[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exercise-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exercise-therapy":32},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,28,0,25,[9,52,96,130,158,186,217,242,271,295,320,352,382,414,444,472,503,525,552,590,618,649,669,693,715],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":35,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100645009","empowerher-hybrid-digital-intervention-for-breast-cancer-survivors-100645009",false,"NCT07676591","EmpowerHer: Hybrid Digital Intervention for Breast Cancer Survivors","EmpowerHer: Protocol for a Multicentre Randomized Controlled Trial Evaluating a Hybrid Digital Exercise and Education Intervention for Breast Cancer Survivors Across Five European Countries","EmpowerHer","Inclusion Criteria:\n\n* Women aged 18-65 years.\n* History of breast cancer.\n* Completed primary treatment (surgery, chemotherapy, and\u002For radiotherapy; adjuvant hormone therapy is permitted).\n* No evidence of active or metastatic disease at enrolment.\n* Able to provide informed consent and communicate in the local language.\n* Own and are able to use a smartphone.\n* Willing to engage in the exercise program.\n\nExclusion Criteria:\n\n* Cognitive impairment preventing safe participation or questionnaire completion.\n* Uncontrolled medical conditions that contraindicate exercise (e.g., unstable cardiac disease).\n* Concurrently enrolled in another structured exercise or survivorship study.\n* Pregnant or breastfeeding.","FEMALE","18 Years","65 Years",{"count":22,"type":23},147,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to learn if a 12-week hybrid exercise and education program (EmpowerHer) works to improve health-related quality of life in breast cancer survivors aged 35 to 65.\n\nThe main questions it aims to answer are:\n\n* Does the EmpowerHer program improve the everyday quality of life of participants?\n* Does the program lower fatigue, anxiety, and depression while raising physical fitness?\n\nResearchers will compare the EmpowerHer program to usual medical care to see if the program works better to help survivors recover.\n\nParticipants will:\n\n* Use a mobile application at home at least twice a week for structured exercise.\n* Read short educational modules on the mobile application about health after cancer.\n* Attend weekly in-person motivational group sessions with a program facilitator.\n* Complete health and physical tests at the start, at 12 weeks, and 3 months later.",[29,30,31,32,33,34],"Breast Cancer","Cancer Survivors","Quality of Life","Exercise Therapy","Social Support","Mobile Applications",[36,32,37,34,33,38,31],"Breast Cancer Survivors","Digital Health","Multicentre Randomized Controlled Trial","NOT_YET_RECRUITING","2026-06-23",{"date":42,"type":43},"2026-06-30","ACTUAL",{"date":45,"type":23},"2027-07-01",{"date":47,"type":23},"2028-06-30",{"name":49,"class":50},"University of Valencia","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":63,"briefSummary":64,"conditions":65,"keywords":75,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":95},"100603978","early-exercise-based-rehabilitation-in-patients-hospitalized-for-acute-pulmonary-embolism-100603978","NCT07143539","Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism","Early Exercise-based Rehabilitation in High-risk Patients Hospitalized for Acute Pulmonary Embolism: a Pragmatic Multicenter Randomized Partially Blinded Superiority Trial","RehabPE","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Hospitalization for objectively confirmed acute symptomatic PE, defined as intraluminal filling defect of a segmental or more proximal pulmonary artery on computed tomography pulmonary angiography (CTPA) or a high-probability ventilation-perfusion scintigraphy, and admission within the past 7 days\n3. Increased risk for post-PE syndrome, defined as simplified Pulmonary Embolism Severity Index (sPESI) ≥1 point at the time of admission\n4. Written informed consent\n\nExclusion Criteria:\n\n1. Contraindication to EBR (known unstable cardiac conditions like angina pectoris, severe valvular heart disease, or severe resting pulmonary hypertension)\n2. Medical condition that clearly precludes participation in EBR (e.g., inability to walk, unstable joints, severe neurological impairment)\n3. Recently completed (i.e., \\\u003C6 months), ongoing, or planned in- or outpatient EBR, or planned supervised outpatient physiotherapy for any indication\n4. Planned hospitalization during follow-up (e.g., elective surgery or inpatient chemotherapy)\n5. Contraindication to anticoagulation\n6. Life expectancy \\\u003C1 year based on the treating physician's clinical judgement\n7. Known pregnancy\n8. Inability to speak German or French\n9. Participation in another study that prohibits concurrent participation in RehabPE\n10. Unable to provide informed consent (e.g., due to dementia)\n11. Unwilling to provide informed consent\n12. Prior enrollment in this study","ALL",{"count":62,"type":23},160,[26],"Up to half of patients with pulmonary embolism (PE) suffer from impaired quality of life, reduced physical capacity, and symptoms like shortness of breath even three months after diagnosis, despite standard treatment with anticoagulation (blood thinners). The randomized RehabPE trial investigates whether an early, structured rehabilitation program with physical training and patient education can prevent such long-term effects.\n\nThe study includes hospitalized patients with acute symptomatic PE who are at increased risk of impaired quality of life three months after diagnosis. After informed consent, patients are randomly assigned to one of two groups: one receives an early 6-8-week, center-based rehabilitation program; the other receives standard follow-up care without rehabilitation. The intervention group completes 16-18 outpatient sessions of endurance and strength training, along with two education sessions covering the condition, treatment, and symptom management.\n\nOver 180 days, changes in quality of life, physical exercise capacity, breathlessness, and psychological symptoms, and the time to return to work \u002F usual daily activities will be monitored and compared between groups.",[66,32,67,68,69,70,71,72,73,74],"Venous Thromboembolism (VTE)","Quality of Life (QOL)","Anxiety Depression","Humans","Exercise Tolerance","Rehabilitation Exercise","Dyspnea","Functional Status","Pulmonary Embolism (Diagnosis)",[76,77,78,79,80,81,82,83,84],"pulmonary embolism","deep vein thrombosis","excercise-based rehabilitation","post-PE syndrome","health-related quality of life","anxiety","depression","dyspnea","impact of early excercise-based rehabilitation","RECRUITING","2026-06-11",{"date":88,"type":43},"2026-06-12",{"date":90,"type":43},"2025-12-17",{"date":92,"type":23},"2028-06",{"name":94,"class":50},"Insel Gruppe AG, University Hospital Bern",6,{"id":97,"slug":98,"hasResults":12,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":24,"phases":106,"briefSummary":107,"conditions":108,"keywords":114,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":51},"100640235","evaluating-the-feasibility-of-prehabilitation-delivery-models-for-patients-preparing-for-ovarian-cancer-surgery-100640235","NCT07609082","Evaluating the Feasibility of Prehabilitation Delivery Models for Patients Preparing for Ovarian Cancer Surgery","Assessing Delivery Approaches for Prehabilitation Trials in Ovarian Cancer: A Pilot Feasibility Patient-Preference Trial","ADAPT-OC","Inclusion Criteria:\n\n* Female\n* Aged ≥18 years\n* Scheduled for cytoreductive surgery for an ovarian mass suspected or confirmed of cancer\n* Surgery planned ≥3 weeks from time of booking\n* No contraindications to exercise on the CSEP Get Active Questionnaire\n* Able to provide written informed consent\n* Able to understand and communicate in English\n\nExclusion Criteria:\n\n* Pregnancy\n* Surgery scheduled \\\u003C3 weeks from booking\n* Receiving neoadjuvant chemotherapy\n* Positive contraindications to exercise on the CSEP Get Active Questionnaire\n* End-stage or advanced renal disease limiting safe protein supplementation\n* Malnutrition as assessed by a registered dietician",{"count":105,"type":23},36,[26],"The goal of this clinical trial is to learn whether high-dose multimodal prehabilitation, delivered either in person or remotely with coaching and web application support, is feasible and acceptable for women preparing for ovarian cancer surgery. It will also examine which delivery model patients prefer and the factors influencing patient preferences.\n\nThe main questions ADAPT-OC aims to answer are:\n\n1. Can participants achieve the prescribed aerobic exercise target of at least 10 MET-hours per week before surgery?\n2. Do patients prefer in-person prehabilitation, remote prehabilitation, or education-only care, and what factors influence that preference?\n\nThe researchers will compare in-person prehabilitation, remote prehabilitation, and education-only care to see which delivery approach is most feasible, acceptable, and practical for patients with suspected ovarian cancer.