectious diseases (e.g., hepatitis, human immunodeficiency virus or Creutzfeldt-Jakob disease).\n* Having a history of drug or alcohol abuse.\n* Having colour vision deficiency (e.g., colour blindness).\n* Having a family history of aneurysm.\n* Taking medications that affect brain function.","50 Years","70 Years",{"count":302,"type":22},240,"This 18-month study tracks how physical fitness relates to executive function in older adults, aiming to determine if fitness improvements predict better cognitive performance. Participants complete assessments at baseline and 18 months, including cardiorespiratory fitness (YMCA bike test), muscle strength (chest and leg press tests), and executive function (computer tasks with brain activity recording via EEG). Additional measures include physical activity questionnaires, cognitive screening (MMSE), memory tests (digit span), demographics (age, sex, education), and blood tests for APOE ε4 gene status. No exercise program will be provided, allowing observation of natural fitness-cognition relationships in daily life.",[30,305,306],"Event-Related Potentials","Physical Fitness","2025-07-15",{"date":309,"type":39},"2025-07-23",{"date":311,"type":39},"2025-01-10",{"date":313,"type":22},"2027-07-31",{"name":315,"class":46},"National Taiwan Normal University",{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":56,"sex":17,"minAge":323,"maxAge":4,"enrollmentInfo":324,"targetDuration":4,"studyType":136,"phases":4,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":47},"100596676","health-related-physical-fitness-and-executive-function-in-older-adults-a-prospective-study-100596676","NCT07048561","Health-related Physical Fitness and Executive Function in Older Adults: A Prospective Study","Changes in Health-related Physical Fitness on the Behavioural and Electrophysiological Aspects of Cool and Hot Executive Function in Older Adults: A Prospective Study","Inclusion Criteria:\n\n* Age 65 or above.\n* Able to engage in fitness testing.\n* Normal vision or corrected-to-normal vision.\n\nExclusion Criteria:\n\n* Suffering from cardiopulmonary-related diseases.\n* Suffering from cognitive, neurological or psychiatric disorders (e.g., dementia, Parkinson's disease, epilepsy, depression, schizophrenia, etc.).\n* Suffering from infectious diseases (e.g., hepatitis, human immunodeficiency virus or Creutzfeldt-Jakob disease).\n* Having a history of drug or alcohol abuse.\n* Having colour vision deficiency (e.g., colour blindness).\n* Having a family history of aneurysm.\n* Taking medications that affect brain function.","65 Years",{"count":325,"type":22},200,"This study aims to explore the relationship between health-related physical fitness and behavioural and electrophysiological aspects of cool and hot executive function in older adults through a year prospective study design. The main questions it aims to answer whether changes in health-related physical fitness will positively predict changes in behavioural and electrophysiological aspects of cool and hot executive functions in older adults. The participants will be asked to complete pre-test, a one-year observation period, and post-test. Both pre- and post-tests will measure health-related physical fitness, executive function, and various demographic variables and covariates. Health-related physical fitness assessments include cardiorespiratory endurance (YMCA submaximal cycle test), muscular strength (grip strength, chest press, and leg press), muscular endurance (30-second chair stand, 30-second bicep curl), flexibility (range of motion), and balance (Balance Error Scoring System). Executive function will be measured using the Stroop test and emotional Stroop test, with concurrent EEG recording of brain activity. Demographic variables and covariates include sex, age, years of education, annual income, Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire (IPAQ) Taiwan short form, World Health Organisation Quality of Life Brief Assessment (WHOQOL-BREF) Taiwan version, Geriatric Depression Scale, Mini-Mental State Examination (MMSE), digit span tests, and step count recorded by mobile phones or watches over the previous month, resting heart rate, and resting blood pressure. No interventions will be conducted during the one-year observation period, maintaining participants' normal daily living