[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"experimental\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:experimental":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100567638","using-ecological-momentary-data-to-inform-a-web-intervention-for-romantic-partners-concerned-about-their-loved-ones-drinking-100567638",false,"NCT06670794","Using Ecological Momentary Data to Inform a Web Intervention for Romantic Partners Concerned About Their Loved Ones' Drinking","CP Inclusion Criteria:\n\n* be at least 18 years old\n* be in a romantic relationship with their partner\n* be living with their partner,\n* have a computer, tablet, or mobile phone with Internet access\n* have no plans to separate from their partner in the next 60 days\n* indicate no concerns they would be physically hurt by their partner on the Intimate Partner Screen\n\nCP Exclusion Criteria:\n\n* drinking scores at or above the threshold for DP participation\n\nDP Inclusion Criteria:\n\n* be at least 18 years old\n* misuses alcohol as defined by their scores (4+ for women\u002Fnon-gender confirming, 5+ for men) on the consumption portion of the Alcohol Use Disorder Identification Test (AUDIT-C) (Dawson et al., 2005)\n* has a computer, tablet, or mobile phone with Internet access\n* indicates no concerns they would be physically hurt by their partner\n\nDP Exclusion Criteria:\n\n* current alcohol treatment\n* currently concerned about their partner's drinking",true,"ALL","18 Years",{"count":19,"type":20},160,"ESTIMATED","INTERVENTIONAL",[23],"NA","Aim 1. Couples (N=50 dyads) with a Concerned Partner (CP) and a Drinking Partner (DP) will independently complete baseline and follow-up surveys and a 21-day EMA with three daily reports on their communication and DP's drinking. Aim 2. Iteratively develop a four-session web based intervention and evaluate the WBI's feasibility and acceptability with 15 CPs. Aim 3. Perform a pilot randomized controlled trial (RCT) comparing WBI to psychoeducation control in 110 couples.",[26,27],"Experimental","Control Condition",[29,30,31,32,33,34],"alcohol","alcohol use disorder","community reinforcement and family training","concerned partners","concerned significant others","communication","NOT_YET_RECRUITING","2026-07-01",{"date":38,"type":39},"2026-07-02","ACTUAL",{"date":41,"type":20},"2026-09-29",{"date":43,"type":20},"2027-02-28",{"name":45,"class":46},"University of Florida","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100627704","early-phase-1-what-is-the-role-of-type-iiiiv-muscle-afferents-in-airway-resistance-and-thermoregulatory-responses-to-exercise-100627704","NCT07452094","What is the Role of Type III\u002FIV Muscle Afferents in Airway Resistance and Thermoregulatory Responses to Exercise?","Type III\u002FIV Muscle Afferents in Airway and Thermoregulatory Responses","Inclusion Criteria:\n\n* regularly physically active as determined via questionnaires (Par-Q \\& You)\n* maximal aerobic power 30 mL\u002Fmin\u002Fkg (female), 40 mL\u002Fkg\u002Fmin (male)\n\nExclusion Criteria:\n\n* current smokers\n* acute bronchial asthma\n* diabetics\n* chronic back pain\n* peripheral neuropathy\n* chronic obstructive airway or status asthmaticus\n* obese (body mass index \\> 30 kg\u002Fm2)\n* convulsive disorders\n* requiring daily medications that may affect responses to exercise (e.g. anti-hypertensive, anti-arrhythmogenics, blood thinners)\n* history of drug abuse\n* history of disease\u002Fdysfunction that could cause complication with exercise (e.g. cardiovascular, respiratory, neurological, musculoskeletal)\n* irregular or absent menstrual cycle\n* pregnant or suspected pregnancy\n* adverse response to physical exercise\n* current or history of esophageal or gastric disease, or frequent heart burn (\\>2x per week)\n* Lidocaine allergy","40 Years",{"count":56,"type":20},15,[58],"EARLY_PHASE1","Exercise places serious demands on the body. These demands are fundamentally caused by increases in oxygen demand and the consequent increase in body temperature. These demands are met by several physiological responses, including increases in heart rate, blood pressure, breathing and blood flow. These responses must be proportional to the increase in demand and some signal must relay information from the muscle to the brain. Group III\u002FIV afferents do just this. They relay information about the muscle (movement, temperature, acidity, etc.) up to the brain so that appropriate responses are mounted. There is strong evidence in animals that group III\u002FIV afferents play a key role in making breathing easier (decreasing airway resistance) and initiating sweating and blood flow responses. There has been no research on the role of group III\u002FIV afferents on these fundamental exercise responses in humans. The investigators propose to isolate the role of group III\u002FIV afferents on regulate airway resistance, sweating and blood flow responses to exercise in humans.",[61,26],"Placebo - Control",[63,64,65,66,67,68],"Group III\u002FIV afferents","exercise","thermoregulation","sweating","blood flow","airway resistance","2026-02-27",{"date":71,"type":39},"2026-03-05",{"date":73,"type":20},"2026-04-01",{"date":75,"type":20},"2027-04-01",{"name":77,"class":46},"Northern Arizona University",1]