[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"extubation-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:extubation-failure":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,43,73,96,130,168,202,231,256,272,294,317],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100473544","the-diaphragmatic-initiated-ventilatory-assist-diva-trial-100473544",false,"NCT05446272","The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial","DIVA","Inclusion Criteria:\n\n* Gestational age of 23 0\u002F7- 28 6\u002F7 weeks at birth\n* Intubated in the first 7 days of life\n* Undergoing extubation following at least 12 hours of invasive mechanical ventilation\n* Post-natal age \\\u003C32 weeks Post menstrual age at time of extubation\n\nExclusion Criteria:\n\n* Major congenital anomalies, including pulmonary hypoplasia\n* Neurologic disorders affecting respiratory drive (other than apnea of prematurity)\n* Esophageal bleeding or other contraindication to NG\u002FOG catheter placement\n* Current weight \\\u003C500 grams (based on Edi catheter approval)\n* Study ventilator not available at time eligibility criteria are met\n* Planned surgery or invasive procedure within 5 days of extubation\n* Informed consent not provided","ALL","0 Days","9 Weeks",{"count":20,"type":21},478,"ESTIMATED","INTERVENTIONAL",[24],"NA","DIVA is a pragmatic randomized clinical trial (RCT) to determine: among (P) preterm infants born 23 0\u002F7-28 6\u002F7 weeks gestation undergoing extubation from mechanical ventilation, whether (I) Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) (C) compared with Non-synchronized nasal intermittent positive pressure ventilation (NS-NIPPV), will reduce the incidence of (O) extubation failure within (T) 5 days (120 hours) of extubation.",[27,28,29],"Extubation Failure","Bronchopulmonary Dysplasia","Death","RECRUITING","2026-06-24",{"date":33,"type":34},"2026-06-25","ACTUAL",{"date":36,"type":34},"2022-08-03",{"date":38,"type":21},"2027-12-31",{"name":40,"class":41},"University of Pennsylvania","OTHER",20,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100644604","assessment-of-reintubation-risk-using-multiple-parameters-in-postoperative-intensive-care-unit-patients-100644604","NCT07672106","Assessment of Reintubation Risk Using Multiple Parameters in Postoperative Intensive Care Unit Patients","Inclusion Criteria:\n\nAdult patients aged 18 years and older\n\nPatients requiring postoperative intensive care follow-up after major surgery, including abdominal, vascular, orthopedic, or ear, nose, throat, head and neck surgery\n\nPatients extubated in the operating room and admitted to the intensive care unit with spontaneous breathing\n\nPatients without any clinical condition preventing the planned measurements within the first 0-2 hours after ICU admission (T0 and T1)\n\nPatients for whom written informed consent can be obtained from the patient or legally authorized representative\n\nPatients admitted to the intensive care unit within the specified study period after ethics committee approval and enrolled consecutively\n\nExclusion Criteria:\n\nPatients younger than 18 years of age\n\nPatients who leave the operating room intubated or are admitted to the intensive care unit while intubated\n\nPatients with a tracheostomy\n\nPatients with a history of diaphragmatic paralysis\n\nPatients with a significant neuromuscular disease, such as ALS, myasthenia gravis, or similar conditions\n\nPatients with conditions that significantly prevent ultrasound measurements, including marked subcutaneous emphysema, large dressings or bandages covering the measurement area, inability to access the measurement site due to drains or the surgical field, or inability to obtain technically adequate images\n\nPatients in whom the planned measurements cannot be performed due to clinical instability requiring emergency intubation immediately after ICU admission\n\nPatients from whom informed consent cannot be obtained, or patients or legally authorized representatives who refuse participation","18 Years",{"count":51,"type":21},600,"OBSERVATIONAL","This prospective, non-interventional observational study will evaluate the risk of reintubation in adult postoperative patients admitted to the intensive care unit after major surgery. Reintubation after extubation is an important clinical problem because it may increase complications, prolong mechanical ventilation, and extend intensive care and hospital stay.\n\nThe study will include adult patients who are extubated in the operating room and admitted to the intensive care unit with spontaneous breathing. Within the first hours after ICU admission, bedside ultrasound measurements of diaphragm thickness, parasternal intercostal muscle thickness, and lung ultrasound score will be performed. The ROX index will also be calculated using oxygen saturation, inspired oxygen concentration, and respiratory rate. Perioperative fluid balance will be recorded from anesthesia and patient files.