[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exercise-training\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exercise-training":32},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,34,0,25,[9,52,96,123,152,185,225,254,270,298,323,360,384,416,439,469,503,523,553,590,617,642,669,700,730],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100627161","effects-of-mobilization-using-a-powered-lower-limb-exoskeleton-with-prolonged-mechanical-ventilation-100627161",false,"NCT07445035","Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation","Physiological and Functional Adaptations Associated With Robot-assisted Lower-limb Activity in Ventilator-dependent Hospitalized Patients","Inclusion Criteria:\n\n* Able to maintain a seated position for at least 1 minute.\n* The participant or their legal representative is able to sign the informed consent form.\n\nExclusion Criteria:\n\n* Inability to follow instructions.\n* Intubation\u002Ftracheostomy prior to current admission.\n* Diagnosis of severe left heart failure.\n* Diagnosis of neuromuscular disorders.\n* Unable to stand.\n* Complete paralysis of the lower extremities.\n* Presence of unhealed ulcers in the lower extremities.\n* Deep vein thrombosis of the lower extremities.\n* Lower-limb amputation.\n* Severe hypertension\n* Severe cardiac conditions\n* Severe bilateral joint disorders\n* Severe pain while standing\n* Severe osteoporosis\n* Lower-limb fracture\n* Ongoing epileptic seizure","ALL","45 Years","65 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged mechanical ventilation admitted to a Respiratory Care Center. The goal is to provide clinical evidence for integrating rehabilitation and respiratory care in this patient population.",[28,29,30,31,32],"Prolonged Mechanical Ventilation","Ventilator Weaning","Ventilator Dependent","Exoskeleton Device","Exercise Training",[34,35,36,37,38],"prolonged mechanical ventilation","ventilator weaning","lower limb muscle strengthening","exoskeleton robot","exercise training","RECRUITING","2026-06-29",{"date":42,"type":43},"2026-07-01","ACTUAL",{"date":45,"type":43},"2026-06-26",{"date":47,"type":22},"2026-12-31",{"name":49,"class":50},"Fu Jen Catholic University","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":78,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":95},"100644951","the-impact-of-enhanced-music--natural-visuals-on-emotional-health-100644951","NCT07676110","The Impact of Enhanced Music & Natural Visuals on Emotional Health","Impacts of Music, Audio Enhancements, Audio Guidance, and Visuals on Physical and Emotional Well-being. (Emotional Health - Longitudinal 1 Randomized, Controlled Multi-center Study)","Inclusion Criteria:\n\n* You are 13 years of age or older\n* You can read, write, and speak English at a 5th-grade level or higher\n* You are legally capable of providing informed consent (adult participants) or capable of providing assent (child participants)\n* To the best of your knowledge, you are willing and able to commit to the session(s) and activities of this study\n* You are willing and able to use the sound-delivery and data-collection apparatus of this study\n* You are willing to use your own personal equipment. Depending on the study, you may need to have your own ear buds\u002Fheadphones and\u002For a \"smart\" device with internet and\u002For Bluetooth access (e.g., smartphone, iPad).\n* You have normal hearing in both ears.\n* You never experience ringing noises or buzzing sensations in your ears (tinnitus)\n* You do not use a heart\u002Fcardiac pacemaker and do not have any history of cardiac rhythm disturbances, such as cardiac conduction delays or blocks\n* You have no known history of fainting, fainting, spells or seizures, spinning sensations, or trouble with balance (medical terms include epilepsy, seizures, syncope, vertigo, nystagmus)\n* You do not use of any of the following medications: Beta blockers, steroids, ephedrine, acute anti-anxiety medication (e.g., benzodiazepines such as diazepam\u002FValium, lorazepam\u002FAtivan or clonazepam\u002FKlonopin), or acute or chronic pain medications (including narcotics and codeine)\n* For any study session, you will not be under the influence of any substances that could prevent safe participation and will not have consumed e.g., alcohol, THC, Psilocybin, or other mood-altering drugs in the 12 hours preceding the session.\n\nExclusion Criteria:\n\n\\-",true,"13 Years",{"count":62,"type":22},200,[25],"The investigators are conducting research on factors related to the self-regulation of mood and arousal states across a range of everyday activities as well as different levels of stress. Behavioral interventions-such as meditation, listening to music, or visualizing art or nature-offer important alternatives and\u002For adjunctive strategies to pharmaceutical tools or other mechanisms supporting physical and emotional well-being. This research will expand on the knowledge base regarding the impact of biophysical stimulation and\u002For frame of mind on an individual's self-directed management of physical and emotional health. Motivation, confidence, and composure are critical aspects of self-efficacy, framing a person's mindset to make healthy choices across daily activities.\n\nThe research in this protocol is carried out across multiple sites and studies by means of digital tools and a consistent participant experience workflow. Together, these resources are intended to support individuals across multiple self-directed experiences utilized in the maintenance of their basic health. Before, during, and after session experiences, the participant provides objective (physiological) responses and\u002For subjective (self-report) responses and reflections; some studies also include interviews or focus groups. The combined set of responses can be summarized, connected to other measures, and input to machine learning models to improve personalization of stimuli. By studying the effects of soundBrilliance experiences across a variety of contexts and participant samples, the investigators can better refine each element of the stimulus to improve satisfaction, tolerance, and targeted outcomes.",[66,67,68,69,70,32,71,72,73,74,75,76,77],"Emotion Management Skills","Lifestyle, Healthy","Lifestyle Intervention","Recovery","Exercise and Recovery","Anxiety and Mood Disorders","Sleep","Motivation","Comfort","Pain Management","Rehabilitation","Creativity and Mindfulness",[79,80,81,82,83,84],"Music","Visuals","Visual Imagery","Biophysical Stimuli","Emotional Health","Emotional Management","2026-06-23",{"date":87,"type":43},"2026-06-30",{"date":89,"type":43},"2026-05-25",{"date":91,"type":22},"2027-06",{"name":93,"class":94},"soundBrilliance LLC","INDUSTRY",3,{"id":97,"slug":98,"hasResults":12,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":12,"sex":17,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":23,"phases":107,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":51},"100642769","acute-effects-of-visual-feedback-assisted-inspiratory-muscle-training-after-lobectomy-100642769","NCT07646288","Acute Effects of Visual Feedback-Assisted Inspiratory Muscle Training After Lobectomy","Evaluation of the Acute Effects of Respiratory Muscle Strength Training With Visual Feedback in Lung Cancer Patients Undergoing Lobectomy","Inclusion Criteria:\n\n* Volunteering to participate in the study,\n* Being clinically stable,\n* Being a lung cancer patient scheduled for lobectomy,\n* Being between 18 and 75 years of age,\n* Being able to cooperate with the tests to be performed.\n\nExclusion Criteria:\n\n* Presence of any orthopedic or neurological problem that prevents walking,\n* History of any surgery involving the thoracic wall,\n* Having diseases that may affect respiratory parameters, such as severe heart failure or severe chronic obstructive pulmonary disease (COPD).","18 Years","75 Years",{"count":106,"type":22},40,[25],"This study aims to evaluate the acute effects of inspiratory muscle training performed with and without a mobile application providing visual feedback on exercise motivation, patient adherence, dyspnea perception, usability, and patient satisfaction in lung cancer patients undergoing lobectomy via video-assisted thoracic surgery. Participants will perform conventional inspiratory muscle training without visual feedback in the morning on postoperative day 1 after transfer to the ward. After at least two hours of rest, the same exercise protocol will be repeated with a smart adaptor connected to a mobile application to provide visual feedback. Inspiratory muscle training will be performed using a threshold-loading device at 40% of maximal inspiratory pressure, with three sets of ten breaths. Outcomes will be assessed before and\u002For after each session as appropriate.",[110,111,32,112,113],"VATS","Respiratory Muscles","Lung Cancer (NSCLC)","Lobectomy","2026-06-11",{"date":116,"type":43},"2026-06-15",{"date":118,"type":43},"2025-12-01",{"date":120,"type":22},"2027-03-01",{"name":122,"class":50},"Hacettepe University",{"id":124,"slug":125,"hasResults":12,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":12,"sex":17,"minAge":103,"maxAge":104,"enrollmentInfo":130,"targetDuration":4,"studyType":23,"phases":132,"briefSummary":133,"conditions":134,"keywords":138,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":51},"100613469","exercise-and-the-immune-response-in-lung-cancer-100613469","NCT07267000","EXERCISE AND THE IMMUNE RESPONSE IN LUNG CANCER","ImmuEX","Inclusion Criteria:\n\n* Patients suffering from non-small cell or small-cell lung cancer of any histologic subtype, irrespective of routine treatment regimen\n* ECOG 