\n\nParticipants will:\n\n* Choose their preferred study group, or be randomly assigned if they have no preference\n* Complete physical assessments, questionnaires, and interviews at baseline, 1-3 days before surgery, and 4 weeks after surgery\n* If assigned to a prehabilitation group, complete aerobic exercise, protein supplementation, and daily breathing exercises before surgery\n* Attend weekly coaching sessions with a trained prehabilitation coach\n* Use the KingstonPrehab web application to track exercise, nutrition, breathing practice, and progress toward activity goals",[109,110,111,112,32,113],"Prehabilitation","Preoperative Aerobic Training","Preoperative Care","Ovarian Cancer","Postoperative Outcomes",[115,116,117,118,119,120],"postoperative outcomes","prehabilitation","nutritional support","psychological support","exercise therapy","ovarian cancer","2026-05-19",{"date":123,"type":43},"2026-05-27",{"date":125,"type":23},"2026-05-14",{"date":127,"type":23},"2027-05-14",{"name":129,"class":50},"Jordan Leitch",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":12,"sex":60,"minAge":138,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":24,"phases":141,"briefSummary":142,"conditions":143,"keywords":146,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":4},"100636145","comparative-effects-of-multicomponent-training-concerning-elastic-band-training-on-physical-fitness-postural-balance-and-health-related-quality-of-life-in-older-women-100636145","NCT07561879","Comparative Effects of Multicomponent Training Concerning Elastic Band Training on Physical Fitness, Postural Balance, and Health-related Quality of Life in Older Women","Comparative Effects of Multicomponent Training Concerning Elastic Band Training on Physicalfunctional Fitness, Postural Balance, and Health-related Quality of Life in Older Womean: a Randomized Controlled Trial.","RCT","Inclusion Criteria:\n\n* individuals over 70 - 75 years of age;\n* the ability to understand and follow contextually appropriate instructions through simple commands\n* independence, defined as a score of at least 43 points on the Preventive Medical Examination for Older People from the Chilean Ministry of Health (in Spanish, EMPAM) (MINSAL, 2012)\n* the ability to comply with at least 85% attendance of the scheduled intervention sessions.\n\nExclusion Criteria:\n\n* having any form of disability\n* having musculoskeletal injuries or being under physical rehabilitation that would prevent participation in usual physical activities\n* being permanently or temporarily unable to engage in physical activity.","60 Years",{"count":140,"type":23},40,[26],"Objective: To compare the effects of MCT versus EBT on functional fitness, postural balance, and HRQoL in older women. Methods: Single-blind, parallel-group randomized controlled trial lasting 16 weeks (2 sessions\u002Fweek, 60 min). Twenty",[144,32,145],"Aged","Physical Performance",[147,148,31],"Postural Balance","cognitive function","2026-04-24",{"date":151,"type":43},"2026-05-01",{"date":153,"type":23},"2026-04-01",{"date":155,"type":23},"2026-06-01",{"name":157,"class":50},"Universidad Católica del Maule",{"id":159,"slug":160,"hasResults":12,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":20,"enrollmentInfo":165,"targetDuration":4,"studyType":24,"phases":166,"briefSummary":167,"conditions":168,"keywords":173,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":51},"100592600","splinting-vs-exercise-in-de-quervains-tenosynovitis-100592600","NCT06995534","Splinting vs Exercise in De Quervain's Tenosynovitis","Comparison of Static Hand-Wrist Splinting and Exercise Therapy in the Management of De Quervain's Tenosynovitis","Inclusion Criteria:\n\n* Adults aged between 18 and 65 years\n\nPatients experiencing wrist pain and tenderness for less than 3 months and clinically diagnosed with acute or subacute De Quervain's tenosynovitis\n\nVisual Analog Scale (VAS) pain score ≥ 3\n\nExclusion Criteria:\n\n* History of trauma\n\nWrist fractures\n\nLocal infection\n\nPresence of rheumatologic diseases (e.g., rheumatoid arthritis, psoriatic arthritis)\n\nPresence of symptomatic hand osteoarthritis\n\nContinuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids\n\nReceipt of physical therapy for the hand or wrist within the past 3 months\n\nCorticosteroid injection into the hand or wrist within the past 3 months\n\nDiagnosed with significant neurological disorders (e.g., upper motor neuron disease)\n\nPresence of uncontrolled systemic diseases (e.g., uncontrolled diabetes mellitus, congestive heart failure, chronic kidney disease, hepatic failure)\n\nMajor psychiatric disorders\n\nCommunication difficulties",{"count":140,"type":23},[26],"De Quervain's disease is a painful tenosynovitis of the abductor pollicis longus and extensor pollicis brevis muscle tendons located in the first dorsal compartment. The primary treatment for De Quervain's disease is conservative; surgical intervention is rarely required. Currently, there is no standardized treatment protocol supported by strong, up-to-date evidence.\n\nThe aim of this study is to compare the effectiveness of a static hand-wrist resting splint and exercise therapy in the conservative treatment of De Quervain's tenosynovitis. Patients will be evaluated in terms of pain levels, functional\u002Fsymptom status, hand-finger strength, pressure pain threshold (PPT), tendon cross-sectional area measured by ultrasound, and the presence of effusion findings (semiquantitative; 0-3), and patient satisfaction.",[169,32,170,171,172],"Splints","De Quervains Tenosynovitis","Pain Management","Ultrasonographic",[174,170,119,175,172],"pain","splints","2026-03-21",{"date":178,"type":43},"2026-03-24",{"date":180,"type":43},"2025-05-29",{"date":182,"type":23},"2026-04-30",{"name":184,"class":185},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",{"id":187,"slug":188,"hasResults":12,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":12,"sex":60,"minAge":4,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":24,"phases":196,"briefSummary":197,"conditions":198,"keywords":201,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":216},"100626077","feasibility-of-integrating-street-racket-into-ambulatory-pulmonary-rehabilitation-100626077","NCT07430943","Feasibility of Integrating Street Racket Into Ambulatory Pulmonary Rehabilitation","Acceptability, Appropriateness and Feasibility of Integrating Street Racket Into Ambulatory Pulmonary Rehabilitation: A Prospective, Single-Arm Feasibility Study","APRacket","Inclusion Criteria:\n\n* Any sex or gender\n* Age \\>18 years\n* Prescribed APR by a physician and currently participating in APR at the USZ\n* Physically and psychologically capable of following instructions and standing\u002Fwalking for up to one hour (short, seated breaks are allowed if needed)\n\nExclusion Criteria:\n\n* Require supplemental oxygen therapy that cannot be delivered via a portable backpack system (e.g., large oxygen cylinders on wheels, which pose a fall risk)\n* Are unable to follow study procedures due to language barriers, psychological conditions, or orthopaedic limitations that prevent them from standing or walking for up to one hour\n* Require walking aids due to impaired balance (e.g., walking sticks, rollator, etc.)",{"count":195,"type":23},12,[26],"This study looks at whether Street Racket is a feasable activity that can be added to pulmonary rehabilitation for people with chronic lung disease. Participants complete short questionnaires at the start and end of the program to rate the feasibility and rate their breathlessness during each session. Attendance is recorded to understand how well the activity is used and whether there are any barriers.",[199,200,32],"Pulmonary Rehabilitation","Physical Activities",[202,203,119,204,205,206],"pulmonary rehabilitation","street racket","COPD","ILD","pulmonary hypertension","2026-03-09",{"date":209,"type":43},"2026-03-12",{"date":211,"type":43},"2026-03-05",{"date":213,"type":23},"2027-02-28",{"name":215,"class":50},"Mona Lichtblau",2,{"id":218,"slug":219,"hasResults":12,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":24,"phases":227,"briefSummary":228,"conditions":229,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":241},"100573449","activity-coaching-during-pelvic-radiation-therapy-100573449","NCT06746428","Activity Coaching During Pelvic Radiation Therapy","ACTIVATE: A Pilot Randomized Activity Coaching Trial to Increase Vitality and Energy During Post-operative Pelvic Radiation Therapy for Endometrial Cancer","ACTIVATE","Inclusion Criteria:\n\n* At least 18 years of age\n* Pathologic diagnosis of endometrial cancer (any histology, Stage I-IVA)\n* Has undergone modified radical or radical hysterectomy\n* Plan to receive adjuvant treatment with pelvic external beam radiation therapy at ISCI\n* ECOG performance status of 0-1\n* Patient has a computer, smart phone, or tablet virtual access to the web-based platform and email\n* Able to read, understand and provide written informed consent\n* Deemed appropriate for unmonitored exercise by treating physician based on the following evidence-based criteria (1)\n\n  * Walk without any assistance or assistance device\n  * Absence of significant cognitive impairment\n  * Absence of high risk for falls\n* Participant does not need to refrain from any activity\n\nExclusion Criteria:\n\n* Unable to schedule and attend coaching visits\n* Participation in a regular exercise program of ≥150 minutes of moderate intensity exercise a week at baseline\n* Unable to perform the five-times stand test\n* Medical comorbidities including:\n\n  * Unstable angina\n  * Uncontrolled dysrhythmias\n  * Acute pulmonary embolus\n  * Active pulmonary infection",{"count":226,"type":23},16,[26],"Research has shown that for women who are undergoing pelvic radiation therapy, fatigue is a common side effect. Fatigue that occurs during radiation therapy can make it harder to perform daily living activities. While there are studies that recommend exercise as a treatment for fatigue in cancer patients and survivors, there are currently no studies that focus on the role of exercise for women undergoing pelvic radiation therapy. The purpose of this study is to see if incorporating an activity coaching program is helpful in improving treatment-related fatigue for women undergoing pelvic radiation therapy for endometrial cancer.",[230,231,32],"Radiation Therapy","Gynecologic Cancer","2026-03-02",{"date":234,"type":43},"2026-03-03",{"date":236,"type":43},"2025-01-27",{"date":238,"type":23},"2026-07-01",{"name":240,"class":50},"Inova Health Care Services",4,{"id":243,"slug":244,"hasResults":12,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":250,"sex":18,"minAge":19,"maxAge":251,"enrollmentInfo":252,"targetDuration":4,"studyType":24,"phases":254,"briefSummary":255,"conditions":256,"keywords":261,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":51},"100620796","mat-pilates-on-body-awareness-and-physical-activity-levels-in-sedentary-emerging-adulthood-women-100620796","NCT07362277","Mat Pilates on Body Awareness and Physical Activity Levels in Sedentary Emerging Adulthood Women","The Effect of Mat Pilates on Body Composition and Physical Activity Levels in Sedentary Women Emerging Adulthood","mat pilates","Inclusion Criteria:\n\n* Possess the ability to read and understand Turkish, be between the ages of 18 and 29,\n* I have a sedentary lifestyle, possess the cognitive ability to understand and interpret survey questions, and for sedentary participants, not have engaged in regular exercise for 2 months, have a Physical Activity Score (IPAQ) -short form of less than 600 Metabolic Equivalent of Task (MET) minutes per week, and body weight below 130 kg.