\n\nPatients will be followed for 48 to 72 hours after ICU admission to determine whether reintubation is required. The study aims to assess whether respiratory muscle ultrasound findings, lung ultrasound score, ROX index, and perioperative fluid balance can help predict reintubation risk in postoperative ICU patients. No additional treatment or intervention will be applied as part of the study, and all clinical decisions will be made by the responsible intensive care team according to routine clinical practice.",[55,27,56,57,58],"Postoperative Respiratory Failure","Lung Ultrasonography Score","Diaphragm Thickness","Parasternal Intercostal Muscle Thickness",[60,61,62,55],"lung ultrasonography score","Diaphragm thickness","parasternal intercostal muscle thickness","2026-06-22",{"date":65,"type":34},"2026-06-26",{"date":67,"type":34},"2026-04-28",{"date":69,"type":21},"2026-10-28",{"name":71,"class":41},"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":72},"100641424","swallowing-assessment-for-predicting-extubation-failure-in-critically-ill-patients-100641424","NCT07659275","Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients","Prospective Evaluation of the Prognostic Performance of an Orotracheal Tube-Adapted Swallowing Biomechanics Assessment for Predicting Extubation Failure in Critically Ill Patients","APEX","Inclusion Criteria:\n\n* Age ≥18 years.\n* Admission to an intensive care unit.\n* Invasive mechanical ventilation for ≥48 hours.\n* Successful completion of a spontaneous breathing trial according to local practice.\n* Ability to undergo bedside swallowing biomechanics assessment using the APEX score before extubation.\n* Written informed consent from the patient or legally authorized representative, when required by local regulations.\n\nExclusion Criteria:\n\n* Presence of a tracheostomy.\n* Decision to withhold or withdraw life-sustaining treatments.\n* Structural abnormalities of the upper airway or face precluding APEX assessment.\n* Conditions preventing assessment of swallowing biomechanics (e.g., maxillofacial trauma, recent head and neck surgery, or other conditions judged by the investigator to interfere with the evaluation).",{"count":82,"type":21},800,"Extubation failure, defined as the need for reintubation after planned removal of the endotracheal tube, occurs in up to 20% of critically ill patients and is associated with prolonged mechanical ventilation, longer intensive care unit (ICU) stay, and increased mortality. Current assessments of extubation readiness focus primarily on respiratory performance and do not routinely evaluate upper airway protective function.\n\nThe Airway Protection for Extubation (APEX) score is a bedside assessment tool based on swallowing biomechanics designed to evaluate airway protection before extubation. In a pilot prospective cohort study, the APEX score demonstrated promising performance for identifying patients at increased risk of extubation failure.\n\nThis prospective multicenter cohort study will be conducted across ICUs in Brazil to externally validate the APEX score in critically ill adults undergoing planned extubation. The study will evaluate the discrimination, calibration, and clinical utility of the APEX score for predicting extubation failure and will assess its performance across different patient populations and hospital settings.\n\nThe results of this study may support the incorporation of a simple bedside assessment of swallowing biomechanics into extubation readiness evaluation and contribute to more individualized decision-making regarding extubation in critically ill patients.",[27,85,86],"Mechanical Ventilation","Critical Illness","NOT_YET_RECRUITING","2026-06-15",{"date":63,"type":34},{"date":91,"type":21},"2027-03-30",{"date":93,"type":21},"2030-10-30",{"name":95,"class":41},"Universidade Federal de Pernambuco",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":103,"sex":16,"minAge":49,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":107,"conditions":108,"keywords":111,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100639198","combined-rsbi-tof-and-bis-for-prediction-of-extubation-success-100639198","NCT07577453","Combined RSBI, TOF, and BIS for Prediction of Extubation Success","Predictive Value of Combined RSBI, TOF, and BIS Monitoring for Extubation Success After General Anesthesia","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* ASA physical status I-III\n* Patients scheduled for elective surgery under general anesthesia\n* Patients undergoing endotracheal intubation during general anesthesia\n* Patients receiving neuromuscular blocking agents during anesthesia\n* Patients planned for extubation in the operating room\n* Availability of pre-extubation RSBI, TOF ratio, and BIS measurements\n* Written informed consent obtained from the patient\n\nExclusion Criteria:\n\n* Emergency surgery\n* Age \\\u003C18 years or \\>80 years\n* ASA