[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exotropia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exotropia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100627283","risk-factors-and-surgical-outcomes-of-strabismus-reoperation-100627283",false,"NCT07446621","Risk Factors And Surgical Outcomes Of Strabismus Reoperation","Risk Factors And Surgical Outcomes Of Strabismus Reoperation: A Clinical Study","RSOR","Inclusion Criteria:\n\n* Patients diagnosed with horizontal strabismus (esotropia or exotropia).\n\n  * Patients undergoing repeat surgery for correction of residual, recurrent, undercorrected, or overcorrected horizontal strabismus.\n  * Availability of sufficient medical records documenting previous strabismus surgery.\n  * Ability to attend scheduled postoperative follow-up visits.\n  * Written informed consent obtained from the patient or legal guardian.\n\nExclusion Criteria:\n\n* Combined vertical and horizontal strabismus.\n\n  * Paralytic strabismus.\n  * Restrictive strabismus.\n  * Strabismus associated with neurological or syndromic conditions.\n  * Patients with incomplete or insufficient documentation of previous surgical procedures.\n  * Patients unwilling or unable to complete follow-up.","ALL",{"count":19,"type":20},62,"ESTIMATED","INTERVENTIONAL",[23],"NA","Horizontal strabismus, commonly known as inward or outward deviation of the eyes, is a frequent eye condition that may require surgical correction. Although the first surgery is often successful, some patients develop residual or recurrent eye misalignment and require a second operation (reoperation).\n\nThis study aims to identify the clinical and surgical factors that may increase the risk of undercorrection, overcorrection, or recurrence after the first surgery. It also evaluates the outcomes and success rate of repeat surgery in patients with horizontal strabismus.\n\nPatients undergoing reoperation will receive a complete ophthalmological examination before surgery. The surgical plan will be individualized based on previous surgical history and current eye findings. All procedures will be performed under general anesthesia by the same surgeon. Participants will be followed for three months after surgery to assess eye alignment, movement, and possible complications.\n\nThe results of this study may help improve surgical planning and predict which patients are at higher risk of requiring additional surgery in the future.",[26,27,28],"Strabismus","Esotropia","Exotropia",[30,31,32,33,34,35,36,37],"Horizontal strabismus","Strabismus reoperation","Recurrent strabismus","Ocular alignment","Prism diopters","Paediatric strabismus surgery","Orthotropia","Ocular motility","NOT_YET_RECRUITING","2026-03-06",{"date":41,"type":42},"2026-03-09","ACTUAL",{"date":44,"type":20},"2026-03",{"date":46,"type":20},"2027-07",{"name":48,"class":49},"Assiut University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":50},"100619877","comparative-study-of-muscle-transplantation-versus-y-splitting-recession-technique-in-treatment-of-large-angle-exotropia-100619877","NCT07350330","Comparative Study of Muscle Transplantation Versus Y Splitting Recession Technique in Treatment of Large Angle Exotropia","Inclusion Criteria:\n\n* Age should be of more than 6 years Exotropia of an angle ranging from 50 to 70 PD Myopic or hypermetropic refraction\n\nExclusion Criteria:\n\n* history of previous squint surgery significant vertical deviation incomitant squint in the form of paralytic or restrictive disorder any neurological disease","6 Years",{"count":59,"type":20},30,[23],"This study is designed to correct large-angle exotropia by monocular surgery. It compares two augmented recession techniques, which are recession with muscle transplantation and recession with Y splitting.",[28],"RECRUITING","2026-01-14",{"date":66,"type":42},"2026-01-20",{"date":68,"type":42},"2025-10-30",{"date":70,"type":20},"2026-12-30",{"name":72,"class":49},"Ain Shams University",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":50},"100468444","a-eyedrops-on-ocular-alignment-and-binocular-vision-100468444","NCT05379855","A-eyedrops on Ocular Alignment and Binocular Vision","The Effects of Atropine Eyedrops on Ocular Alignment and Binocular Vision","Inclusion Criteria:\n\n* The age ranged from 5 to 14 years;\n* Astigmatism \\\u003C 2.5D, spherical power: - 1.00D \\~ -6.00D; difference between eyes in spherical power \\\u003C 1.5D, difference between eyes in astigmatism \\\u003C 1.00D;\n* Intraocular pressure \\\u003C 21mmHg;\n* Ocular alignment fulfilling the following criteria：Exophoria with an exodeviation at near \\> 6PD12; Intermittent exotropia with an exodeviation ≤25 PD both at distance and at near, Titmus \\\u003C=400 arc seconds; Intermittent exotropia patients underwent strabismus surgery, 6 months after operation, fulling the criteria of exophoria and intermittent exotropia mentioned before.