[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exhaustion-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exhaustion-disorder":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,89,117],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100576556","characterization-treatment-and-long-term-follow-up-of-fatigued-patients-in-primary-care-100576556",false,"NCT06786832","Characterization, Treatment, and Long-term Follow-up of Fatigued Patients in Primary Care","iFAS","Inclusion Criteria:\n\n1. age 18-67\n2. enrollment at a primary care clinic in Region Stockholm\n3. severe, functionally disabling fatigue as a central symptom for at least 3 months\n4. The fatigue has an identifiable start and hence has not been life-long;\n5. The fatigue is not a direct effect of an active disease process motivating another treatment (e.g., hypo-\u002Fhyperthyroidism, anemia, cancer, dementia) or the effect of medication\n6. regular access to a computer and to the Internet\n7. ability to read and write in Swedish.\n8. ability to visit a study center for participation in potential assessments and treatment sessions (maximum 60 minutes) and to take part of written material via the internet.\n\nExclusion Criteria:\n\n1. substance abuse disorder in the past 6 months\n2. Current or past psychosis or bipolar disorder\n3. Primary psychiatric disorder of such severity that it merits evidence-based treatment (e.g., obsessive compulsive disorder, moderate to severe depression, post-traumatic stress disorder, anorexia nervosa)\n4. elevated risk for suicide\n5. deliberate self harm in the past 6-months (e.g., cutting, burning, poisoning);\n6. BMI\\>40\n7. Initiated or changed psychopharmacological medication (e.g., for depression or anxiety disorders) in the past month\n8. ongoing chemotherapy\n9. intellectual disability (e.g., severe autism) that affects ability to work with the treatment\n10. pregnancy\n11. life circumstances that complicate or make treatment impossible (e.g., domestic violence, ongoing legal disputes, disputes with social insurance agency, planed or on-going work capacity assesment regarding permanent work disability pension or planed surgery)\n12. ongoing psychological treatment and\u002For multimodal rehabilitation.\n13. working night shifts","ALL","18 Years","67 Years",{"count":20,"type":21},190,"ESTIMATED","INTERVENTIONAL",[24],"NA","The overarching purpose of this project is to further the understanding of fatigue as a symptom in primary care patients, and to build evidence for a highly accessible treatment targeting fatigue that can be readily implemented in primary care clinics.\n\nData will be collected within a randomized controlled superiority trial. The primary aim is to evaluate the effectiveness of a transdiagnostic cognitive behavioral therapy (tCBT) for fatigued patients as compared to care as usual (CAU). Primary outcome will be change in fatigue severity (as measured by the Checklist Individual Strengths, fatigue subscale) pre- to post-treatment (6 months), with long-term controlled follow-up after 12 months. A register-based follow-up will be conducted up to 60 months post baseline. Moderators and mechanisms of treatment effect will be investigated with the aim to identify potential subgroups of fatigued individuals across and within diagnostic categories that may respond differently to treatment. Lastly, a health economic evaluation of long-term treatment effects will be conducted, which incorporates much needed detailed mapping of care as usual for fatigued patients.",[27,28,29,30,31],"Fatigue","Fatigue Post Viral","Exhaustion Disorder","Fatigue Symptom","Fatigue Related to Cancer Treatment",[33,34,35,36,37,27,38,39,40,41],"Psychological treatment","Primary care","cognitive behavioral therapy","blended treatment","randomized controlled trial","burnout","chronic stress","register data","cognitive testing","RECRUITING","2026-03-09",{"date":45,"type":46},"2026-03-11","ACTUAL",{"date":48,"type":46},"2025-02-06",{"date":50,"type":21},"2033-01",{"name":52,"class":53},"Karolinska Institutet","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":22,"phases":66,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":54},"100624299","step-by-step-back---a-feasibility-study-of-a-physical-activity-intervention-for-adults-with-stress-related-exhaustion-100624299","NCT07407829","Step by Step Back - A Feasibility Study of a Physical Activity Intervention for Adults With Stress-related Exhaustion","Step by Step Back - A Feasibility Study of a CBT-Based Physical Activity Intervention for Stress-Related Exhaustion","Inclusion Criteria\n\n* Adult aged 20 to 64 years.\n* Experiencing stress-related exhaustion, assessed in regular clinical care (for example, symptoms consistent with exhaustion disorder or a closely related stress-related condition).\n* Symptoms are not in the acute phase (participant is able to engage in outpatient psychological treatment and gradual physical activity).\n* Elevated fatigue\u002Fexhaustion at screening, indicated by scores on screening questionnaires (Karolinska Exhaustion Disorder Scale and Multidimensional Fatigue Inventory).\n* Able to understand spoken and written Swedish.\n* Has access to a smartphone, tablet, or computer with an internet connection to complete study questionnaires and activity logging.\n* No medical condition that makes physical activity unsafe, based on clinical screening and participant self-report.\n\nExclusion Criteria\n\n* Currently receiving psychological treatment outside the recruiting clinic that is expected to interfere with participation in the program or study assessments.\n* Current or past diagnosis of a psychotic disorder.