physical status IV or higher\n* Known or anticipated difficult airway\n* Anticipated difficult extubation\n* Preoperative mechanical ventilation\n* Planned postoperative mechanical ventilation or transfer to the intensive care unit while intubated\n* Known neuromuscular disease\n* Severe chronic respiratory failure\n* Severe chronic obstructive pulmonary disease associated with respiratory failure\n* Significant neurological disease affecting respiratory drive or level of consciousness\n* Conditions or medications that may interfere with reliable neuromuscular monitoring\n* Inability to obtain reliable RSBI, TOF ratio, or BIS measurements\n* Refusal to participate\n* Incomplete perioperative or post-extubation outcome data",true,"80 Years",{"count":106,"type":21},150,"This prospective observational study aims to evaluate the predictive value of the combined use of the rapid shallow breathing index, train-of-four ratio, and bispectral index for extubation success after general anesthesia. Adult patients undergoing elective surgery under general anesthesia and planned for extubation in the operating room will be included.\n\nBefore extubation, RSBI, TOF ratio, BIS value, respiratory parameters, and relevant perioperative data will be recorded. The decision to extubate will be made by the attending anesthesiologist according to routine clinical practice and will not be altered by the study protocol. Patients will be followed for 30 minutes after extubation to assess extubation success or the development of complications such as desaturation, laryngospasm, need for airway intervention, mask ventilation, or reintubation.\n\nThe primary aim is to determine whether the combined RSBI, TOF, and BIS model predicts extubation success more accurately than each parameter alone.",[109,27,110],"Extubation Success","Postoperative Respiratory Complications",[112,113,114,115,116,117,118,119,120,121],"Extubation","Extubation Succcess","Extubation failure","General anesthesia","Rapid shallow breathing index","TOF ratio","Bispectral index","Neuromuscular monitoring","Postoperative respiratory complications","Prediction model","2026-05-09",{"date":124,"type":34},"2026-05-13",{"date":88,"type":21},{"date":127,"type":21},"2026-08-15",{"name":129,"class":41},"Gaziantep City Hospital",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":138,"enrollmentInfo":139,"targetDuration":141,"studyType":52,"phases":4,"briefSummary":142,"conditions":143,"keywords":151,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":167},"100600524","a-new-tool-for-extubation-readiness-in-mechanically-ventilated-patients-readiness-for-extubation-score-100600524","NCT07098611","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score (REXs STUDY)","REXs","Inclusion Criteria:\n\n\\- Patients who are in the weaning process from mechanical ventilation after being connected to invasive mechanical ventilation in the intensive care unit.\n\nExclusion Criteria:\n\n* Patients without legal guardian consent.\n* Tracheostomized patients.\n* Patients enrolled in other studies.\n* Individuals with diaphragmatic pacers.\n* Pregnant patients.","89 Years",{"count":140,"type":21},470,"6 Weeks","Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability, and adequate respiratory effort. Successful extubation is defined as not requiring invasive support within 48 hours. Due to the complexity of ICU patients, various clinical parameters and multi-component scores have been developed to predict extubation success. This study aims to develop and evaluate a multi-component score, the Readiness for EXtubation score (REXs), to predict extubation readiness in ICU patients under invasive mechanical ventilation.",[144,145,146,147,27,148,149,150],"Ventilator Weaning","Respiration, Artificial","Respiratory Failure","Extubation Readiness","Extubation Succeeded","Intensive Care Patients Invasively Ventilated","Weaning Invasive Mechanical Ventilation",[152,153,154,155,156,157],"mechanical ventilation","extubation","weaning","readiness","prediction","score","2026-04-29",{"date":160,"type":34},"2026-05-05",{"date":162,"type":34},"2025-06-15",{"date":164,"type":21},"2026-12-30",{"name":166,"class":41},"Medipol University",7,{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":176,"maxAge":177,"enrollmentInfo":178,"targetDuration":180,"studyType":52,"phases":4,"briefSummary":181,"conditions":182,"keywords":189,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":72},"100600102","rehabilitation-practices-in-critically-ill-patients-receiving-invasive-mechanical-ventilation-in-the-intensive-care-unit-100600102","NCT07093125","Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.","An Observational Study on Rehabilitation Practices in the ICU for Critically Ill Patients Undergoing Invasive Mechanical Ventilation - Report (REPOrt)","REPOrt","Inclusion Criteria:\n\n* Patients admitted to a participating ICU\n* Adult patients (aged 16 years or older, depending on local regulations for the definition of \"adults\")\n* Patients who have received invasive ventilation for at least 48 hours\n* Patients who have obtained written informed consent from the patient or next of kin (if local legislation demands so)\n\nExclusion Criteria:\n\n• Patients admitted for withdrawn of life sustain therapy","16 Years","100 Years",{"count":179,"type":21},2400,"28 Days","This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.