[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exercise-induced-muscle-damage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exercise-induced-muscle-damage":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,88,113,147],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100645063","effects-of-inter-set-rest-intervals-on-muscle-damage-after-flywheel-exercise-in-untrained-men-rct-100645063",false,"NCT07679971","Effects of Inter-Set Rest Intervals on Muscle Damage After Flywheel Exercise in Untrained Men (RCT)","Effects of Different Inter-Set Rest Intervals on Indirect Markers of Muscle Damage and Mechanical Parameters After Flywheel Resistance Training in Untrained Men: A Randomized Parallel-Group Clinical Trial","Inclusion Criteria:\n\n* Age between 18 and 40 years;\n* Apparently healthy and clinically able to perform physical exercise;\n* No participation in structured resistance training during the previous 6 months;\n* Agreement to comply with all study visits and procedures;\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* History of lower-limb musculoskeletal injury or surgery that may impair performance or safety during the proposed exercise protocol;\n* Current pain, injury, or functional limitation in the lower limbs;\n* Use of ergogenic aids that may affect physical performance or muscle recovery;\n* Use of analgesic or anti-inflammatory medication during the study period;\n* Failure to attend the scheduled visits required for the primary outcome assessment.",true,"MALE","18 Years","40 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized parallel-group clinical trial will compare the acute effects of three different inter-set rest intervals during a single lower-limb flywheel resistance exercise session in untrained men. Participants will be randomly allocated to one of three groups: 1-minute, 2-minute, or 3-minute inter-set rest interval. The primary outcome will be the change in maximal voluntary isometric contraction of the knee extensors 48 hours after exercise. Secondary outcomes will include mechanical variables during the exercise session, countermovement jump performance, knee flexor maximal voluntary isometric contraction, muscle soreness, pressure pain threshold, range of motion, ultrasound-derived muscle thickness and echo intensity, perceived exertion, perceived discomfort, perceived recovery status, creatine kinase, and lactate dehydrogenase.",[28],"Exercise-induced Muscle Damage",[30,31,32,33,34],"Flywheel exercise","Resistance training","Muscle damage","Maximal voluntary isometric contraction","Untrained men","NOT_YET_RECRUITING","2026-06-25",{"date":38,"type":39},"2026-07-01","ACTUAL",{"date":41,"type":22},"2026-06",{"date":43,"type":22},"2026-07",{"name":45,"class":46},"Federal University of Vicosa","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":84,"leadSponsor":86,"locationsCount":47},"100644079","effect-of-cordyceps-supplementation-timing-on-physiological-responses-and-aerobic-adaptation-in-athletes-100644079","NCT07664345","Effect of Cordyceps Supplementation Timing on Physiological Responses and Aerobic Adaptation in Athletes","Optimization of Athlete Recovery: Effects of Cordyceps Supplementation Timing on Inflammatory Response, Oxidative Stress, Muscle Damage, and Aerobic Adaptation Following Acute and Chronic Exercise Training","CORD-RECOV","Inclusion Criteria:\n\n* Male or female participants aged 19-21 years.\n* Students enrolled in the Sport Coaching Education Program (Pendidikan Kepelatihan Olahraga).\n* Apparently healthy and free from known cardiovascular, metabolic, respiratory, neuromuscular, or musculoskeletal disorders that could affect participation in exercise training.\n* Regularly participate in physical exercise at least three times per week during the previous three months.\n* Willing to comply with all study procedures, exercise protocols, supplementation schedules, and assessment sessions.\n* Provide written informed consent before participation.\n\nExclusion Criteria:\n\n* Current injury or musculoskeletal condition that limits participation in exercise training.\n* History of cardiovascular disease, uncontrolled hypertension, diabetes mellitus, respiratory disease, or other medical conditions that may increase exercise-related risk.