[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exercise-recovery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exercise-recovery":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,54,95,119,150,187,219,243,281,304],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100634963","effects-of-cistanche-supplementation-on-anaerobic-exercise-performance-and-recovery-in-men-with-different-athletic-training-levels-100634963",false,"NCT07546513","Effects of Cistanche Supplementation on Anaerobic Exercise Performance and Recovery in Men With Different Athletic Training Levels","Effects of Cistanche Supplementation on Anaerobic Exercise Performance and Recovery in Men With Different Athletic Training Levels: A Double-Blind, Randomized, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Male, aged 18 to 25 years\n* Body mass index (BMI) between 18.5 and 25.0 kg\u002Fm²\n* Able and willing to provide written informed consent\n* Willing to comply with study procedures, supplementation, training, and assessments\n* Belonging to one of the following athletic training strata:\n* High-level elite stratum: Chinese National Level-1 Athlete standard in sprint-related events, regular training in past 12 months and active during study\n* Amateur stratum: regular exercise-training background in past 12 months without National Level-1 status\n\nExclusion Criteria:\n\n* Use of steroids or ergogenic supplements during study\n* Known cardiovascular, metabolic, musculoskeletal, or other conditions making participation unsafe or affecting outcomes\n* Current use of medications affecting muscle growth, recovery, hormones, or high-intensity performance\n* Current injury or limitation preventing safe participation\n* Known allergy or intolerance to supplement\u002Fplacebo ingredients\n* Participation in another clinical trial or structured intervention during study period\n* Inability or unwillingness to comply with protocol\n* Any other condition deemed unsuitable by investigators",true,"MALE","18 Years","25 Years",{"count":21,"type":22},56,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is a double-blind, randomized, placebo-controlled trial designed to examine whether 8 weeks of Cistanche deserticola supplementation, when combined with a standardized anaerobic training program, can improve anaerobic exercise performance, recovery, and selected body composition outcomes in young adult men with different athletic training levels.\n\nParticipants will be assigned to receive either Cistanche deserticola extract or a matched placebo while completing the same supervised anaerobic training program. The study will assess changes in anaerobic performance, including Wingate test outcomes and jump performance, as well as recovery-related indicators such as blood lactate, creatine kinase, malondialdehyde, testosterone, cortisol, and the testosterone-to-cortisol ratio. Body composition outcomes, including body fat percentage and skeletal muscle mass, will also be evaluated.\n\nThe purpose of this study is to determine whether Cistanche deserticola supplementation provides additional benefits beyond training alone, and whether these effects differ between highly trained and recreationally trained participants.",[28,29,30,31],"Athlete","Elite Athlete","Sport Performance","Exercise Recovery",[33,34,35,36,37,38,39,40],"Cistanche","anaerobic performance","exercise recovery","explosive power","lactate","muscle damage","body composition","randomized controlled trial","NOT_YET_RECRUITING","2026-06-30",{"date":44,"type":45},"2026-07-02","ACTUAL",{"date":47,"type":22},"2026-06-25",{"date":49,"type":22},"2026-09-15",{"name":51,"class":52},"Beijing Sport University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":16,"sex":17,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":93,"locationsCount":53},"100644079","effect-of-cordyceps-supplementation-timing-on-physiological-responses-and-aerobic-adaptation-in-athletes-100644079","NCT07664345","Effect of Cordyceps Supplementation Timing on Physiological Responses and Aerobic Adaptation in Athletes","Optimization of Athlete Recovery: Effects of Cordyceps Supplementation Timing on Inflammatory Response, Oxidative Stress, Muscle Damage, and Aerobic Adaptation Following Acute and Chronic Exercise Training","CORD-RECOV","Inclusion Criteria:\n\n* Male or female participants aged 19-21 years.