[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exercise\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exercise":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,142,0,25,[9,48,75,96,121,143,173,201,234,265,292,318,350,379,407,436,459,482,512,541,565,581,604,626,648],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100645413","yoga-vs-stretching-strengthening-physical-fitness-in-sedentary-young-adults-100645413",false,"NCT07680712","Yoga vs. Stretching-Strengthening: Physical Fitness in Sedentary Young Adults","Comparative Effects of Yoga Versus Stretching-Strengthening Exercises on Physical Fitness in Sedentary Young Adults","Inclusion Criteria:\n\n* Being between 18 and 30 years of age,\n* Having a body mass index (BMI) of less than 30 kg\u002Fm²,\n* Being healthy (having no known systemic, neurological, psychological, or orthopedic diseases),\n* Not having participated in regular exercise within the last six months,\n* Having a sedentary lifestyle according to the World Health Organization (WHO) definition (not performing at least 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic activity per week),\n* Agreeing not to participate regularly in any other physical activity or exercise program for the duration of the study,\n* Voluntarily participating in the study and agreeing to sign the written and verbal informed consent form in accordance with the principles of the Declaration of Helsinki.\n\nExclusion Criteria:\n\n* Individuals with a history of injury, surgery, or pain complaints affecting the musculoskeletal system within the last six months,\n* Individuals with neurological, cardiovascular, respiratory, endocrine, psychiatric, or metabolic diseases,\n* Individuals who participate in any regular sporting activity,\n* Female participants who are pregnant or have a suspected pregnancy,\n* Individuals who state that they will not be able to participate regularly in the exercise program or will not be able to complete the study,\n* Individuals who do not provide written and verbal informed consent to participate in the study.",true,"ALL","18 Years","30 Years",{"count":22,"type":23},50,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to learn if yoga or stretching-strengthening exercises are more effective in sedentary young adults who are currently healthy but at risk due to inactivity. The main questions it aims to answer are:\n\nWhich exercise type leads to better improvements in physical fitness, mental well-being, and sleep quality based on a person's starting profile?\n\nHow do initial levels of balance and muscle strength affect how well a person responds to these exercises?\n\nResearchers will compare a yoga group to a stretching-strengthening exercise group to see if one approach is more effective than the other for specific types of individuals.\n\nParticipants will:\n\nBe evaluated for their starting physical fitness (balance and strength) and psychological health.\n\nPerform either yoga or stretching-strengthening exercises regularly during the study period.\n\nComplete surveys about their mood, stress levels, and sleep quality.\n\nBe re-tested at the end of the program to measure changes and improvements.",[29,30],"Sedentary Lifestlye","Exercise",[32,33,34],"physical exercise","physical inactivity","healthy lifestyle","NOT_YET_RECRUITING","2026-06-29",{"date":38,"type":39},"2026-07-02","ACTUAL",{"date":41,"type":23},"2026-06-22",{"date":43,"type":23},"2027-03",{"name":45,"class":46},"Istanbul University - Cerrahpasa","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100645350","effects-of-a-12-week-t10-exercise-program-on-shooting-performance-upper-extremity-function-balance-and-reaction-time-in-competitive-air-pistol-athletes-100645350","NCT07681427","Effects of a 12-week T10 Exercise Program on Shooting Performance, Upper Extremity Function, Balance and Reaction Time in Competitive Air Pistol Athletes","The Effects of a 12-Week T10 Exercise Program on Shooting Performance, Upper Extremity Function, Balance, and Reaction Time in Air Pistol Athletes: A Randomized Controlled Trial","Air pistol T10","Inclusion Criteria:\n\n* Age between 18 and 40 years.\n* Competitive air pistol athletes with at least 2 years of regular shooting experience.\n* Participating in shooting training for at least 6 hours per week.\n* Being in the preseason training period.\n* Willing to participate and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Current upper extremity musculoskeletal injury or pain.\n* History of upper extremity orthopedic surgery.\n* Neurological or cognitive disorders affecting participation.\n* Visual or hearing impairments that may interfere with testing or shooting performance.\n* Inflammatory joint disease involving the lower extremities.\n* History of lower extremity orthopedic surgery or musculoskeletal deformity affecting performance.\n* Rheumatologic, metabolic, or cardiovascular disease.\n* Body mass index (BMI) \\>30 kg\u002Fm².\n* Current use of psychiatric medication.\n* Failure to attend two consecutive intervention sessions during the study period.","40 Years",{"count":58,"type":23},24,[26],"Air pistol shooting requires a high level of postural stability, upper extremity neuromuscular control, and concentration to achieve optimal performance. Prolonged maintenance of the shooting position may lead to shoulder muscle fatigue, reduced joint stability, and impaired shooting accuracy. Although sport-specific exercise programs have been recommended to improve physical performance in shooters, the effectiveness of the T10 exercise program has not yet been investigated in this population. This randomized controlled trial aims to evaluate the effects of a 12-week T10 exercise program, in addition to routine training, on shooting performance in competitive air pistol athletes. Secondary outcomes include upper and lower extremity functional performance, balance, muscular endurance, upper extremity stability, grip strength, medicine ball throw performance, and visual and auditory reaction time. Participants will be randomly allocated to either an intervention group receiving the T10 exercise program plus routine training or a control group continuing routine training alone. Assessments will be performed at baseline and after the 12-week intervention. The findings of this study may provide evidence for the effectiveness of a sport-specific neuromuscular exercise program in enhancing shooting performance and physical function in competitive air pistol athletes.",[62,30],"Physiotherapy and Rehabilitation",[64,65,66],"air pistol","T10 exercise","performance","2026-06-26",{"date":38,"type":39},{"date":70,"type":23},"2026-07-10",{"date":72,"type":23},"2027-12-15",{"name":74,"class":46},"Hacettepe University",{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":81,"targetDuration":4,"studyType":24,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":89,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":47},"100526696","developing-a-nutritional-supplement-to-increase-collagen-synthesis-in-people-100526696","NCT06138106","Developing a Nutritional Supplement to Increase Collagen Synthesis in People","Inclusion Criteria:\n\n* Young healthy adults (18-30 y)\n\nExclusion Criteria:\n\n* Pregnancy\n* Smoking\n* Receiving any medication that may interfere with the study outcomes",{"count":82,"type":23},20,[26],"The purpose of this study is to test whether a natural product supplement can potentiate the increase in collagen synthesis following the ingestion of collagen protein. The investigators have developed a model of natural (GRAS certified) products that stimulate collagen synthesis, in vitro. The investigators will determine whether the natural product supplement can potentiate the collagen synthetic response to the ingestion of collagen protein. Basal and fed serum will be isolated and these samples will be used to treat human engineered ligaments.",[86,87,30],"Dietary Supplements","Connective Tissue","RECRUITING",{"date":36,"type":39},{"date":91,"type":39},"2023-11-21",{"date":93,"type":23},"2026-12-01",{"name":95,"class":46},"University of California, Davis",{"id":97,"slug":98,"hasResults":12,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":12,"sex":103,"minAge":19,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":24,"phases":106,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":47},"100644632","the-effect-of-a-post-operative-exercise-programme-versus-standard-care-on-physical-fitness-of-patients-with-breast-cancer-undergoing-deep-inferior-epigastric-perforator-diep-flap-reconstruction-surgery-100644632","NCT07672392","The Effect of a Post-operative Exercise Programme Versus Standard Care on Physical Fitness of Patients With Breast Cancer Undergoing Deep Inferior Epigastric Perforator (DIEP) Flap Reconstruction Surgery","EXERCISE DIEP","Inclusion Criteria:\n\n1. Women aged 18 years and older\n2. Candidates who have already been selected to undergo mastectomy and reconstruction by the breast MDT for the following indications:\n\n   1. Genetic mutation carriers undergoing risk-reducing mastectomy.\n   2. Ductal carcinoma in situ (DCIS) requiring mastectomy.\n   3. Early invasive breast cancer requiring mastectomy.\n   4. The tumour must not have skin involvement and no evidence of invasive disease within 1cm of skin, nipple or pectoralis major muscle (as proven on MRI).