0 or 1\n\nExclusion Criteria:\n\n* Kachexia (BMI\\\u003C18.5)\n* instable bone metastases\n* orthopedic condition rendering the patient unable to ride a stationary bike\n* any medical contraindication for exercise and training\n* a living will against basic or advanced life support",{"count":131,"type":22},50,[25],"This project is about the effect of a 12-week training therapy intervention in patients suffering from non-small cell and small-cell lung cancer. It has widely been accepted that exercise is preventive against certain types of cancer. Individuals following an active lifestyle have a significantly lower risk for several chronic diseases, including cancer, as compared to sedentary ones. However, evidence is still lacking for exercise as part of routine cancer treatment. It has widely been accepted that exercise strongly impacts immune response, and might influence antitumor immune response as well. In this study, patients suffering from lung cancer undergo either a 12-week training program consisting of moderate-intensity continuous exercise (MICE), or a 12-week program with high-intensity interval exercise. Both groups will be compared to a control group receiving standard exercise recommendations. The immunologic response, i.e. cytokine profiles and changes in peripheral blood mononuclear cell (PBMC) characteristics will be the main endpoint. Blood will be taken from the patients at different timepoints, and blood samples will be tested for these immunologic changes. FACS analysis will be used to assess the properties of immune cells and potential changes upon the exercise regimen. Mitochondrial function will be assessed via the Seahorse machine, and mass spectrometry (lipidomics) will be used for the analysis of lipid profile changes.",[135,32,136,137],"Non-Small Cell Lung Cancer","Immunotherapy","Small Cell Cancer Of The Lung",[139,140,136,141,142],"Non-small cell lung cancer","Exercise","Outcome","Small-cell lung cancer","2026-06-08",{"date":145,"type":43},"2026-06-09",{"date":147,"type":43},"2026-04-01",{"date":149,"type":22},"2029-05-01",{"name":151,"class":50},"Medical University of Graz",{"id":153,"slug":154,"hasResults":12,"nctId":155,"briefTitle":156,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":59,"sex":159,"minAge":160,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":23,"phases":162,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":51},"100639209","effects-of-estrogen-on-muscle-gain-during-12-weeks-of-exercise-in-post-menopausal-women-100639209","NCT07617454","Effects of Estrogen on Muscle Gain During 12-weeks of Exercise in Post-menopausal Women","HER-MUSCLE","Inclusion Criteria:\n\n* 1-10 years since last menstrual bleeding\n* Age \\> 40 years old\n* BMI 20-30\n\nExclusion Criteria:\n\n* Follicular stimulating hormone \\\u003C 30 mmol\u002FL\n* Systematic strength training during the last year (\\> 1 strength training session per week)\n* Injuries to the legs which may prevent participation in the physical training program\n* Magnetizable metals or electrical devices implanted in the body, such as a pacemaker\n* Use of medication that can influence the effect of immobilization and\u002For training\n* Muscular or joint disorders which may affect the results\n* Metabolic diseases (such as diabetes and cardiovascular diseases)\n* Previous or present liver or cancer disease\n* Current or previous thrombosis\n* Porphyria\n* Epilepsia\n* Systemic autoimmune disease\n* Edema\n* Smoking or use of other nicotine containing products\n* Claustrophobia\n* Addictive behavior, defined as abuse of cannabis, opioids, or other intoxicating substances.\n* Lack of ability to cooperate\n* Blood parameters out of normal range at the health check\n* Blood pressure above 140\u002F90 mmHg","FEMALE","40 Years",{"count":21,"type":22},[25],"As females age and transition through menopause, the decline in oestrogen level profoundly affects skeletal muscle mass and function. HER-MUSCLE aims to unravel the mechanisms by which oestrogen enhances muscle growth, providing insights for targeted therapies to improve the health and physical function of postmenopausal females.\n\nFocusing on postmenopausal females, an increasingly at-risk demographic, HER-MUSCLE addresses a critical gap in understanding how oestrogen influences muscle mass and function during anabolic (exercise) conditions.\n\nThe project involves:\n\n1. Clinical Trial: Postmenopausal females will receive either oestrogen or placebo, twelve weeks of exercise training to detect oestrogen regulatory role on muscle mass and function.\n2. Molecular Analysis: Advanced techniques will study the muscle microenvironment, focusing on muscle stem cells (MuSCs), fibro-adipogenic progenitors (FAPs), and other cells critical for muscle regeneration and maintenance.\n3. Mitochondrial Function assessed in vivo via magnetic resonance spectroscopy: The impact of oestrogen on mitochondrial health will be examined, exploring how it preserves mitochondrial function and ability to recovery and resist fatigue in response to muscle contractions.\n\nOur preliminary data indicate that oestrogen can promote muscle protein synthesis. HER-MUSCLE aims to pave the way for novel therapeutic strategies to manage sarcopenia in postmenopausal women, ultimately leading to better health outcomes and enhanced well-being for this growing population segment.",[165,32],"Menopause Related Conditions",[167,168,169,170,171,172,173,174,175],"Physical exercise","Strength training","Cardiovascular training","Muscle hypertrophy","Estrogen","Mitochondria function","Muscle strength","Menopause","Muscle mass","2026-05-23",{"date":178,"type":43},"2026-06-01",{"date":180,"type":43},"2026-02-01",{"date":182,"type":22},"2027-08-01",{"name":184,"class":50},"Mette Hansen",{"id":186,"slug":187,"hasResults":12,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":12,"sex":17,"minAge":103,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":196,"conditions":197,"keywords":211,"overallStatus":214,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":224},"100640479","reaction-vad-trial-remote-exercise-training-via-telemedicine-in-patients-with-long-term-ventricular-assist-devices-100640479","NCT07611188","REACTION-VAD Trial: Remote Exercise Training Via Telemedicine in Patients With Long-Term Ventricular Assist Devices","Efficacy and Safety of a Remote Conditioning Program in Patients Supported With a Ventricular Assist Device: THE RE-ACTION-VAD TRIAL.","REACTION-VAD","Inclusion Criteria (must meet all):\n\n* Recent LVAD Implantation (\\\u003C6 months)\n* Clinical stability (defined as meeting all of the following criteria): discharge from the LVAD implantation hospitalization, absence of inotropic medication, hemoglobin \\>9 g\u002FdL, and no active infection.\n* Inability to participate in a supervised rehabilitation program (due to lack of availability, or inability because geographical reasons).\n\nExclusion Criteria (any):\n\n* Functional Inability to Perform Cardiopulmonary Exercise Testing\n* Prior Participation in a Supervised Rehabilitation Program (after the LVAD implantation)",{"count":194,"type":22},78,[25],"Current international guidelines recommend that patients with a heart pump (left ventricular assist device, LVAD) participate in supervised exercise cardiac rehabilitation programs. However, not all patients with a heart pump are able to attend to a supervised program on a daily basis.\n\nThe goal of this clinical trial is to determine whether a home-based exercise program helps patients with a heart pump improve their exercise capacity and quality of life, guided by telemedicine tools including a mobile app, smartwatch, and remote medical checkups. The study will also provide information about the safety of this program by monitoring for any issues or symptoms during home activity.\n\nThe trial aims to answer the following questions:\n\n* Does a 12-week remote exercise program improve patients' exercise capacity? This will be measured using the 6-minute walk test and a cardiopulmonary exercise test.\n* Is it safe for patients to follow this exercise plan at home while being monitored through a mobile app and smartwatch?\n* Does the program improve quality of life and reduce feelings of anxiety or depression? This will be assessed using widely validated questionnaires, such as the Kansas City Cardiomyopathy Questionnaire.\n\nResearchers will compare the remote exercise program to standard care, which usually does not include exercise for patients who are unable to attend the hospital daily.\n\nParticipants will:\n\n* Join the study voluntarily after signing a consent form.\n* Be randomly assigned, with a 50% chance of being in either the exercise group (following a structured plan with a mobile app) or the usual care group (receiving general written advice), to see which approach works best for recovery.\n* Follow a 12-week home-based routine if in the exercise group, including warm-up routine, walking or cycling, respiratory exercises, and light strength training, all supported by the mobile app, smartwatch, and professional monitoring.