\n* Students enrolled in the Sport Coaching Education Program (Pendidikan Kepelatihan Olahraga).\n* Apparently healthy and free from known cardiovascular, metabolic, respiratory, neuromuscular, or musculoskeletal disorders that could affect participation in exercise training.\n* Regularly participate in physical exercise at least three times per week during the previous three months.\n* Willing to comply with all study procedures, exercise protocols, supplementation schedules, and assessment sessions.\n* Provide written informed consent before participation.\n\nExclusion Criteria:\n\n* Current injury or musculoskeletal condition that limits participation in exercise training.\n* History of cardiovascular disease, uncontrolled hypertension, diabetes mellitus, respiratory disease, or other medical conditions that may increase exercise-related risk.\n* Use of antioxidant supplements, herbal supplements, ergogenic aids, or anti-inflammatory medications within four weeks prior to study enrollment.\n* Known allergy or hypersensitivity to Cordyceps or any component of the study supplements.\n* Smoking or excessive alcohol consumption during the study period.\n* Failure to comply with supplementation or exercise protocols.\n* Participation in another research study during the study period.\n* Participants presenting acute infection, fever, or inflammatory conditions within two weeks prior to baseline assessment.","19 Years","21 Years",{"count":65,"type":22},30,[25],"Athletes frequently perform high-intensity exercise to improve physical performance and aerobic capacity. However, such training can induce exercise-induced muscle damage, oxidative stress, and inflammatory responses that may delay recovery and compromise subsequent training adaptations. Optimizing recovery strategies is therefore essential to maintain performance, reduce injury risk, and support long-term athletic development.\n\nCordyceps is a medicinal mushroom that contains several bioactive compounds, including cordycepin and polysaccharides, which have demonstrated antioxidant, anti-inflammatory, and immunomodulatory properties. Although previous studies have reported beneficial effects of Cordyceps supplementation on exercise performance and physiological function, limited evidence exists regarding the optimal timing of supplementation relative to exercise.\n\nThis study aims to investigate the effects of different Cordyceps supplementation timing strategies on physiological responses and aerobic adaptation following acute and chronic exercise training. Participants will be assigned to receive Cordyceps supplementation before exercise, after exercise, or placebo. The study will evaluate biomarkers of inflammation (IL-6), oxidative stress (MDA), muscle damage (CK), aerobic capacity (VO2max), and neuromuscular performance assessed using countermovement jump (CMJ) testing.\n\nThe findings of this study are expected to provide evidence-based recommendations regarding nutritional recovery strategies and supplementation timing to optimize recovery and training adaptation in athletes and physically active individuals.",[31,69,70,71,72],"Exercise-induced Muscle Damage","Oxidative Stress","Sports Performance","Aerobic Capacity",[74,75,76,31,77,78,70,79,80,81,82,83,84,85,86],"Cordyceps","Cordyceps Supplementation","Supplement Timing","Athletic Performance","Sports Nutrition","Inflammation","Creatine Kinase","Interleukin-6","Malondialdehyde","VO2max","Countermovement Jump","VALD ForceDecks","Exercise Adaptation","2026-06-17",{"date":89,"type":45},"2026-06-24",{"date":91,"type":22},"2026-07-01",{"date":49,"type":22},{"name":94,"class":52},"Surabaya State University",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":16,"sex":102,"minAge":18,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":23,"phases":106,"briefSummary":107,"conditions":108,"keywords":4,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":53},"100629251","does-the-development-of-the-repeated-bout-effect-depend-on-oxidative-stress-and-inflammation-100629251","NCT07472244","Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation?","ANTI-RBE","Inclusion Criteria:\n\n* 18 - 45 years of age\n* BMI 18.5 - 29.9 kg\u002Fm2\n* Able to perform 20-minutes of bench stepping exercise\n* Capable and willing to provide consent (oral and written)\n\nExclusion Criteria:\n\n* Familiarised with bench stepping exercise procedures\n* Not cleared for exercise