[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"extracorporeal-cardiopulmonary-resuscitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:extracorporeal-cardiopulmonary-resuscitation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,67,97],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100640435","perception---super-early-neuroprognostication-in-ecpr-patients-100640435",false,"NCT07584187","PERCEPTION - Super-Early Neuroprognostication in eCPR Patients","Super-Early Neuroprognostication in eCPR Patients: Feasibility of Automated Pupillometry and Cerebral Near-Infrared Spectroscopy - A Prospective Feasibility Study","PERCEPTION","Inclusion Criteria:\n\n* All patients ≥ 18 years evaluated for eCPR treatment at the Department of Emergency Medicine\n\nExclusion Criteria:\n\n* Return of spontaneous circulation before ECMO initiation.\n* Anatomical infeasibility for measurement, including but not limited to:\n* Severe facial trauma or deformity preventing the placement of the automated pupillometry device.\n* Scalp injuries, dressings, or conditions that interfere with the correct positioning of near-infrared spectroscopy (NIRS) sensors.\n* Pre-existing ocular conditions that preclude reliable pupillometry (e.g., enucleation, opaque cornea, or severe anisocoria unrelated to neurological status).","ALL","18 Years",{"count":20,"type":21},45,"ESTIMATED","OBSERVATIONAL","Background Extracorporeal cardiopulmonary resuscitation (eCPR) is a rescue therapy for a selected group of patients. Extracorporeal membrane oxygenation (ECMO) is initiated to bypass the cardiac system and bridge time to definitive treatment of the cardiac arrest (CA) origin. eCPR treatment is very time-critical and, if indicated, should be initiated as early as possible. Patient selection for this highly specific treatment is challenging and relies on numerous factors. In the following phase of intensive care treatment, neuroprognostication is performed. However, following current guidelines, this is only recommended 72hours after CA. Once ECMO is initiated, a complex intensive care treatment is expected, without a guarantee for full neurological recovery. There is a recognized clinical need for more precise selection criteria, alongside predictive values, to enable earlier, reliable neuroprognostication.\n\nAim This study aims to investigate whether super-early neuroprognostication before ECMO initiation is feasible. Super-early neuroprognostication will be performed using automated pupillometry and cerebral near-infrared spectroscopy (cNIRS) before ECMO initiation.\n\nMethods Patients evaluated for eCPR treatment at the Department of Emergency Medicine will be included in this study. By a study member not involved in clinical treatment, cNIRS and automated pupillometry will be performed before ECMO initiation and at predefined intervals: 10-20 minutes after ECMO Initiation, 1 hour (±15 minutes), 2 hours (±15 minutes), and 3 hours (±15 minutes). Follow-up measurements will be taken 24 hours (± 6 hours), 48 hours (± 6 hours), and 72 hours ± 6 hours after ECMO initiation. The secondary objective is to interpret the collected data regarding outcome parameters.",[25,26,27,28],"Resuscitation","Extra Corporeal Life Support","ECMO","Extracorporeal Cardiopulmonary Resuscitation",[30,27,31],"eCPR","CPR","RECRUITING","2026-05-12",{"date":35,"type":36},"2026-05-14","ACTUAL",{"date":33,"type":36},{"date":39,"type":21},"2028-10",{"name":41,"class":42},"Medical University of Vienna","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":43},"100546628","refractory-cardiac-arrest-treated-on-field-by-ecmo-100546628","NCT06397417","Refractory Cardiac Arrest Treated On Field By ECMO","Prognosis of Refractory Out-of-hospital Cardiac Arrests Treated With Extracorporeal Cardiopulmonary Resuscitation (ECMO) by the Urgent Medical Aid Service (SAMU) of Paris","ReCATOBE","Inclusion Criteria:\n\n* All patients who have benefited from an installation or attempted installation of an extracorporeal membrane oxygenation (ECMO) device following a non-traumatic refractory cardiac arrest as part of the ECMO TEAM of the Samu de Paris during the time of the study.\n* Obtaining non-opposition from the patient or a relative in the event of the patient's death or a lasting state of health preventing them from becoming aware of the study.