\n\nExclusion Criteria:\n\n* Participants with chronic, neurological, orthopedic, rheumatic systemic and\u002For lung disease, those who exercise\u002Fsport, have a history of malignancy, are pregnant, have a history of fracture in the last year,\n* I have chronic kidney or liver disease, have cardiovascular disease, and have peripheral vestibular disorder were excluded.",true,"29 Years",{"count":253,"type":23},54,[26],"This study investigating the effects of mat pilates on body awareness and physical activity levels in sedentary women transitioning to adulthood, 27 control groups and 27 mat pilates exercise groups will be included. The groups will be compared at the end of an 8-week exercise program. Participants' socio-demographic characteristics, body awareness (using the Body Awareness Questionnaire), and physical activity level (using the Tegner Physical Activity Questionnaire and the International Physical Activity Questionnaire short-form scales) will be assessed.",[32,257,258,259,260],"Awareness","Sedentary Behavior","Woman's Role","Exercise",[32,257,258,259,260],"2026-01-22",{"date":264,"type":43},"2026-01-23",{"date":266,"type":43},"2025-12-05",{"date":268,"type":23},"2026-02-20",{"name":270,"class":50},"Necmettin Erbakan University",{"id":272,"slug":273,"hasResults":12,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":277,"eligibilityCriteria":278,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":279,"targetDuration":4,"studyType":24,"phases":281,"briefSummary":282,"conditions":283,"keywords":286,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":51},"100418114","improving-cognitive-function-through-high-intensity-interval-training-in-breast-cancer-patients-undergoing-chemotherapy-100418114","NCT04724499","Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy","Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy (The CLARITY Trial)","CLARITY","Inclusion Criteria:\n\n* Written informed consent prior to any study-related procedures\n* Women newly diagnosed (Stage I-III) breast cancer.\n* Over the age of 18 years; children under the age of 18 will be excluded due to rarity of disease\n* The effects of exercise on the developing fetus are unknown. For this reason, women of child-bearing potential must agree to undergo a pregnancy test and to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately.\n* Will receive (neo)adjuvant chemotherapy\n* Speak English\n* Able to provide physician clearance to participate in the exercise program\n* Able to initiate a supervised exercise program (free from any cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity)\n* Have not experienced a weight reduction ≥10% within the past 6 months\n* Currently participate in less than 60 minutes of structured exercise\u002Fweek\n* Does not smoke (no smoking during previous 12 months)\n* Willing to travel to DFCI for assessments (54 visits total for those who elect the exercise group with on campus training session, 6 visits for those that elect the exercise at home option, 6 visits for those assigned to the control group)\n* Ability to understand and the willingness to sign a written informed consent document.\n\nExclusion Criteria:\n\n* Patients should not have any uncontrolled illness including ongoing or active infection, uncontrolled diabetes, hypertension or thyroid disease\n* Patients with other active malignancies are ineligible for this study.\n* Patients with metastatic disease\n* Medical history of coronary heart or artery disease, chronic or acute congestive heart failure or history of systolic or diastolic insufficiencies\n* Participates in more than 60 minutes of structured exercise\u002Fweek\n* Orthopedic or other restrictions or contraindications to high-intensity (cycling) exercise\n* Have a pacemaker or any implantable device that are not MRI safe; the BWH\u002FDFCI Standard MRI screening form\n* Is unable to travel to DFCI\n* Patients who are pregnant\n* Patients with claustrophobia\n* Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study.",{"count":280,"type":23},30,[26],"The purpose of this research is to determine whether a 16-week high intensity interval training (HIIT) exercise program will improve brain health among women undergoing chemotherapy and also improve cardiovascular (heart) function.\n\nThe names of the study interventions involved in this study are\u002Fis:\n\n* High-Intensity Interval Training (HIIT)",[29,284,32,285],"Chemotherapy Effect","Cognitive Change",[29,284,32,285],"2026-01-20",{"date":262,"type":43},{"date":290,"type":43},"2021-07-14",{"date":292,"type":23},"2027-04-01",{"name":294,"class":50},"Dana-Farber Cancer Institute",{"id":296,"slug":297,"hasResults":12,"nctId":298,"briefTitle":299,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":301,"targetDuration":4,"studyType":24,"phases":303,"briefSummary":304,"conditions":305,"keywords":308,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":318,"locationsCount":51},"100617514","investigation-of-the-effects-of-high-intensity-interval-exercise-and-moderate-intensity-continuous-exercise-on-limb-volume-functional-capacity-and-quality-of-life-in-patients-with-lipedema-100617514","NCT07319611","Investigation of the Effects of High-Intensity Interval Exercise and Moderate-Intensity Continuous Exercise on Limb Volume, Functional Capacity, and Quality of Life in Patients With Lipedema","Inclusion Criteria:\n\n* Female participants aged 18-65 years\n* Able to read and write (literate)\n* Clinically diagnosed with lipedema according to Halk and Damstra criteria\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Illiteracy\n* Refusal or inability to provide written\u002Fsigned consent\n* Lower extremity fracture, trauma, or surgery within the past 12 months\n* Cardiopulmonary diseases that contraindicate exercise participation\n* Development of intolerance exercise sessions",{"count":302,"type":23},69,[26],"This randomized controlled clinical study aims to investigate and compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), when combined with intermittent pneumatic compression (IPC) therapy, on limb volume, functional capacity, pain, fatigue, anxiety, depression, sleep quality, and quality of life in women with lipedema.\n\nLipedema is a chronic, progressive adipose tissue disorder primarily affecting women, characterized by abnormal and symmetrical fat accumulation in the lower extremities that does not improve with weight loss or limb elevation. It is often misdiagnosed as obesity or lymphedema, leading to delayed treatment. Lipedema causes pain, swelling, bruising, mobility limitation, and reduced quality of life.\n\nConservative treatment options include compression therapy, manual lymphatic drainage, and exercise. IPC is a non-invasive treatment used to reduce limb volume and pain while improving function and quality of life. Exercise is also a cornerstone of conservative management, but the optimal exercise intensity for lipedema remains unclear.\n\nIn this study, 69 female patients aged 18-65 years diagnosed with lipedema according to Halk and Damstra criteria will be randomly assigned into three groups:\n\nIPC + Home-based walking program\n\nIPC + High-Intensity Interval Training (HIIT)\n\nIPC + Moderate-Intensity Continuous Training (MICT)\n\nAll participants will receive 15 IPC sessions (3 times per week for 5 weeks). The exercise programs (HIIT or MICT) will continue for 10 weeks, supervised by a physiotherapist. The home-based group will be encouraged to walk ≥10,000 steps daily using a pedometer application.\n\nPrimary outcome: Change in limb volume measured by circumferential measurements and the truncated cone formula.\n\nSecondary outcomes: Pain (VAS), functional capacity (6-Minute Walk Test), muscle strength (dynamometry), pressure pain threshold (algometry), physical activity (IPAQ-SF), lower extremity function (LEFS), quality of life (SF-12), sleep quality (PSQI), fatigue (FSS), and anxiety\u002Fdepression (HADS).\n\nMeasurements will be taken at baseline (T0), after 15 IPC sessions (T1), and after 30 total sessions or 10 weeks (T2).\n\nThe investigators hypothesize that both HIIT and MICT combined with IPC will provide superior improvements in physical and psychological outcomes compared to IPC with a home-based walking program alone.",[306,32,307],"Lipedema","High Intensity Interval Training",[309,310,311],"lipedema","high intensity interval training","moderate intensity continuous training","2025-12-20",{"date":314,"type":43},"2026-01-06",{"date":316,"type":23},"2025-12-25",{"date":238,"type":23},{"name":319,"class":50},"Marmara University",{"id":321,"slug":322,"hasResults":12,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":326,"eligibilityCriteria":327,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":20,"enrollmentInfo":328,"targetDuration":4,"studyType":24,"phases":330,"briefSummary":331,"conditions":332,"keywords":337,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":51},"100584442","effects-of-education-and-exercise-on-pain-psychosocial-factors-and-upper-limb-function-in-non-specific-neck-pain-100584442","NCT06889389","Effects of Education and Exercise on Pain, Psychosocial Factors, and Upper Limb Function in Non-specific Neck Pain.","Effects of Pain Neuroscience Education and Therapeutic Exercise on Pain, Catastrophizing, Kinesiophobia and Upper Limb Function in Patients With Non-specific Neck Pain.","PNE-EXNP","Inclusion Criteria:\n\n* Subjects aged between 18 and 65 years\n* Subjects with non-specific neck pain at the time of the intervention, scoring at least 3 on the NPRS scale.