by health questionnaires or physical activity readiness questionnaire\n* Participants exhibiting any alteration in clinical inflammation parameters due to other cause\n* Participants currently being prescribed any anti-inflammatory medications","ALL","45 Years",{"count":105,"type":22},52,[25],"Eccentric exercise, particularly when novel and strenuous, can cause soreness and inflammation, impairing subsequent exercise performance. These performance decrements are attributable to oxidative stress and inflammation. Interestingly, a single bout of eccentric exercise can confer protective effects, ameliorating the negative consequences in subsequent bouts. This is termed the repeated bout effect (RBE), which would be of interest to athletes considering the detrimental effects of strenuous eccentric exercise. Athletes regularly consume supplements in hope of attenuating the performance decrements after strenuous eccentric exercise\n\n. However, considering the dose-response relationship between the initial performance decrement and the magnitude of the RBE , supplements may diminish the obtainment of the RBE. This notion remains untested, and so the proposed project is a double-blind, placebo-controlled, parallel group study aiming to assess the effects of acute vitamin C and ibuprofen supplementation on the development of the RBE. These two supplements were chosen as they are most frequently and successfully used in the literature to target oxidative stress (vitamin C) and inflammation (ibuprofen). Additionally, these doses (and the timing of supplements) were chosen to mimic protocols reporting beneficial effects",[31],"RECRUITING","2026-03-13",{"date":112,"type":45},"2026-03-16",{"date":114,"type":45},"2025-09-01",{"date":116,"type":22},"2027-02-28",{"name":118,"class":52},"University of Bath",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":16,"sex":102,"minAge":18,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":23,"phases":130,"briefSummary":131,"conditions":132,"keywords":133,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":53},"100620585","training-health-recovery-and-improvement-via-levagen-evaluation-100620585","NCT07359534","Training Health Recovery and Improvement Via Levagen+® Evaluation","Recovery Following a Prolonged Period of Intensified Exercise Training: Evaluating the Impact of Levagen+® on Alleviating Physical, Physiological and Psychological Stress.","THRIVE","Inclusion Criteria:\n\n* Healthy subjects\n* Males and females (18-50 years of age)\n* Trained cyclists\u002Ftriathletes indicated by:\n* Minimum functional threshold power (FTP, an indication of the highest average power output a cyclist can maintain for 60 minutes) of 2.9W\u002Fkg for males and 2.5W\u002Fkg for females\n* Minimum 2 years of 5 hours cycling training a week\n\nExclusion Criteria:\n\n* \\\u003C18, \\>50 years\n* Following a restrictive diet plan\n* Consumption of \\>14 units of alcohol\u002Fweek\n* Allergies to test foods\u002Fdrinks\n* Illnesses or on medication (with a possible effect on taste and\u002For appetite)\n* Devices such as pacemakers\n* Smokers\n* Gastrointestinal disorders\n* Eating disorders","50 Years",{"count":129,"type":22},20,[25],"INTRODUCTION:\n\nSports supplements and ergogenic aids are widely used for performance enhancement in recreational and professional sports. Athletes undergo intense training to improve their cardiorespiratory and muscular systems, aiming for positive adaptations. However, intensified training without appropriate dietary support can pose risks such as inadequate muscle recovery, weakened immune function, and reduced sleep quality, leading to increased susceptibility to illness and heightened physiological and psychological stress. The recent removal of cannabidiol (CBD) from the World Anti-Doping Agency (WADA) prohibited list has increased its popularity among athletes for its potential benefits on recovery and sleep. However, concerns about its safety and legality in sport persist, leading many governing bodies to caution against its use.\n\nPalmitoylethanolamide (PEA), a Generally Recognised as Safe (GRAS) supplement, exhibits anti-inflammatory effects and supports joint health. It also shows potential for stress and anxiety management, with ongoing research demonstrating this. Levagen+®, a formulated PEA, offers a safe, legal alternative to CBD, showing promise for recovery and sleep improvements. Additionally, PEA demonstrates neuroprotective and immunomodulating properties, indicating the potential benefits for athlete health, performance, and recovery. However, further research is needed to confirm Levagen+®'s efficacy as an ergogenic aid, especially in endurance sports.