\n* Visit the hospital three times over six months for medical checkups, including walking and exercise tests, blood analyses, and questionnaires about physical and emotional health.",[198,199,200,201,202,203,204,205,32,206,207,208,209,210],"Heart Failure","Advanced Heart Failure","Left Ventricular Assist Device","LVAD","Cardiac Rehabilitation","Telemedicine","Remote Exercise","Ventricular Assist Device","Conditioning Therapy","Cardiopulmonary Exercise Test","Six Minute Walk Test","Quality of Life","Telerehabilitation",[200,199,198,202,212,203,213,209,207,210],"Remote rehabilitation","6 minute walking test","NOT_YET_RECRUITING","2026-05-20",{"date":217,"type":43},"2026-05-28",{"date":219,"type":22},"2026-05",{"date":221,"type":22},"2030-12",{"name":223,"class":50},"Puerta de Hierro University Hospital",10,{"id":226,"slug":227,"hasResults":12,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":231,"eligibilityCriteria":232,"healthyVolunteers":12,"sex":17,"minAge":160,"maxAge":4,"enrollmentInfo":233,"targetDuration":4,"studyType":23,"phases":235,"briefSummary":236,"conditions":237,"keywords":241,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":51},"100640872","right-ventricular-response-to-exercise-among-patients-with-chronic-obstructive-pulmonary-disease-100640872","NCT07576894","Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease","Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease","ReV UP COPD","Inclusion Criteria:\n\n* COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \\[FEV1\u002FFVC\\] \\\u003C0.7)\n* Age \\>= 40 years\n\nExclusion Criteria:\n\n* Exacerbation of COPD in the 3 months prior to enrollment\n* Change in COPD therapy in the 3 weeks prior to enrollment\n* Requirement of \\>6 LPM supplemental oxygen at rest\n* Requirement of \\>10 LPM supplemental oxygen with exertion\n* Active\u002Funcontrolled cardiovascular disease (e.g. hypertension with blood pressure \\>150\u002F100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; uncontrolled arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)\n* Volume overload (jugular vascular distension or greater than trace peripheral edema)\n* World Health Organization Functional Class IV\n* Known pulmonary hypertension with mean pulmonary artery pressure \\>45 mmHg\n* Untreated severe obstructive sleep apnea and\u002For obesity hypoventilation syndrome\n* Active malignancy (other than skin)\n* Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance\u002Fgait instability, etc.)\n* Pregnancy\n* Body mass index \\\u003C18 or \\>35\n* Hematocrit \\\u003C25% or \\>55%\n* For subset undergoing right heart catheterization, chronic anticoagulation that is unable to be held for the study visit\n* For subset undergoing right heart catheterization or exercise training, forced expiratory volume in 1 second of \\\u003C20%\n* For exercise training, already engaged in routine exercise training (\\>30 minutes at \\>3 METs 3 times\u002Fweek or more)\n* For exercise training, inability to complete initial in-person exercise training sessions for approximately 35 minutes 3x\u002Fweek for 3 weeks (followed by exercise training sessions with an option for hybrid remote\u002Fin-person participation)\n* For exercise training with an option for hybrid remote exercise training, any medical conditions which threaten the safety of remote exercise training (e.g. imbalance\u002Fgait instability, etc.).",{"count":234,"type":22},60,[25],"This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.",[238,239,140,240,32],"COPD","Pulmonary Hypertension","Right Ventricular (RV) Dysfunction",[238,242,140,243,244],"Pulmonary hypertension","Pulmonary rehabilitation","Exercise training","2026-05-04",{"date":247,"type":43},"2026-05-08",{"date":249,"type":43},"2025-08-01",{"date":251,"type":22},"2030-08-01",{"name":253,"class":50},"University of Colorado, Denver",{"id":255,"slug":256,"hasResults":12,"nctId":257,"briefTitle":230,"officialTitle":230,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":12,"sex":17,"minAge":160,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":23,"phases":260,"briefSummary":261,"conditions":262,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":264,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":51},"100508144","phenotyping-resting-and-exertional-right-ventricular-dysfunction-among-patients-with-chronic-obstructive-pulmonary-disease-100508144","NCT05896579","Inclusion Criteria:\n\n* COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \\[FEV1\u002FFVC\\] \\\u003C0.7)\n* Age \\>= 40 years\n\nExclusion Criteria:\n\n* Exacerbation of COPD in the 3 months prior to enrollment\n* Change in COPD therapy in the 3 weeks prior to enrollment\n* Requirement of \\>6 LPM supplemental oxygen at rest\n* Requirement of \\>10 LPM supplemental oxygen with exertion\n* Active\u002Funcontrolled cardiovascular disease (e.g. hypertension with blood pressure \\>150\u002F100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)\n* Volume overload (jugular vascular distension or greater than trace peripheral edema)\n* World Health Organization Functional Class IV\n* Known pulmonary hypertension with mean pulmonary artery pressure \\>45 mmHg\n* Untreated severe obstructive sleep apnea or obesity hypoventilation syndrome\n* Active malignancy (other than skin)\n* Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance\u002Fgait instability, etc.)\n* Pregnancy\n* Body mass index \\\u003C18 or \\>40\n* Hematocrit \\\u003C25% or \\>55%\n* For invasive CPET, chronic anticoagulation that is unable to be held for the study visit\n* For invasive CPET, forced expiratory volume in 1 second of \\\u003C20%",{"count":234,"type":22},[25],"This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.",[238,239,263,140,32],"Right Ventricular Dysfunction",{"date":247,"type":43},{"date":266,"type":43},"2023-08-22",{"date":268,"type":22},"2030-08",{"name":253,"class":50},{"id":271,"slug":272,"hasResults":12,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":59,"sex":278,"minAge":279,"maxAge":103,"enrollmentInfo":280,"targetDuration":4,"studyType":23,"phases":281,"briefSummary":282,"conditions":283,"keywords":286,"overallStatus":214,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":4},"100634992","the-effects-of-throwers-ten-exercises-performed-with-an-external-focus-100634992","NCT07546890","The Effects of Thrower's Ten Exercises Performed With an External Focus","The Effects of Thrower's Ten Exercises Performed With an External Focus on Functional Performance, Balance, and Shooting Performance in Adolescent Basketball Players","The Effects of","Inclusion Criteria:\n\n* Adolescent male basketball players aged 10-18 years\n* With at least one year of continuous participation in basketball\n* Basketball players who participate in regular training at least two days per week\n\nExclusion Criteria:\n\n* Participants will be excluded if they have a history of upper or lower extremity surgery within the past six months\n* do not regularly attend training sessions\n* do not consent to participate","MALE","10 Years",{"count":21,"type":22},[25],"The aim of this study is to comprehensively investigate the effects of the Thrower's Ten exercise program-commonly recommended to enhance shoulder stability and strength in athletes-when applied using an external focus of attention approach (i.e., directing attention toward an object or movement outside the body), on functional performance, shoulder stability, balance, and throwing performance in adolescent basketball players.\n\nThis study has been designed to examine the effects of performing the Thrower's Ten exercises with an external focus of attention on functional performance, shoulder stability, balance, and throwing performance in adolescent basketball players. Athletes will be randomly assigned to two groups: the experimental group will perform the exercises using an external focus of attention, whereas the control group will perform the same exercises without any specific attentional focus.\n\nThe methods employed in this study are expected to effectively address the research objectives. The data collection tools and analytical techniques to be used are based on validated and widely accepted tests in the literature. Functional performance will be assessed using the Closed Kinetic Chain Upper Extremity Stability Test, balance will be evaluated using the Upper Extremity Y Balance Test, and throwing performance will be measured using the Medicine Ball Throw Test.",[284,32,285],"External Focus (e.g., Performing the Exercise by Directing the Individual's Attention to a Laser Beam)","Adolescent",[287,288,289],"basketball","throwers ten exercise","functional performance","2026-04-20",{"date":292,"type":43},"2026-04-23",{"date":294,"type":22},"2026-04-25",{"date":296,"type":22},"2026-07-20",{"name":122,"class":50},{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":304,"eligibilityCriteria":305,"healthyVolunteers":59,"sex":278,"minAge":306,"maxAge":307,"enrollmentInfo":308,"targetDuration":4,"studyType":23,"phases":310,"briefSummary":311,"conditions":312,"keywords":4,"overallStatus":214,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":4},"100634528","microgreens-and-mirnas-100634528","NCT07540858","Microgreens and miRNAs","The Effect of Mikrofiliz Application on Serum miRNA Levels Associated With Muscle Damage, Recovery, and the Central Nervous System Following Eccentric Loading","GreenmiRNAs","Inclusion Criteria:Recreationally trained athletes were recruited and randomly allocated to either a microgreen supplementation group or a control group. Inclusion criteria were: (i) being an active athlete, (ii) absence of medical contraindications to exercise (verified by medical clearance), (iii) voluntary participation, and (iv) full adherence to the study protocol.