\n3. Candidates for breast reconstruction with DIEP.\n4. Fluent in English\n5. Fit for general anaesthetic Signed informed consent form\n\nExclusion Criteria:\n\n1. Advanced breast cancer with skin involvement.\n2. Undergoing bilateral DIEP reconstruction or other forms of breast reconstruction (e.g., TRAM, implant-based, LD flap).\n3. Pregnancy\n4. Lactation Patients with insufficient English to sign an informed consent (i.e. interpreter required).","FEMALE",{"count":105,"type":23},78,[26],"All patients undergoing mastectomy for breast cancer should be offered the option of reconstructive surgery. The Deep Inferior Epigastric Perforator Flap or DIEP reconstruction as it is commonly referred to, is becoming the favoured reconstruction by both patients and surgeons as it gives a great cosmetic outcome as well as being a good option for patients who may have to undergo radiotherapy treatment after their surgery.\n\nExercise has been demonstrated in previous research to improve tolerance of treatment (particularly chemotherapy), post operative fatigue and the overall quality of life in patients undergoing cancer treatment. Furthermore, it has shown to improve survival in patients who are being treated for breast cancer. The investigators are undertaking this study to investigate whether a structured exercise programme will improve patients fitness after surgery and ultimately improve their recovery after their reconstructive surgery. To do this, half of the people taking part will be undertaking a structured exercise programme and the other half will not and will be assessing which group recover better after their surgery. Currently, no breast reconstruction patients in Ireland are receiving a formal \"exercise prescription\" after their surgery so will be looking to see if this helps people recover better before it is made standard care for every breast patient in Ireland.",[109,30],"Breast Cancer",[111,112,30],"Breast cancer","DIEP Reconstruction","2026-06-23",{"date":67,"type":39},{"date":116,"type":39},"2024-08-01",{"date":118,"type":23},"2028-12-30",{"name":120,"class":46},"Royal College of Surgeons, Ireland",{"id":122,"slug":123,"hasResults":12,"nctId":124,"briefTitle":125,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":24,"phases":131,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":136,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":47},"100644490","methodological-study-of-exercise-and-hypoxic-conditions-in-healthy-subjects-100644490","NCT07671638","Methodological Study of Exercise and Hypoxic Conditions in Healthy Subjects","ExHyp","Inclusion Criteria:\n\n* Healthy male or female volunteers\n* Aged 18-55\n* Body Mass Index \\\u003C30 kg\u002Fm²\n* Participants covered by a social security scheme\n* Participants capable of signing an informed consent form\n* Negative pregnancy test and highly effective contraception for women of childbearing age\n\nExclusion Criteria:\n\n* Cardiorespiratory, metabolic and neurological disorders, or other conditions assessed during the inclusion consultation that may affect physiological responses to exercise or hypoxia\n* Pharmacological treatment taken during the study, other than oral or implantable contraceptive medication for female volunteers of childbearing age","55 Years",{"count":130,"type":23},305,[26],"The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during inhalation of a gas mixtures with various oxygen contents (similar to exposure at high altitude).",[134,30,135],"Healthy Subjects (HS)","Hypoxia",{"date":67,"type":39},{"date":138,"type":23},"2026-06-15",{"date":140,"type":23},"2031-12-31",{"name":142,"class":46},"University Hospital, Grenoble",{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":24,"phases":153,"briefSummary":154,"conditions":155,"keywords":158,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":47},"100643364","evaluation-of-the-effectiveness-of-capacitive-and-resistive-energy-transfer-therapy-for-lateral-epicondylitis-100643364","NCT07634224","Evaluation of the Effectiveness of Capacitive and Resistive Energy Transfer Therapy for Lateral Epicondylitis","Effectiveness of Capacitive and Resistive Energy Transfer Therapy in Patients With Lateral Epicondylitis: A Sham-Controlled, Double-Blind Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients with lateral epicondylitis who have experienced elbow pain for at least 6 weeks and have at least two positive provocative tests (Cozen's, Mill's, or Maudsley's test).\n* Age between 18 and 65 years.\n* Unilateral pain and tenderness over the lateral epicondyle lasting longer than 6 weeks.\n* Clinically diagnosed lateral epicondylitis.\n* No cognitive impairment.\n* Willingness to participate and provide informed consent.\n\nExclusion Criteria:\n\n* History of interventional injection to the affected elbow within the previous 3 months.\n* Receipt of physical therapy for the affected elbow within the previous 3 months.\n* Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) within the previous 2 weeks.\n* History of fracture or surgery involving the affected elbow.\n* Presence of a chronic inflammatory disease.\n* History of malignancy.\n* Active infection.\n* Pregnancy.\n* Presence of a cardiac pacemaker or other electronic implant.\n* Coagulation disorders.\n* Cervical radiculopathy, entrapment neuropathy, or peripheral nerve injury.\n* Body mass index (BMI) ≥ 35 kg\u002Fm².","65 Years",{"count":152,"type":23},62,[26],"This prospective, randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy of Capacitive and Resistive Energy Transfer (TECAR) therapy in patients with lateral epicondylitis. Participants will be randomly assigned to either a TECAR plus exercise group or a sham TECAR plus exercise group.\n\nBoth groups will receive a standardized home exercise program including elbow and wrist range-of-motion, stretching, eccentric strengthening, and handgrip strengthening exercises. The TECAR group will additionally receive active TECAR therapy, while the control group will receive sham TECAR treatment using the same device and treatment protocol without therapeutic energy delivery.\n\nOutcome assessments will be performed by a blinded evaluator at baseline, immediately after treatment, and at 1- and 2-month follow-up visits. The study aims to determine whether TECAR therapy provides additional benefits in pain relief, functional improvement, and clinical outcomes when combined with exercise therapy in patients with lateral epicondylitis.",[156,157,30],"Lateral Epicondylitis","Capacitive and Resistive Electric Transfer Therapy",[159,160,161,162,163],"Lateral epicondylitis","Capacitive and resistive energy transfer therapy (TECAR)","Exercise therapy","Rehabilitation","Randomized controlled trial","2026-06-09",{"date":166,"type":39},"2026-06-11",{"date":168,"type":39},"2026-05-11",{"date":170,"type":23},"2027-05-11",{"name":172,"class":46},"Gaziantep City Hospital",{"id":174,"slug":175,"hasResults":12,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":12,"sex":18,"minAge":180,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":24,"phases":184,"briefSummary":185,"conditions":186,"keywords":189,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":194,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":47},"100642620","active-airways-for-children-and-young-people-with-asthma-100642620","NCT07643753","Active Airways for Children and Young People With Asthma","The Feasibility of an Exercise and Asthma Educational Programme 'Active Airways' on Health Outcomes in Children and Young People With Asthma With All Severities","Inclusion Criteria:\n\nWilling and able to consent to participate in the trial\n\nAble to understand written and spoken English\n\nA diagnosis of Mild to Moderate Asthma or Severe Asthma based on the European Respiratory Society (ERS)\u002F American Thoracic Society (ATS) consensus statement on Severe Asthma\n\nAble to participate in a formal exercise programme\n\nAged 10-17 years\n\nAble to engage in focus groups\n\nApproximately 130cm tall (to be able to complete cardiopulmonary exercise testing (CPET))\n\nExclusion Criteria:\n\nSelf-reported uncontrolled severe exercise-induced breathlessness\n\nRequired a course of antibiotics or oral corticosteroids within the 4 weeks prior to the study commencing\n\nChildren with severe co-morbidities that will not allow them to participate in an exercise programme e.g. Severe neuromuscular disorders, recent fractures or surgeries, cognitive or behavioural conditions.\n\nParticipant is unable or unwilling, in the opinion of the investigator, to give informed consent","10 Years","17 Years",{"count":183,"type":23},60,[26],"What is this study about? The investigators want to see if exercise and education sessions can help children and young people (aged 10-17) with asthma, manage the participants asthma better.\n\nThe investigators will place participants that are recruited to this study into one of three groups by a computer (randomly):\n\nGroup 1:\n\nUsual Care: Continue with normal asthma treatment.\n\nGroup 2:\n\nEducation: Usual care + a 45-minute online asthma education class once a week.