\n\nExclusion Criteria:\n\n\\- Minor patients",{"count":53,"type":21},840,"Out-of-hospital cardiac arrest without resumption of spontaneous circulatory activity despite advanced medical resuscitation is considered refractory. Under certain well-defined conditions, today in many cities around the world and particularly in Paris, it benefits from resuscitation called ECPR (extracorporeal cardiopulmonary resuscitation). This technique consists of the installation of an extracorporeal membrane oxygenation (ECMO) device allowing organ perfusion while waiting for a resumption of cardiac activity. Since 2011, the Paris SAMU (SAMU 75) has set up a team capable of implementing ECPR for refractory out-of-hospital cardiac arrests. This team based within the SAMU of Paris at the Necker hospital (ECMO team) composed of an emergency doctor or anesthesiologist-resuscitator, a nurse anesthetist and an ambulance driver intervenes in Paris and its nearby region at the request of medical regulation. Given the growing development of this activity, it is essential to measure its effectiveness in real-life conditions.",[56,28],"Out-of-Hospital Cardiac Arrest",[56,28],"2025-09-05",{"date":60,"type":36},"2025-09-12",{"date":62,"type":36},"2025-03-05",{"date":64,"type":21},"2046-03",{"name":66,"class":42},"Assistance Publique - Hôpitaux de Paris",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":43},"100576798","rapid-prehospital-access-to-ecpr-in-prague-100576798","NCT06789978","Rapid Prehospital ACcess to ECPR in Prague","Prehospital Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study in Prague","RACE","Inclusion Criteria:\n\n* Estimated age 18-70 years\n* Refractory out-of-hospital cardiac arrest (3 unsuccessful defibrillations and\u002For at least 10 minutes of resuscitation in case of pulseless electrical activity)\n* Witnessed cardiac arrest\n* ECPR team available\n* ECPR team alert within 20 minutes from the emergency call\n\nExclusion Criteria:\n\n* Unwitnessed cardiac arrest\n* Asystole\n* ETCO2 less than 10 mmHg upon ECPR team arrival\n* Known limitations of intensive care (Do Not Resuscitate - DNR status)\n* Known severe neurological impairment prior to cardiac arrest (mRS 4-6)\n* Suspected or known pregnancy","70 Years",{"count":77,"type":21},20,"INTERVENTIONAL",[80],"NA","A prospective pilot feasibility study of prehospital ECPR in patients with refractory OHCA",[83,28],"Out of Hospital Cardiac Arrest",[85,86,27,87],"Cardiac arrest","ECPR","Prehospital","2025-02-12",{"date":90,"type":36},"2025-02-14",{"date":92,"type":36},"2025-01-20",{"date":94,"type":21},"2026-06-16",{"name":96,"class":42},"General University Hospital, Prague",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":75,"enrollmentInfo":105,"targetDuration":4,"studyType":78,"phases":107,"briefSummary":108,"conditions":109,"keywords":115,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100577980","the-osiris-ecpr-trial-100577980","NCT06805344","The OSIRIS ECPR Trial","Out-of-hospital Refractory Cardiac Arrest Treated with Extracorporeal Cardiopulmonary Resuscitation","OSIRIS","Inclusion Criteria:\n\n1. Age ≥18 and ≤ 70 years presumed or known\n2. Witnessed OHCA\n3. Bystander CPR provided\n4. Presumed cardiac or unknown cause\n5. An initial documented shockable rhythm of VF (ventricular fibrillation) or pulseless VT (ventricular tachycardia)\n6. Minimum of ≥ 10 min of ACLS without ROSC or at least ≥ 3 defibrillations in ongoing VF\u002Fpulseless VT\n7. Body morphology able to accommodate a mechanical chest compression device\n8. ECPR team and intensive care unit (ICU) capacity in the receiving center available\n9. Estimated transfer time from the scene to the hospital ≤ 30 minutes or to the scene ≤ 30 minutes\n10. Eligible for intensive care without restrictions or limitations\n\nExclusion Criteria:\n\n1. ACLS ≥ 30 minutes before randomization\n2. Known limitations in care or a Do Not Attempt to Resuscitate (DNAR) order\n3. Known severe disease making 90-day survival unlikely\n4. Known bleeding diathesis or acute or recent intracranial bleeding\n5. Known, obvious or suspected pregnancy\n6. Known pre-arrest severe cognitive dysfunction (mRS ≥ 4)\n7. Known hypothermia as a cause of cardiac arrest",{"count":106,"type":21},686,[80],"The OSIRIS trial is an investigator-initiated, multicenter, multinational, open-label, randomized controlled trial with a 2:1 concealed allocation of refractory out-of-hospital cardiac arrest (OHCA) patients to the extracorporeal cardiopulmonary resuscitation (ECPR) based approach versus the conventional cardiopulmonary resuscitation (CCPR) approach.",[110,111,112,113,28,114],"Cardiac Arrest","Ventricular Fibrillation","Out-Of-Hospital Cardiac Arrest","Sudden Cardiac Arrest","Extracorporeal Membrane Oxygenation",[116,117,118,119],"cardiac arrest","extracorporeal cardiopulmonary resuscitation","extracorporeal membrane oxygenation","out-of-hospital cardiac arrest","NOT_YET_RECRUITING","2025-01-30",{"date":123,"type":36},"2025-02-03",{"date":125,"type":21},"2025-02",{"date":127,"type":21},"2030-06",{"name":96,"class":42}]