\n\nThe aim of this trial is to explore the effects of Levagen+® supplementation on physical, physiological and psychological recovery during a prolonged period (one week) of intensified cycling training, when administered over a period of 45 days.",[31],[134,35,135,136,137,138,139,140],"nutraceutical","sport","cycling","inflammation","muscle recovery","sleep quality","Palmitoylethanolamide","2026-01-21",{"date":143,"type":45},"2026-01-22",{"date":145,"type":45},"2025-03-10",{"date":147,"type":22},"2026-04-30",{"name":149,"class":52},"University of Westminster",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":16,"sex":102,"minAge":18,"maxAge":127,"enrollmentInfo":157,"targetDuration":4,"studyType":23,"phases":159,"briefSummary":160,"conditions":161,"keywords":167,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":53},"100567804","dose-response-impact-of-glucosyl-hesperidin-citrapeak-on-exercise-performance-blood-flow-stress-cognition-and-other-perceptual-indicators-100567804","NCT06672952","Dose-Response Impact of Glucosyl-Hesperidin (CitraPeak) on Exercise Performance, Blood Flow, Stress, Cognition, and Other Perceptual Indicators","HES","Inclusion Criteria:\n\n1. Participants who are between 18 - 50 years of age\n2. Body mass index values will range from \\>25.0 \\\u003C 30.0 kg\u002Fm2\n3. The average body mass index for entire study cohort will be less than 27.0 kg\u002Fm2. As such an ongoing calculation of the recruited cohort's mean body mass index will be maintained and people will only be randomized into the study if the average cohort body mass index value does not exceed 27.0 kg\u002Fm2\n4. Free-living and independent\n5. In good health absent of being overweight or mildly obese with no other signs or symptoms of cardiovascular, respiratory, metabolic, immune, psychiatric, or musculoskeletal disease or disorders\n6. Willingness to maintain consistent sleep duration the evening before study visits\n7. Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, and carry out all study-related procedures\n8. Regular completion of at least 180 minutes of moderate to vigorous exercise per week for the past 6 months\n\nExclusion Criteria:\n\n1. Not currently completing at least 180 minutes of moderate to vigorous exercise per week for the past 6 months\n2. Positive medical history and\u002For is currently being treated for some form of heart disease, cardiovascular disease\n3. Currently being treated for kidney disease, renal failure, or has dialysis performed on regular intervals\n4. Has liver disease or some form of clinically diagnosed hepatic impairment\n5. Diagnosed with having Type I or Type II diabetes (determined as fasting blood glucose \\> 126 mg\u002FdL)\n6. Diagnosed with or is being treated for some form of thyroid disease\n7. Diagnosed with major affective disorder or other psychiatric disorder that required hospitalization in the prior year\n8. Diagnosed with some form of immune disorder (i.e., HIV\u002FAIDS)\n9. History of cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit).\n10. Participant has an abnormality or obstruction of the gastrointestinal tract precluding swallowing (e.g., dysphagia) and digestion (e.g., known intestinal malabsorption, celiac disease, inflammatory bowel disease, chronic pancreatitis, steatorrhea)\n11. Positive medical history for any neurological condition or neurological disease\n12. Currently prescribed a statin drugs (i.e., Lipitor, Livalo, Crestor, Zocor, etc.) or any hypertension medications (i.e., Beta-blockers, ACE Inhibitors, Alpha blockers, Vasodilators, etc.)\n13. Current smoker (average of \\> 1 pack per day within the past 3 months) has quit within the past six months. This includes all forms of nicotine\n14. Intake of any drugs (prescribed or over the counter) or dietary supplements that are known or are purported to weight loss such as thermogenics, hydroxycitric acid, ephedra, capsaicin, etc.