\n\nGroup 3:\n\nExercise \\& Education: Usual care + 3 exercise sessions a week and asthma education classes.",[187,30,188],"Asthma Childhood","Children",[190,191,192,193],"asthma","children","exercise","physical activity",{"date":166,"type":39},{"date":196,"type":23},"2026-07",{"date":198,"type":23},"2030-09",{"name":200,"class":46},"University of Leicester",{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":24,"phases":211,"briefSummary":212,"conditions":213,"keywords":219,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":233},"100643238","aconselha--movimento-protocol-for-online-training-on-physical-activity-and-sedentary-behavior-counseling-100643238","NCT07636291","Aconselha + Movimento: Protocol for Online Training on Physical Activity and Sedentary Behavior Counseling","Development, Implementation, and Effectiveness Evaluation of a Training Program for Health Workers on Physical Activity and Sedentary Behavior: Protocol of Aconselha + Movimento","ACONSELHA+","Inclusion Criteria:\n\n* Healthcare professionals working in Primary Health Care Units (UBS) in Florianópolis (SC), Rio Claro (SP), or São José dos Pinhais (PR) during the data collection period\n* Professionals who are actively working in their positions at the time of recruitment\n* Professionals who voluntarily agree to participate and provide informed consent\n\nExclusion Criteria:\n\n* Professionals who are not actively working during the data collection period\n* Professionals who do not provide informed consent\n* Professionals with incomplete baseline assessment data",{"count":210,"type":23},3306,[26],"This study aims to develop, implement, and evaluate the effectiveness of an online training program on physical activity and sedentary behavior counseling for primary health care workers. The training program is designed to improve competencies related to physical activity and sedentary behavior counseling within primary health care settings. Health professionals working in primary health care units from selected municipalities in Brazil will be invited to participate. Outcomes related to counseling competencies and professional practices will be assessed before and after participation in the training program.",[214,30,215,216,217,218],"Counseling","Competence","Motor Activity","Primary Health Care Providers","Primary Health Care",[220,221,30,222,223,224],"counseling","Motor activity","Health Centers","Public Health","Primary health care","2026-06-03",{"date":164,"type":39},{"date":228,"type":39},"2026-03-11",{"date":230,"type":23},"2026-12-15",{"name":232,"class":46},"Universidade Federal do Paraná",3,{"id":235,"slug":236,"hasResults":12,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":12,"sex":18,"minAge":242,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":24,"phases":245,"briefSummary":246,"conditions":247,"keywords":254,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":258,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":47},"100643674","from-exercise-oncology-research-to-clinical-practice-100643674","NCT07635589","From Exercise Oncology Research to Clinical Practice","Bridging the Gap Between Exercise Oncology Research and Its Implementation in Clinical Practice","PAC ICare","Inclusion Criteria:\n\n* Have received a cancer diagnosis (inclusive of primary, recurrent; and\u002For metastatic disease);\n* Over the age of 19 years;\n* Able to participate in mild levels of activity as a minimum;\n* Be pretreatment, or receiving active cancer treatment, or have received cancer treatment within the past six months and are still under active oncology care, or beyond six months if they continue to be under active oncology care;\n* Able to provide informed written consent in English; and\n* Have access to internet service and a device that can support video calling (for online programs).\n\nExclusion Criteria:\n\n* Severe cognitive, physical, psychiatric, or uncontrolled medical condition(s) resulting in an inability to provide consent and\u002For safely participate in the study.","19 Years",{"count":244,"type":23},500,[26],"Building on previous research that shows the benefits of exercise, this study aims to find out how best to implement exercise in real-world settings. The study will assess the feasibility and acceptability of an embedding an automated referral tool and an exercise professional into standard cancer care impacts clinician referral and patient uptake of exercise programming. The study will assess how effective the exercise program is at improving patients' physical health, quality of life, symptom management, and overall wellbeing during different stages of their cancer journey (e.g., before treatment, on treatment, after treatment).",[248,30,249,250,251,252,253],"Cancer","Implementation of Evidence Based Programs","Cost Effectiveness","Rehabilitation Exercise","Prehabilitation","Survivorship",[248,30,255,256,257,250],"Implementation Science","Mixed-Methods","Effectiveness-Implementation",{"date":164,"type":39},{"date":260,"type":23},"2026-09-01",{"date":262,"type":23},"2029-12",{"name":264,"class":46},"Melanie Keats",{"id":266,"slug":267,"hasResults":12,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":17,"sex":18,"minAge":128,"maxAge":273,"enrollmentInfo":274,"targetDuration":276,"studyType":277,"phases":4,"briefSummary":278,"conditions":279,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":47},"100571927","physical-and-cognitive-aging-study-in-older-adults-100571927","NCT06726616","Physical and Cognitive Aging Study in Older Adults","PASOS: Physical and Cognitive Aging Study in Older Adults","PASOS","Inclusion Criteria:\n\n• Hispanic and non-Hispanic adults age 55-85 years, at least 8th grade education, community dwelling.\n\nAdditional Inclusion for Hispanic Americans\n\n* Self-identify as Hispanic American\n* Report Spanish as primary language • No evidence of dementia or mild cognitive impairment based on cognitive screening \\[i.e., Montreal Cognitive Assessment (MoCA) administered during Visit 1; ≥26 among non-Hispanic White, ≥25 among Hispanics, ≥24 among non-Hispanic Blacks (Milani et al., 2018)\\]\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Artificial joint or severe disability that would make it impossible or contraindicated performing the isokinetic test\n* Sensory loss (vision, hearing) or motor deficits that would preclude participation in the experimental tasks or neuropsychological assessment\n* Previous major strokes or other known significant brain abnormalities or diseases affecting the brain and\u002For cognition (e.g., Parkinson disease, multiple sclerosis, seizure disorder, brain surgery, moderate TBI, REM Behavior Sleep Disorder, untreated sleep apnea, etc.)\n* Unstable and uncontrolled medical conditions (metastatic cancer, HIV, moderate-severe kidney disease, uncontrolled diabetes, uncontrolled hypertension, severe cardiac disease, etc.). No current cancer diagnosis.\n* Current or past history of major psychiatric disturbance including schizophrenia, or active psychosis, bipolar disorder, current major depressive episode, current alcohol or substance abuse or history thereof within the past six months\n* Use of antipsychotics, sedatives, or other medications with significant anticholinergic properties (due to potential influence on memory)\n* Use of prescribed 'memory enhancing' medications, such as Aricept or Namenda\n* Previous participation in a cognitive or physical activity training study within the last 6 months or current involvement in another study involving cognitive, physical or other intervention at the time of enrollment","85 Years",{"count":275,"type":23},100,"12 Months","OBSERVATIONAL","Hispanic Americans are the fastest growing older adult group in the United States, disproportionally increasing the risk of an Alzheimer's disease and related dementias diagnosis. Efforts to reduce this risk and mitigate the related cognitive\u002Fphysical declines are critical. The aim of this study is to assess the feasibility of enrolling older adults into an aging trajectory cohort, while generating preliminary data on associations of physical and cognitive aging trajectories. Our secondary objective is to generate preliminary data on the association of standard measures of physical activity and physical function with cognitive status. This study fits within our longitudinal research goal to reduce dementia incidence by understanding the mechanisms that drive the cognitive-physical aging trajectory.",[280,281,282,283,30],"Older Adults (65 Years and Older)","Hispanic Americans","Cognitive Aging","Aging, Healthy",{"date":285,"type":39},"2026-06-04",{"date":287,"type":39},"2025-03-19",{"date":289,"type":23},"2027-09-20",{"name":291,"class":46},"University of Florida",{"id":293,"slug":294,"hasResults":12,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":4,"eligibilityCriteria":298,"healthyVolunteers":12,"sex":103,"minAge":19,"maxAge":4,"enrollmentInfo":299,"targetDuration":4,"studyType":24,"phases":301,"briefSummary":302,"conditions":303,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":47},"100467293","prehabilitation-for-ovarian-cancer-patients-100467293","NCT05364879","Prehabilitation for Ovarian Cancer Patients","The Impact of Prehabilitation Exercise on Frailty and Treatment Outcomes in Ovarian Cancer Patients","Inclusion Criteria:\n\n* 18 years or older\n* Have a confirmed diagnosis of stage III or IV ovarian cancer\n* Scheduled to receive cytoreductive surgery as part of their treatment plan\n* Must have a minimum of 4-weeks between the time of study enrollment