\n\n\\-\n\nExclusion Criteria: Exclusion criteria included: recent musculoskeletal injury (within 6 months), chronic disease or regular medication use, lack of structured training in the previous year, and smoking or alcohol consumption. Participants failing to comply with the protocol, experiencing adverse events, or engaging in high-intensity physical activity during the follow-up period were withdrawn\n\n\\-","19 Years","24 Years",{"count":309,"type":22},15,[25],"In this study, we investigated the impact of a comprehensive microgreen and wheatgrass juice protocol on the miRNA response following a standardized EIMD model and whether microgreen consumption could modulate key miRNA markers of neuromuscular regeneration and metabolic adaptation, thereby offering a novel nutritional approach to enhancing holistic recovery in athletes.",[32,313,314],"Microgreens","miRNAs","2026-04-15",{"date":290,"type":43},{"date":318,"type":22},"2026-05-12",{"date":320,"type":22},"2026-07-30",{"name":322,"class":50},"Çanakkale Onsekiz Mart University",{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":329,"eligibilityCriteria":330,"healthyVolunteers":59,"sex":17,"minAge":331,"maxAge":19,"enrollmentInfo":332,"targetDuration":4,"studyType":23,"phases":334,"briefSummary":335,"conditions":336,"keywords":345,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":51},"100631596","pain-in-aging-former-athletes-masters-athletes-and-nonathletes-100631596","NCT07502742","Pain in Aging Former Athletes, Master's Athletes, and Nonathletes","Pain in Athletes INtervention (PAIN): A Randomized Crossover Clinical Trial in Aging Former Athletes, Master's Athletes, and Nonathletes","PAIN","Inclusion Criteria (General):\n\n* Age: 35 years through 65 years\n* Current master's athlete, former competitive athletes, or non-athlete control (see details below)\n* Ability to participate in exercise and exercise testing based on the Physical Activity Readiness Questionnaire (PAR-Q+)\n\nExclusion Criteria (General):\n\n* Currently pregnant or planning to become pregnant during the study\n* Currently taking heart rate lowering medications (e.g., betablockers) that would impact exercise testing\n* Contraindications to ice such as Raynaud's, cryoglobulinemia, cold urticaria, and\u002For impaired circulation or sensation\n* Fibromyalgia and\u002For chronic regional pain syndrome (CRPS)\n* Myocardial infarction or pulmonary embolism in the last 12 months, active cancer, a pacemaker, or any additional condition or disease that would preclude the individual from being able to perform the tests safely\n\nParticipants will be enrolled into one of the following three mutually exclusive groups according to the following criteria:\n\n1. Former Competitive Athlete: Prior participation in competitive sports at the Tier 3 level or above as per McKay et al. (2022): i.e., \"national-level representatives who are performing structured and\u002For periodized training and are developing proficiency in skills required to perform their sport at the highest level; this tier includes individuals participating in Provincial\u002FState or Academy Programs\" or higher participation in sport; Not currently participating in any recreational or competitive sports over the last 5 years (Tier 2 or above)\n2. Master's Athlete: Currently (within the past year) participating in sports at the Tier 2 level or above (i.e., committed to sports-specific training at least 3 times per week with the intent to compete)(McKay et al., 2022)\n3. Nonathlete Control: No prior participation in sport at the Tier 3 (Highly Trained\u002FNational) Level or above and not currently participating in any competitive sports (i.e., Tier 2 or above) (McKay et al., 2022) for at least 5 years","35 Years",{"count":333,"type":22},90,[25],"The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus aerobic) compared with both current master's athletes and nonathletes.\n\nThe main questions this study aims to address are:\n\n1. How do former athletes, master's athletes, and nonathletes experience pain?\n2. How do different types of moderate-intensity exercise (strength versus aerobic exercise) influence pain in former athletes, master's athletes, and nonathletes?\n\nParticipants will complete 3 different testing sessions:\n\n1. Baseline testing including assessments of strength, cardiorespiratory fitness, and pain;\n2. Strength exercise: pain assessments will occur before and after moderate-intensity strength training exercise;\n3. Aerobic exercise: pain assessments will occur before and after moderate-intensity aerobic exercise.\n\nThere will be a washout period of approximately one week or greater between each of the three different testing sessions. The order of conditions (strength versus aerobic exercise) will be randomized (crossover randomized trial design).",[337,75,338,32,339,340,341,342,343,209,344],"Pain","Athlete","Sports Medicine","Strength Training Effects","Aerobic Exercise","Strength Training","Aging","Sports",[346,347,337,348,349,140,76,343,350],"Former Athlete","Master's Athlete","Quantitative Sensory Testing","Randomized Crossover Clinical Trial","Sport","2026-03-27",{"date":353,"type":43},"2026-03-31",{"date":355,"type":43},"2026-03-02",{"date":357,"type":22},"2028-05",{"name":359,"class":50},"Marquette University",{"id":361,"slug":362,"hasResults":12,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":366,"eligibilityCriteria":367,"healthyVolunteers":59,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":368,"targetDuration":4,"studyType":23,"phases":370,"briefSummary":371,"conditions":372,"keywords":373,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":51},"100525549","guided-episodic-future-thinking-to-increase-physical-activity-adherence-and-promote-healthy-brain-aging-100525549","NCT06123182","Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging","Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging Among Mid-Life Adults: Phase II","GETActiveHIT","Inclusion Criteria:\n\n* speak English\n* have access to reliable communication (a telephone or cell phone, computer, etc.)\n* normal or corrected to normal vision and hearing\n* ambulatory (without the use of assistive devices)\n* physically underactive\n* able to give informed consent\n* able to exercise continuously on the recumbent stepper exercise device for 4 minutes greater than or equal to 25 watts to demonstrate ability to perform exercise on stepper \\& no aerobic exercise contraindications or other safety\u002Fphysical concerns\n* able to communicate with investigators, follow 2-step command \\& correctly answer consent comprehension questions\n* stable blood pressure and statin medication doses for 30 days as these affect vascular health\u002Fhemodynamics\n* willing and able to safely enter magnetic resonance (MR) scanner and attempt the MR scan\n* willing and able to attempt a blood draw\n\nExclusion Criteria:\n\n* patients with arrhythmias or acute cardiac events will be excluded due to potential complications with the supervised moderate exercise\n* at risk for hazard due to magnetic fields due to MR safety concerns\n* have any neurologic or psychiatric disorder except depression, anxiety (including post-traumatic stress disorder)\n* have history of seizures or head trauma due to MR data quality",{"count":369,"type":22},160,[25],"The goal of this behavioral clinical trial is to learn how to increase physical activity in mid-life adults. Specifically, can guided imagery that includes creating mental pictures increase excitement about working out.\n\nParticipants will be asked to complete testing at the beginning of the study, following 6-weeks of an in-person exercise program, and 6-weeks after finishing the exercise program. Testing will include an exercise test, MRI, questionnaires, computer tasks, and a blood draw.",[32,343],[374,375],"Adherence","Guided Imagery","2026-03-23",{"date":351,"type":43},{"date":379,"type":43},"2024-02-23",{"date":381,"type":22},"2027-05",{"name":383,"class":50},"University of Kansas Medical Center",{"id":385,"slug":386,"hasResults":12,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":12,"sex":17,"minAge":103,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":393,"phases":4,"briefSummary":394,"conditions":395,"keywords":404,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":51},"100613051","adherence-to-home-based-exercises-in-musculoskeletal-disorders-100613051","NCT07261553","Adherence to Home-Based Exercises in Musculoskeletal Disorders","Adherence to Home-Based Exercise Programs Among Patients With Musculoskeletal Disorders and Its Influencing Factors","Inclusion criteria:\n\n* Be 18 years of age or older\n* To have a musculoskeletal disease (degenerative, neurological or orthopedic)\n* To be given a home exercise program\n* To have cognitive and language functions to communicate, to be a volunteer\n\nExclusion criteria:\n\n* Those with major psychiatric illness\n* Those with cognitive dysfunction\n* Those with communication disorders, reluctant\u002Freluctant to participate\n* Those with any condition other than a primary degenerative, orthopedic, or neurological disease that could significantly affect exercise adherence, including musculoskeletal or systemic disorders (e.g., severe anemia, heart failure, respiratory failure, uncontrolled diabetes, inflammatory rheumatic disease, recent fractures, or active infections).",{"count":392,"type":22},252,"OBSERVATIONAL","Home exercise program is recommended by physicians to patients and their relatives to do at home and It is a treatment option in which the physician describes how to do it. Home workout program to be completed at home to complement and reinforce their program in the clinic It is a personalized set of therapeutic exercises that are taught. There are factors that can change exercise compliance; There are some reasons why some patients adhere to the prescribed home exercise program and others do not.\n\nAdherence to home exercises is a major issue in rehabilitation and the reasons for this are multifactorial; It includes both psychological and specific conditions factors that vary between each individual and these conditions should be taken into account by clinicians in designing personalized exercise programs.