\n\nExclusion Criteria:\n\n* Pregnancy\n* Severe illnesses: diabetes, cancer, neurological conditions, depression, etc.\n* Subjects impairments or disorders\n* Subjects who have received physiotherapy treatment within the last month\n* Subjects currently undergoing concurrent physiotherapy treatment for this condition\n* Subjects with specific neck pain, such as any traumatic pathology, whiplash, or diagnoses associated with neurological compromise or peripheral nerve damage\n* Physiotherapy students or professional physiotherapists",{"count":329,"type":23},81,[26],"Pain neuroscience education is currently one of the techniques being explored in physiotherapy for pain management. The benefits of this technique are gradually becoming evident in various published studies. So far, it has been widely studied for its short-term effects, but the education provided has typically been generic, not focused on exercise. However, it is suggested that this technique should be combined with exercise to achieve the expected outcomes. Therefore, pain education should be tailored to the specific physical activities the subject will perform to maximise its effectiveness. The primary aim of this study is to analyse the outcome of combining exercise with tailored pain neuroscience education on aspects such as pain, kinesiophobia, catastrophizing, exercise conceptualization, and upper limb function in subjects with neck pain. The secondary aim is to evaluate the relationship between kinesiophobia and catastrophizing and their impact on the results of various upper limb performance tests. Finally, the effects of therapeutic exercise alone will be compared with those of therapeutic exercise combined with pain neuroscience education, focusing on pain, kinesiophobia, catastrophizing, and exercise conceptualization. A double-blind, randomised clinical trial has been designed, in which three intervention protocols will be applied to 81 subjects with non-specific neck pain: education with exercise, exercise alone, and placebo alone. Subjects with non-specific neck pain who meet the inclusion criteria will be enrolled. Demographic characteristics of the subjects, as well as pain, kinesiophobia, catastrophizing, and upper limb performance test scores, will be assessed. This study aims to explore the potential relevance of a pain neuroscience education session prior to therapeutic exercise, as well as to influence the clinical recommendations made by clinicians during treatment.",[333,334,32,335,336],"Neck Pain","Patient Education","Fear","Pain",[338,339,340,341,342],"Neck pain","Pain neuroscience education","Exercise therapy","Kinesiophobia","Pain catastrophizing","2025-12-19",{"date":345,"type":43},"2025-12-29",{"date":347,"type":43},"2025-03-28",{"date":349,"type":23},"2026-10-30",{"name":351,"class":50},"Universidad Miguel Hernandez de Elche",{"id":353,"slug":354,"hasResults":12,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":359,"enrollmentInfo":360,"targetDuration":4,"studyType":24,"phases":362,"briefSummary":363,"conditions":364,"keywords":369,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":380,"locationsCount":51},"100515395","smartphone-based-remote-symptom-monitoring-to-improve-postoperative-rehabilitation-exercise-adherence-after-video-assisted-thoracic-surgery-vats-for-lung-cancer-100515395","NCT05990946","Smartphone-based Remote Symptom Monitoring to Improve Postoperative Rehabilitation Exercise Adherence After Video-assisted Thoracic Surgery (VATS) for Lung Cancer","A Prospective, Randomized, Controlled Study to Evaluate the Impact of Remote Symptom Management Via Smartphone App Based on Electronic Patient-Reported Outcomes on Rehabilitation Exercise Adherence After Minimally Invasive Surgery in Lung Cancer Patients","Inclusion Criteria:\n\n* Age 18-75 years old\n* Undergoing minimally invasive lung cancer resection\n* Able to use smartphones and complete electronic questionnaires\n* Signed informed consent\n\nExclusion Criteria:\n\n* conversions to open thoracotomy during surgery\n* ECOG score \\> 1\n* Received neoadjuvant therapy\n* Previous lung resection surgery\n* Unable to exercise due to physical limitations\n* Continuous systemic corticosteroid use within 1 month before enrollment\n* Unresolved toxicity above Grade 1 from previous treatments\n* Significant comorbidities or medical history","75 Years",{"count":361,"type":23},736,[26],"Brief Summary: This randomized controlled trial aims to evaluate whether active remote symptom monitoring and management via a smartphone app utilizing electronic patient-reported outcomes (ePRO) can improve adherence to prescribed outpatient pulmonary rehabilitation exercises among postsurgical lung cancer patients. Eligible patients will use the app for perioperative care and be randomized to an intervention group receiving ePRO-based symptom monitoring with clinician feedback or a control group receiving ePRO without feedback. The primary outcome is rehabilitation exercise adherence rate over 1 month after discharge. If proven effective, the app-enabled remote rehabilitation model can be scaled up to enhance recovery for more postoperative patients.\n\nDue to slower-than-expected recruitment, an interim analysis was introduced through a protocol amendment. The amendment was approved by the Ethics Committee before conducting the analysis, and the plan was incorporated into the updated study record. The interim review evaluated feasibility and informed the addition of mean weekly exercise duration as a co-primary endpoint with adjusted statistical thresholds.",[365,366,367,368,32],"Lung Neoplasms, Non-Small Cell Lung Cancer","Postoperative Complications","Patient Reported Outcome Measures","Telerehabilitation",[370,371,372,373,374],"Exercise Adherence","ePRO","Remote Monitoring","Postoperative Rehabilitation","Symptom Management","2025-11-27",{"date":266,"type":43},{"date":378,"type":43},"2023-06-01",{"date":42,"type":23},{"name":381,"class":50},"Zhongshan People's Hospital, Guangdong, China",{"id":383,"slug":384,"hasResults":12,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":4,"eligibilityCriteria":388,"healthyVolunteers":12,"sex":60,"minAge":389,"maxAge":19,"enrollmentInfo":390,"targetDuration":4,"studyType":24,"phases":392,"briefSummary":393,"conditions":394,"keywords":398,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":51},"100585864","schroth-and-scapular-muscle-activation-in-hyperkyphosis-100585864","NCT06907914","Schroth and Scapular Muscle Activation in Hyperkyphosis","The Effect of Schroth Exercises on Scapular Muscle Activation in Children With Thoracic Hyperkyphosis","Inclusion Criteria:\n\n* Thoracic kyphosis angle (Cobb) between ≥40° and \\\u003C70° on lateral radiographs\n* Aged 7-18 years\n* Risser stage 0-5, indicating ongoing skeletal development\n\nExclusion Criteria:\n\n* Congenital or rigid spinal deformities\u002Fanomalies\n* Major musculoskeletal surgery or trauma, especially involving the spine\n* Physiotherapeutic intervention for the spine in the last 6 months\n* Current brace use\n* BMI ≥ 30\n* Regular upper extremity sports involvement (e.g., swimming, volleyball) at least twice a week for one year\n* More than 60 minutes of moderate-to-high intensity physical activity per week\n* Visual impairments or light sensitivity\n* Positive vestibular (Unterberger) test\n* Hearing impairments\n* Cognitive difficulties affecting comprehension\n* Systemic diseases (diabetes, hypothyroidism, infection, malignancy)\n* Neurological disorders\n* Active rheumatic diseases","7 Years",{"count":391,"type":23},56,[26],"This randomized controlled trial aims to investigate the effects of Schroth exercises on scapular muscle activation in children with thoracic hyperkyphosis. A total of 56 participants will be randomly assigned to either the Schroth exercise group or the control group receiving postural education. The intervention group will complete an 8-week supervised Schroth program focusing on three-dimensional correction, rotational breathing, and postural awareness. Primary outcome is scapular muscle activation measured by surface EMG. Secondary outcomes include muscle strength, scapular endurance, kyphotic appearance, posture, and pain. The results will guide clinical management and preventive strategies for children with postural thoracic hyperkyphosis.",[395,396,397,32],"Hyperkyphosis, Adolescent","Muscle Activation","Scapula; Deformity, Acquired",[399,400,401,402,403,404],"Spine","Schroth","sEMG","Physiotehrapy","Scapula","Thoracic Hyperkyphosis","2025-09-25",{"date":407,"type":43},"2025-10-01",{"date":409,"type":43},"2025-06-15",{"date":411,"type":23},"2026-08-01",{"name":413,"class":50},"Istanbul University - Cerrahpasa",{"id":415,"slug":416,"hasResults":12,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":420,"eligibilityCriteria":421,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":20,"enrollmentInfo":422,"targetDuration":4,"studyType":24,"phases":424,"briefSummary":425,"conditions":426,"keywords":429,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":442,"locationsCount":51},"100606228","virtual-reality-based-rehabilitation-in-chronic-low-back-pain-effects-on-muscle-architecture-balance-and-satisfaction-vr-lbprehab-100606228","NCT07172828","Virtual Reality-Based Rehabilitation in Chronic Low Back Pain: Effects on Muscle Architecture, Balance, and Satisfaction (VR-LBPREHAB)","Investigation of the Effects of Virtual Reality-Based Rehabilitation on Muscle Architecture, Balance Control, and Patient Satisfaction in Individuals With Chronic Low Back Pain","VR-LBPREHAB","Inclusion Criteria:\n\n* Age 18-65 years.\n* Chronic low back pain persisting for ≥ 3 months.\n* Literacy and Montreal Cognitive Assessment (MoCA) score \\> 21.\n* Voluntary participation with signed informed consent.\n\nExclusion Criteria:\n\n* Malignancy.\n* Pregnancy.\n* History of epilepsy (including photosensitive seizures), dementia, migraine, or other neurological disorders limiting VR use.