[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"extremely-deep-caries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:extremely-deep-caries":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,67,90],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100642792","influence-of-proximal-caries-on-outcome-of-direct-pulp-capping-in-permanent-mandibular-molars-with-reversible-pulpitis-100642792",false,"NCT07578662","Influence of Proximal Caries on Outcome of Direct Pulp Capping in Permanent Mandibular Molars With Reversible Pulpitis","Influence of Proximal Caries on Outcome of Direct Pulp Capping in Permanent Mandibular Molars With Reversible Pulpitis: A Prospective Study","Inclusion Criteria:\n\n1. Mature permanent mandibular molars with extremely deep caries that penetrate the entire thickness of dentine as detected on radiograph with reversible pulpitis will be included.\n2. Participant with Reversible pulpitis will be diagnosed clinically based on discomfort experienced by the participant when a stimulus such as cold or sweet is applied and goes away within a couple of seconds following the removal of the stimulus, with no significant radiographic changes in the periapical region of the suspect tooth and the pain experienced is not spontaneous.\n3. The pulpal sensibility will be confirmed through positive response to electric and cold tests (Endo frost) and the presence of bleeding after caries excavation. 4.Pulpal and the periapical diagnosis will be established based on the diagnostic terminology approved by American Association of Endodontists (AAE, 2019).\n\n5.Teeth with a negative response to palpation and percussion testing and radiographic finding of periapical index (PAI) score ≤2 and healthy periodontium (probing pocket depth ≤3 mm and mobility within normal limit) will be included. 6.Teeth in which hemostasis achieved within 5 mins will be included.\n\n7.Only pulp exposures with size 0.5-1 mm will be included\n\n\\-\n\nExclusion Criteria:\n\n1. Mechanical or pulp exposure due to trauma\n2. absence of exposure after excavation of caries\n3. failure to achieve hemostasis within 5 mins\n4. irreversible pulpitis and teeth having periapical lesions\n5. periodontal disease, resorptive defects, calcified canals, as assessed by radiographic examination will serve as criteria for exclusion.\n6. Also immunocompromised, Pregnant and subjects having systemic diseases will be excluded -","ALL","15 Years","40 Years",{"count":20,"type":21},154,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of the study is to assess the Influence of proximal caries on outcome of direct pulp capping in permanent mandibular molars with sign of reversible pulpitis. objective- Primary objective- To evaluate and compare the clinical and radiographic outcome of Direct pulp capping in mandibular molars with occlusal and proximal carious lesions. Secondary objective- To evaluate and compare 1.OHRQoL after Direct pulp capping in occlusal and proximal lesion. 2. Postoperative pain, after Direct pulp capping in occlusal and proximal lesion Subjects of age group 15 - 40 yrs will be included and divided into two groups 1) Permanent mature molars with proximal carious lesion 2)Permanent mature molars with occlusal carious lesion.",[27,28],"Reversible Pulpitis","Extremely Deep Caries",[30],"direct pulp capping","RECRUITING","2026-06-08",{"date":34,"type":35},"2026-06-10","ACTUAL",{"date":37,"type":35},"2026-04-29",{"date":39,"type":21},"2028-04-28",{"name":41,"class":42},"Postgraduate Institute of Dental Sciences Rohtak","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":64,"leadSponsor":66,"locationsCount":43},"100616016","outcome-of-direct-pulp-capping-and-partial-pulpotomy-in-reversible-pulpitis-100616016","NCT07300124","Outcome of Direct Pulp Capping and Partial Pulpotomy in Reversible Pulpitis","Inclusion Criteria:\n\n1. Patients aged 15-40 years.\n2. Mature permanent mandibular molars with extremely deep caries on radiograph, giving positive response to pulp sensibility test.\n3. Pulpal bleeding can be controlled within 10 minutes\n4. Patients having normal periapical status with periapical index (PAI) score ≤ 2\n5. Periodontally healthy teeth\n6. Positive response to pulp sensibility test\n\nExclusion Criteria:\n\n1. Non restorable teeth\n2. Negative response to vitality testing\n3. Presence of sinus tract or soft tissue swelling\n4. Absence of deep carious lesions radiographically\n5. Radiographic signs of internal or external root resorption\n6. Patient had moderate to severe pain, but preferred root canal treatment\n7. Presence of sound dentin over pulp and pulp not exposed intraoperatively\n8. Pulp haemorrhage could not be arrested within 10 minutes.\n9. Necrotic pulp evident upon exposure\n10. Pregnant women\n11. Absence of antagonist teeth\n12. Intake of antibiotics in last 30 days",true,{"count":52,"type":21},138,[24],"AIM: -The aim of the study is to compare the outcome of Direct Pulp Capping and Partial Pulpotomy in mature permanent teeth with Reversible Pulpitis OBJECTIVES: - Primary Objective: to compare the difference in clinical and radiographic outcome of direct pulp capping and partial pulpotomy in mature permanent teeth with Reversible Pulpitis. Secondary objective: To evaluate and compare postoperative pain after Direct Pulp Capping and Partial Pulpotomy in teeth with Reversible Pulpitis STUDY GROUPS: - Subjects of age group 15 to 40 years will be included and divided into two groups\n\n1. Direct Pulp Capping in Permanent mature molars with Reversible Pulpitis\n2. Partial Pulpotomy in Permanent mature molars with Reversible Pulpitis",[27,28],[57,58],"Partial Pulpotomy","Direct pulp