\n\nHome exercise programs constitute a fundamental component of rehabilitation and are widely prescribed by physicians support therapeutic gains beyond the clinical environment. These individualized programs aim to maintain functional improvements, reduce symptoms, and promote self-management among individuals with musculoskeletal disorders. Although adherence to home-based exercises is recognized as a key determinant of rehabilitation outcomes, non-adherence remains a persistent challenge. Despite growing emphasis on the importance of exercise compliance, the existing literature provides relatively limited and insufficient evidence regarding the factors that influence adherence across different musculoskeletal conditions, including degenerative, orthopedic, and neurological disorders.\n\nAddressing this gap, the present prospective longitudinal cohort study aims to evaluate adherence to individualized home-based exercise programs among patients with diverse musculoskeletal conditions and to determine whether adherence behaviors differ across diagnostic groups. In addition, the study seeks to identify demographic, clinical, psychosocial, and functional factors associated with exercise compliance. By integrating structured clinical evaluations with validated outcome measures, this study aims not only to clarify the determinants of exercise adherence but also to contribute to the development of more effective, condition-specific strategies to enhance sustained engagement in home-based rehabilitation.",[32,396,397,398,399,400,401,402,403],"Adherence, Treatment","Musculoskeletal Disease","Rehabilitation Exercise","Adherence, Patient","Home Exercise Program","Stroke","Orthopedic Operations","Degeneration of Spine and Osteoarticular",[400,405,398,397,399],"adherence","2026-03-21",{"date":408,"type":43},"2026-03-25",{"date":410,"type":43},"2024-12-30",{"date":412,"type":22},"2026-05-15",{"name":414,"class":415},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",{"id":417,"slug":418,"hasResults":12,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":59,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":423,"targetDuration":4,"studyType":23,"phases":425,"briefSummary":426,"conditions":427,"keywords":4,"overallStatus":214,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":4},"100535126","reducing-heart-failure-risk-in-late-life-with-physical-activity-100535126","NCT06247774","Reducing Heart Failure Risk in Late-Life With Physical Activity","Reducing Heart Failure Risk in Late-Life With Physical Activity: Impact on Cardiac Structure and Function and Proteomic Signatures","Inclusion Criteria:\n\n* Hypertension (controlled on stable medication regimen)\n* Structural heart abnormality (LVH or LA enlargement)\n* LVEF \\> 50%\n* Sedentary\n* BMI \\\u003C30\n\nExclusion Criteria:\n\n* Diabetes\n* Unable to exercise\n* Supplemental oxygen use\n* Pulmonary hypertension\n* Sleep apnea\n* Regular exercise training\n* Devices that limit ability to achieve target heart rate\n* Moderate to severe valve disease\n* Recent (within 3 months) major CV event or planned procedures (within 6 months)\n* Terminal illness, life expectancy \\\u003C6 months\n* Inability or unwillingness to comply with study requirements\n* No access to smart phone\u002Ftablet",{"count":424,"type":22},42,[25],"The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise.\n\nThe main question it aims to answer is to identify protein signatures associated with the benefits of a cardiac rehabilitation exercise program.\n\nThe trial will enroll 42 participants, who will be randomized to a 12 week cardiac rehabilitation exercise program versus control arm and asked to participate in the following at the beginning and end of study:\n\n* Cardiopulmonary exercise test (CPET)\n* Echocardiogram\n* Physical function test\n* 6-minute walk test\n* Hand grip strength\n* Quality of life questionnaire\n* Blood draws\n\nResearchers will compare results between those who do and don't participate in the exercise program.",[428,32,202,429],"Hypertension","Proteomics","2026-03-10",{"date":432,"type":43},"2026-03-12",{"date":434,"type":22},"2026-06",{"date":436,"type":22},"2029-05",{"name":438,"class":50},"Brigham and Women's Hospital",{"id":440,"slug":441,"hasResults":12,"nctId":442,"briefTitle":443,"officialTitle":444,"acronym":445,"eligibilityCriteria":446,"healthyVolunteers":59,"sex":17,"minAge":103,"maxAge":160,"enrollmentInfo":447,"targetDuration":4,"studyType":23,"phases":449,"briefSummary":450,"conditions":451,"keywords":456,"overallStatus":214,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":465,"leadSponsor":467,"locationsCount":51},"100617408","adaptive-self-efficacy-based-ai-coaching-for-cycling-100617408","NCT07318233","Adaptive Self-Efficacy-Based AI Coaching for Cycling","Adaptive Self-Efficacy-Based AI Coaching for Enhanced Indoor Cycling Performance: A Personalized Machine Learning Approach","AI","Inclusion Criteria:\n\n* Age 18-40 years\n\n  * Recreationally active\n  * Familiar with stationary cycling\n  * Able to complete 20 minutes of vigorous cycling\n\nExclusion Criteria:\n\n* Cardiovascular, metabolic, or respiratory conditions\n\n  * Medications affecting heart rate response\n  * Lower extremity injury within past 3 months\n  * Competitive cyclists (\\>10 hours cycling\u002Fweek)\n  * Pregnancy",{"count":448,"type":22},120,[25],"The primary objective of this study is to evaluate whether adaptive, AI-delivered personalized self-efficacy-based AI coaching based on real-time physiological and performance feedback enhance indoor cycling power output during a 20-minute time trial compared to static affirmations and exercise-only control conditions.",[32,452,453,454,455],"Exercise Behavior","Exercise Adherence Challenges","Motivation for Physical Activity","Motivational Enhancement",[457,458,459,460],"Physical Activity","AI affirmations","just-in-time adaptive intervention","cycling","2026-02-27",{"date":463,"type":43},"2026-03-03",{"date":178,"type":22},{"date":466,"type":22},"2028-12-28",{"name":468,"class":50},"University of Miami",{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":473,"acronym":474,"eligibilityCriteria":475,"healthyVolunteers":12,"sex":17,"minAge":476,"maxAge":477,"enrollmentInfo":478,"targetDuration":479,"studyType":393,"phases":4,"briefSummary":480,"conditions":481,"keywords":487,"overallStatus":214,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":501,"locationsCount":4},"100626161","walking-function-outcomes-following-surgical-correction-with-rehabilitation-versus-physical-therapy-alone-in-charcot-marie-tooth-disease-a-bidirectional-cohort-study-100626161","NCT07432035","Walking Function Outcomes Following Surgical Correction With Rehabilitation Versus Physical Therapy Alone in Charcot-Marie-Tooth Disease: A Bidirectional Cohort Study","CMT-WALK","Inclusion Criteria:\n\n* Participants aged 12 years or older at the time of enrollment\n* Genetically or clinically confirmed CMT, based on established diagnostic criteria\n* Presence of foot deformity and\u002For gait impairment attributable to CMT, as determined by a treating clinician\n* Ability to ambulate at least 10 meters, with or without assistive devices\n* Medically eligible for either functional surgical intervention or structured physical therapy, as determined by the treating team\n* Willingness and ability to participate in longitudinal follow-up assessments\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Previous major foot or ankle surgery that substantially altered lower-limb biomechanics\n* Presence of non-CMT-related neurological disorders affecting gait (eg, stroke, Parkinson disease, multiple sclerosis)\n* Severe musculoskeletal conditions unrelated to CMT that limit walking ability (eg, advanced hip or knee osteoarthritis)\n* Active lower-limb infection, ulceration, or acute injury at the time of enrollment\n* Severe cognitive impairment or psychiatric condition precluding reliable participation\n* Medical contraindications to surgery or exercise-based rehabilitation, when relevant\n* Inability to complete baseline functional assessments or anticipated inability to complete follow-up","12 Years","60 Years",{"count":62,"type":22},"5 Years","The goal of this study is to compare changes in walking ability in people with Charcot-Marie-Tooth disease (CMT) who receive two different treatment approaches for foot deformities that affect walking.\n\nCMT is an inherited nerve condition that can cause muscle weakness, loss of sensation, and foot deformities. These changes often make walking difficult and can reduce independence and quality of life. Treatment options commonly include physical therapy alone or surgery to correct foot alignment followed by rehabilitation. However, it is not clear whether one approach leads to better long-term walking outcomes.\n\nThe main question this study aims to answer is whether individuals who undergo functional foot surgery followed by rehabilitation experience different changes in walking ability over time compared with those who receive structured physical therapy alone.\n\nResearchers will compare walking performance between these two treatment groups over a period of up to two years. Walking ability will be evaluated using standardized walking tests and patient questionnaires.\n\nParticipants included in this study are individuals with CMT-related foot deformities that affect walking and who received either surgery followed by rehabilitation or physical therapy alone. Researchers will analyze changes in walking ability over time and determine how many participants achieve meaningful improvement.