\n* Surgery within the past 6 months.\n* Received physiotherapy or rehabilitation services in the past 6 months.\n* Presence of acute infection.\n* Unhealed fracture.\n* Withdrawal of informed consent at any stage of the study.",{"count":423,"type":23},48,[26],"Chronic low back pain is a common musculoskeletal disorder that causes pain, disability, and reduced quality of life. It is often related to changes in trunk muscle function, thoracolumbar fascia morphology, and impaired balance control. Although conventional motor control exercises are effective, patient motivation and adherence can be limited. Virtual reality (VR)-based rehabilitation offers interactive and engaging environments that may improve compliance and provide additional therapeutic benefits.\n\nThis study is a randomized controlled trial designed to investigate the effects of VR-based rehabilitation compared with conventional motor control exercises in individuals with chronic low back pain. A total of 40-50 participants aged 18-65 will be recruited and randomly assigned to one of two groups: (1) VR-based rehabilitation or (2) conventional exercise therapy. Both programs will last 8 weeks, delivered three times per week for 40 minutes per session.\n\nThe primary outcomes include muscle architecture assessed by ultrasound imaging, thoracolumbar fascia morphology, and postural balance control measured by force platform tests. Secondary outcomes include pain intensity, disability, fear-avoidance beliefs, quality of life, and patient satisfaction.\n\nThe findings of this study are expected to provide new insights into the role of VR in rehabilitation and contribute to evidence-based strategies for managing chronic low back pain. By exploring the effects on both physical and patient-reported outcomes, the study may highlight innovative approaches to improve adherence, reduce pain, and enhance daily function in affected individuals.",[427,428,147,32],"Chronic Low Back Pain (CLBP)","Musculoskeletal Pain",[430,431,432,433,434,32],"Low Back Pain","Virtual Reality Rehabilitation","Muscle Architecture","Thoracolumbar Fascia","Balance Control","2025-09-08",{"date":437,"type":43},"2025-09-15",{"date":439,"type":23},"2025-10-13",{"date":441,"type":23},"2026-12-25",{"name":443,"class":50},"Hacettepe University",{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":4,"enrollmentInfo":451,"targetDuration":4,"studyType":24,"phases":452,"briefSummary":453,"conditions":454,"keywords":457,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":464,"startDateStruct":466,"completionDateStruct":468,"leadSponsor":470,"locationsCount":51},"100576560","paraffin-wax-and-exercise-prospective-100576560","NCT06786884","Paraffin Wax and Exercise Prospective","A Pilot, Randomized Controlled Trial Evaluating the Effectiveness of Paraffin Wax On Burn Patient Function, Range of Motion and Scar","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients with burn scar that crosses an upper or lower extremity joint (shoulder, elbow, wrist, hand, hip, knee, ankle)\n* Patients that have been prescribed a rehabilitation program where paraffin wax could be used as an adjunct to rehab exercise therapy\n\nExclusion Criteria:\n\n* Adults unable to provide informed consent\n* Injury etiology other than burn (ex: cutaneous trauma, cold injury, etc.)\n* Pregnant women\n* Prisoners",{"count":280,"type":23},[26],"This study is being done to test if paraffin wax can be used to improve the range of motion and function for scars across joints when used in combination with scar rehabilitation therapy sessions. For those randomized to receive it, the paraffin wax will be used alongside the participants' exercise therapy treatments. Currently, treatments that are used in addition to rehabilitation therapy for increasing range of motion across joints in the burn population are limited. By getting more information about how paraffin wax may or may not work, patients in the future that have scars may be able to be helped.",[455,456,32],"Burn","Scar",[458,459,460,461,462],"paraffin wax","burn scar","scar","burn","range of motion","2025-06-10",{"date":465,"type":43},"2025-06-13",{"date":467,"type":43},"2025-01-06",{"date":469,"type":23},"2027-02",{"name":471,"class":50},"Medstar Health Research Institute",{"id":473,"slug":474,"hasResults":12,"nctId":475,"briefTitle":476,"officialTitle":477,"acronym":478,"eligibilityCriteria":479,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":20,"enrollmentInfo":480,"targetDuration":4,"studyType":24,"phases":482,"briefSummary":483,"conditions":484,"keywords":489,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":501,"locationsCount":51},"100592090","energy2mob-study-obesity-management-in-bergued-100592090","NCT06988904","ENERGY2MOB STUDY: OBESITY MANAGEMENT IN BERGUEDÀ","EFFECTIVENESS OF THE GROUP-BASED NUTRITION EDUCATION PROGRAMME FOR OBESITY MANAGEMENT IN BERGUEDÀ: A RANDOMISED CLINICAL TRIAL. ENERGY2MOB STUDY","ENERGY2MOB","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Overweight (BMI 27-30 kg\u002Fm²) or obesity (BMI 30-40 kg\u002Fm²)\n* Availability to attend at least 80% (6 out of 8) of the group sessions\n\nExclusion Criteria:\n\n* Significant language barriers (unable to communicate in Catalan or Spanish)\n* Previous bariatric surgery\n* Moderate to severe cognitive impairment\n* Severe psychiatric disorders preventing participation in group sessions",{"count":481,"type":23},136,[26],"Background: Obesity is a prevalent multifactorial disease worldwide and has become a significant public health concern. The latest data from the 2022 Catalonia Health Survey show that 56.2% of men and 43.7% of women are overweight or obese, and 39% of children aged 6 to 12 years have excess weight. Excess adiposity poses a health risk as it is associated with various chronic diseases such as type 2 diabetes mellitus, hypertension, and dyslipidaemia, all of which affect quality of life and increase mortality risk.\n\nHypothesis: The Energy2MOB obesity management programme in Berguedà is a group-based intervention incorporating nutrition education and physical activity. It aims to reduce excess body weight and the risk of chronic diseases, including type 2 diabetes mellitus, dyslipidaemia, and hypertension, through a multicomponent approach that enhances dietary habits, physical activity, and emotional eating regulation.\n\nObjectives\n\n* Assess the effectiveness of the Energy2MOB programme in reducing body weight by 5-10% among adults with obesity in the Berguedà health region.\n* Measure lifestyle modifications, including dietary habits, physical activity, and emotional eating.\n\nMethodology: A randomised clinical trial with two groups (control and intervention) over one year, including individuals aged 18-65 years in the Berguedà health region with overweight grade II (BMI 27-30 kg\u002Fm²) or obesity (BMI 30-40 kg\u002Fm²). Exclusion criteria include significant language barriers, previous bariatric surgery, moderate to severe cognitive impairment, and severe psychiatric disorders preventing participation in sessions. Participants must attend at least 80% of the programme.\n\nMeasurements\n\n* Sociodemographic factors: sex, age, education level, marital status, employment status.\n* Lifestyle factors: alcohol and tobacco use, dietary habits, physical activity, emotional eating, health-related quality of life.\n* Anthropometric parameters: body weight, height, BMI, waist circumference.\n* Blood pressure, medication use, biochemical parameters (fasting glucose, glycated haemoglobin, lipid profile, liver and kidney function markers, C-reactive protein).\n\nStatistical Analysis: Accepting an alpha risk of 0.05 and a statistical power above 0.8 in a bilateral contrast, 68 subjects per group are required to detect a difference of at least 2.5 kg. A common standard deviation of 4.77 is assumed, with an estimated 15% dropout rate. Sample size calculations were performed using GRANMO version 8.0 (https:\u002F\u002Fwww.datarus.eu\u002Fca\u002Faplications\u002Fgranmo\u002F; consulted in November 2024).\n\nExpected Outcomes, Applicability, and Relevance: This study aims to generate scientific evidence on the effectiveness of multicomponent group-based interventions focused on improving nutrition, physical activity, and psychological well-being in obesity and chronic disease management. It seeks to create an environment that facilitates behavioural changes, leading to weight reduction and improved quality of life. The findings will also contribute to the development of a practical guide for addressing excess weight in primary healthcare settings.