\n* Current or past diagnosis of bipolar disorder.\n* Severe mental health condition requiring another primary treatment approach at this time (for example, severe major depressive disorder, post-traumatic stress disorder, or an eating disorder).\n* Ongoing substance use disorder.\n* Medical condition or acute illness that makes physical activity inappropriate at this time (for example, recent blood clot, severe infection, or other serious condition).\n* Severe musculoskeletal condition that substantially limits ability to perform physical activity.\n* Started antidepressant medication within the past 4 weeks.\n\nAdditional notes (not eligibility criteria):\n\nParticipants may use psychotropic medication (for example, antidepressants, sleep medication, or anxiety medication) if the medication regimen is stable. Participants will be asked to report any medication changes during the study period. Mild to moderate comorbid anxiety or depression is allowed if stress-related exhaustion is the primary clinical problem.","20 Years","64 Years",{"count":65,"type":21},20,[24],"The goal of this clinical study is to learn whether a psychologist- or psychotherapist-guided physical activity program can be delivered and used as part of regular care for adults experiencing stress-related exhaustion. The program is designed to be integrated into regular psychological treatment as usual and supports participants in developing physical activity habits in a gradual, individualized, and sustainable way.\n\nThe main questions this study aims to answer are:\n\n* Can participants complete the program and attend the planned sessions?\n* Do participants and clinicians find the program acceptable, relevant, and useful?\n* Is the program safe, and do any negative experiences occur during the program?\n* What practical barriers and facilitators affect participation and delivery in routine care?\n* What descriptive patterns of change are seen in physical activity, symptoms, and everyday functioning from before to after the program?\n\nThe program is based on cognitive behavioral therapy (CBT) and acceptance and commitment therapy (ACT). It includes strategies to help participants set meaningful goals, take step-by-step actions toward those goals, and respond more flexibly to uncomfortable thoughts, emotions, and body sensations that may arise in relation to physical activity.\n\nAbout 12 to 20 participants will take part. The program is designed to be integrated into about 5 to 6 individual sessions delivered over a flexible time period, depending on each participant's pace and circumstances.\n\nParticipants will:\n\n* Take part in the physical activity program as part of their regular psychological treatment\n* Complete online questionnaires before and after the program\n* Log their physical activity during the program\n* Provide feedback after the program (and some participants will also take part in an interview)\n\nThe results will be used to assess whether the program is feasible and acceptable for participants and clinicians and to inform further refinement and future evaluation.",[29,69],"Stress-Related Disorders",[71,72,27,73,74,75,76,77,78,79],"Stress-related exhaustion","Exhaustion disorder","Burnout","Physical activity intervention","Exercise therapy","Feasibility study","Cognitive behavioral therapy (CBT)","Acceptance and Commitment Therapy (ACT)","Psychological flexibility","2026-02-05",{"date":82,"type":46},"2026-02-12",{"date":84,"type":46},"2025-11-13",{"date":86,"type":21},"2026-10-01",{"name":88,"class":53},"The Swedish School of Sport and Health Sciences",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":4},"100613886","comparing-act-recuperation-and-act-plus-vocational-support-for-clinical-burnout-100613886","NCT07272421","Comparing ACT, Recuperation, and ACT Plus Vocational Support for Clinical Burnout","A Three-Arm Randomized Controlled Trial Comparing Online ACT, Recuperation, and ACT Plus Vocational Support for Clinical Burnout","Inclusion Criteria:\n\n* Age 18 years or older\n* Self-reported or clinically verified symptoms consistent with clinical burnout (e.g., pronounced fatigue, cognitive difficulties, and reduced stress tolerance following prolonged psychosocial stress)\n* Currently on ≥25% sick leave and experiencing significant functional impairment in work or daily life due to these symptoms\n* Stable occupation or engagement (employment or studies)\n* Ability to read and write Swedish\n* Daily access to the internet\n\nExclusion Criteria:\n\n* Sick leave \\> 2 years for the current episode\n* Severe acute psychiatric conditions, including: severe depression, bipolar disorder, untreated PTSD, schizophrenia, or other psychotic disorders\n* Current substance abuse\n* Active suicidal ideation (as assessed during clinical evaluation)",{"count":97,"type":21},210,[24],"This study compares three different online psychological treatments for people with clinical burnout (stress-related exhaustion) who are on sick leave or have major difficulties coping at work or in daily life. Many patients with burnout receive broad, recuperation-focused interventions (rest, stress reduction, lifestyle changes), but there is still no clearly evidence-based treatment or agreed clinical model. It is also known that returning to work can be difficult, and there is a need for more structured support.\n\nIn this trial, 210 adults in Sweden with clinical burnout will be randomly assigned to one of three 10-week, internet-based treatments:\n\nOnline Acceptance and Commitment Therapy (ACT) A structured, values-based CBT approach that focuses on helping participants clarify what matters to them, relate differently to difficult thoughts and feelings, and gradually re-engage in meaningful activities despite exhaustion.