conditions.",[328,329,30,330,305],"Older Adults (65 Years and Older)","Fitness Testing","Prospective Study","2025-06-29",{"date":333,"type":39},"2025-07-02",{"date":335,"type":39},"2025-06-01",{"date":337,"type":22},"2027-03-31",{"name":315,"class":46},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":56,"sex":17,"minAge":132,"maxAge":323,"enrollmentInfo":346,"targetDuration":348,"studyType":136,"phases":4,"briefSummary":349,"conditions":350,"keywords":357,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":4},"100591815","3-dimensional-evaluation-of-body-perception-100591815","NCT06985329","3-Dimensional Evaluation of Body Perception","Evaluation of Neurocognitive Skills, VisuoSpatial Perception and Perspective Perception in Amputees","Inclusion criteria for the amputee group:\n\n* Acquired amputees\n* Aged 18-65 years\n* Using a prosthesis for at least six months\n* At least a primary school graduate\n* Individuals who can adapt to prolonged, attention-demanding activities will be included.\n* Standardised Mini Mental State Examination score of \\>24.\n\nFollowing the recruitment of the amputee group, a healthy control group will be recruited to match it in terms of age, gender and educational status.\n\nInclusion criteria for the healthy control group:\n\n* Age range: 18-65 years\n* At least a primary school graduate\n* Individuals who can adapt to prolonged, attention-demanding activities will be included.\n* Standardised Mini Mental State Examination score of \\>24.\n\nExclusion criteria for the amputee group:\n\n* Individuals with congenital amputation\n* Those with phantom limb pain and\u002For sensation\n* Those with an open wound on the stump\n* Bilateral amputation\n* Any neurological or psychiatric diagnosis\n* Those using sedative medication and\u002For its derivatives\n* Have vision and related problems\n* Individuals who are illiterate\n* Individuals participating in treatments targeting body representation (e.g. imagery-based treatments or progressive motor visualisation) will not be included in the study.\n\nExclusion criteria for the Healthy Control Group:\n\n* Having any neurological or psychiatric diagnosis\n* Using sedative medication and\u002For its derivatives\n* People with vision and related problems\n* Illiterate individuals will not be included in the study.",{"count":347,"type":22},60,"15 Days","The goal of this observational study is to evaluate the changing body perception of amputees aged 18-65 years using prostheses through different personal perspectives of the right-left distinction. In addition, we aimed to examine the relationship between possible changes in body perception and visual spatial perception and neurocognitive performances. The main questions that this study aimed to answer are as follows:\n\n1. Is there a difference between the amputee group and the control group in terms of parameters related to body perception?\n2. Is there a difference between the amputee group and the control group in terms of neurocognitive skills?\n3. Is there any difference between the amputee group and the control group in terms of visual spatial perception abilities?\n\nTo examine whether changes in body perception in amputees affect neurocognitive performance, visuospatial perception and perspective perception and the relationship between them will be compared with a healthy control group.\n\nThe assessments to be applied to both groups can be summarised as follows:\n\n* Demographic information such as age, gender, and education level will be recorded.\n* Mini-mental state test will be used to assess the cognitive level.\n* Edinburgh Handedness Scale will be used to determine the dominant side.\n* Right-left discrimination and personal perspective perception will be assessed using a desktop programme.\n* The clock drawing test and Benton line orientation test will be used to visual spatial perception.