\n\nKeywords (maximum 6): Adult obesity, primary health care, group interventions, dietary interventions, multicomponent interventions, Mediterranean diet.",[485,486,32,487,488],"Mediterranean Diet","Overweight or Obese Adults","Cardiovascular Diseases","Psychological Well Being",[490,491,492,493],"obesity and overweight","primary health care","Mediterranean diet","dietary interventions","2025-05-22",{"date":496,"type":43},"2025-05-25",{"date":498,"type":23},"2025-06-07",{"date":500,"type":23},"2026-03-07",{"name":502,"class":50},"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina",{"id":504,"slug":505,"hasResults":12,"nctId":506,"briefTitle":507,"officialTitle":507,"acronym":508,"eligibilityCriteria":509,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":20,"enrollmentInfo":510,"targetDuration":4,"studyType":24,"phases":512,"briefSummary":513,"conditions":514,"keywords":515,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":521,"leadSponsor":523,"locationsCount":51},"100588220","personalized-physical-back-training-program-to-improve-physical-functioning-in-people-with-non-specific-low-back-pain-100588220","NCT06938568","Personalized Physical Back Training Program to Improve Physical Functioning in People With Non-specific Low Back Pain","LIFDI","Inclusion Criteria:\n\n* Access to the University Sports of the Lucerne Universities (i.e., students, employees, alumni, subscribers)\n* NSLBP for at least 6 weeks\n* Activity limiting NSLBP (at least one activity with a PSFS Score of ≤ 50\u002F100 on a scale from 0 = unable to perform due to NSLBP to 100 = able to perform at the same level as before NSLBP)\n* Age between 18 and 65 years\n* Understand the German language\n* Willing to participate in the study\n* Written informed consent\n\nExclusion Criteria:\n\n* Specific LBP\n* Red flags associated with any serious pathology or specific LBP,\n* Being on a waiting list for or less than 12 months post any surgery of the lower back\n* Pregnancy or given birth within the last 12 months\n* Diagnosed central neurological disease\n* Not allowed to exercise\n* Participant in the feasibility study\n* Expecting to be absent for more than 2 weeks during the intervention period",{"count":511,"type":23},180,[26],"Personalized medicine and individualized therapeutic approaches are prominent in current research. But are these approaches also effective for treating non-specific low back pain (NSLBP)? NSLBP is one of the most common musculoskeletal issues, which can impair physical well-being, reduce the quality of life, and limit physical functioning. Additionally, it contributes to substantial direct and indirect healthcare costs, such as frequent doctor visits and work absences. Despite NSLBP being a significant burden for both individuals and society, effective alleviation methods remain unclear. The investigators' research project therefore aims to investigate whether personalized therapy, specifically a personalized physical back training program, can effectively address NSLBP. Within the context of NSLBP, the investigators' specific aim is to improve physical functioning as this outcome is considered relevant from all perspectives, including those of patients, clinical professionals, researchers, and guidelines.",[32,430],[516,260],"Physical Functioning","2025-05-01",{"date":519,"type":43},"2025-05-04",{"date":517,"type":43},{"date":522,"type":23},"2027-12",{"name":524,"class":50},"Claudio Perret",{"id":526,"slug":527,"hasResults":12,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":4,"eligibilityCriteria":531,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":4,"enrollmentInfo":532,"targetDuration":4,"studyType":24,"phases":534,"briefSummary":536,"conditions":537,"keywords":539,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":544,"lastUpdatePostDateStruct":545,"startDateStruct":547,"completionDateStruct":548,"leadSponsor":550,"locationsCount":51},"100588441","phase-3-pah-exercise-study-100588441","NCT06941441","PAH Exercise Study","Remotely-Monitored Exercise to Enhance Functional Outcomes in Patients With Pulmonary Arterial Hypertension (PAH) Initiating Sotatercept Therapy: A Single-site Feasibility Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Documented diagnostic right heart catheterization (RHC) at any time prior to screening confirming the diagnosis of WHO PAH Group 1 in any of the following subtypes: Idiopathic PAH, Heritable PAH, Drug\u002Ftoxin-induced PAH, PAH associated with CTD, PAH associated with simple, congenital systemic-to-pulmonary shunts at least 1 year following repair\n* Symptomatic PH classified as WHO FC II or III\n* Baseline RHC performed during the Screening Period documenting a minimum PVR of ≥ 5 WU and a pulmonary capillary wedge (PCWP) or left ventricular end-diastolic pressure of ≤ 15 mmHg\n* Receiving stable background therapy for PAH for \\>90 days and will continue receiving throughout trial. Background treatments may consist of monotherapy, double therapy, or triple therapy with currently available medications for PAH.\n* Initiation of Sotatercept is clinically indicated\n* Willing and able to participate in a remotely-monitored home exercise program for 24 weeks\n* Ability to adhere to study visit schedule and understand and comply with all protocol requirements\n* Ability to understand and provide written informed consent\n\nExclusion Criteria:\n\n* Diagnosis of PH WHO Groups 2, 3, 4, or 5\n* Diagnosis of the following PAH Group 1 subtypes: human immunodeficiency virus (HIV)-associated PAH, PAH associated with portal hypertension, schistosomiasis-associated PAH and pulmonary veno-occlusive disease\n* Hemoglobin at screening above gender-specific ULN\n* Baseline platelet count \\\u003C 50,000\u002Fmm3 (\\\u003C 50.0 × 109\u002FL) at screening\n* Uncontrolled systemic hypertension as evidenced by sitting systolic BP \\> 160 mmHg or sitting diastolic BP \\> 100 mmHg during screening visit after a period of rest; Baseline systolic BP \\\u003C 90 mmHg at screening\n* Pregnant or breastfeeding females\n* Clinical laboratory liver and kidney function tests outside of normal range\n* Currently enrolled in or have completed any other investigational product study within 30 days for small-molecule drugs or within 5 half-lives for biologics prior to the date of signed informed consent\n* Prior exposure to sotatercept (ACE-011) or luspatercept (ACE-536) or known allergic reaction to either one\n* History of full pneumonectomy\n* Initiation of a structured exercise program within 90 days prior or planned initiation during the study\n* Known history of portal hypertension or chronic liver disease, including hepatitis B and\u002For hepatitis C (with evidence of recent infection and\u002For active virus replication), defined as mild to severe hepatic impairment (Child-Pugh Class A-C).\n* Cardiac related history: History of restrictive, constrictive, or congestive cardiomyopathy; History of atrial septostomy within 180 days prior to the screening visit; ECG with Fridericia's corrected QT interval (QTcF) \\> 500 ms during the Screening Period; Personal or family history of long QT syndrome (LQTS) or sudden cardiac death; Left ventricular ejection fraction (LVEF) \\\u003C 45% on historical ECHO within 12 months prior to the screening visit; Any symptomatic coronary disease events (prior myocardial infarction, percutaneous coronary intervention, coronary artery bypass graft surgery, or cardiac anginal chest pain) within 6 months prior to the screening visit. Note: Anginal pain can be ignored as an exclusion criterion if coronary angiography shows no obstructions\n* Cerebrovascular accident within 3 months prior to the screening visit\n* Acutely decompensated heart failure within 14 days prior to the screening visit, as per investigator assessment\n* Significant (≥ 2+ regurgitation) mitral regurgitation or aortic regurgitation valvular disease\n* Received intravenous inotropes (e.g., dobutamine, dopamine, norepinephrine, vasopressin) within 30 days prior to the screening visit",{"count":533,"type":23},10,[535],"PHASE3","Ten patients with PAH who are stable and eligible to initiate sotatercept therapy will participate in a 26 week study that consists of a 24-week intervention period where patients will receive complimentary sotatercept as prescribed, plus a tailored, progressive home exercise program with wrist-worn fitness tracker and oxygen saturation monitoring.",[538,32],"Pulmonary Arterial Hypertension (PAH)",[540,541,542,543],"PAH","pulmonary arterial hypertension","sotatercept","exercise","2025-04-15",{"date":546,"type":43},"2025-04-23",{"date":544,"type":43},{"date":549,"type":23},"2026-09-30",{"name":551,"class":50},"University of Washington",{"id":553,"slug":554,"hasResults":12,"nctId":555,"briefTitle":556,"officialTitle":557,"acronym":558,"eligibilityCriteria":559,"healthyVolunteers":12,"sex":60,"minAge":560,"maxAge":561,"enrollmentInfo":562,"targetDuration":4,"studyType":24,"phases":564,"briefSummary":565,"conditions":566,"keywords":575,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":588,"locationsCount":51},"100587090","controlled-evaluation-of-an-exercise-program-for-overweight-adolescents-100587090","NCT06923865","Controlled Evaluation of an Exercise Program for Overweight Adolescents","Now! Project - a Controlled Evaluation of a Physical Activity Program for Adolescents With Overweight","Now!","Inclusion Criteria:\n\n* BMI above the 90th percentile for their age and gender (WHO reference table)\n* Deficits in movement motivation and motor skills\n* No health complaints or movement-restricting conditions\n* No health risks for maximal exertion\n* Ability to verbally communicate pain or discomfort\n* Unremarkable PAR-Q questionnaire\n* Signed parental consent form\n\nExclusion Criteria:\n\n* Acute or chronic illness\n* Inability to follow the study procedures (e.g., language barriers, psychological disorders)","12 Years","14 Years",{"count":563,"type":23},150,[26],"Physical activity decreases as young people get older, especially during the shift from early to late adolescence. Unfortunately, around 81% of school-aged children worldwide between the ages of 11 and 17 do not meet the recommendation of at least one hour of physical activity per day - and this is also true in Switzerland. Not being active enough, whether normal weight or overweight, can lead to long-term health problems and is a major factor in becoming overweight over time. This results in healthcare costs and negatively affects quality of life. Supporting physical activity in overweight youth requires well-rounded, thoughtful programs.\n\nThe investigators studying the impact of the movement programs now! and now!+ on the physical activity and health of young people. The goal is to look at both physical and mental changes equally.\n\nTaking part in this study involves minimal physical or mental risk for the participants. These small risks from the testing methods and activities are taken into account in how the program is explained and carried out.\n\nThe benefits for the participants - feeling healthier and fitter physically, and more confident and capable mentally - clearly outweigh any potential risks, thanks to the additional, guided, and personalized exercise program.\n\nThe participants take part in the now! and now!+ exercise programs run by the Basel-Stadt Sports Office and the DSBG. now! is a 90-minute group session with up to 14 young people, while now!+ is a 90-minute small-group session with 2 to 4 participants. Both programs take place once a week over a 12-month period and pause during school holidays (38 training weeks in total).