\n\nThe findings from this study may help clinicians and individuals with CMT better understand how different treatment strategies influence walking function over time.",[482,483,484,32,485,486],"Charcot Marie Tooth Disease (CMT)","Pes Cavovarus","Surgery","Neuromuscular Diseases (NMD)","Gait Disorders",[488,489,490,491,492,493],"Charcot Marie Tooth disease","Walking performance","Functional surgery","Physical therapy","Gait impairment","Propensity score matching","2026-02-24",{"date":496,"type":43},"2026-02-25",{"date":498,"type":22},"2026-02-11",{"date":500,"type":22},"2028-02-10",{"name":502,"class":50},"Peking University Third Hospital",{"id":504,"slug":505,"hasResults":12,"nctId":506,"briefTitle":507,"officialTitle":508,"acronym":4,"eligibilityCriteria":509,"healthyVolunteers":59,"sex":17,"minAge":103,"maxAge":331,"enrollmentInfo":510,"targetDuration":4,"studyType":23,"phases":511,"briefSummary":512,"conditions":513,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":516,"startDateStruct":518,"completionDateStruct":520,"leadSponsor":521,"locationsCount":51},"100624562","exercise-approaches-and-physical-activity-level-in-inactive-adults-100624562","NCT07411248","Exercise Approaches and Physical Activity Level in Inactive Adults","Effects of Different Exercise Approaches on Physical Activity Level and Health Outcomes in Inactive Adults","Inclusion Criteria:\n\n* Taking fewer than 5,000 steps per day and classified as physically inactive according to the International Physical Activity Questionnaire-Short Form (\\\u003C600 MET-min\u002Fweek)\n* Residing in Istanbul\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Diagnosis of end-stage congestive heart failure\n* Presence of malignant or unstable arrhythmia\n* Lack of adequate infrastructure to participate in technology-based physical activity programs\n* Presence of mental dysfunction\n* Presence of acute musculoskeletal injury\n* Pregnancy\n* Answering \"YES\" to any item on the Physical Activity Readiness Questionnaire (PAR-Q)",{"count":21,"type":22},[25],"This randomized, controlled, single-blind study aims to compare the effects of different exercise approaches on physical activity level and health-related outcomes in inactive adults. Thirty inactive individuals aged 18-35 years will be randomly assigned to supervised face-to-face group exercise, mobile application-based exercise, or video-based home exercise. Exercise programs will be performed three days per week for eight weeks and will include aerobic, strengthening, and flexibility exercises.",[514,515,32],"Healthy Participants","Inactivity",{"date":517,"type":43},"2026-02-13",{"date":519,"type":43},"2025-01-06",{"date":355,"type":22},{"name":522,"class":50},"Biruni University",{"id":524,"slug":525,"hasResults":12,"nctId":526,"briefTitle":527,"officialTitle":528,"acronym":4,"eligibilityCriteria":529,"healthyVolunteers":12,"sex":17,"minAge":103,"maxAge":530,"enrollmentInfo":531,"targetDuration":4,"studyType":23,"phases":533,"briefSummary":534,"conditions":535,"keywords":539,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":549,"leadSponsor":551,"locationsCount":51},"100617770","effects-of-exercise-with-visual-feedback-in-parkinsons-disease-100617770","NCT07322939","Effects of Exercise With Visual Feedback in Parkinson's Disease","Effects of Visual Indicator Exercises for the Trunk and Lower Extremities on Activity and Participation in Parkinson's Disease","Inclusion Criteria\n\n* Individuals diagnosed with idiopathic Parkinson's disease\n* Disease severity classified as stage 1 to 3 according to the Modified Hoehn and Yahr Scale\n* Patients receiving oral antiparkinsonian treatment only\n\nExclusion Critera\n\n* Presence of musculoskeletal, cardiovascular, or vestibular disorders that may interfere with the completion of the assessments or treatment protocol\n* Presence of additional neurological or psychiatric disorders other than Parkinson's disease\n* Presence of visual impairment insufficient to perceive visual feedback","85 Years",{"count":532,"type":22},32,[25],"Patients with Parkinson's disease who apply to the Hasan Kalyoncu University Application and Research Center and meet the inclusion criteria will be included in the study. The included participants will be randomly assigned into either the intervention group or the control group using a sealed-envelope method. Both groups will undergo a standard exercise program, consisting of posture, strengthening, and balance training, under the supervision of a physiotherapist for 8 weeks, 3 days per week. In addition to this, the intervention group will receive an additional exercise program incorporating visual feedback using a laser pointer, targeting the trunk and lower extremities, also under the supervision of a physiotherapist for 8 weeks, 3 days per week.",[536,537,32,538],"Parkinson Disease","Balance Impairment","Postural Control",[540,541,542,543,544],"parkinson disease","balance","postural control","visual feedback","exercise","2026-01-24",{"date":547,"type":43},"2026-01-27",{"date":118,"type":43},{"date":550,"type":22},"2026-05-05",{"name":552,"class":50},"Hasan Kalyoncu University",{"id":554,"slug":555,"hasResults":12,"nctId":556,"briefTitle":557,"officialTitle":558,"acronym":559,"eligibilityCriteria":560,"healthyVolunteers":12,"sex":17,"minAge":160,"maxAge":104,"enrollmentInfo":561,"targetDuration":563,"studyType":393,"phases":4,"briefSummary":564,"conditions":565,"keywords":570,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":588,"locationsCount":51},"100605622","predictive-factors-of-response-to-phase-ii-cardiac-rehabilitation-in-heart-failure-with-reduced-ejection-fraction-100605622","NCT07164911","Predictive Factors of Response to Phase II Cardiac Rehabilitation in Heart Failure With Reduced Ejection Fraction","Prédiction Des réponses du Patient Porteur d'Une Insuffisance Cardiaque à Fraction d'éjection altérée à Une Phase II de réadaptation Cardiaque","PrédicRéa","Inclusion Criteria:\n\n* Heart failure with reduced ejection fraction \\\u003C 40%\n* NYHA functional class ≥ II\n* Clinically stable for at least 6 weeks\n* On optimized medical therapy for at least 6 weeks\n* Prescription for phase II cardiac rehabilitation\n* BMI between 20-30 kg·m-²\n* Physical activity level: sedentary or physically active but untrained\n* Signed informed consent to participate in the study\n* Affiliation to the French national health insurance system\n\nExclusion Criteria:\n\n* Contraindication to regular adapted physical activity\n* Uncontrolled arterial hypertension\n* Secondary respiratory disease such as emphysema or chronic obstructive pulmonary disease (COPD)\n* Secondary cardiovascular disease\n* Individuals under legal protection or deprived of liberty\n* Pregnant or breastfeeding women",{"count":562,"type":22},62,"1 Month","Exercise intolerance, measured as peak oxygen consumption (VO₂peak) during exercise in patients with heart failure with reduced ejection fraction (HFrEF). Change in VO₂peak (ΔVO₂peak), which serves as a prognostic marker for HFrEF engaged in exercise based cardiac rehabilitation program (ExCR). Responders to ExCR generally show improved cardiac function but some patients with HFrEF do not respond to ExCR. VO₂peak depends on three major components of oxygen transport: Pulmonary (lungs), circulatory (heart and vessels) and skeletal muscle (oxygen utilization) functions. These physiological responses to ExCR may be influenced by epigenetic regulation, specifically the expression of circulating microRNAs (c-miRNAs).\n\nLinking non-invasive measurements and epigenetic markers could 1) identify which component of the oxygen transport chain is most impaired and 2) allow personalized interventions to maximize VO₂peak improvements.\n\nThe primary objective of this stidy is to assess the association between changes in VO₂peak during exercise training and circulating microRNA expression (miR-146a, miR-191, miR-23a, miR-140, miR-1, miR-21, miR-133a, miR-17-5p, miR-3200-3p).\n\nThe secondary objective is to examine the relationship between pulmonary, cardiovascular, and neuromuscular adaptations to exercise and circulating microRNA expression.",[566,202,32,567,568,569],"HFrEF - Heart Failure With Reduced Ejection Fraction","Exercise Adaptations","Exercise Intolerance","Exercise Intervention",[571,572,573,574,575,576,577,578,579,580],"Exercise-based cardiac rehabilitation in patients with reduced left ventricular ejection fraction","VO2peak","MicroRNA","Muscle Oxygenation","arterial stiffness","cardiac output","stroke volume","Oxygen alveolar-arterial gradient","alveolar ventilation","minute ventilation","2025-12-08",{"date":583,"type":43},"2025-12-16",{"date":585,"type":43},"2025-11-25",{"date":587,"type":22},"2027-11-30",{"name":589,"class":415},"Centre Hospitalier de Corbie",{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":4,"eligibilityCriteria":596,"healthyVolunteers":12,"sex":17,"minAge":476,"maxAge":597,"enrollmentInfo":598,"targetDuration":4,"studyType":23,"phases":599,"briefSummary":600,"conditions":601,"keywords":603,"overallStatus":214,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":609,"startDateStruct":611,"completionDateStruct":613,"leadSponsor":615,"locationsCount":4},"100612770","comparison-of-structured-exercise-and-exergaming-in-pediatric-onset-multiple-sclerosis-100612770","NCT07257900","Comparison of Structured Exercise and Exergaming in Pediatric-Onset Multiple Sclerosis","Effects of Video Game-Based Exercise Training on Physical Activity, Balance, Fatigue, and Quality of Life in Pediatric-Onset Multiple Sclerosis Patients","Inclusion Criteria:\n\n* Children and adolescents aged 12-22 years.