\n* A computer based program called The Central Nervous System (CNS) Vital Signs Neurocognitive Test Battery will be used to asesses neurocognitive abilities.",[351,352,353,354,355,30,356],"Body Image","Cognition","Decision Making","Visuospatial\u002FPerceptual Abilities","Neurocognitive Function","Amputation",[351,352,358,356,34,353,359],"Neuropsychological Test","Visuospatial Skills","2025-05-14",{"date":362,"type":39},"2025-05-22",{"date":364,"type":22},"2025-06",{"date":366,"type":22},"2026-06-15",{"name":368,"class":46},"Trakya University",{"id":370,"slug":371,"hasResults":11,"nctId":372,"briefTitle":373,"officialTitle":374,"acronym":4,"eligibilityCriteria":375,"healthyVolunteers":11,"sex":17,"minAge":132,"maxAge":4,"enrollmentInfo":376,"targetDuration":4,"studyType":23,"phases":378,"briefSummary":379,"conditions":380,"keywords":386,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":47},"100585068","act-for-mental-health-in-neurological-disorders-100585068","NCT06897553","ACT for Mental Health in Neurological Disorders","Acceptance and Commitment Therapy- Based Group Therapy for Mental Health in Neurological Disorders","Inclusion Criteria:\n\n* Value above a cut-off of the DASS-21 subscales (depression \\> 10, anxiety \\> 6, and stress \\> 10)\n* Sufficient cognition and language ability (clinical rating)\n* Sufficient therapy motivation (clinical rating)\n\nExclusion Criteria:\n\n* Behavioral disorders (e.g., high irritability or apathy in clinical rating)\n* Other severe mental disorder (dementia, psychosis, personality disorders, intellectual disability)\n* Simultaneous psychotherapy or neuropsychological therapy",{"count":377,"type":22},44,[25],"The goal of this clinical trial is to examine the efficacy of this manual for mental health in people with mixed neurological disorders, including post-COVID. These conditions are often associated with cognitive impairment, which may hamper the effects of psychoterapy. Executive functioning and especially the ability to abstract thinking may be useful for individuals using Acceptance and Commitment Therapy. Therefore, the main questions research questions are:\n\n* Is this intervention effective in improving mental health?\n* Do executive functions predict the extent of social participation and mental health at the end of therapy? Participants will take part in 8 weekly group therapy sessions of 100 minutes each.",[381,382,30,383,206,384,385],"Neurological Disorders","Mental Health","Depression\u002FAnxiety","Brain Injury","Post-COVID",[387,388,389,390,391,392,393,394,395,385],"Acceptance and Commitment Therapy (ACT)","group therapy","neurological disorders","brain injury","anxiety","stress","depression","executive functioning","abstraction ability","2025-03-25",{"date":398,"type":39},"2025-03-27",{"date":400,"type":39},"2024-12-01",{"date":402,"type":22},"2026-12-31",{"name":404,"class":46},"Bielefeld University",{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":409,"acronym":4,"eligibilityCriteria":410,"healthyVolunteers":56,"sex":17,"minAge":132,"maxAge":4,"enrollmentInfo":411,"targetDuration":4,"studyType":23,"phases":413,"briefSummary":414,"conditions":415,"keywords":416,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":47},"100570702","examining-executive-functions-in-medical-students-across-different-types-of-study-breaks-100570702","NCT06710678","Examining Executive Functions in Medical Students Across Different Types of Study Breaks","Inclusion Criteria:\n\n* have and regularly use some form of social media\n* able to perform light physical activity such as walking or upper body movement\n\nExclusion Criteria:\n\n* no social media usage\n* color blindness (cognitive tests require color perception)\n* ADHD or other known conditions that affect attention and\u002For concentration,\n* current concussion\n* any condition that prevents upper or lower body physical activity.",{"count":412,"type":22},120,[25],"This study aims to expand on previous findings and compare the effects of an active break (ten minutes of walking or upper body movement), a digital break (ten minutes of phone use), and no break on memory and attention in medical students after a prolonged period of studying. The List Learning Task, Stroop Test, and Sustained Attention to Response Task will be administered to measure memory, executive function, and attention, respectively. Information on how different types of breaks affect memory and attention may prompt medical students to be more mindful and intentional of the way they spend their time in between studying.",[30],[417,418,257,71,419],"study breaks","social media","medical students","2024-11-26",{"date":422,"type":39},"2024-11-29",{"date":424,"type":39},"2024-11-19",{"date":426,"type":22},"2025-08-01",{"name":428,"class":46},"New York Institute of Technology"]