\n\nEach session includes a warm-up, a strength or endurance training block, and a coordination phase. The program is modular and adapted to the physical and personal needs of each participant. This ensures that overweight adolescents are not overstrained and don't develop symptoms like pain, frustration, or lack of motivation (Behringer et al., 2011), while still allowing for a training stimulus that supports physical improvement.\n\nThe results of the evaluations are directly used to improve and further develop the exercise program. The overall project includes three rounds, each consisting of one year of training and three test sessions, each lasting about two hours. The now! and now!+ programs are held weekly for a total of 38 weeks per year, with breaks during school holidays.\n\nEach of the three test sessions includes the same set of assessments (see \"Study Intervention\") and follows a set order: The process begins with measuring body size and blood pressure, followed by a static retinal vessel analysis. After these medical checks, participants do a 5-minute warm-up on a stationary bike at a set resistance level. Then, strength tests are performed: knee extension on the IsoMed 2000, handgrip strength, and jump power on the Leonardo force plate. The endurance test using spiroergometry marks the end of the physical assessments.\n\nFinally, impulse control is tested, and participants complete a set of questionnaires. At the end of the session, each participant is given an actigraph (a small motion sensor worn on the body) to track their physical activity over the following seven days.",[567,568,32,569,570,571,31,572,573,574],"Adolescent","Pediatric Obesity","Health Promotion","Program Evaluation","Impulse Control Disorders","Retinal Vessels","Strength Training Effects","Aerobic Capacity",[576,577,578,579,580],"Overweight adolescents","Youth physical activity","Motor performance in children","Impulse control and fitness","training in peer groups","2025-04-04",{"date":583,"type":43},"2025-04-11",{"date":585,"type":23},"2025-06-01",{"date":587,"type":23},"2029-12",{"name":589,"class":50},"University Hospital, Basel, Switzerland",{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":4,"eligibilityCriteria":596,"healthyVolunteers":250,"sex":60,"minAge":20,"maxAge":4,"enrollmentInfo":597,"targetDuration":4,"studyType":24,"phases":599,"briefSummary":600,"conditions":601,"keywords":604,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":616,"locationsCount":4},"100447544","aquatic-exercise-and-reactive-balance-100447544","NCT05107817","Aquatic Exercise and Reactive Balance","Catching and Throwing Exercises to Improve Reactive Balance: A Randomized Controlled Trial Protocol for the Comparison of Aquatic and Dry-land Training Environments","Inclusion Criteria:\n\n* Ability to stand using a double-leg stance for one minute of time\n* Ability to walk independently\n* Normal or corrected to normal vision\n* Normal or corrected to normal hearing based on a qualitative assessment\n\nExclusion Criteria:\n\n* Any neurological or musculoskeletal disorders that may inhibit the participation in the training and testing protocols\n* A concussion within the past one year before the participation\n* Any cognitive deficiencies (e.g., memory, concentration, or attention disorder)\n* One or more 'yes' answered on the Physical Activity Readiness Questionnaire (PAR-Q)\n* Fear of water",{"count":598,"type":23},44,[26],"The present clinical trial aims to identify if skills acquired during aquatic exercise are more effectively transferred to a reactive balance task than land exercise. This study is designed as a double-blinded, randomized controlled clinical trial. Forty-four older adults aged 60 years or above who meet the eligibility criteria will be recruited and randomized into an aquatic exercise group or land exercise group. Each group will participate in the same balance training exercise during a single session that includes a ball throwing and catching task. A modified lean-and-release test will be implemented on land immediately before, after, and one week after the training session. The outcomes will include reaction time, rapid response accuracy, and mini-BESTest scores obtained from stepping and grasping reactions.",[602,144,603,147,260,32],"Aging","Accidental Falls",[605,606,607,608],"Reactive balance","Aquatic exercise","Aquatic therapy","Fall prevention","2025-04-03",{"date":611,"type":43},"2025-04-08",{"date":613,"type":23},"2026-01",{"date":615,"type":23},"2027-09",{"name":617,"class":50},"Eadric Bressel",{"id":619,"slug":620,"hasResults":12,"nctId":621,"briefTitle":622,"officialTitle":623,"acronym":4,"eligibilityCriteria":624,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":138,"enrollmentInfo":625,"targetDuration":4,"studyType":24,"phases":627,"briefSummary":628,"conditions":629,"keywords":632,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":641,"lastUpdatePostDateStruct":642,"startDateStruct":644,"completionDateStruct":645,"leadSponsor":647,"locationsCount":51},"100566938","cognitive-functional-therapy-for-treating-individuals-with-chronic-shoulder-pain-100566938","NCT06661681","Cognitive Functional Therapy for Treating Individuals With Chronic Shoulder Pain","Cognitive Functional Therapy Versus Therapeutic Exercises for the Treatment of Individuals With Chronic Shoulder Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Men or women;\n* Age between 18 and 60 years;\n* Presence of shoulder pain for more than 3 months;\n* Pain intensity of 4 points or more on the 11-point Numeric Pain Rating Scale.\n* High level of disability or moderate level of irritability.\n\nExclusion Criteria:\n\n* History of fracture or surgery of the clavicle, scapula, and\u002For humerus, surgical stabilization or rotator cuff repair;\n* History of dislocation, instability (positive sulcus sign or apprehension test), and\u002For rotator cuff tear (positive drop arm test);\n* Adhesive capsulitis verified by the presence of gradual onset pain associated with stiffness and reduced passive and active mobility;\n* Ongoing pregnancy;\n* Reproduction of shoulder pain radiating to the entire upper limb during cervical or thoracic spine tests (positive Spurling test);\n* Neurological or systemic diseases that may alter muscle strength and sensitivity such as rheumatoid arthritis, fibromyalgia, lupus, gout, and diabetes;\n* Corticosteroid injection in the shoulder region in the last 3 months;\n* Physiotherapy treatment in the last 6 months.\n* Active treatment for cancer",{"count":626,"type":23},72,[26],"Shoulder pain is a debilitating musculoskeletal condition with functional, physical, and psychological impacts. Interventions for chronic shoulder pain should address the biopsychosocial model, with Cognitive Functional Therapy emerging as a promising physiotherapy approach. Cognitive Functional Therapy approaches the multidimensional nature of pain, integrating physical and cognitive aspects.\n\nThe aim of this randomized controlled trial is to compare the effects of Cognitive Functional Therapy with therapeutic exercise on biological aspects of pain (pain intensity, disability, function, perception of improvement\u002Fdeterioration, and central pain processing), and psychosocial aspects of pain (sleep quality, self-efficacy, and biopsychosocial factors). The hypothesis of this study is that CFT will lead to greater improvements in these outcomes compared to therapeutic exercise.",[630,32,631],"Chronic Shoulder Pain","Psychosocial Rehabilitation",[633,634,635,636,637,638,639,640],"Shoulder pain","Subacromial pain","Rotator cuff related shoulder pain","Shoulder Impingement","Chronic pain","Psychosocial","Rehabilitation","Biopsychosocial","2025-02-17",{"date":643,"type":43},"2025-02-19",{"date":641,"type":43},{"date":646,"type":23},"2026-11-25",{"name":648,"class":50},"Federal University of Paraíba",{"id":650,"slug":651,"hasResults":12,"nctId":652,"briefTitle":653,"officialTitle":654,"acronym":4,"eligibilityCriteria":655,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":138,"enrollmentInfo":656,"targetDuration":4,"studyType":24,"phases":658,"briefSummary":659,"conditions":660,"keywords":661,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":641,"lastUpdatePostDateStruct":663,"startDateStruct":665,"completionDateStruct":666,"leadSponsor":668,"locationsCount":51},"100557788","cognitive-functional-therapy-for-chronic-shoulder-pain-pilot-and-feasibility-study-100557788","NCT06542666","Cognitive Functional Therapy for Chronic Shoulder Pain: Pilot and Feasibility Study","Cognitive Functional Therapy Versus Therapeutic Exercises for Treating Individuals With Chronic Shoulder Pain: A Pilot and Feasibility Study","Inclusion Criteria:\n\n* Men and women;\n* Age between 18 and 60 years;\n* Presence of shoulder pain for more than 3 months;\n* Pain intensity of 4 points or more on the 11-point Numeric Pain Rating Scale during the past week.\n* High level of disability or moderate level of irritability.\n\nExclusion Criteria:\n\n* History of fracture or surgery of the clavicle, scapula, and\u002For humerus, surgical stabilization or rotator cuff repair;\n* History of dislocation, instability (positive sulcus sign or apprehension test), and\u002For rotator cuff tear (positive drop arm test);\n* Adhesive capsulitis verified by the presence of gradual onset pain associated with stiffness and reduced passive and active mobility;\n* Ongoing pregnancy;\n* Reproduction of shoulder pain radiating to the entire upper limb during cervical or thoracic spine tests (positive Spurling test);\n* Neurological or systemic diseases that may alter muscle strength and sensitivity such as rheumatoid arthritis, fibromyalgia, lupus, gout, and diabetes;\n* Corticosteroid injection in the shoulder region in the last 3 months;\n* Physiotherapy treatment in the last 6 months.",{"count":657,"type":23},24,[26],"This pilot randomized controlled clinical trial (RCT) will assess the feasibility and identify the key components necessary for conducting the main RCT, which will involve the comparison of Cognitive Functional Therapy with Therapeutic Exercises in individuals with chronic shoulder pain. The main questions it aims to answer are:\n\n* What barriers to the participation of the included individuals might arise?