\n* Diagnosed with pediatric-onset multiple sclerosisaccording to the 2017 revised McDonald criteria.\n* Expanded Disability Status Scale (EDSS) ≤ 6\n* Participate in online exercise sessions via Zoom\n\nExclusion Criteria:\n\n* Presence of orthopedic problems affecting mobility.\n* Blurred vision or visual disturbances that could interfere with exergaming or exercise performance.\n* Any comorbid medical, neurological, or psychiatric condition that could influence physical performance or study outcomes.\n* History of relapse or corticosteroid treatment within the last three months.","22 Years",{"count":21,"type":22},[25],"This study will examine how two different exercise programs affect children and young adults with pediatric-onset multiple sclerosis (POMS). POMS is a type of multiple sclerosis that begins in childhood or adolescence and can cause fatigue, weakness, balance problems, and difficulty moving. This study aims to evaluate the effectiveness of a video game-based exercise program (exergaming) compared with traditional exercise training in enhancing balance, physical activity levels, reducing fatigue, and improving quality of life in individuals with pediatric-onset multiple sclerosis. Approximately 30 participants aged 12 to 22 years old who have been diagnosed with POMS and have mild to moderate symptoms (Extended Disability Status Scale \\[EDSS\\] score below 6) will participate in the study.\n\nParticipants will be randomly assigned to one of two groups:\n\nTraditional Exercise Group: Participants will receive structured exercise instruction via live Zoom sessions (a tele-rehabilitation model). For 8 weeks, twice a week, they will perform supervised aerobic, strength, and balance exercises, each lasting approximately 45 minutes.\n\nExercise Game Group: Participants will perform similar aerobic, strength training, and balance exercises using the Nintendo Switch Ring Fit Adventure™ video game system.\n\nResearchers will evaluate participants' physical activity levels, balance, fatigue, and quality of life parameters at baseline and after completing the 8-week intervention.\n\nThe study aims to determine whether the exergaming program can help participants increase their physical activity, reduce fatigue, and improve balance and daily functioning compared with traditional exercise. This approach offers an engaging and technology-supported way to incorporate physical activity into the rehabilitation of young people with POMS.",[602,32],"Pediatric-Onset Multiple Sclerosis (POMS)",[604,605,606,607,608],"Pediatric-onset multiple sclerosis","Physiotherapy","Exergaming","Exercises","telerehabilitation",{"date":610,"type":43},"2025-12-02",{"date":612,"type":22},"2025-12",{"date":614,"type":22},"2027-12",{"name":616,"class":50},"Istanbul University - Cerrahpasa",{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":621,"acronym":4,"eligibilityCriteria":622,"healthyVolunteers":12,"sex":159,"minAge":4,"maxAge":4,"enrollmentInfo":623,"targetDuration":4,"studyType":23,"phases":624,"briefSummary":625,"conditions":626,"keywords":628,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":633,"lastUpdatePostDateStruct":634,"startDateStruct":636,"completionDateStruct":638,"leadSponsor":640,"locationsCount":51},"100602785","moderate-intensity-exercise-and-pain-sensitization-in-breast-cancer-survivors-a-case-based-study-100602785","NCT07128030","Moderate-Intensity Exercise and Pain Sensitization in Breast Cancer Survivors: A Case-Based Study","Inclusion Criteria:\n\n* Adult women diagnosed with stage I-III breast cancer\n* Completion of active treatment (surgery, chemotherapy, and\u002For radiotherapy) at least 6 months prior to enrollment\n* Presence of persistent pain or altered sensation in the upper quadrant of the affected limb related to oncologic treatment\n\nExclusion Criteria:\n\n* Bilateral breast cancer\n* Locoregional recurrence\n* Other malignancies\n* Pre-existing pain not related to cancer treatment\n* Neurological or cognitive disorders\n* Non-Spanish speakers\n* Contraindications to moderate-intensity physical activity",{"count":224,"type":22},[25],"The aim of this study was to evaluate the feasibility, safety, and acceptability of a supervised, combined moderate-intensity aerobic and resistance training program designed to reduce pain sensitization in BCS with persistent pain. Secondary objectives included assessing changes in pain intensity, somatosensory sensitivity, and temporal summation, while tertiary objectives focused on improvements in quality of life and functional capacity.",[32,627,75],"Breast Cancer",[629,630,631,632],"pain severity","pain sensibilization","quantitative sensory testing","physical activity","2025-11-19",{"date":635,"type":43},"2025-11-24",{"date":637,"type":43},"2025-08-23",{"date":639,"type":22},"2026-02-23",{"name":641,"class":50},"Universidad Rey Juan Carlos",{"id":643,"slug":644,"hasResults":12,"nctId":645,"briefTitle":646,"officialTitle":647,"acronym":4,"eligibilityCriteria":648,"healthyVolunteers":59,"sex":17,"minAge":103,"maxAge":160,"enrollmentInfo":649,"targetDuration":4,"studyType":23,"phases":651,"briefSummary":652,"conditions":653,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":660,"lastUpdatePostDateStruct":661,"startDateStruct":663,"completionDateStruct":665,"leadSponsor":667,"locationsCount":51},"100609605","effects-of-breathing-training-and-nitrate-on-exercise-at-simulated-altitude-100609605","NCT07216755","Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude","Impact of Respiratory Muscle Training and Nitrate Therapy on Exercise Tolerance in Simulated Altitude","Inclusion Criteria:\n\n* Healthy adults between 18 and 40 years old.\n\nRecreationally active (performing ≥3 hours of structured physical activity per week).\n\nNon-smokers for at least the past 6 months.\n\nFree from any known cardiovascular, pulmonary, metabolic, or neuromuscular disease as determined by health screening questionnaire and medical history.\n\nAble to perform cycle ergometer exercise to volitional fatigue.\n\nWilling to abstain from high-nitrate foods and supplements (e.g., beets, spinach, arugula) for 48 hours prior to each testing session.\n\nAble and willing to provide written informed consent and comply with all study procedures.\n\nExclusion Criteria:\n\n* Diagnosis of or history of heart disease, hypertension, diabetes, or chronic respiratory disorders (e.g., asthma, COPD).\n\nCurrent use of medications or supplements known to affect cardiovascular, metabolic, or respiratory function (e.g., beta-blockers, nitrates, stimulants).\n\nSmoking, vaping, or tobacco use within the past 6 months.\n\nKnown allergy or intolerance to beetroot products or nitrates.\n\nParticipation in another interventional research study within the past 30 days.\n\nPregnant or breastfeeding women.\n\nAny orthopedic or musculoskeletal limitation preventing safe exercise testing.\n\nFailure to meet inclusion criteria or inability to complete familiarization and baseline testing.",{"count":650,"type":22},80,[25],"This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory systems, which may limit endurance performance. By combining RMT-designed to strengthen the muscles involved in breathing-with nitrate therapy, which enhances nitric oxide availability and vascular function, this study aims to determine whether these interventions independently or synergistically improve oxygen delivery, reduce physiological strain, and enhance exercise performance. The findings will help identify non-pharmacological strategies to improve physical performance and tolerance to hypoxia in both clinical and operational environments.",[654,655,656,32,568,657,658,659],"Healthy Adults","Mechanical Ventilation Dependence","Hypoxia","Dietary Supplement","Nitrate Supplementation","Inspiratory Muscle Training","2025-10-13",{"date":662,"type":43},"2025-10-15",{"date":664,"type":43},"2025-09-01",{"date":666,"type":22},"2028-08-31",{"name":668,"class":50},"Embry-Riddle Aeronautical University",{"id":670,"slug":671,"hasResults":12,"nctId":672,"briefTitle":673,"officialTitle":674,"acronym":4,"eligibilityCriteria":675,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":676,"targetDuration":4,"studyType":23,"phases":678,"briefSummary":679,"conditions":680,"keywords":684,"overallStatus":214,"whyStopped":4,"lastUpdateSubmitDate":691,"lastUpdatePostDateStruct":692,"startDateStruct":694,"completionDateStruct":696,"leadSponsor":698,"locationsCount":4},"100608704","freefrail-project-a-multicomponent-intervention-for-the-management-of-frailty-in-primary-care-a-randomized-controlled-trial-100608704","NCT07205016","FreeFrail Project: A Multicomponent Intervention for the Management of Frailty in Primary Care: A Randomized Controlled Trial","FreeFrail Project: Effectiveness of a Multicomponent Intervention Including Dual-task Exercise to Increase Functionality and Cognitive Performance in Frail and Pre-frail Individuals Over 65 Years Aged in Primary Care Compared to Usual Care: Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 65 or older\n* Frailty according to Fragil-VIG index (\\>0,20)\n* Barthel index \\> 60\n* Able to perform physical exercise\n* Able to understand and communicate in Catalan or Spanish\n\nExclusion Criteria:\n\n* Decompensated \u002F Unstable cardiovascular disease or recent diagnosed\n* Upper or lower injury with functional impairment\n* Institutionalized patient.