[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"exposure-occupational\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:exposure-occupational":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100621874","use-of-anti-cd146-autoantibodies-for-the-diagnosis-of-pulmonary-diseases-secondary-to-occupational-exposure-to-silica-100621874",false,"NCT07376291","Use of Anti-CD146 Autoantibodies for the Diagnosis of Pulmonary Diseases Secondary to Occupational Exposure to Silica","CD146-SILICE","Inclusion Criteria for non-exposed group:\n\n* Subject, male or female, aged 18 or over\n* Subject with low exposure to silica \\\u003C0.1 mg\u002Fm3 in the course of their professional activity, quantified during an occupational health consultation using an employment-exposure matrix\n* Subjects capable of consenting to participate in the study by signing a written informed consent form\n* Subjects who are beneficiaries of or affiliated with a social security system\n\nInclusion Criteria for exposed group:\n\n* Subject, male or female, aged 18 or over\n* Subject with moderate or high exposure to silica (\\>= 0.1 mg\u002Fm3) in the course of their professional activity, quantified during an occupational health consultation using an employment-exposure matrix.\n* Subjects capable of consenting to participate in the study by signing a written informed consent form\n* Subjects who are beneficiaries of or affiliated with a social security system\n\nExclusion Criteria for each group:\n\n* Minor subject\n* Subject refusing to undergo the examinations required by the protocol\n* Contraindications to respiratory function tests: Recent eye or throat surgery, recent myocardial infarction or pulmonary embolism, poorly controlled high blood pressure, recent pneumothorax.\n* Pregnant or breastfeeding women, patients under guardianship or curatorship, deprived of liberty","ALL","18 Years",{"count":19,"type":20},110,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective, multicenter study aims to evaluate the relevance of anti-CD146 autoantibodies (AACD146) as biological markers for the early diagnosis of pulmonary diseases related to occupational exposure to silica. Silica exposure is a recognized risk factor for fibrotic, inflammatory, and cancerous respiratory diseases. Currently, no specific biological marker exists. The hypothesis is that AACD146 reflects early effects of silica exposure. The study will include 110 participants divided into two groups (exposed vs. non-exposed) and will compare AACD146 prevalence according to exposure level and the presence of respiratory diseases.",[26,27],"Exposure Occupational","Pulmonary Diseases",[29,30,31],"silica","Exposure occupational","Pulmonary diseases","NOT_YET_RECRUITING","2026-01-29",{"date":35,"type":36},"2026-02-02","ACTUAL",{"date":38,"type":20},"2026-06",{"date":40,"type":20},"2028-06",{"name":42,"class":43},"Assistance Publique Hopitaux De Marseille","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":65,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100613748","french-military-firefighters-to-assess-relationships-between-exposome-and-health-100613748","NCT07270627","French Military Firefighters to Assess Relationships Between Exposome and Health.","Cohorte Militaire et Son Exposome : étude Pilote rétrospective au Sein de la Population Des Sapeurs-pompiers (Actuellement en Exercice et Anciens Sapeurs-pompiers) de la Brigade Des Sapeurs Pompiers de Paris","COMITEX-BSPP","Inclusion Criteria:\n\n* Active-duty or veteran military personnel from French Paris firefighter brigade.\n* Aged at least 18.\n* Not opposed to participate to the study\n\nExclusion Criteria:\n\n* Opposition to participate\n* veterans under legal protection",true,{"count":54,"type":20},15000,"OBSERVATIONAL","The aim of the study is to describe professional exposures and health events among French military firefighters (both active-duty personnel and veterans) and identify potential relationships between the exposome (the total history of occupational and personal exposures) and health status in these populations. The study is based on a self-administered questionnaire that collects retrospective and present information about exposures and health conditions.",[58,26,59,60,61,62,63,64],"Health Adult Subjects","Health Behavior, Risky","Occupational Health","Exposure","Firefighters","Military Personnel","Observational Study",[66,67,68,69,70],"Occupational exposure","health","military","exposome","occupational","2025-11-26",{"date":73,"type":36},"2025-12-08",{"date":75,"type":20},"2026-01-01",{"date":77,"type":20},"2026-12",{"name":79,"class":43},"Direction Centrale du Service de Santé des Armées"]