[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"external-ventricular-drain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:external-ventricular-drain":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100622196","ventriculostomy-associated-infections-lactic-focus-on-csf-lactate-and-sampling-site-100622196",false,"NCT07380477","VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site","CSF Lactate and Ventriculostomy Associated Infections in Patients With Acute Brain Injury - a Prospective, Observational Cohort Study.","LACTIC","Inclusion Criteria:\n\n* Age \\>18 years\n* EVD in situ\n* Admission to the neuro-ICU or neurosurgical step-down unit at Rigshospitalet, Denmark\n* Diagnosis of acute brain injury categorized as traumatic brain injury, subarachnoid haemorrhage, intracranial haemorrage, intraventricular haemorrhage\n\nExclusion Criteria:\n\n* Patient or closest relatives do not understand written and spoken Danish or English\n* Patients transferred to Rigshospitalet with an EVD\n* Patients with brain injury due to existing brain infection (e.g., meningitis, intracranial empyema or abscess, encephalitis)\n* Patients with existing ventriculoperitoneal or ventriculoatrial shunt at the time of admission\n* Patients with primary or secondary brain cancer\n* Patients died or in palliative care","ALL","18 Years",{"count":20,"type":21},148,"ESTIMATED","6 Months","OBSERVATIONAL","This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to:\n\n1. investigate various biomarkers, with a primary focus on the development of cerebrospinal fluid lactate in relation to ventriculostomy-associated infection;\n2. compare proximal and distal sample results obtained from an external ventricular drain;\n3. describe the natural progression of various biomarkers in blood and cerebrospinal fluid following acute brain injury.",[26,27,28,29],"Acute Brain Injury","Hydrocephalus","External Ventricular Drain","External Ventricular Drainage Associated Infection","RECRUITING","2026-01-28",{"date":33,"type":34},"2026-02-02","ACTUAL",{"date":36,"type":34},"2025-01-15",{"date":38,"type":21},"2029-10-01",{"name":40,"class":41},"Rigshospitalet, Denmark","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":42},"100551955","prediction-of-undesired-obstruction-in-external-ventricular-drains-100551955","NCT06466811","Prediction of Undesired Obstruction in External Ventricular Drains.","Identification of Patients at Risk of Undesired Obstruction in External Ventricular Drain: Development of a Score Based on the Extent of Intra-ventricular Hemorrhage. A Single-Center, Prospective Observational Study.","EVD-OBS","Inclusion Criteria :\n\nPatient older than 18 years old,\n\n* admitted to the ICU,\n* with first EVD inserted for less than 12 hours,\n* and brain imaging (CT or MRI) available in the timespan \"24 hours before to 24 hours after\" the EVD insertion.\n\nExclusion Criteria :\n\n* EVD intentionally occluded immediately after its insertion,\n* purulent cerebrospinal fluid\n* Pregnant or breast-feeding patient\n* Moribund patient or patient with decision of withholding or withdrawing life-sustaining treatment within the 12 hours\n* Patient with no health insurance\n* Patient under guardianship",{"count":52,"type":21},640,"Acute obstructive hydrocephalus often complicates intraventricular hemorrhage (IVH). The insertion of an external ventricular drain (EVD) is typically necessary in order to alleviate intracranial pressure by draining excess fluid. However, dysfunction of the EVD whether due to malposition or obstruction, can exacerbate hydrocephalus in an already compromised brain. EVD dysfunction must therefore be promptly detected and treated.\n\nConsequently, identifying high-risk patients and closely monitoring them is imperative. While IVH is known to increase the risk of obstruction in the natural cerebrospinal fluid outflow tract, its association with ventricular drain obstruction remains unproven.",[55,56,28],"Intensive Care Unit","Intraventricular Hemorrhage",[58,59,60,61,62,63],"Intensive care unit","External ventricular drain","Neuromeningeal infection","Obstruction","Intraventricular hemorrhage","Functional outcome","2024-07-11",{"date":66,"type":34},"2024-07-12",{"date":68,"type":34},"2024-07-04",{"date":70,"type":21},"2026-12-01",{"name":72,"class":41},"Nantes University Hospital"]