\n15. Participants who are lactating, pregnant or planning to become pregnant\n16. Have a known sensitivity or allergy to any of the study products\n17. History of alcohol or substance abuse in the 12 months prior to screening\n18. Receipt or use of an investigational product in another research study within 30 days of beginning the study protocol\n19. Any orthopedic limitation that would prevent participation in a general fitness program\n20. Any condition or abnormality that, in the opinion of the investigator, would compromise the safety of the participant or the quality of the study data",{"count":158,"type":22},60,[25],"The purpose of this study is to evaluate the dose-dependent effects of glucosyl-hesperidin (CITRAPEAK) supplementation on exercise performance, recovery indicators, blood flow, cognitive function, mood, sleep, and fuel utilization in recreationally active adults.",[162,31,163,164,165,166],"Exercise Performance","Cognitive Function","Nitric Oxide","Blood Flow","Endurance Exercise",[168,169,170,171,172,173,174,175,176,177],"exercise performance","aerobic capacity","anaerobic power","mood","nitric oxide","cognitive function","glucosyl-hesperidin","training readiness","fuel utilization","endothelial function","2025-12-05",{"date":180,"type":45},"2025-12-12",{"date":182,"type":45},"2025-04-15",{"date":184,"type":22},"2026-01-01",{"name":186,"class":52},"Lindenwood University",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":102,"minAge":194,"maxAge":195,"enrollmentInfo":196,"targetDuration":4,"studyType":23,"phases":198,"briefSummary":199,"conditions":200,"keywords":205,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":53},"100598552","cpod-patients-tolerance-of-intermittent-exercise-with-inter-exercise-recovery-under-normoxic-hypoxia-100598552","NCT07072975","CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia","HypoChronoPerf","Inclusion Criteria:\n\n* from 40 to 60 years\n* follow-up in the pneumology unit of CHU Amiens - Picardie\n* Chronic Obstructive Pulmonary Disease stade II\n* Body mass index from 20 to 30 kg.m-2\n* Tiffeneau index \\\u003C 70% of predicted value\n* FEV1 from 50 to 80% of predicted values\n* Smoking cessation since at least 1 week\n* Sedentary or physical active\n* Affiliate to social security\n* Written consent\n\nExclusion Criteria:\n\n\\-","40 Years","60 Years",{"count":197,"type":22},50,[25],"Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. This study examine the impact of the acute manipulation of oxygen availability during inter-exercise recovery period of an intermittent cycling exercise on perceptual responses.\n\nthis randomized, controlled, study include adult patient with COPD. On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed.\n\nHypoxic exposure during inter-repetition recovery phases would reduce the ventilatory load during exercise. What's more, patients would not be forced to perform the sporting gesture in a restricted space or wearing a mask, limiting dyspnea and the perceived difficulty of the effort. Lastly, the induction of hypoxic stress during the re-training session helped to improve patients' sleep.",[201,31,202,203,204],"Intermittent Hypoxia","Intermittent Exercise","Rating Exertion Perception","Sleep",[206,35,207,208,209],"intermittent hypoxia","intermittent exercise","rating exertion perception","sleep","2025-09-30",{"date":212,"type":45},"2025-10-01",{"date":214,"type":22},"2025-10",{"date":216,"type":22},"2027-08",{"name":218,"class":52},"Centre Hospitalier Universitaire, Amiens",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":225,"enrollmentInfo":226,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":228,"conditions":229,"keywords":230,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":53},"100588252","human-tecar-on-exercise-preconditioning-and-post-exercise-recovery-100588252","NCT06938984","Human TECAR on Exercise Preconditioning and Post-exercise Recovery","Inclusion Criteria:\n\n* Physically active male participants;\n* Do not present a history of musculoskeletal injury in the regions of the hips, knees and calves in the month preceding the study;\n* Are not using pharmacological agents;\n* Voluntarily commit to participate in all stages of the study.