\n* Use of antioxidant supplements, herbal supplements, ergogenic aids, or anti-inflammatory medications within four weeks prior to study enrollment.\n* Known allergy or hypersensitivity to Cordyceps or any component of the study supplements.\n* Smoking or excessive alcohol consumption during the study period.\n* Failure to comply with supplementation or exercise protocols.\n* Participation in another research study during the study period.\n* Participants presenting acute infection, fever, or inflammatory conditions within two weeks prior to baseline assessment.","19 Years","21 Years",{"count":21,"type":22},[25],"Athletes frequently perform high-intensity exercise to improve physical performance and aerobic capacity. However, such training can induce exercise-induced muscle damage, oxidative stress, and inflammatory responses that may delay recovery and compromise subsequent training adaptations. Optimizing recovery strategies is therefore essential to maintain performance, reduce injury risk, and support long-term athletic development.\n\nCordyceps is a medicinal mushroom that contains several bioactive compounds, including cordycepin and polysaccharides, which have demonstrated antioxidant, anti-inflammatory, and immunomodulatory properties. Although previous studies have reported beneficial effects of Cordyceps supplementation on exercise performance and physiological function, limited evidence exists regarding the optimal timing of supplementation relative to exercise.\n\nThis study aims to investigate the effects of different Cordyceps supplementation timing strategies on physiological responses and aerobic adaptation following acute and chronic exercise training. Participants will be assigned to receive Cordyceps supplementation before exercise, after exercise, or placebo. The study will evaluate biomarkers of inflammation (IL-6), oxidative stress (MDA), muscle damage (CK), aerobic capacity (VO2max), and neuromuscular performance assessed using countermovement jump (CMJ) testing.\n\nThe findings of this study are expected to provide evidence-based recommendations regarding nutritional recovery strategies and supplementation timing to optimize recovery and training adaptation in athletes and physically active individuals.",[62,28,63,64,65],"Exercise Recovery","Oxidative Stress","Sports Performance","Aerobic Capacity",[67,68,69,62,70,71,63,72,73,74,75,76,77,78,79],"Cordyceps","Cordyceps Supplementation","Supplement Timing","Athletic Performance","Sports Nutrition","Inflammation","Creatine Kinase","Interleukin-6","Malondialdehyde","VO2max","Countermovement Jump","VALD ForceDecks","Exercise Adaptation","2026-06-17",{"date":82,"type":39},"2026-06-24",{"date":38,"type":22},{"date":85,"type":22},"2026-09-15",{"name":87,"class":46},"Surabaya State University",{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":16,"sex":94,"minAge":18,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":23,"phases":98,"briefSummary":99,"conditions":100,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":47},"100609816","effects-of-a-5-week-probiotic-supplementation-intervention-on-markers-of-delayed-onset-muscle-soreness-100609816","NCT07219498","Effects of a 5-Week Probiotic Supplementation Intervention on Markers of Delayed Onset Muscle Soreness","Inclusion Criteria:\n\n* complete a minimum of 150 minutes a week of at least moderate intensity exercise in either an endurance-based or resistance-based training style based on a self-reported physical activity over the past month\n* good general health with no injuries or health conditions that would affect physical activity\n* willing to abstain from consistent NSAID use and other probiotic supplements over the course of this study\n\nExclusion Criteria:\n\n* known musculoskeletal injuries or physical limitations that could interfere with performing the designated physical activity required\n* underlying conditions that could place them at an increased risk during exercise such as cardiovascular, respiratory, or metabolic diseases\n* currently take a probiotic supplement, are prescribed and taking an antibiotic during the intervention, or report using NSAIDs or steroids within the recovery time window\n* report using an NSAID more than twice a week on a regular basis","ALL","30 Years",{"count":97,"type":22},24,[25],"The purpose of this study is to evaluate how probiotic supplementation (PS) influences post-exercise