[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exercise-induced-hypoalgesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exercise-induced-hypoalgesia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100637952","the-role-of-fatigue-associated-with-strength-training-in-exercise-induced-hypoalgesia-100637952",false,"NCT07577622","The Role of Fatigue Associated With Strength Training in Exercise-induced Hypoalgesia","The Role of Fatigue Associated With Different Protocols of Strength Training in Exercise-induced Hypoalgesia: A Randomized Crossover Trial","FATIGUEIH","Inclusion Criteria:\n\n* Healthy, asymptomatic subjects\n* Being physically active\n\nExclusion Criteria:\n\n* Experiencing episodes of acute pain in any part of the body.\n* Having chronic pain or a recent history of chronic pain conditions considered resolved within the last 6 months.\n* Having a serious illness or inability to perform moderate or intense physical activity.\n* Having taken pain relievers, fever reducers, anti-inflammatory drugs (NSAIDs), steroids, opioids, or similar medications in the 24 hours before a session.\n* Having consumed alcohol or other psychoactive substances, caffeine, or other stimulants in the 24 hours before a session.\n* Having performed tiring physical activity or strength exercise in the 24 hours before a session.",true,"ALL","18 Years","45 Years",{"count":22,"type":23},27,"ESTIMATED","INTERVENTIONAL",[26],"NA","Strength exercise is an active and dynamic activity that involves applying force against a resistance. This produces fatigue, seen as a reduced ability to apply force during and after the exercise, and perceived effort, which is a person's subjective feeling of how hard they are working.\n\nStrength exercise can also be used for therapy, as it has many benefits for different parts of the body. One of these is changing how the individual feels pain. It has been shown that doing strength exercises can reduce pain perception, a phenomenon called exercise-induced hypoalgesia (EIH), although the exact physical reasons and the amount of exercise needed to cause this effect are not yet known.\n\nOne of the most studied exercises in this area is the leg extension machine. This is a specific exercise where the legs move freely (open kinetic chain) and the machine guides the movement, which helps keep things stable and limits the effect of other factors. It is usually used to strengthen and grow the muscles in the front of the thigh, especially the quadriceps, but it can also be used to study the effects on EIH.\n\nThe main goal of this study is to see if fatigue and perceived effort during strength exercise are important for EIH to happen in healthy people. Participants will complete 3 sessions, at least 7 days apart. These will include a control session and 2 sessions designed to show different levels of fatigue. Before, during, and after the sessions, the investigators will measure pain sensitivity, isometric strength, and perceived effort. Also, there will be a test to find the maximum weight for 10 repetitions and several questionnaires to collect basic info (sex, age, height...), weekly physical activity, experience with strength training, and other factors like sleep quality, stress, and mood. All this information will be completely anonymous when the study results are shared.",[29,30],"Exercise Induced Hypoalgesia","Healthy Adult Volunteer",[32,33,34,35,36,37],"Fatigue","Exercise","Hypoalgesia","Strength training","Healthy adult","leg extension","NOT_YET_RECRUITING","2026-05-05",{"date":41,"type":42},"2026-05-11","ACTUAL",{"date":44,"type":23},"2026-05-15",{"date":46,"type":23},"2027-06-30",{"name":48,"class":49},"Universidad Miguel Hernandez de Elche","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100618128","exercise-induced-hypoalgesia-in-pain-free-stroke-and-healthy-populations-a-cohort-study-100618128","NCT07327593","Exercise Induced Hypoalgesia in Pain-free Stroke and Healthy Populations: a Cohort Study","Inclusion Criteria:\n\nHealthy cohort:\n\n* Age \\> 18 years\n* No neurological damage\n* No medical conditions that could affect the test\n\nPost-stroke cohort:\n\n* Age \\> 18 years\n* Ischemic or hemorrhagic stroke (time since onset \\> 3 months)\n\nExclusion Criteria:\n\nHealthy cohort:\n\n* Any medical condition that could affect the test (respiratory, cardiovascular, metabolic diseases, for example)\n* Pain in any location, of duration \\> 1 week in the 3 months preceding the trial.\n\nPost-stroke cohort:\n\n* Unable to participate in the test (no possibility of transfer or active pedaling)\n* Medical contraindication to cardiovascular training for any reason\n* Inability to follow instructions or communicate sensations during training\n* Other neurological pathology, cardiac pathology (unstable angina, arrhythmias, aortic or left ventricular problems, myocarditis, pericarditis), pulmonary pathology that affects the test (pulmonary embolisms, pulmonary hypertension, etc.), renal or metabolic problems (severe renal dysfunction, uncontrolled diabetes, etc.), acute infection or fever, neurosurgery within 6 weeks prior to inclusion in the study\n* Pain in any location, lasting \\> 1 week in the 3 months prior to the trial.