\n\nOnline Recuperation-focused treatment An active comparison condition that emphasizes rest, recuperation, and healthy daily routines. It provides psychoeducation and practical tools for sleep, relaxation, physical activity, pacing, and balance in everyday life, but does not include ACT-specific methods such as exposure or values work.\n\nOnline ACT plus Vocational Support The same ACT program as in group 1, together with three additional sessions with a licensed psychologist focused on work. These sessions help the participant identify work-related barriers, plan a gradual return-to-work (RTW), and formulate a written RTW plan that can be shared with the employer and treating physician.\n\nAll three treatments are delivered via a secure digital platform. Participants work through weekly online modules, receive written feedback from a therapist, and have three video sessions during the 10-week period. Clinical psychology students in their final semester deliver the ACT and recuperation treatments, and licensed psychologists deliver the ACT + vocational support condition.\n\nThe study has two primary aims:\n\n1. to test whether online ACT reduces self-rated burnout symptoms more than the recuperation-focused treatment at the end of treatment, and\n2. to test whether adding structured vocational support to ACT reduces the total number of registered sick-leave days in the year after treatment, compared with ACT alone.\n\nKey secondary outcomes include perceived stress, depression, anxiety, insomnia, everyday memory problems, quality of life, functional impairment, treatment response and remission, treatment credibility and satisfaction, and cost-effectiveness. Outcomes are measured before treatment, weekly during treatment (for selected measures), immediately after treatment, and at 6- and 12-month follow-ups. Sick-leave data are obtained from the Swedish Social Insurance Agency.\n\nTo be eligible, participants must be 18 years or older, have symptoms consistent with clinical burnout (including pronounced fatigue and reduced stress tolerance after prolonged psychosocial stress), be on at least 25% sick leave or have marked functional impairment due to these symptoms, have a stable occupation or study situation, and be able to read and write Swedish. People with very long sick leave (more than two years), severe psychiatric conditions (such as severe depression, bipolar disorder, untreated PTSD, or psychosis), current substance abuse, or active suicidal ideation will not be included.\n\nPotential risks include temporary increases in distress, fatigue, or symptom awareness when working with emotions, behavior change, or work-related issues. Participants are monitored closely through weekly questionnaires and therapist contact. If risk for self-harm or serious deterioration is detected, a licensed psychologist will perform a risk assessment and, if needed, refer the participant to appropriate health care.\n\nThe hope is that this study will identify effective, scalable, and theory-based online treatments for clinical burnout and clarify whether adding structured vocational support improves long-term work outcomes.",[73,101,29],"Clinical Burnout",[103,104,73,105,106],"ACT","Online","Return To Work","Recovery","NOT_YET_RECRUITING","2025-11-26",{"date":110,"type":46},"2025-12-09",{"date":112,"type":21},"2025-12-01",{"date":114,"type":21},"2027-12-31",{"name":116,"class":53},"Uppsala University",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":131,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":4},"100599070","returning-to-work-after-stress-related-sick-leave-an-effectiveness-trial-of-work-focused-treatments-in-primary-care-100599070","NCT07079709","Returning to Work After Stress-Related Sick Leave: An Effectiveness Trial of Work-Focused Treatments in Primary Care","ReWork","Inclusion Criteria:\n\n1. be on sick leave at least 50%\n2. be diagnosed with a primary diagnosis adjustment disorder (F43.2-F.43.9) including exhaustion disorder (F43.8A)\n3. be of working age (18-60 years)\n4. be able to understand verbal and written Swedish or English\n5. give informed consent\n\nExclusion Criteria:\n\n1. other psychiatric conditions that require prioritization for immediate or simultaneous treatment: specifically, a current diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or organic mental disorder; current high risk of suicide; or recent (within 3 months) history of substance use disorder)\n2. other ongoing or recent (within 6 months) psychological treatment for stress-related disorders","60 Years",{"count":126,"type":21},204,[24],"The goal of this clinical trial is to learn if work-focused cognitive behaviour (WCBT) works to treat patients on sick leave due to non-traumatic long-term stress-related disorders. The main questions it aims to answer are:\n\n* Is WCBT more effective in improving work ability compared to standard care?\n* Do participants in WCBT have less sick leave days than those in standard care?\n* Is WCBT more effective in improving health outcomes and function than standard care?\n* Is WCBT a more cost-effective treatment option than standard care? Researchers will compare WCBT to standad care to see if there are differences in effect.\n\nParticipants will participate in:\n\n* WCBT\n* Standard care",[101,29,130],"Adjustment Disorder With Work Inhibition",[132,133,134,135,136],"Work-focused CBT","WCBT","Sick leave","Clinical burnout","Cognitive behaviour therapy","2025-07-14",{"date":139,"type":46},"2025-07-23",{"date":141,"type":21},"2025-08-01",{"date":143,"type":21},"2034-12-01",{"name":52,"class":53}]