recovery in healthy, physically active young adults. Researchers aim to determine if the Lactobacillus casei probiotic strain reduces symptoms of delayed onset muscle soreness (DOMS) based on perceived muscle soreness, pressure pain threshold, and power output following exercise induced muscle damage (EIMD).",[101,102],"Exercise Induced Muscle Damage","Delayed Onset Muscle Soreness (DOMS)","RECRUITING","2026-04-30",{"date":106,"type":39},"2026-05-04",{"date":108,"type":39},"2026-02-05",{"date":110,"type":22},"2026-12-31",{"name":112,"class":46},"University of Minnesota",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":16,"sex":94,"minAge":18,"maxAge":95,"enrollmentInfo":120,"targetDuration":4,"studyType":23,"phases":122,"briefSummary":123,"conditions":124,"keywords":126,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":47},"100609196","acute-cryotherapy-on-musculoskeletal-function-and-biomarkers-100609196","NCT07211412","Acute Cryotherapy on Musculoskeletal Function and Biomarkers","Effects of Acute Cryotherapy on Musculoskeletal Function and Biomarkers for Inflammation, Oxidative Stress, and Muscle Damage","Inclusion Criteria:\n\n* apparently healthy\n* normotensive\n* non-smokers (all tobacco products including e-cigarettes)\n\nExclusion Criteria:\n\n* Cardiovascular diseases (including hypertension)\n* pregnancy\n* any musculoskeletal injury 6 months prior the study",{"count":121,"type":22},60,[25],"In 2020, Dubois and Esculier proposed a paradigm shift in the acute management of musculoskeletal injuries, advocating for the transition from the traditional PRICE protocol- Protect, Rest, Ice, Compression, Elevation-to the more holistic PEACE \\& LOVE framework. This updated model emphasizes Protection, Elevation, Avoiding anti-inflammatories, Compression, and Education, followed by Load, Optimism, Vascularization, and Exercise. Notably, the PEACE \\& LOVE approach omits the use of ice, a decision that has sparked considerable debate. While the rationale centers on avoiding interference with the natural inflammatory and regenerative processes, this omission stands in contrast to a substantial body of animal research suggesting that cryotherapy can mitigate secondary tissue injury by reducing inflammation and metabolic activity. Despite its widespread clinical use, human studies have yet to provide conclusive evidence supporting or refuting the efficacy of cryotherapy in acute injury management, leaving clinicians to navigate between tradition, emerging evidence, and evolving philosophies of care. Even though it is important to consider natural inflammation for a better regenerative process, animal models have shown that the original injury can elicit oxidative stress, which will enhance cellular damage (secondary damage) and inflammation. Clinically, it is unknown if this secondary damage would increase functional impairment.\n\nTherefore, this proposal will determine if cryotherapy can decrease secondary damage, after exercise-induced muscle damage, and if this decrease is associated to lower inflammation, oxidative stress and functional impairments.",[101,125],"Cryotherapy",[127,125,128,129,130,131,132,133,134,135,136,137],"Exercise induced muscle damage","Cold-pack","Ice-pack","Eccentric exercise","Creatine kinase","c-reactive protein","interlukin-6","8-isoprostane","Range of motion","Maximal Voluntary Isometric Contraction","Pain","2025-10-01",{"date":140,"type":39},"2025-10-08",{"date":142,"type":22},"2025-10-15",{"date":144,"type":22},"2026-05-15",{"name":146,"class":46},"University of Texas, El Paso",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":16,"sex":94,"minAge":18,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":23,"phases":158,"briefSummary":159,"conditions":160,"keywords":168,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":47},"100577217","a-randomized-double-blind-study-to-assess-the-effect-of-a-postbiotic-on-oxidative-stress-and-exercise-performance-100577217","NCT06795425","A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance","A Randomized, Double-Blinded, Placebo-Controlled, Parallel Study, to Assess the Effect of a Novel Postbiotic Blend on Exercise Induced Oxidative Stress Markers and Exercise Performance","PBE","INCLUSION CRITERIA\n\nTo be eligible for inclusion, the participant must fulfill all of the following criteria:\n\n1. Male or female participants between 18 - 45 years of age\n2. Signed informed consent.