and scheduled surgery\n* Be able to attend in-person and\u002For virtual exercise sessions\n* Be fluent in English\n* Have oncologist approval\n\nExclusion Criteria:\n\n* Have already completed surgery\n* Unstable cardiac or respiratory disease, injury or any other co-morbid disease that may make it unsafe for participants to exercise\n* Significant cognitive impairment (e.g., do not have the capacity to consent, unable to follow exercise instructions)",{"count":300,"type":23},108,[26],"Individuals with ovarian cancer have very poor survival rates. This is because the cancer is not usually detected until it has reached advanced stages. How long an individual survives also is determined by the cancer treatment they receive. Although there are best treatment practices to improve survival, some women have other conditions that limit treatment options. One such condition seen in as many as 50% of women with advanced ovarian cancer is frailty (an age-related decline in function and health). This is a major concern as doctors will often have to change how the cancer is treated based on the patient being frail. For example, patients living with frailty are less likely to have their full tumor removed during surgery. They are also more likely to have complications with surgery, stay in the hospital longer, and recover less well from surgery overall. Patients living with frailty also are more likely to experience delays in their chemotherapy starting, receive lower doses of chemotherapy and\u002For receive fewer cycles of chemotherapy. These changes in treatment may decrease how long a patient survives after diagnosis. Thus, research is needed to explore strategies to decrease frailty in patients who require treatment for advanced ovarian cancer. An option gaining more attention is physical exercise (e.g. walking, repeatedly rising from a chair). Exercise performed before surgery, which is called prehabilitation, can improve how well a patient recovers after surgery and increase how long they survive. Research has shown that prehabilitation is very beneficial for patients undergoing surgery for heart disease. However, it is not clear whether prehabilitation works for those with advanced ovarian cancer that are going to have surgery. Therefore, the investigators want to explore how a 4+ week exercise program performed while waiting for surgery for advanced ovarian cancer changes frailty and how a patient recovers after surgery. The investigators will specifically look whether the exercise program: 1) reduces how frail a patient is before surgery; 2) improves how well the patient recovers after surgery; and 3) affects the patient's chemotherapy treatment plan. This study will provide important information about the ability of prehabilitation exercise to improve surgical and treatment outcomes in women with advanced ovarian cancer. Overall, it is believed that exercise has the potential to improve the survival of advanced ovarian cancer patients.",[252,30,304,305,306,307,308],"Frailty","Ovarian Cancer","Surgical Complication","Treatment Outcomes","Enhanced Recovery After Surgery","2026-05-28",{"date":311,"type":39},"2026-06-01",{"date":313,"type":39},"2023-01-03",{"date":315,"type":23},"2027-08-31",{"name":317,"class":46},"Nova Scotia Health Authority",{"id":319,"slug":320,"hasResults":12,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":17,"sex":18,"minAge":325,"maxAge":4,"enrollmentInfo":326,"targetDuration":4,"studyType":24,"phases":327,"briefSummary":328,"conditions":329,"keywords":332,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":47},"100638005","energy-cost-and-metabolic-intensity-of-pilates-exercises-in-older-adults-100638005","NCT07621523","Energy Cost and Metabolic Intensity of Pilates Exercises in Older Adults","Energetic Cost and Metabolic Intensity of Pilates Exercises in Older Adults: A Randomized Crossover Study","Inclusion Criteria:\n\n* Age 60 years or older;\n* Body mass index (BMI) between 22 and 27 kg\u002Fm²;\n* Not currently undergoing dietary treatment or program for weight gain or loss;\n* No severe musculoskeletal disorders (e.g., osteoarthritis grade III or IV, moderate-to-severe pain ≥ 4 on the NRS 0-10 scale) or neurological conditions (e.g., Parkinson's disease, Alzheimer's disease, multiple sclerosis);\n* Continuously practicing Pilates for at least 6 months prior to enrollment, with a minimum frequency of twice per week.\n\nExclusion Criteria:\n\n* Chronic decompensated conditions that may pose health risks during exercise (e.g., uncontrolled hypertension, bronchitis, asthma);\n* Any history of cardiovascular events (e.g., coronary artery disease, stroke, heart failure, arrhythmias, valvular heart disease);\n* Decompensated metabolic diseases or use of medications with recognized direct impact on energy and glycemic metabolism, including antidiabetics and systemic corticosteroids;\n* Positive response to any item on the Physical Activity Readiness Questionnaire (PAR-Q).","60 Years",{"count":82,"type":23},[26],"Pilates is one of the most popular forms of exercise among older adults worldwide. However, no study has measured how many calories a Pilates session burns or how hard the body works during it in people aged 60 and over. This information is important for exercise professionals who prescribe Pilates for health promotion goals such as weight management and cardiovascular fitness.\n\nThis study will measure the energy cost and metabolic intensity of two types of Pilates - mat Pilates and equipment-based Pilates - in older adults using a portable indirect calorimetry system (Cosmed K5). Results will be compared to treadmill walking at 4.8 km\u002Fh, a well-established moderate-intensity activity.\n\nTwenty men and women aged 60 years or older with at least 6 months of continuous Pilates experience will complete three exercise sessions in a randomized order: (1) mat Pilates, (2) equipment-based Pilates, and (3) treadmill walking. Each Pilates session will consist of 9 exercises, with stretching exercises used as warm-up and cool-down and 7 strengthening exercises performed in the main portion of the session (\\~50 min). Oxygen consumption, energy expenditure, heart rate, and perceived exertion will be measured throughout each session.",[330,30,331],"Energy Metabolism","Aging",[333,334,335,336,337,338,339,340],"Pilates","Energy expenditure","Metabolic equivalents","Indirect calorimetry","Older adults","Exercise intensity","Treadmill walking","Crossover study","2026-05-27",{"date":343,"type":39},"2026-06-02",{"date":345,"type":23},"2026-06",{"date":347,"type":23},"2026-12",{"name":349,"class":46},"Universidade Estadual do Norte do Parana",{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":357,"targetDuration":4,"studyType":24,"phases":359,"briefSummary":360,"conditions":361,"keywords":364,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":377,"locationsCount":47},"100637074","home-based-exercise-programs-for-fall-prevention-in-parkinson-disease-100637074","NCT07590700","Home-Based Exercise Programs for Fall Prevention in Parkinson Disease","Effectiveness of Fall-Preventive Home Exercise Programs in Patients With Parkinson Disease: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of Parkinson disease confirmed by a neurologist\n* Hoehn and Yahr stage 3 or 4 Parkinson disease\n* Diagnosis of Parkinson disease for at least 5 years\n* Willingness to participate in the study and provide written informed consent\n* Ability to walk independently or with minimal assistance\n* Mini-Mental State Examination score \\>24\n\nExclusion Criteria:\n\n* Balance or gait impairment due to causes other than Parkinson disease, such as severe orthopedic problems or another neurological disease\n* Red flags suggestive of Parkinson-plus syndromes, such as symmetric onset, early falls, early-onset dementia, or gaze palsy\n* History of serious fall-related injury or surgery within the last 6 months\n* Any additional health condition that would prevent participation in the exercise program during the study period",{"count":358,"type":23},30,[26],"Falls are common in patients with Parkinson disease and may lead to reduced mobility, fear of falling, loss of independence, and injury. Exercise-based rehabilitation programs may help improve balance, gait, and physical performance in this population.\n\nThis randomized controlled trial aims to compare the effectiveness of two home-based exercise programs in patients with Parkinson disease: the Otago Exercise Program and a structured home exercise program. Participants will be randomly assigned to one of two groups. Both groups will receive exercise education and will perform their assigned home exercise program for 6 weeks.