\n* Subjects and their parents or legal guardians have signed informed consent and are willing to accept randomized grouping and regular follow-up.\n\nExclusion Criteria:\n\n* Amblyopia\n* Have heart disease or serious respiratory disease\n* Allergic to atropine, cyclopentantone, propoxybenzocaine and benzalkonium chloride;\n* Those who have used contact lenses, bifocal lenses, or other measures to control myopia (including atropine);\n* No binocular vision;\n* Combined with vertical strabismus≥5PD, abnormal oblique muscle function≥ 2+, cyclodeviation, DVD or A-V pattern, paralytic and restrictive strabismus, comitant esotropia；\n* Previous history of other ocular surgery;\n* Severe complications during or after strabismus surgery, such as perforation of the sclera, tear and detachment of extraocular muscle; postoperative eye movement limitation; visual acuity decreased after operation;\n* Combined with other ocular diseases;\n* Craniofacial malformations affecting the orbits;\n* significant neurological disorders;\n* Birth less than 34 weeks or birth weight less than 1500 g;\n* Intraocular pressure \\> 21mmhg;\n* Unable to cooperate with the examination.","5 Years","14 Years",{"count":83,"type":20},339,[23],"Atropine is a non-selective muscarinic acetylcholine (M) receptor antagonist that paralyzes the ciliary muscle, dilates the pupil, and reduces the power of accommodation. Current studies have confirmed the effect of low concentrations of atropine drops in slowing the progression of myopia. In the atropine treatment for myopia (ATOM2) study, there was a rapid and dose-dependent decrease in accommodation after atropine drops: after 2 weeks of use, accommodation decreased from baseline 16.2D to 11.3D (4.9D) in the 0.01% atropine drops group, from baseline 16.7D to 3.8D (12.9D) in the 0.1% atropine group, and from baseline 15.8 D to 2.2 D (13.6 D) in the 0.5% atropine group; one year after withdrawal, there was some recovery of the accommodation in all the three groups, but it was still lower than the baseline values for each group, with a mean decrease of 2.56 D.Similar results were found in the Low-concentration Atropine for Myopia Progression (LAMP) Study by Janson C. Yam, 0.05% atropine drops reduced the accommodation by approximately 2D on average after 1 year of treatment.\n\nIn general, if accommodation decreases by 2D or more compared to normal values, accommodation insufficiency is considered. There is a linkage between accommodation and convergence called accommodative convergence-to-accommodation (AC\u002FA) which is closely related to exotropia. It was reported that the amount of accommodation required to maintain binocular fusion in patients with intermittent exotropia was greater than that of normal controls. In addition, pupil size and visual acuity are also factors that affect accommodation. In summary, the reduced accommodation amplitude, pupil dilation, and blurred near vision caused by atropine drops would affect the progression of intermittent exotropia and the ocular alignment after the surgery. In most cases, the reduced accommodation and convergence might induce exotropia, but in some patients, they may use more accommodative stimuli to compensate the insufficiency of accommodation, and there may be an increase in convergence or even esotropia.\n\nTaken together, due to the effect of atropine drops on pupil size, near visual acuity, and accommodation amplitude, the investigators hypothesize that atropine drops are likely to affect binocular vision and ocular alignment in patients with exotropia and exophoria.",[28,87,88],"Exophoria","Myopia",[90,91,92,93,94,95],"atropine","myopia","ocular alignment","binocular vision","exotropia","exophoria","2025-02-24",{"date":98,"type":42},"2025-02-25",{"date":100,"type":42},"2024-03-02",{"date":102,"type":20},"2027-02-01",{"name":104,"class":49},"Eye & ENT Hospital of Fudan University"]