\n\nExclusion Criteria:\n\n* Present musculoskeletal or joint injuries during data collection;\n* Present history of musculoskeletal injury in the regions of the hips, knees and calves in the month preceding the study.","35 Years",{"count":197,"type":22},[25],"TECAR therapy (Transfer of Energy Capacitive and Resistive) is a type of diathermy that uses radiant energy to generate endogenous heat. However, to the date there are no studies investigating the effects of TECAR therapy on exercise preconditioning and post-exercise recovery in humans. Therefore, the aim of this project is to assess the effects of different treatment protocols of TECAR therapy on. exercise preconditioning and post-exercise recovery in humans",[31],[231,232,233],"TECAR therapy","Post-exercise recovery","Preconditioning","2025-05-06",{"date":236,"type":45},"2025-05-11",{"date":238,"type":45},"2025-04-23",{"date":240,"type":22},"2025-05-30",{"name":242,"class":52},"University of Nove de Julho",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":16,"sex":250,"minAge":18,"maxAge":19,"enrollmentInfo":251,"targetDuration":4,"studyType":23,"phases":253,"briefSummary":254,"conditions":255,"keywords":261,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":53},"100588115","pre-sleep-creatine-enhances-anaerobic-power-in-recreationally-active-females-100588115","NCT06937190","Pre-Sleep Creatine Enhances Anaerobic Power in Recreationally Active Females","SleepCrM","Inclusion Criteria:\n\nFemale, aged 18 to 25 years\n\nRecreationally active (engaging in structured resistance training 3-4 times per week for the past 6 months)\n\nRegular menstrual cycles (used for scheduling purposes)\n\nAble and willing to provide informed consent\n\nAgreement to maintain normal diet and training routines throughout the study\n\nExclusion Criteria:\n\nHistory of musculoskeletal injury affecting lower or upper limbs within the past 6 months\n\nKnown allergy or intolerance to creatine or maltodextrin\n\nUse of performance-enhancing substances or supplements within the last 30 days\n\nUse of recovery modalities such as massage, cryotherapy, or compression garments during the study period\n\nCurrent use of anti-inflammatory medication\n\nPregnancy or breastfeeding\n\nInability to comply with study protocol or scheduled assessments","FEMALE",{"count":252,"type":22},24,[25],"This study is a randomized, double-blind, placebo-controlled trial designed to examine the effects of pre-sleep creatine monohydrate supplementation on anaerobic performance and muscle damage markers in recreationally active females. Participants will be randomly assigned to receive either 5 grams of creatine monohydrate or a placebo 30 minutes before sleep for seven consecutive days. Anaerobic performance will be assessed using the Wingate Anaerobic Test, evaluating peak and average power output and fatigue index. Blood samples will be collected before and after the supplementation period to analyze markers of muscle damage, including creatine kinase and lactate dehydrogenase. This study aims to provide insight into the efficacy of short-term, time-specific creatine supplementation for enhancing performance and recovery.",[256,78,31,257,258,259,260],"Anaerobic Performance","Muscle Fatigue","Creatine Supplementation","Recreational Physical Activity","Female Athletes",[262,263,264,265,266,267,268,269,270,271,272],"Creatine Monohydrate","Pre-Sleep Supplementation","Anaerobic Power","Wingate Test","Muscle Damage Markers","Creatine Kinase (CK)","Lactate Dehydrogenase (LDH)","Female Exercise Performance","Nutritional Ergogenic Aid","Resistance Training","Recovery Enhancement",{"date":274,"type":45},"2025-04-22",{"date":276,"type":45},"2025-04-01",{"date":278,"type":22},"2025-07-10",{"name":280,"class":52},"Ankara Yildirim Beyazıt University",{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":16,"sex":102,"minAge":18,"maxAge":194,"enrollmentInfo":288,"targetDuration":4,"studyType":23,"phases":289,"briefSummary":290,"conditions":291,"keywords":294,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":300,"leadSponsor":302,"locationsCount":53},"100563529","this-repeated-measures-parallel-group-investigation-will-examine-the-influence-of-short-term-melatonin-supplementation-5mg-3-x-day-for-72-hours-on-cellular-responses-functional-performance-and-recovery-following-an-acute-bout-of-dynamic-resistance-exercise-in-resistance-trained-men-and-women-100563529","NCT06617351","This Repeated Measures Parallel-group Investigation Will Examine the Influence of Short-term Melatonin Supplementation (5mg, 3 x Day for 72 Hours) on Cellular Responses, Functional Performance and Recovery Following an Acute Bout of Dynamic Resistance Exercise in Resistance Trained Men and Women","The Effect of Melatonin Supplementation on Immune Cell Responses and Functional Recovery Following Acute Resistance Exercise","Inclusion Criteria:\n\n* Male or female between the ages of 18-40 years old.