\n* Terminal or tumoral processes\n* People who participated in another clinical trial or exercise programme during last year\n* Diagnosis of severe dementia",{"count":677,"type":22},220,[25],"The primary aim is to assess the effectiveness of a multicomponent intervention including dual-task exercise in improving functionality and cognitive performance and in reducing frailty among community-dwelling adults aged ≥65 years compared to usual care. Secondary objectives include evaluating its impact on pain, anxiety or depression, sleep quality, quality of life, physical activity, handgrip strength, and polypharmacy.\n\nA double-blind, randomized, parallel-group controlled trial will be conducted in primary care centers in Lleida. Frail older adults (≥65 years) will be recruited and randomly allocated to either the intervention group, receiving a structured cognitive-motor dual-task based multicomponent program, or the control group, receiving usual care. Outcomes will be assessed using validated tools at baseline and follow-up.",[681,682,32,683],"Frail Elderly","Dual Task Exercises in Elderly People","Frailty",[685,686,687,688,689,690],"primary care Health [MeSH]","multicomponent intervention","exercise therapy [MeSH]","cognitive-motor dual-task","frail elderly [MeSH]","frailty [MeSH]","2025-09-24",{"date":693,"type":43},"2025-10-03",{"date":695,"type":22},"2026-01",{"date":697,"type":22},"2026-10",{"name":699,"class":50},"Universitat de Lleida",{"id":701,"slug":702,"hasResults":12,"nctId":703,"briefTitle":704,"officialTitle":705,"acronym":706,"eligibilityCriteria":707,"healthyVolunteers":59,"sex":17,"minAge":19,"maxAge":708,"enrollmentInfo":709,"targetDuration":4,"studyType":23,"phases":711,"briefSummary":712,"conditions":713,"keywords":716,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":720,"lastUpdatePostDateStruct":721,"startDateStruct":723,"completionDateStruct":725,"leadSponsor":727,"locationsCount":729},"100550929","transfer-effects-of-stationary-bicycle-perturbation-training-on-older-adults-cycling-skills-100550929","NCT06453473","Transfer Effects of Stationary Bicycle Perturbation Training on Older Adults' Cycling Skills","The Transfer Effects of Stationary Bicycle Perturbation Training on Older Adults' Cycling Skills and Behavior (BiPerAge): a Single Blind Randomized Controlled Trial","BiPerAge","Inclusion Criteria:\n\n* Ability and willingness to provide informed consent and accept randomization to either study arm\n* Ability to come to cycle course testing locations\n* ≥3 errors in pre-test of cycle course\n\nExclusion Criteria:\n\n* Severe diseases e.g. ischemic heart disease which restricts exercise, chronic obstructive pulmonary disease (COPD), uncontrolled blood pressure, manifest osteoporosis or any other disease leading to increased fracture risks\n* A period less than one year after hip or knee replacement surgery or after fractures of the lower extremities\n* Amputation of a lower limb\n* Neurological diseases or 6-month after a stroke\n* Inability to ambulate independently\n* Severe visual impairments (blindness), non-compensable hearing\n* Cognitive impairment, scoring less than 24 on the MMSE (Mini-Mental State Examination), inability to understand and follow instructions\n* Participation in another intervention trial at the same time or within the previous 6 months","100 Years",{"count":710,"type":22},127,[25],"The Israeli research group of this trial has developed the Perturbation Stationary Bicycle Robotics (PerStBiRo) system that can challenge balance while sitting. With this system, unexpected perturbations can be provided under controlled and safe conditions. Within the BiPerAge-project it will be evaluated if 20 training sessions (20 minutes each) on the PerStBiRo system will lead to transfer effects on safe cycling skills of community-dwelling older adults (age 65 years and older). The ability to cycle safely will be tested prior and after the training period using a cycling course, which consists of variant tasks requiring motor and cognitive skills.",[714,32,715],"Older Adults","Bicycling",[715,717,718,719],"Perturbation","Balance control","Falls","2025-09-09",{"date":722,"type":43},"2025-09-16",{"date":724,"type":43},"2025-03-12",{"date":726,"type":22},"2027-03-31",{"name":728,"class":50},"University of Erlangen-Nürnberg Medical School",2,{"id":731,"slug":732,"hasResults":12,"nctId":733,"briefTitle":734,"officialTitle":735,"acronym":4,"eligibilityCriteria":736,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":737,"targetDuration":4,"studyType":23,"phases":738,"briefSummary":739,"conditions":740,"keywords":745,"overallStatus":214,"whyStopped":4,"lastUpdateSubmitDate":750,"lastUpdatePostDateStruct":751,"startDateStruct":753,"completionDateStruct":754,"leadSponsor":756,"locationsCount":51},"100595037","frailty-intervention-in-postoperative-hip-fracture-inpatients-100595037","NCT07027241","Frailty Intervention in Postoperative Hip Fracture Inpatients","Multicomponent Exercise and Nutrition Based Frailty Intervention in Postoperative Hip Fracture Inpatients","Inclusion Criteria:\n\n* Older adults \\>\u002F= 65\n* Clinical Frailty Score 4-6 (This includes patients with very mild, mild and moderate frailty. This would be in keeping with literature quoting frailty interventions where patients who are 'pre-frail' and frail are included)\n* Post fragility hip fracture (including subtrochanteric fracture)\n* Post hip fracture surgery (all types including total hip replacement, hemiarthroplasty, IM nailing)\n* Medically stable postoperatively\n* No weightbearing restriction\n* Mobile pre-admission (including aids and max assist of 1 person)\n\nExclusion Criteria:\n\n* Medically unstable (NEWS \\>3, unless a higher cutoff is stipulated by the primary medical researcher)\n* Non fragility hip fracture (fracture from non osteoporotic aetiology, pathologic fracture)\n* Hip surgery for other aetiology (prosthetic joint infection, arthritis, implant loosening, avascular necrosis, periprosthetic fracture)\n* Polytrauma\n* Delirium or severe cognitive impairment (as defined by inability to follow instructions and unable to provide informed consent)\n* Pre-existing neurologic or cardiovascular disorders that would affect participation\u002F compliance with exercise intervention\n* Open hip fracture\n* Other lower limb orthopaedic disorders that affect participation\u002F compliance with exercise intervention\n* Terminal illness with \\\u003C\u002F= 6 months to live\n* Active treatment for cancer (systemic chemotherapy or radiotherapy, patients on oral chemotherapeutic agents\u002F checkpoint inhibitors will be eligible for inclusion)\n* Nursing Home Resident\n* Severe lower limb pain post-op\n* Severe skin issues\u002F ulcers in non-operated lower limb that would preclude utilisation of ankle weights\n* Swallowing disorders\u002F difficulty\n* Renal impairment with eGFR \\\u003C30\n* Hepatic failure\n* Patients with a dairy\u002F soy allergy",{"count":131,"type":22},[25],"Hip fracture is a big health concern in older adults, and can lead to increased risk of death, reduced level of independence \\& mobility, reduced quality of life, and higher likelihood of admission to nursing homes. Frailty is a medical condition associated with ageing that results in a reduced ability to do daily tasks. A frail older adult is also less able to recover well from conditions that may affect their wellbeing (for example, infections, falls resulting in injuries or hospital admissions). Frailty is common in older adults with hip fractures.\n\nThere has been increasing research showing that frailty can be slowed down and improved by a combination of nutritional supplementation and exercise. However, most of the research in this area has been in frail older adults living at home or in nursing homes. The exercise or nutritional programs in these studies tend to be carried out over weeks or months. There are very few studies looking at older adults in hospital and how exercise and nutrition help with frailty over shorter periods of time, even more so in patients who have sustained an injury.\n\nThere is, however, very little research in hospital based frailty programs in older patients who have suffered major trauma. It is well known that standing up and starting to walk soon after a hip fracture improves time to recovery, reduces hospital length of stay and death. Hence, physiotherapy on the first day after hip fracture surgery is now recommended. However, there needs to be more research to aid in developing physiotherapy and exercise programs that are safe and doable in the care of hip fracture patients despite limited resources in our healthcare system.\n\nSimilarly, although malnutrition is common in frail older adults with hip fractures, the benefits of nutritional supplementation in these patients is not fully understood. It is known that having a hip fracture puts a person at risk of muscle breakdown and increasing protein intake is recommended to help reduce this risk. Research on exercise and nutrition based frailty programs specific to hip fracture patients is strongly needed, specifically the development of that are doable and safe in the hospital setting that can help improve outcomes in hip fracture patients after surgery.\n\nThe investigators believe that a multicomponent exercise and nutrition based frailty program will be safe, doable and acceptable in frail older adults after hip fracture surgery.",[741,742,342,743,32,744],"Hip Fractures (ICD-10 72.01-72.2)","Frailty at Older Adults","Resistance Training","Protein Supplementation",[746,140,747,748,749,683],"Hip fracture","Nutrition","Protein supplementation","Strength and resistance training","2025-06-16",{"date":752,"type":43},"2025-06-18",{"date":249,"type":22},{"date":755,"type":22},"2026-02",{"name":757,"class":50},"Royal College of Surgeons, Ireland"]