\n\nParticipants will be evaluated at baseline, at week 3, and at the end of week 6. The study will assess fall-related outcomes, freezing of gait, functional mobility, gait parameters, postural control, and physical performance. The results may help determine which home-based exercise approach is more effective for reducing fall risk and improving functional outcomes in patients with Parkinson disease.",[362,363,30],"PARKINSON DISEASE (Disorder)","Falls Prevention",[365,366,367,368,369],"parkinson disease","fall prevention","Otago","Home-based","Execise","2026-05-15",{"date":372,"type":39},"2026-05-19",{"date":374,"type":39},"2026-02-08",{"date":376,"type":23},"2026-08",{"name":378,"class":46},"Uludag University",{"id":380,"slug":381,"hasResults":12,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":4,"eligibilityCriteria":385,"healthyVolunteers":12,"sex":18,"minAge":325,"maxAge":4,"enrollmentInfo":386,"targetDuration":4,"studyType":24,"phases":388,"briefSummary":389,"conditions":390,"keywords":393,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":47},"100588956","creatine-and-resistance-training-in-older-adults-with-mild-cognitive-impairment-100588956","NCT06948149","Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment","Examining the Effects of Creatine Supplementation and Resistance Training on Cognition and Brain Health in Older Adults With Mild Cognitive Impairment: a 26 Week Randomized Controlled Trial","To be eligible to participate in this study participants must:\n\n1. be 60 years of age or older,\n2. live independently in the community,\n3. have normal or corrected-to-normal vision and hearing,\n4. read, write, and speak English fluently,\n5. be right-handed,\n6. have subjective feelings of memory decline in the past 5 years,\n7. have MoCA scores 19-25\u002F30 (assessed at baseline session),\n8. be able to exercise at a moderate pace using resistance training for 60 minutes 3x\u002Fweek,\n9. receive clearance from a physician to participate in an exercise program, and 10) receive confirmation from a physician that they meet all criteria to be included in this study.\n\nParticipants are ineligible if they:\n\n1. cannot partake or commit to exercise training 3x\u002Fweek for 26 weeks or have regularly (\\>1x\u002Fweek) engaged in exercise training over the past 3 months;\n2. cannot partake or commit to consuming a daily supplement for 26 weeks or consumed nutritional supplements containing creatine monohydrate over the past 3 months;\n3. have a known allergy to creatine monohydrate or dextrose;\n4. have been diagnosed with a neurological disorder (e.g., Alzheimer's disease, Parkinson's disease);\n5. have pre-existing kidney disease, heart disease, or liver abnormalities;\n6. have one or more uncontrolled chronic or psychiatric conditions (e.g., hypertension, diabetes, depression, anxiety);\n7. are taking medication that may impact kidney function (e.g., non-steroidal anti-inflammatory drugs, such as ibuprofen and naproxen); or\n8. are ineligible or uncomfortable with MRI (have metal or electronic implants, claustrophobia) or blood sampling.",{"count":387,"type":23},200,[26],"The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function in older adults with mild cognitive impairment. Previous studies have shown that resistance training improves cognition and brain health in older adults. Creatine is naturally occurring in the human body and is known to decline with age. Studies have shown that creatine increases muscle mass and bone density in older adults when supplemented. Some research has suggested that creatine may also improve cognition and brain health. However, little is known about how creatine supplementation affects the aging brain and body alone and when combined with resistance training, especially in those with known cognitive impairment.\n\nIn this study, participants will be randomly assigned to one of four groups: 1) creatine and resistance training, 2) placebo and resistance training, 3) creatine and active control (balance and tone classes), or 4) placebo and active control. Participants in the creatine groups will take creatine every day during the study. Participants in the placebo groups will take a look-alike substance that contains no drug every day during the study. Participants in the resistance training groups will attend three 60-minute classes per week that target each major muscle group and will increase in difficulty during the study. Participants in the active control group will attend three 60-minute classes per week that will consist of balance, stretching, and range of motion exercises. This group accounts for variables such as physical training received by traveling to the training centres, social interaction, and changes in lifestyle secondary to study participation.\n\nResearchers will collect information before and after the 26 weeks to see if creatine supplementation and\u002For resistance training have any effects on cognition, brain health, and\u002For physical function. The investigators suspect that both creatine supplementation and resistance training will improve cognition, brain health, and physical function alone. However, it is thought that the combination of creatine supplementation and resistance training will improve cognition, brain health, and physical function more.",[391,30,392],"Creatine","Mild Cognitive Impairment (MCI)",[394,193,395,396,397,398],"older adults","cognition","neuroimaging","mobility","Mild Cognitive Impairment","2026-05-14",{"date":372,"type":39},{"date":402,"type":39},"2026-01-01",{"date":404,"type":23},"2027-12",{"name":406,"class":46},"Western University, Canada",{"id":408,"slug":409,"hasResults":12,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":413,"eligibilityCriteria":414,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":415,"targetDuration":4,"studyType":24,"phases":417,"briefSummary":418,"conditions":419,"keywords":423,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":47},"100636501","high-energy-laser-in-the-conservative-treatment-of-rhizarthrosis-100636501","NCT07566507","High-Energy Laser in the Conservative Treatment of Rhizarthrosis","High Intensity Laser Therapy (HL) vs Exercise in Thumb Osteoarthritis","HLEX-TO","Inclusion Criteria:\n\n* arthrosis of the trapezoid-metacarpal with stage 1 or 2 of the Eaton-Littler radiographic classification and pain (recent radiograph within 6 months previously);\n* clinical picture that has been occurring for at least 6 months;\n* pain scored with VAS scale at least 4\u002F10.\n\nExclusion Criteria:\n\n* rheumatoid arthritis or outcomes of trauma in the affected area, contra-indications to treatment with laser therapy (neoplasia, pregnancy, thrombocytopenia, epilepsy, uncompensated heart disease or arrhythmia, pacemaker, local infections),\n* corticosteroid infiltration or physical therapy in the previous 4 weeks.",{"count":416,"type":23},42,[26],"Osteoarthritis (OA) is a degenerative joint disease that can affect the hands and is particularly debilitating when it involves the trapeziometacarpal joint (rhizarthrosis). It causes pain, deformity, limited movement and strength, joint instability, resulting in significant limitations in daily activities.Many conservative treatments, such as medications, therapeutic exercises, physical therapy, and orthoses, are effective for managing hand OA. For patients who do not respond to conservative treatments, surgical intervention will be necessary.",[420,421,422,30],"Thumb Osteoarthritis","Hand Injuries","Laser",[424,425,426,427,192],"hand","rehabilitation","conservative","lasertherapy","2026-05-13",{"date":370,"type":39},{"date":431,"type":39},"2025-11-01",{"date":433,"type":23},"2028-12-01",{"name":435,"class":46},"Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari",{"id":437,"slug":438,"hasResults":12,"nctId":439,"briefTitle":440,"officialTitle":441,"acronym":4,"eligibilityCriteria":442,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":56,"enrollmentInfo":443,"targetDuration":4,"studyType":24,"phases":444,"briefSummary":445,"conditions":446,"keywords":447,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":452,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":47},"100615839","sex-differences-in-cold-induced-changes-in-maximal-fat-oxidation-100615839","NCT07297823","Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation","Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation: A Pilot Study","Inclusion Criteria:\n\n* Age 18-40 years (inclusive)\n* Weight stable (no change in body mass greater than 5 lbs. within the previous 6 months.\n* Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits\n* Competency in English as informally assessed by comprehension of the Informed Consent. This study involves maximal exercise testing; for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.