\n* Healthy and ready for physical activity as determined by the Physical Activity Readiness Questionnaire (PAR-Q+) and Medical History Questionnaire (MHQ).\n* Active resistance training for a minimum of 6 months as defined by 3 resistance training sessions (muscle strengthening activities such as free weights, weight machines, or calisthenics, etc.) per week with at least one lower body session as determined by the training history questionnaire.\n* Premenopausal, with an identifiable onset of menses (early follicular phase) as determined by the menstrual status questionnaire (female participants only)..\n* Not currently pregnant and no intention to become pregnant for the duration of participation (female participants only).\n* Currently free from and willing to abstain from dietary supplements that are viewed by study investigators to confound the outcomes of the study (e.g., creatine, beta-alanine) for the duration of the study. Participants currently using supplements will be permitted to enroll in the study following a 4-week washout period of these supplements.\n* Willing to adhere to all pre-testing visit instructions including abstaining from exercise for the duration of the study and abstaining from alcohol for 24 hours prior to visit 2 as well as for 24 hours before visit 3 until completion of the study.\n* Currently be consuming ≤ 300mg caffeine per day on average and willing to keep caffeine intake consistent throughout the duration of the study. Participants must also be willing to abstain from caffeine intake for 12 hours prior to visits 3, 4 and 5 and not consume caffeine the morning of these visits.\n* Free from previous or current lower body injuries that are viewed by the investigators to potentially limit ability of the participant to perform the exercise intervention or functional assessments.\n* Not regularly taking any type of prescription or over-the-counter medication which might affect the assessments, or having any chronic illnesses, which require medical care.\n* Considered by the study investigators to have a high likelihood of successful venipuncture following an initial examination of the participants antecubital fossa by a certified phlebotomist and verbal discussion of the participants blood draw history (including history of unsuccessful venipunctures, known issues with the locating\u002Fpalpating of veins in the antecubital fossa by a phlebotomist, and whether these difficulties are more apparent on one arm compared to the other).\n\nExclusion Criteria:\n\n* Individual does not agree to participate in this study.\n* Individual does not meet inclusion criteria to participate in the study protocols as determined via the PAR-Q+, medical history questionnaire, training history questionnaire, and\u002For the caffeine consumption questionnaire.\n* Currently taking melatonin\n* Regularly taking any type of prescription or over-the-counter medication which might affect the assessments, or having any chronic illnesses, which require medical care.\n* Not currently meeting requirements for resistance trained status.\n* Current known pregnancy or intent to become pregnant during the study period.\n* Not regularly having periods or amenorrheic, as determined by Menstrual Status Questionnaire (MSQ).\n* Currently taking any performance-enhancing drug (determined from health and activity questionnaire).\n* Currently taking a nutritional supplement viewed by the research team to confound the outcomes of the study and not willing to abstain from taking the supplement during the course of the study or not willing to undergo a 4-week wash-out period prior to participating if required.\n* Evaluated as having a low likelihood of successful venipuncture by a certified phlebotomist.",{"count":252,"type":22},[25],"Oral Melatonin is a commercially available product available alone and as a constituent in a number of supplements. Previous research suggests that short-term supplementation with oral melatonin may amplify the recovery response to damaging resistance exercise via modulation of subsequent immune and inflammatory responses. However the effects of oral melatonin on neutrophil and monocyte invasion\u002Fmigration, a critical step in the resolution of skeletal muscle tissue homeostasis, has not been examined. An oral melatonin supplement (5mg) will be provided three times daily beginning 24-hours before and ending 48-hours after an acute bout of damaging resistance exercise (total 15mg\u002Fday for 3 days).