capping","NOT_YET_RECRUITING","2025-12-10",{"date":62,"type":35},"2025-12-23",{"date":60,"type":21},{"date":65,"type":21},"2027-12-10",{"name":41,"class":42},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":16,"minAge":74,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":43},"100611604","effectiveness-of-pulpotomy-vs-root-canal-treatment-in-extremely-deep-caries-100611604","NCT07242742","Effectiveness of Pulpotomy vs. Root Canal Treatment in Extremely Deep Caries","Effectiveness of Pulpotomy vs. Root Canal Treatment in Extremely Deep Caries: A Randomized Controlled Trial Conducted in Supervised Undergraduate Clinics","Inclusion Criteria:\n\n* Aged 12 years or older\n* Mature maxillary or mandibular permanent tooth with extremely deep restorations\u002Fcaries penetrating the entire thickness of dentine on the radiograph without a radiopaque zone separating the lesion from the pulp (Bjorndal et al., 2019)\n* Tooth may or may not be symptomatic at the time of recruitment but must be responsive to cold and EPT sensibility testing\n* Tooth is restorable and can be adequately isolated during treatment\n* One tooth per patient\n\nExclusion Criteria:\n\n* Teeth with difficult access and unpredictable isolation using a rubber dam\n* Teeth aberrant root canal morphology, extreme root curvatures (\\>30 degrees), calcified canals\u002Fsclerosed pulp\n* Teeth indicated for elective root canal treatment for restorative purposes\n* Teeth with apical periodontitis\n* Presence of apical radiolucency\n* Any evidence of purulence or excessive bleeding that cannot be controlled with a cotton pellet with 1.25% hypochlorite for 10 minutes\n* History of trauma to the tooth\n* Teeth with active periodontal disease (pocket depth \\>5mm)\n* Patients with complex medical histories that may affect their caries experience and healing ability (immunocompromised, radiotherapy etc.)\n* Patients who are pregnant or breast-feeding\n* Patients who are unable to consent","12 Years",{"count":76,"type":21},93,[24],"Recent clinical trials comparing pulpotomy versus root canal treatment (RCT) have shown promising outcomes; however, the current evidence lacks generalisability to general practitioners. It remains to be elucidated whether these favourable results can be replicated in a primary care setting. This study aims to address that gap by involving senior dental students undergoing supervised university education and training, with the potential to inform future best practice guidelines and promote the adoption of vital pulp therapy (VPT) as a predictable treatment alternative in the general dental population.\n\nThe clinical procedure involves complete caries-free excavation carried out under rubber dam isolation. After confirming vital pulp status-demonstrated by bleeding upon entry, participants will be randomised to receive one of two treatments: RCT or full pulpotomy.\n\nOutcomes will include clinical and radiographic success or failure of the intervention at 12 months. Additionally, patient-reported outcomes will be collected, specifically pain experienced and the use of analgesia during the immediate post-operative period (days 3 and 7).",[28,80],"Pulpitis","2025-11-17",{"date":83,"type":35},"2025-11-21",{"date":85,"type":35},"2025-07-16",{"date":87,"type":21},"2027-07",{"name":89,"class":42},"National University Hospital, Singapore",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":99,"conditions":100,"keywords":103,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":43},"100602401","outcome-of-partial-pulpotomy-in-moderate-and-severe-pulpitis-100602401","NCT07123025","Outcome of Partial Pulpotomy in Moderate and Severe Pulpitis","Inclusion Criteria:\n\n1. Patients aged 15-40 years.\n2. Mature permanent mandibular molars with extremely deep caries on radiograph, giving positive response to pulp sensibility test.\n3. For Moderate Pulpitis- strong, heightened and prolonged reaction to cold, which can last for minutes, possibly percussion sensitive and spontaneous dull pain that can be more or less suppressed with pain medication.\n\n   For Severe Pulpitis- Severe spontaneous pain and clear pain reaction to warmth and cold stimuli, often, sharp to dull throbbing pain, patients have trouble sleeping because of the pain (gets worse when lying down). Tooth is very sensitive to touch and percussion.\n4. Pulpal bleeding can be controlled within 10 minutes\n5. Patients having normal periapical status with periapical index (PAI) score ≤ 2\n6. Periodontally healthy teeth\n7. Positive response to pulp sensibility test\n\nExclusion Criteria:\n\n1. Non restorable teeth\n2. Negative response to vitality testing\n3. Presence of sinus tract or soft tissue swelling\n4. Absence of deep carious lesions radiographically\n5. Radiographic signs of internal or external root resorption\n6. Patient had moderate to severe pain, but preferred root canal treatment\n7. Presence of sound dentin over pulp and pulp not exposed intraoperatively\n8. Pulp haemorrhage could not be arrested within 10 minutes.\n9. Necrotic pulp evident upon exposure\n10. Pregnant women\n11. Absence of antagonist teeth",{"count":97,"type":21},120,[24],"The aim of the study is to compare the outcome of Partial Pulpotomy in mature permanent teeth with moderate and severe pulpitis.\n\nOBJECTIVE: Primary objective- to compare the difference in clinical and radiographic outcome of partial pulpotomy in mature permanent teeth with moderate and severe Pulpitis. Secondary objective- To evaluate and compare OHRQoL and postoperative pain after Partial Pulpotomy in teeth with Moderate Pulpitis and Severe Pulpitis. Subjects of age group 15 to 40 years will be included and divided into two groups\n\n1. Permanent mature molars with Moderate Pulpitis\n2. Permanent mature molars with Severe Pulpitis",[101,102,28],"Moderate Pulpitis","Severe Pulpitis",[104],"partial pulpotomy","2025-08-21",{"date":107,"type":35},"2025-08-28",{"date":109,"type":35},"2025-04-18",{"date":111,"type":21},"2027-04-18",{"name":41,"class":42}]