\n* Use of beta-blockers, antidepressants, or any medication that may alter heart rate measurements",{"count":58,"type":23},60,[26],"Exercise has shown multiple beneficial effects in both healthy and post-stroke populations. One of these is the acute reduction in sensitivity to painful stimuli, called exercise-induced hypoalgesia (EIH). This phenomenon has been studied since 1979 and has shown improvements in pain thresholds with both aerobic and resistance training in healthy, pain-free populations and different chronic pain conditions.\n\nAlthough there has been extensive research on EIH in healthy populations and those with chronic musculoskeletal pain, surprisingly little attention has been given to individuals with neurological pathologies. Chronic pain is found in more than 50% of patients after stroke, and 70% of affected individuals experience pain on daily activities. Reported prevalences of post-stroke pain (PSP) between different studies, but there is a general consensus that it is an underreported phenomenon. Patients with pain experience greater cognitive and functional decline, fatigue, depression and lower quality of life.\n\nMultiple factors contribute to PSP, and various approaches exist to treat all the variables influencing it. This study aims to compare the effects of exercise on pain perception in healthy individuals and stroke patients without pain, using the same cardiovascular training protocol, to better understand the mechanisms of EIH and its maintenance after stroke, ultimately aiming to improve the treatment of people with stroke.",[62,63,29],"Stroke","Pain",[62,63,65,66],"Exercise induced hypoalgesia","Cardiovascular training","RECRUITING","2026-03-17",{"date":70,"type":42},"2026-03-20",{"date":72,"type":23},"2026-04",{"date":74,"type":23},"2026-11",{"name":76,"class":49},"Neuron, Spain",2,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":24,"phases":88,"briefSummary":89,"conditions":90,"keywords":96,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":114,"locationsCount":50},"100615273","pain-perception-and-exercise-induced-hypoalgesia-across-circadian-rhythms-100615273","NCT07290465","Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms","Exploring Pain Perception Through Exercise-Induced Hypoalgesia Across Circadian Rhythms for Healthy Participants","Inclusion Criteria:\n\n* Healthy participants\n* age 18 to 40 years\n* good level of English that allow the enrolled participant to provide informed consent and complete the questionnaires provided\n* being categorized as \"moderate\" in the International Physical Activity Questionnaire (IPAQ)\n\nExclusion Criteria:\n\n* inability to report pain intensity reliably\n* consumption of narcotics or tobacco products\n* regularly taking pain medications and analgesics\n* pregnant or planning to get pregnant\n* surgery within the last 12 months\n* acute or chronic pain conditions\n* uncontrolled hypertension\n* cardiovascular diseases, pulmonary diseases, neurological diseases with significant changes in somatosensory and pain perception, metabolic diseases, serious systemic diseases or conditions that restrict normal daily activities, inflammatory conditions (e.g. rheumatoid arthritis), or orthopedic injuries\n* intolerable pain during the pain perception test\n* serious psychiatric conditions (e.g., schizophrenia and bipolar disorder) or psychological disorders (e.g., depression) that may affect pain thresholds (16).\n* Severe sleep disorders and circadian rhythm disturbances\n* BMI \\> 30\n* serious fatigue or delayed-onset muscle soreness (9) at least 24 h after exercise sessions or a sudden change in activity for more than one week","40 Years",{"count":87,"type":23},56,[26],"The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years.\n\nThe main questions it aims to answer are:\n\n* Does the time of day (morning vs. evening) influence changes in pain perception following exercise?\n* Do chronotype, sex, or stimulation site (bony vs. muscular) alter the magnitude of this effect?\n\nParticipants will:\n\n* Complete questionnaires\n* Undergo quantitative sensory testing\n* Attend both morning and evening sessions in randomized crossover order",[29,91,92,93,94,95],"Circadian Rhythm","Pain Perception","Healthy Participants","Chronotype","Physical Therapy",[97,92,91,94,93,98,99,100,101,102,103,104,95,105,106,107],"Exercise-Induced Hypoalgesia","High-Intensity Functional Training","Supervised Deep Breathing","Pressure Pain Threshold (PPT)","Pain pressure tolerance threshold (PPTol)","Quantative Sensory Testing","Bony Landmarks","Muscular Landmarks","Randomized Control Trial","Crossover","Pain Management","2025-12-04",{"date":110,"type":42},"2025-12-18",{"date":112,"type":23},"2026-01",{"date":72,"type":23},{"name":115,"class":49},"Medipol University"]