\n\nGoals:\n\n1. To investigate the effect of melatonin on systemic and cellular responses following an acute bout of damaging resistance exercise.\n2. To investigate the effect of melatonin on measures of functional performance before and during recovery from an acute bout of damaging resistance exercise.",[292,293,31],"Cell Migration","Cell Invasion",[295,35],"melatonin","2024-09-26",{"date":298,"type":45},"2024-10-01",{"date":298,"type":22},{"date":301,"type":22},"2025-07-31",{"name":303,"class":52},"University of Central Florida",{"id":305,"slug":306,"hasResults":11,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":4,"eligibilityCriteria":310,"healthyVolunteers":16,"sex":102,"minAge":18,"maxAge":225,"enrollmentInfo":311,"targetDuration":4,"studyType":23,"phases":313,"briefSummary":314,"conditions":315,"keywords":4,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":53},"100472157","clinical-study-to-evaluate-the-effects-of-two-novel-hydration-beverage-formulas-on-rehydration-in-healthy-adults-100472157","NCT05428228","Clinical Study to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults","A Randomized, Placebo Controlled, Semi-Blind, Crossover Study to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults","Inclusion Criteria:\n\n* Healthy adult male and female participants who are between 18 and 49 years of age (inclusive). Are in good general health (no active or uncontrolled diseases or conditions) and can ingest the assigned amount of fluid at each visit. Have a body mass index (BMI) between 17.0 and 29.9 kg\u002Fm2 (inclusive). Exercise regularly as per physical activity guidelines for Americans \\[structured exercise for a minimum of 150 cumulative minutes per week (low end) to 500 cumulative minutes of exercise per week (high-end)\\] and willing to maintain the same level of physical activity throughout the study period. Can maintain their exercise status at the beginning of the study throughout the study period. Can achieve a peak VO2 at screening that is at least 60% of their age and gender matched normative value per American College of Sports Medicine recommendations. Have normal or acceptable to the investigator vital signs (BP and HR) at screening. Individuals with childbearing potential: Agree to have urine pregnancy test performed on each trial day. Able to agree to the requirements and restrictions of this study, willing to give voluntary consent, able to understand and read the questionnaires, and carry out all study-related procedures.\n\nExclusion Criteria:\n\n* Female participants who are lactating, pregnant or planning to become pregnant during the study. Carry a diagnosis of diabetes. Weigh less than or equal to 80 pounds at any visits. Answer \"yes\" to any of the questions asked on the screening questionnaire (Appendix 10.2.1). Have a history of a diagnosis of celiac disease, chronic pancreatitis, steatorrhea, unstable thyroid disease, major affective disorder, psychiatric disorder that required hospitalization in the prior year, immune disorder (i.e., HIV\u002FAIDS), cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit). Use any dietary supplements that may impact hydration status within the 30 days prior to the baseline visit (Familiarization Trial\u002FVisit 2). Participants must observe a 30-day washout period of no supplementation to be eligible. Consume more than two standard alcoholic drinks per day. Use of inhalables, smokables, or the like (e.g., cigarettes, vaporizers, water pipes, or cannabis) within 30 days prior to the first dose of the study product or for the duration of the study. Have a medical condition that may impact ability to exercise or ability to ingest prescribed fluid volume. Smoking tobacco products.",{"count":312,"type":22},16,[25],"The aim of the clinical trial is to evaluate the efficacy of two novel hydration products on rehydration following exercise.",[316,317,162,31,318],"Dehydration","Rehydration","Cognitive Performance","2024-07-26",{"date":321,"type":45},"2024-07-29",{"date":323,"type":45},"2022-10-01",{"date":325,"type":22},"2024-09-01",{"name":327,"class":52},"Liquid I.V."]