\n* Regular exercise (i.e., at least 150 minutes of moderate-vigorous exercise per week)\n\nExclusion Criteria:\n\n* Use of hormonal contraceptives\n* History of autonomic, cardio-pulmonary, and\u002For metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and\u002For diabetes)\n* Pregnancy or breast feeding\n* Habitual use of tobacco\u002Fnicotine products or recreational drugs (2 or more uses within the previous month)",{"count":82,"type":23},[26],"The purpose of this research study is to determine if the cold-induced change in fat burning during exercise is different between females and males.",[30],[192,448,449,450,451],"fat","temperature","cold","metabolism",{"date":370,"type":39},{"date":454,"type":39},"2026-04-15",{"date":456,"type":23},"2027-06-30",{"name":458,"class":46},"Colorado State University",{"id":460,"slug":461,"hasResults":12,"nctId":462,"briefTitle":463,"officialTitle":463,"acronym":4,"eligibilityCriteria":464,"healthyVolunteers":17,"sex":18,"minAge":150,"maxAge":4,"enrollmentInfo":465,"targetDuration":4,"studyType":24,"phases":467,"briefSummary":468,"conditions":469,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":474,"lastUpdatePostDateStruct":475,"startDateStruct":476,"completionDateStruct":478,"leadSponsor":480,"locationsCount":47},"100640256","development-of-a-chatbot-supported-personalized-exercise-program-for-older-adults-and-evaluation-of-its-effects-on-cognitive-functions-100640256","NCT07596082","Development of a Chatbot-supported Personalized Exercise Program for Older Adults and Evaluation of Its Effects on Cognitive Functions","Inclusion Criteria:\n\n* Aged 65 years and older\n* Normal or mildly impaired cognitive status\n* Medical condition that does not prevent participation in physical activity\n* Ability to use a smartphone or tablet (for chatbot access)\n* Voluntary participation\n\nExclusion Criteria:\n\n* Moderate to severe dementia\n* Severe depression or serious psychiatric disorders\n* Acute cardiovascular risk\n* Communication difficulties due to significant hearing or visual impairment\n* Regular engagement in structured exercise within the past 6 months (participants in the maintenance phase of exercise behavior)",{"count":466,"type":23},90,[26],"The purpose of this study is to develop an artificial intelligence-based chatbot application to support exercise behavior in individuals aged 60 and over who do not regularly exercise, and to evaluate its effectiveness. In addition, the study aims to examine the effects of changes in exercise habits on the cognitive (mental) functions of older adults.\n\nIn this study, the impact of a chatbot-supported personalized exercise program on cognitive functions in older individuals will be evaluated. A total of 90 participants is planned for inclusion in this study.\n\nIf you agree to participate in this study, depending on the group you are assigned to, you may receive:\n\n* An artificial intelligence-based chatbot program, along with educational materials about the importance of exercise, or\n* Only educational materials (brochures) prepared by the researchers about the importance of exercise.\n\nAt the beginning of the study, you will be asked to complete a data collection form. The same form will also be administered at week 12 and week 24.\n\nThis form will include:\n\n* Basic information such as your age and gender,\n* Questions about your exercise habits,\n* A brief test to assess your cognitive (mental) functions,\n* Questions evaluating your level of physical activity. The study duration is 24 weeks, including 12 weeks of intervention and 12 weeks of follow-up.",[470,30,471,472,473],"Aged","Cognition","Artificial Intelligence (AI)","Health Behavior","2026-05-12",{"date":372,"type":39},{"date":477,"type":23},"2026-08-01",{"date":479,"type":23},"2026-10-30",{"name":481,"class":46},"Dokuz Eylul University",{"id":483,"slug":484,"hasResults":12,"nctId":485,"briefTitle":486,"officialTitle":487,"acronym":4,"eligibilityCriteria":488,"healthyVolunteers":12,"sex":489,"minAge":490,"maxAge":4,"enrollmentInfo":491,"targetDuration":4,"studyType":24,"phases":492,"briefSummary":494,"conditions":495,"keywords":502,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":474,"lastUpdatePostDateStruct":506,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":511,"locationsCount":47},"100538429","phase-2-vasodilator-and-exercise-study-for-dmd-vaso-rex-100538429","NCT06290713","Vasodilator and Exercise Study for DMD (VASO-REx)","Vasodilators and Exercise as Adjuvant Therapy for Duchenne Muscular Dystrophy (VASO-REx Study)","Inclusion Criteria:\n\n* Diagnosis of DMD confirmed by genetic report\n* Minimum entry age of 6.0 years old\n* Ambulatory\n* On stable glucocorticoid regimen (for \\> 3 months)\n\nExclusion Criteria:\n\n* Contraindication to a Magnetic resonance Imaging examination (e.g. severe claustrophobia, magnetic implants, unable\u002Funwilling to perform test)\n* Presence of unstable medical problems, including severe cardiomyopathy, left ventricular ejection fraction \\\u003C45%, cardiac conduction abnormalities as evidenced on ECG, uncontrolled seizure disorder, uncontrolled hypo or hypertension\n* Presence of a secondary condition that impacts muscle function or muscle metabolism (e.g., myasthenia gravis, endocrine disorder, mitochondrial disease)\n* Presence of a secondary condition leading to developmental delay or impaired motor control (e.g., cerebral palsy) or previous history of unprovoked rhabdomyolysis\n* Contraindications to phosphodiesterase 5 inhibitors (use of nitrates, alpha-adrenergic blockers, other phosphodiesterase 5 inhibitors) or other medications known to modulate blood flow or muscle metabolism\n* Participation in currently approved FDA trials or other investigational clinical trials during the period of the study","MALE","6 Years",{"count":22,"type":23},[493],"PHASE2","Examining two strategies as potential adjuvant therapies for Duchenne muscular dystrophy (DMD); aerobic exercise training (to induce adaptations in skeletal muscle and improve cardiovascular health) and tadalafil, an FDA-approved vasodilator (to optimize blood flow and muscle perfusion which is impaired and often overlooked in DMD). Target: improved muscle function, vascular health, and DMD treatment.",[496,497,498,499,500,30,501],"Duchenne Muscular Dystrophy","Duchenne Disease","Muscular Dystrophy","Muscular Dystrophy in Children","Vasodilation","DMD",[501,503,504,505],"Tadalafil","Drug and Exercise Intervention","Treatment Strategy",{"date":370,"type":39},{"date":508,"type":39},"2024-06-05",{"date":510,"type":23},"2026-11",{"name":291,"class":46},{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":517,"acronym":518,"eligibilityCriteria":519,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":520,"targetDuration":4,"studyType":24,"phases":521,"briefSummary":522,"conditions":523,"keywords":528,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":533,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":539,"locationsCount":47},"100640872","right-ventricular-response-to-exercise-among-patients-with-chronic-obstructive-pulmonary-disease-100640872","NCT07576894","Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease","Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease","ReV UP COPD","Inclusion Criteria:\n\n* COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \\[FEV1\u002FFVC\\] \\\u003C0.7)\n* Age \\>= 40 years\n\nExclusion Criteria:\n\n* Exacerbation of COPD in the 3 months prior to enrollment\n* Change in COPD therapy in the 3 weeks prior to enrollment\n* Requirement of \\>6 LPM supplemental oxygen at rest\n* Requirement of \\>10 LPM supplemental oxygen with exertion\n* Active\u002Funcontrolled cardiovascular disease (e.g. hypertension with blood pressure \\>150\u002F100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; uncontrolled arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)\n* Volume overload (jugular vascular distension or greater than trace peripheral edema)\n* World Health Organization Functional Class IV\n* Known pulmonary hypertension with mean pulmonary artery pressure \\>45 mmHg\n* Untreated severe obstructive sleep apnea and\u002For obesity hypoventilation syndrome\n* Active malignancy (other than skin)\n* Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance\u002Fgait instability, etc.)\n* Pregnancy\n* Body mass index \\\u003C18 or \\>35\n* Hematocrit \\\u003C25% or \\>55%\n* For subset undergoing right heart catheterization, chronic anticoagulation that is unable to be held for the study visit\n* For subset undergoing right heart catheterization or exercise training, forced expiratory volume in 1 second of \\\u003C20%\n* For exercise training, already engaged in routine exercise training (\\>30 minutes at \\>3 METs 3 times\u002Fweek or more)\n* For exercise training, inability to complete initial in-person exercise training sessions for approximately 35 minutes 3x\u002Fweek for 3 weeks (followed by exercise training sessions with an option for hybrid remote\u002Fin-person participation)\n* For exercise training with an option for hybrid remote exercise training, any medical conditions which threaten the safety of remote exercise training (e.g. imbalance\u002Fgait instability, etc.).",{"count":183,"type":23},[26],"This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.",[524,525,30,526,527],"COPD","Pulmonary Hypertension","Right Ventricular (RV) Dysfunction","Exercise Training",[524,529,30,530,531],"Pulmonary hypertension","Pulmonary rehabilitation","Exercise training","2026-05-04",{"date":534,"type":39},"2026-05-08",{"date":536,"type":39},"2025-08-01",{"date":538,"type":23},"2030-08-01",{"name":540,"class":46},"University of Colorado, Denver",{"id":542,"slug":543,"hasResults":12,"nctId":544,"briefTitle":545,"officialTitle":545,"acronym":4,"eligibilityCriteria":546,"healthyVolunteers":12,"sex":103,"minAge":547,"maxAge":548,"enrollmentInfo":549,"targetDuration":4,"studyType":24,"phases":551,"briefSummary":552,"conditions":553,"keywords":556,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":560,"startDateStruct":561,"completionDateStruct":562,"leadSponsor":563,"locationsCount":47},"100622672","impact-of-circadian-exercise-on-metabolic-dysfunction-associated-steatotic-liver-disease-in-postmenopausal-women-100622672","NCT07386665","Impact of Circadian Exercise on Metabolic Dysfunction-Associated Steatotic Liver Disease in Postmenopausal Women","Inclusion Criteria:\n\n* Women aged 45-75 years, postmenopausal for at least two years (stage +1a)\n* Body Mass Index (BMI) \\> 25 and \\\u003C 40 kg\u002Fm²\n* Diagnosed hepatic steatosis (via ultrasound hyperechogenicity, FibroScan CAP score \\>280, or histological confirmation)\n* Sedentary lifestyle (no regular structured exercise)\n* Willingness to be randomized and adhere to study procedures, including all assessments and visits\n* Sufficient Spanish proficiency to understand and follow study instructions\n* Consent to store biological samples for future research\n* Participants should have a healthy circadian rhythm\n\nExclusion Criteria:\n\n* Contraindications for MRI (e.g., claustrophobia, pacemaker, metal implants)\n* History of major cardiovascular, endocrine, neurological, or kidney disease, or any clinical abnormalities (to be judged by the study physician)\n* First-degree family history of sudden cardiac death\n* Alcohol or substance abuse\n* Psychiatric, psychotic, eating, or sleep disorders (to be judged by the study physician)\n* Prior bariatric surgery, diagnosed HIV\u002FAIDS, or inflammatory\u002Fautoimmune diseases\n* Cancer or any medical condition where exercise is contraindicated (to be judged by the study physician)\n* Recent or unstable metabolic conditions (e.g., diabetes, recent medication changes, or use of drugs affecting metabolism)\n* Recent (\\\u003C3 months) use of antibiotics, statins, glucocorticoids, hormonal therapies, amiodarone, or myelosuppressive agents\n* Participation in weight-loss programs or special diets (e.g., ketogenic, high-carb)\n* Shift workers or caregivers with frequent nocturnal disruptions","45 Years","75 Years",{"count":550,"type":23},63,[26],"Type of Study: Clinical Trial\n\nGoal: The goal of this clinical trial is to investigate how performing exercise at different times of day (morning vs. evening) affects liver fat, cardiometabolic health, and gut microbiota in postmenopausal women.\n\nParticipant Population\u002FHealth Conditions: The study will involve 63 sedentary postmenopausal women (aged 45-75) diagnosed with metabolic dysfunction-associated steatotic liver disease.\n\nMain Questions: The main questions this study aims to answer are:\n\n* Does morning exercise reduce hepatic fat more effectively than evening exercise?\n* How does time-of-day-specific exercise influence cardiometabolic markers?\n* Do changes in gut microbiota contribute to the metabolic effects of exercise timing?\n\nParticipants Will:\n\nBe randomized into one of three groups: morning exercise, evening exercise, or a usual-care control group.\n\nFollow the assigned regimen for 12 weeks. The exercise groups will perform supervised aerobic and resistance training three times per week.\n\nProvide blood, stool, and imaging data before and after the intervention to determine the effects of the intervention.\n\nComparison Group:\n\nResearchers will compare the effects of morning vs. evening exercise (and usual care) on hepatic fat reduction and cardiometabolic improvement, as well as changes in gut microbiota.",[554,555,30],"Metabolic Dysfunction-Associated Steatotic Liver Disease","Cardiometabolic Diseases",[30,557,558,559],"Metabolism","Health","Women",{"date":534,"type":39},{"date":311,"type":23},{"date":404,"type":23},{"name":564,"class":46},"Universidad de Almeria",{"id":566,"slug":567,"hasResults":12,"nctId":568,"briefTitle":517,"officialTitle":517,"acronym":4,"eligibilityCriteria":569,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":570,"targetDuration":4,"studyType":24,"phases":571,"briefSummary":572,"conditions":573,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":575,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":580,"locationsCount":47},"100508144","phenotyping-resting-and-exertional-right-ventricular-dysfunction-among-patients-with-chronic-obstructive-pulmonary-disease-100508144","NCT05896579","Inclusion Criteria:\n\n* COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \\[FEV1\u002FFVC\\] \\\u003C0.7)\n* Age \\>= 40 years\n\nExclusion Criteria:\n\n* Exacerbation of COPD in the 3 months prior to enrollment\n* Change in COPD therapy in the 3 weeks prior to enrollment\n* Requirement of \\>6 LPM supplemental oxygen at rest\n* Requirement of \\>10 LPM supplemental oxygen with exertion\n* Active\u002Funcontrolled cardiovascular disease (e.g. hypertension with blood pressure \\>150\u002F100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)\n* Volume overload (jugular vascular distension or greater than trace peripheral edema)\n* World Health Organization Functional Class IV\n* Known pulmonary hypertension with mean pulmonary artery pressure \\>45 mmHg\n* Untreated severe obstructive sleep apnea or obesity hypoventilation syndrome\n* Active malignancy (other than skin)\n* Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance\u002Fgait instability, etc.)\n* Pregnancy\n* Body mass index \\\u003C18 or \\>40\n* Hematocrit \\\u003C25% or \\>55%\n* For invasive CPET, chronic anticoagulation that is unable to be held for the study visit\n* For invasive CPET, forced expiratory volume in 1 second of \\\u003C20%",{"count":183,"type":23},[26],"This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.",[524,525,574,30,527],"Right Ventricular Dysfunction",{"date":534,"type":39},{"date":577,"type":39},"2023-08-22",{"date":579,"type":23},"2030-08",{"name":540,"class":46},{"id":582,"slug":583,"hasResults":12,"nctId":584,"briefTitle":585,"officialTitle":585,"acronym":586,"eligibilityCriteria":587,"healthyVolunteers":17,"sex":18,"minAge":325,"maxAge":588,"enrollmentInfo":589,"targetDuration":4,"studyType":24,"phases":591,"briefSummary":592,"conditions":593,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":598,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":47},"100442999","effect-of-hypoxic-conditioning-on-cerebrovascular-health-in-the-elderly-100442999","NCT05048680","Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly","HYPOXAGE","Inclusion Criteria:\n\n* 60 to 80 years of age;\n* Being physically inactive (less than 150 min\u002Fweek of moderate to intense physical activity);\n* No chronic cardiovascular, respiratory, metabolic or neuromuscular disease counterindicating an exercise training or hypoxic conditioning program;\n* Health coverage;\n* Being able to provide written fully informed consent.\n\nExclusion Criteria:\n\n* Body-mass index \\>30 kg\u002Fm2;\n* Smoking (\\> cigarettes\u002Fday);\n* Alcohol use (\\> 10g\u002Fday);\n* Mental disorder or history of mental disorder;\n* Beta-blockade treatment;\n* Inability or refusal to provide informed consent;\n* No health coverage\n* People exceeding the annual ceiling of allowances received as a result of their participation in other clinical trials;\n* People deprived of freedom by judicial or administrative decision;\n* People subject to legal protection, who cannot be included in clinical trials.","80 Years",{"count":590,"type":23},64,[26],"In line with the ever-growing aging of Western populations, the development of preventive strategies to slow down the effects of aging on cardiovascular health represents a major challenge in order to preserve functional capacities and a sufficient quality of life in the elderly. The alteration of vascular function (at the cerebral and systemic level) with aging is an important feature in the clinical picture including a decrease in physical and cognitive capacities. Although physical activity is recognized as an essential means of combating the effects of aging, optimizing its effects by defining the most effective strategies of practice remains a key objective. Offering alternative interventions to exercise training is also necessary for people who are unwilling or unable to engage in a physical activity program. In this context, hypoxic conditioning, alone or in conjunction with rehabilitative exercise training, is a new therapeutic modality with strong preclinical validity, in particular from a cardiovascular standpoint, and used in other pathologies to improve cardiovascular function and exercise performance and quality of life. Our aim is, therefore, to investigate the effect of hypoxic conditioning (alone or in conjunction with exercise training) on cerebrovascular health in the elderly.",[135,594,595,30,331,596,597],"Cerebral Hypoxia","Brain Diseases","Cognitive Decline","Healthy Aging",{"date":534,"type":39},{"date":600,"type":39},"2021-10-13",{"date":602,"type":23},"2026-09",{"name":142,"class":46},{"id":605,"slug":606,"hasResults":12,"nctId":607,"briefTitle":608,"officialTitle":609,"acronym":610,"eligibilityCriteria":611,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":150,"enrollmentInfo":612,"targetDuration":4,"studyType":24,"phases":613,"briefSummary":614,"conditions":615,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":619,"lastUpdatePostDateStruct":620,"startDateStruct":622,"completionDateStruct":624,"leadSponsor":625,"locationsCount":47},"100598130","whole-body-vibration-and-balneotherapy-in-chronic-low-back-pain-100598130","NCT07067489","Whole-Body Vibration and Balneotherapy in Chronic Low Back Pain","The Effect of Whole-Body Vibration Exercises Combined With Balneotherapy on Pain, Function, and Sleep Quality in Patients With Chronic Low Back Pain","Whole-Body Vib","Inclusion Criteria:\n\n* Voluntary consent to participate in the study\n* Age between 18 and 65 years\n* Having chronic low back pain lasting at least 3 months or recurring at least 3 times per week\n* Diagnosis of chronic low back pain by a physical medicine and rehabilitation specialist\n* Normal neurological examination findings (no abnormal lower extremity reflexes or anesthesia)\n\nExclusion Criteria:\n\n* Presence of radicular pain or radiculopathy\n* Spondylolisthesis, spinal stenosis, vertebral infection, or cauda equina syndrome\n* Vertebral fracture, axial spondyloarthritis\n* History of lumbar spine surgery\n* Inflammatory rheumatic disease, psychiatric or neurological disorders\n* Uncontrolled hypertension, decompensated organ failure, or malignancy\n* Pregnancy or breastfeeding\n* Use of systemic steroids in the last 3 months\n* Major trauma or surgery within the past 6 months\n* Receiving physical therapy or physical modalities within the past 6 months\n* Any health condition that prevents participation in balneotherapy or exercise programs",{"count":183,"type":23},[26],"This randomized controlled clinical trial aims to investigate the effects of whole-body vibration (WBV) exercises combined with balneotherapy on pain, physical function, sleep quality, and daily activity levels in individuals with chronic low back pain.