\n3. Health, which is defined as currently not being treated for an active cardiac, pulmonary, metabolic, immunological, neurological, respiratory, orthopedic, musculoskeletal, psychiatric, or reproductive disease or disorder. With research team and principal investigator discretion, some ongoing treatments will be permitted if a determination is made that the treatment will not increase risk of study participation and the treatment or illness itself will not confound with desired study outcomes.\n4. Physically active, which is defined as performing aerobic or resistance-based physical exercise between 2 and 5 times per week at a rating of perceived intensity (RPE) of 4 or greater (out of 10)\n5. Body mass index values will range from \\>18.5 to \\\u003C 29.9 kg\u002Fm2 (Inclusive)41 (Weir and Jan 2024).\n6. Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, and carry out all study-related procedures.\n\nEXCLUSION CRITERIA\n\nParticipants will be excluded from the study if they meet any of the following criteria:\n\n1. Body mass index \\\u003C18.5 to \\\u003C29.9 kg\u002Fm2 (Inclusive)\n2. Use of antibiotics or probiotics in the previous 3 months\n3. Positive medical history and\u002For is currently being treated for some form of heart or cardiovascular, neurological impairment, disease or condition, immune disorder or disease, thyroid disease, kidney disease, renal failure, regular dialysis, liver disease or other diagnosed hepatic impairment.\n4. Diagnosed with having Type I or Type II diabetes (determined as fasting blood glucose \\> 126 mg\u002FdL)\n5. Diagnosed with major affective disorder or other significant psychiatric disorder or disturbance that required hospitalization or home intervention in the prior year.\n6. History of cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit).\n7. Participant has an abnormality or obstruction of the gastrointestinal tract precluding swallowing (e.g., dysphagia) and digestion (e.g., known intestinal malabsorption, bile acid malabsorption, H.pylori infection, small intestine bacterial overgrowth (SIBO), celiac disease, inflammatory bowel disease, chronic pancreatitis, steatorrhea)\n8. Recently prescribed or change in dosage (within the past 6 months) of statin drug (i.e., Lipitor, Livalo, Crestor, Zocor, etc.), hypertension medications (i.e., Beta-blockers, ACE Inhibitors, Alpha blockers, Vasodilators, etc.), or psychiatric medications.\n9. Consumption (any dose or amount) of any nicotine-containing product (cigarette, cigar, vaping, etc.)\n10. Participants who are lactating, pregnant or planning to become pregnant.\n11. History of alcohol or substance abuse in the 12 months prior to screening\n12. Receipt or use of an investigational product in another research study within 60 days of beginning the study protocol.\n13. Any condition or abnormality that, in the opinion of the investigator, would compromise the safety of the participant or the quality of the study data.\n14. Extensive travel (\\>1 month) that will disrupt original outline of the study protocol.\n15. Participant is consuming a biotic product (pre-, pro-, syn-, or post-) or alters their diet resulting in a change in the amount of prebiotic, probiotic, or fermented foods that are consumed while in the study protocol.","45 Years",{"count":157,"type":22},80,[25],"This is a prospective, randomized, placebo controlled, double-blind study to assess the effects of a postbiotic blend on exercise induced oxidative stress markers and exercise performance in healthy adult.",[63,161,28,162,163,164,165,166,167],"Healthy","Exercise-induced Muscle Soreness","Immune Function","Gut Health","Microbiome Analysis","Exercise Performance","Exercise Metabolism",[169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187],"oxidative stress","antioxidants","postbiotics","ergogenic aid","exercise performance","muscle damage","recovery","gut microbiome","immune function","sleep quality","anxiety","recreationally active","inflammation","endurance training","fecal microbiota","nutritional supplement","aerobic exercise","biomarkers","clinical trial","2025-01-21",{"date":190,"type":39},"2025-01-28",{"date":192,"type":22},"2025-02-01",{"date":194,"type":22},"2026-01-01",{"name":196,"class":46},"Lindenwood University"]