\n* Will the assessment procedures and outcome measures be feasible and suitable?\n* What time will be necessary to conduct the assessments?\n* Will participants be willing to be randomized to the proposed treatment groups?\n* What barriers to the clinical delivery of Cognitive Functional Therapy in the healthcare system might exist?\n* Will the treatment(s) be acceptable to patients?\n* Will participants adhere to the treatment?\n* What will the recruitment rates be per week\u002Fmonth?\n* Will there be any selection bias?\n* Will participant retention be high among the allocation groups?\n* Will the data be complete?\n* What will the data variability be?\n* Will the treatment effects\u002Foutcomes be consistent with expectations and previous literature?",[630,32,631],[633,634,662,636,637,638,639,640],"Rotator cuff related pain",{"date":664,"type":43},"2025-02-18",{"date":641,"type":43},{"date":667,"type":23},"2025-09-01",{"name":648,"class":50},{"id":670,"slug":671,"hasResults":12,"nctId":672,"briefTitle":673,"officialTitle":674,"acronym":675,"eligibilityCriteria":676,"healthyVolunteers":250,"sex":60,"minAge":677,"maxAge":678,"enrollmentInfo":679,"targetDuration":4,"studyType":24,"phases":681,"briefSummary":682,"conditions":683,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":684,"lastUpdatePostDateStruct":685,"startDateStruct":687,"completionDateStruct":689,"leadSponsor":691,"locationsCount":4},"100556217","post-exercise-recovery-and-fst-100556217","NCT06522230","Post Exercise Recovery and FST","Analyzing the Perceived Impact of Fascial Stretch Therapy on the Post-exercise Recovery Process.","FST","Inclusion Criteria:\n\n* Must be an UBCO student athlete who is at least 19 years of age and currently engaged in normal athletic training\n\nExclusion Criteria:\n\n* Student athletes under 19 years of age or currently have an existing musculoskeletal injury or medical condition preventing you from engaging in normal athletic training.","19 Years","40 Years",{"count":680,"type":23},5,[26],"In this pilot study the focus is to assess the perceived impact of Fascial Stretch Therapy (FST) on post-exercise recovery in University athletes. The objective is to determine if FST can expedite recovery and enhance overall well-being by reducing muscle soreness and fatigue. The FST protocol will be implement by a certified FST level 2 practitioner. Upon completion of the FST intervention athletes will complete a self-assessment questionnaire. The study aims to provide empirical support for FST's efficacy in improving post-exercise recovery and contributing to the health and performance of university athletes.",[32],"2024-08-21",{"date":686,"type":43},"2024-08-23",{"date":688,"type":23},"2024-09-01",{"date":690,"type":23},"2025-06-30",{"name":692,"class":50},"University of British Columbia",{"id":694,"slug":695,"hasResults":12,"nctId":696,"briefTitle":697,"officialTitle":697,"acronym":698,"eligibilityCriteria":699,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":20,"enrollmentInfo":700,"targetDuration":4,"studyType":24,"phases":702,"briefSummary":703,"conditions":704,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":706,"lastUpdatePostDateStruct":707,"startDateStruct":709,"completionDateStruct":711,"leadSponsor":713,"locationsCount":241},"100553825","technology-supported-high-intensity-training-in-chronic-low-back-pain-the-techno-hit-trial-100553825","NCT06491121","Technology Supported High Intensity Training in Chronic Low Back Pain: the Techno-HIT Trial","TECHNO-HIT","Inclusion Criteria:\n\n* speak Dutch\n* be 18 to 65 years old\n* have nonspecific CLBP defined as chronic primary musculoskeletal pain (ICD-11: MG30.011) in the low back persisting for at least 12 weeks12, whereby fluctuations in pain can be present and pain can be alternated by remission phases. Furthermore, regarding the specification of 'severity', only participants with a profile consisting of a score of \\>20% on the Modified Oswestry disability Index (i.e. 'moderate disability') will be included.\n* have and make use of a working iOS\u002FAndroid smartphone\n\nExclusion Criteria:\n\n* when they have had spinal fusion surgery\n* when they have a musculoskeletal and\u002For chronic disorder aside from CLBP that could affect the correct execution of the therapy program or evaluation of the outcomes\n* when they have severe comorbidities (e.g., paresis or sensory disturbances by neurological causes, diabetes mellitus, rheumatoid arthritis)\n* when they are pregnant\n* when they have ongoing compensation claims\n* when they are not able to attend regular therapy appointments",{"count":701,"type":23},168,[26],"Chronic low back pain (CLBP) is one of the most common chronic musculoskeletal disorder worldwide and is responsible for the highest levels of disability of all diseases. All state-of-the-art guidelines recommend implementing exercise therapy (ET) in CLBP management. Researchers have shown that a novel ET modality, namely high intensity training (HIT), can be valuable. A clinical evaluation study in a larger spectrum of persons with CLBP in a rehabilitation centre setting is essential. Thereby, technology might support HIT.\n\nThe primary goal of this clinical trial is to evaluate the short- and long-term effectiveness of a time contingent individualized High intensity training (HIT) protocol on disability compared to moderate intensity training (MIT) in persons with severely disabling chronic low back pain (CLBP). Secondary goals entail 1) evaluating short- and long-term effectiveness of HIT on psychosocial correlates, central pain processing, and broad physical fitness, 2) investigating additional effects of (prolonged) HIT at home, 3) investigating added value of technology through a mobile (smartphone) and dashboard (computer) application that offers support during home training, 4) evaluating cost-effectiveness of (technology supported) HIT compared to MIT. The main research question\\[s\\] (RQ) it aims to answer are:\n\n* RQ1: To what extent is HIT effective on the short- and long term to improve disability in persons with severely disabling CLBP compared to MIT as used in usual care?\n* RQ2a: To what extent does HIT have a short- and\u002For long-term effect on central pain processing and psychosocial correlates in persons with severely disabling CLBP?\n* RQ2b:To what extent does HIT have a short- and\u002For long-term effect on outcomes related to broad physical fitness in persons with severely disabling CLBP?\n* RQ3a: To what extent does prolonged (technology-supported) HIT at home provide additional training effects in persons with severely disabling CLBP?\n* RQ3b:To what extent does a mobile application that offers support for HIT at home provide added value for treatment outcomes of persons with severely disabling CLBP?\n* RQ3c:To what extent is the techno-HIT application usable and qualitative (assessed by SUS and uMARS) as a therapeutic support mechanism, as evaluated by persons with severely disabling CLBP?\n* RQ4: To what extent is HIT or HIT supported by a mobile application cost effective compared to MIT for patients with severely disabling CLBP?",[705,32,368],"Chronic Low-back Pain","2024-07-03",{"date":708,"type":43},"2024-07-08",{"date":710,"type":43},"2024-05-27",{"date":712,"type":23},"2029-03",{"name":714,"class":50},"Hasselt University",{"id":716,"slug":717,"hasResults":12,"nctId":718,"briefTitle":719,"officialTitle":720,"acronym":721,"eligibilityCriteria":722,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":359,"enrollmentInfo":723,"targetDuration":4,"studyType":24,"phases":725,"briefSummary":726,"conditions":727,"keywords":729,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":732,"lastUpdatePostDateStruct":733,"startDateStruct":735,"completionDateStruct":737,"leadSponsor":739,"locationsCount":51},"100543713","effect-of-high-intensity-exercise-rehabilitation-on-liver-function-and-insulin-sensitivity-in-patients-with-masld-100543713","NCT06359444","Effect of High Intensity Exercise Rehabilitation on Liver Function and Insulin Sensitivity in Patients With MASLD","Effect of High Intensity Exercise Rehabilitation on Hepatic Fatty Acids (Liver Function), Insulin Sensitivity and Cardiovascular Risk in Patients With MASLD","CENSORIAL","Inclusion Criteria:\n\n* Diagnosed with MASLD by ultrasound, CAP and\u002For biopsy\n* Age between 18 and 75 years old\n* No significant liver fibrosis (Fibroscan \\\u003C 7.5 kPa; if it is between \\>7.5 and \\\u003C10, there must be absence of liver fibrosis in the biopsy)\n\nExclusion Criteria:\n\n* Presence of other liver diseases that may contribute to the clinical presentation in the patient\n* Severe cardiovascular, orthopedic, physical or other illnesses that make it impossible to participate in the study's exercise rehabilitation program or where safety cannot be guaranteed\n* Pregnancy\n* Pharmacological treatment that directly affects MASLD (e.g. GLP-1 analogues)\n* A change in medication in the last three months before the study that affects metabolic disease stability",{"count":724,"type":23},92,[26],"Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide, and is associated with obesity and the metabolic syndrome. Physical activity and lifestyle interventions are among the most recommended treatments for individuals with MASLD.\n\nIn this RCT, we will evaluate the effect of combined exercise training \"strength and aerobic training\" versus \"strength and high intensity training (HIIT)\". The main outcome parameter is the severity of liver steatosis. Patients will be recruited at the fatty liver clinic of the UZ Gent.",[32,728],"Metabolic Dysfunction-associated Steatotic Liver Disease",[543,730,731],"MASLD","liver diseases","2024-06-06",{"date":734,"type":43},"2024-06-07",{"date":736,"type":43},"2024-04-26",{"date":738,"type":23},"2026-03-15",{"name":740,"class":50},"University Ghent"]