[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"extramammary-pagets-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:extramammary-pagets-disease":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100329073","gynecologic-extramammary-pagets-disease-100329073",false,"NCT03564483","Gynecologic Extramammary Paget's Disease","Prospective Registry of Gynecologic Patients With Extramammary Paget's Disease","Inclusion Criteria:\n\n* Females\n* Age 18 years or older\n* Diagnosed with primary or recurrent EMPD of vulva and\u002For perianal region of the body\n* Willing and able to provide signed informed consent\n\nExclusion Criteria:\n\n* Males\n* Diagnosis of Paget's Disease in body areas other than vulvar or perianal region","FEMALE","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","In addition to evaluating treatment outcomes, tissue samples and swabs will be collected as part of this study to allow physicians to better understand Extramammary Paget's Disease (EMPD). The researchers also want to learn more about the microorganisms (microbiome) that live on or near the areas of skin affected by EMPD, in order to better understand this condition.",[24,25,26,27,28,29,30,31,32],"Extramammary Paget's Disease","Extramammary Paget Disease","Paget Disease, Extramammary","Extramammary Paget's Disease of Vulva (Diagnosis)","Extramammary Paget's Disease of Vagina (Diagnosis)","Extramammary Paget's Disease Vulva Invasive","Extramammary Paget's Disease of Anus (Diagnosis)","Extramammary Paget's Disease of Anal Canal (Diagnosis)","Extramammary Paget's Disease of Skin","RECRUITING","2026-01-26",{"date":36,"type":37},"2026-01-28","ACTUAL",{"date":39,"type":37},"2018-02-19",{"date":41,"type":20},"2050-12",{"name":43,"class":44},"Mayo Clinic","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100583245","phase-2-a-study-of-fluorescein-sodium-in-people-undergoing-vulvectomy-for-extramammary-pagets-disease-empd-100583245","NCT06873815","A Study of Fluorescein Sodium in People Undergoing Vulvectomy for Extramammary Paget's Disease (EMPD)","A Single-Arm Prospective Trial of Fluorescein Mapping in Patients Undergoing Vulvectomy for Extramammary Paget's Disease","Inclusion Criteria:\n\n* Age ≥18 years\n* Noninvasive or microinvasive EMPD with a contiguous visible clinical lesion\n* Newly diagnosed or recurrent lesion\n* Scheduled to undergo wide local excision or vulvectomy not requiring resection of the clitoris, urethra, or anus and with the surgeon's judgment that primary closure is possible (V-Y advancement flap closure is allowed)\n\nExclusion Criteria:\n\n* History of allergic reaction to fluorescein sodium\n* Multifocal, noncontiguous clinical lesion\n* Current or previous invasive EMPD\n* History of invasive vulvar, vaginal, or anal cancer\n* Lesion in which resection of the clitoris, urethra, and\u002For anus is deemed to be necessary\n* Lesion in which a primary closure or V-Y advancement flap is believed not to be possible and a larger myocutaneous flap is needed for closure of the defect\n* History of radiation therapy to the vulva and\u002For anus",{"count":54,"type":20},27,"INTERVENTIONAL",[57],"PHASE2","The researchers are doing this study to see if giving people fluorescein sodium as an IV infusion before their vulvectomy for treating extramammary Paget's disease (EMPD) can help surgeons with performing the procedure. The researchers will look at whether fluorescein sodium helps surgeons identify disease cells that should be removed. Other purposes of this study include looking at the following: If there are any complications during or after vulvectomy involving the use of fluorescein sodium. If fluorescein sodium can reveal tissue that surgeons cannot operate on (unresectable tissue).",[24],[61,62,63],"Fluorescein Mapping","Vulvectomy","25-002","2026-01-09",{"date":66,"type":37},"2026-01-12",{"date":68,"type":37},"2025-03-07",{"date":70,"type":20},"2027-03",{"name":72,"class":44},"Memorial Sloan Kettering Cancer Center",7]