\n\nA total of 60 volunteers aged 18 to 65 who have been diagnosed with chronic low back pain by a physical medicine and rehabilitation specialist and who meet the eligibility criteria will be included. Participants will be randomly assigned to two groups. Both groups will receive balneotherapy five days a week for three weeks. After balneotherapy, the first group will perform standard stretching, strengthening, and aerobic exercises designed for low back pain. The second group will receive the same exercise program in combination with WBV exercises using a vibration platform. WBV sessions will include static and dynamic exercises with specific frequency and amplitude settings.\n\nAll participants will be evaluated at baseline and after three weeks using validated measures, including pain intensity (Visual Analog Scale), spinal mobility (Modified Schober Test), balance and reach (Functional Reach Test), physical performance (Sit-to-Stand and Timed Up and Go Tests), disability (Oswestry Disability Index, Roland-Morris Questionnaire), and sleep quality (Pittsburgh Sleep Quality Index).\n\nThe study seeks to determine whether combining WBV with balneotherapy can provide additional benefits over standard exercise alone in managing chronic low back pain.",[616,617,618,30],"Balneology","Whole Body Vibration","Water","2026-04-29",{"date":621,"type":39},"2026-04-30",{"date":623,"type":39},"2025-07-01",{"date":370,"type":23},{"name":378,"class":46},{"id":627,"slug":628,"hasResults":12,"nctId":629,"briefTitle":630,"officialTitle":630,"acronym":631,"eligibilityCriteria":632,"healthyVolunteers":12,"sex":18,"minAge":633,"maxAge":19,"enrollmentInfo":634,"targetDuration":4,"studyType":24,"phases":636,"briefSummary":637,"conditions":638,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":619,"lastUpdatePostDateStruct":642,"startDateStruct":643,"completionDateStruct":645,"leadSponsor":646,"locationsCount":47},"100586502","study-of-the-effect-of-capsinoid-supplementation-on-brown-adipose-tissue-in-obese-adolescents-100586502","NCT06916208","Study of the Effect of Capsinoid Supplementation on Brown Adipose Tissue in Obese Adolescents","ADOBAT","Inclusion Criteria:\n\n* member or beneficiary of a health insurance scheme\n* aged between 11 and 18\n* Body Mass Index Z score corresponding to stage 2 obesity according to the curves of Rolland-Cachera et al., 1991 and an absence of weight loss of more than 5% of the total weight over the last 3 months.\n* effective contraception (in pubescent females)\n\nExclusion Criteria:\n\n* known allergy to capsinoids and\u002For soya\n* inflammatory digestive pathology and\u002For history of digestive tract surgery\n* participation in another study or in a period of exclusion determined by a previous study\n* pregnant, parturient or breastfeeding\n* The holder(s) of parental authority or the adolescent refuse(s) to sign the authorisation or acceptance form, respectively.\n* It proves impossible to provide the adolescent or parental guardian(s) with informed information.","11 Years",{"count":635,"type":23},38,[26],"Among the new strategies being considered for the treatment of obesity and its metabolic complications, the activation of brown adipose tissue (BAT) from white adipose tissue looks promising. Interest in the study of BAT has increased over the last 5-10 years in response to the discovery of functional BAT in humans. The BAT is a tissue specialized in regulating energy expenditure by producing heat through the oxidation of fatty acids contained in the multiple lipid droplets of brown adipocytes. This adipose tissue does not play a storage role, but rather an anti-obesogenic one, thanks to its high metabolic and energetic activity.\n\nIn addition to exposure to cold, which is the major physiological inducer of brown adipocytes, it seems that exercise and the intake of \"adrenergic\" foods can activate the TAB and potentially induce a change from white to brown tissue via the production of adrenalin and myokines. Acute and\u002For chronic effects of thermogenic food supplements have been reported on BAT activation and energy metabolism. The most conclusive of these involve the capsinoids found in sweet peppers and chillies. Weight loss also improves BAT activation.\n\nThe BAT has already been identified in children. A decrease in its volume and activity from childhood to adolescence and during puberty has been reported.\n\nThe main objective of this randomized controlled double-blind study is to investigate the effects of capsinoid dietary supplementation on BAT activity in obese adolescents.\n\nOur general working hypothesis is that capsinoid supplementation, combined with dietary management, leads to an increase in BAT activity.",[639,30,640,641],"Obese Adolescents","Diet Modification","Dietary Supplement",{"date":621,"type":39},{"date":644,"type":39},"2025-03-03",{"date":43,"type":23},{"name":647,"class":46},"University of Avignon",{"id":649,"slug":650,"hasResults":12,"nctId":651,"briefTitle":652,"officialTitle":653,"acronym":654,"eligibilityCriteria":655,"healthyVolunteers":12,"sex":18,"minAge":633,"maxAge":19,"enrollmentInfo":656,"targetDuration":4,"studyType":24,"phases":658,"briefSummary":659,"conditions":660,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":619,"lastUpdatePostDateStruct":662,"startDateStruct":664,"completionDateStruct":666,"leadSponsor":667,"locationsCount":668},"100564216","exercise-snacks-for-breaking-the-sedentary-lifestyle-and-improving-the-physical-fitness-of-obese-adolescents-100564216","NCT06626295","Exercise-snacks for Breaking the Sedentary Lifestyle and Improving the Physical Fitness of Obese Adolescents?","Exercise-snacks: an Effective Solution for Breaking the Sedentary Lifestyle and Improving the Physical Fitness of Obese Adolescents?","SNACKEX","Inclusion Criteria:\n\n* Body mass index Z-score corresponding to stage 2 obesity,\n* no weight loss of more than 5% of total body weight in the past 3 months,\n* parental consent\n* minor\\'s acceptance\n\nExclusion Criteria:\n\n* Contraindication to physical activity\n* current participation in a clinical trial",{"count":657,"type":23},48,[26],"The management of a person with obesity involves long-term behavioral changes with a balanced diet in both quantity and quality, along with the adoption of a more active lifestyle: increasing physical activities and reducing sedentary behaviors. The school setting has been identified as a favorable environment for interventions aimed at reducing and interrupting the time adolescents spend sitting and preventing the associated negative health consequences.\n\nRecently, very short (\\< 1 minute) and intense exercises, called 'exercise-snacks,' have been reported to be effective in adults for 1) improving physical fitness over 6 weeks, and 2) improving vascular function and lowering blood glucose levels over a single day. Additionally, in adolescents with diabetes, they have been shown to reduce body fat. This raises the question of whether adding \\'exercise-snack\\' sessions to a multidimensional care program for hospitalized obese adolescents could further improve their physical fitness in the short and medium term.\n\nThe objective of this project is to compare the effects of a traditional multidimensional care program with the addition of 'exercise-snacks' to the same care program without \\'exercise-snacks\\' on the physical fitness, body composition, vascular function, and physical activity and sedentary behaviors of obese children in the short and medium term. Forty-eight obese adolescents will be included. The \\'exercise-snack\\' group will perform six exercise sessions per day for three weeks in addition to the standard care. The control group will receive only the standard care. Assessments of physical fitness, body composition, vascular health, and questionnaires on physical activity, sedentary behavior, and cognitive restraint will be conducted at the beginning and end of the three-week program, as well as 1 and 3 months after the end of the program.",[639,661,30],"Sedentary Time",{"date":663,"type":39},"2026-05-05",{"date":665,"type":39},"2024-09-09",{"date":345,"type":23},{"name":647,"class":46},2]