\n\nThe primary objective is to provide an overview of current rehabilitation strategies used in ICUs globally.\n\nSecondary objectives include assessing the relationship between rehabilitation and key ICU outcomes such as ICU and hospital mortality, length of stay, duration of invasive ventilation, extubation failures, and long-term outcomes including quality of life and functional performance 28 days post-ICU discharge.\n\nThe study will also compare rehabilitation practices across different geographic and economic regions to identify potential disparities. The study is structured into three modules, with participation contingent on local resources and feasibility.\n\nThe BASIC Module (mandatory for all centers) gathers fundamental data on rehabilitation practices and their association with patient outcomes.\n\nThe EXTENDED Module (optional) collects more detailed information on the type, timing, duration, and safety of rehabilitation interventions, including passive exercises, active mobilization, respiratory therapies, dysphagia training, occupational therapy, and cognitive support.\n\nThe EXTENDED FOLLOW-UP Module (optional) evaluates the patient's quality of life and functional recovery 28 days after ICU discharge. By examining global rehabilitation practices and their impact on patient outcomes, this study aims to improve rehabilitation strategies in ICUs, contributing to better patient care, recovery, and long-term health outcomes.",[85,183,184,185,186,27,187,188],"Pulmonary Rehabilitation","Intensive Care Units (ICUs)","Quality of Life (QOL)","Outcome Assessment","Mortality","Critical Care",[190,85,191,192],"Pulmonary rehabilitation","Intensive Care Unit (ICU)","Rehabilitation Outcomes","2026-04-27",{"date":195,"type":34},"2026-05-04",{"date":197,"type":34},"2025-10-01",{"date":199,"type":21},"2029-10-01",{"name":201,"class":41},"Universita degli Studi di Genova",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":16,"minAge":210,"maxAge":211,"enrollmentInfo":212,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":214,"conditions":215,"keywords":218,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":230},"100578261","prospective-multicentre-mixed-methods-study-to-explore-extubation-practices-and-respiratory-outcomes-in-extremely-preterm-neonates-100578261","NCT06808997","Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates.","Criteria and Reasons for Extubation and Non-extubation in Preterm Infants: A Mixed Methods Study Prospectively Exploring Extubation and Reintubation Practices in Extremely Preterm Infants, and Associated Respiratory Outcomes.","CERAINE","Inclusion Criteria:\n\n* Gestational age \\\u003C 28 weeks of gestation\n* Age at admission to the participating unit \\\u003C24 hours\n\nExclusion Criteria:\n\n* Parental opposition to their infant's clinical data collection\n* Participation in a research protocol with potential impact on extubation and\u002For duration of mechanical ventilation","1 Minute","5 Months",{"count":213,"type":21},100,"The purpose of this observational study is to learn about neonatologists' perceptions of extubation readiness and extubation and reintubation practices in extremely preterm infants in the first 2 weeks of life using prospective qualitative and quantitative data. Actual extubation readiness is defined as successful extubation, defined as no reintubation in the 7 days following extubation.\n\nKey research questions are: How do clinicians assess extubation readiness in this population? Does this assessment correlate with actual extubation success? What factors (reasons, clinical status, ventilatory parameters) are associated with extubation readiness? Patients born before 28 weeks gestational age and admitted to the neonatal intensive care unit (NICU) within the first 24 hours are be included. The attending physician will complete a prospectively administered questionnaire with open-ended and multiple-choice questions to daily assess the decision and rationale for extubation or non-extubation of patients mechanically ventilated during the first 15 days of life.\n\nPatient characteristics, respiratory outcomes, and mortality will be recorded until the end of hospitalisation and\u002For definitive weaning from any ventilatory support or supplemental oxygen.",[216,147,27,217,28,85],"PreTerm Neonate","Respiratory Morbidity",[219,153,152,220],"extremely preterm infants","bronchopulmonary dysplasia","2026-03-11",{"date":223,"type":34},"2026-03-12",{"date":225,"type":34},"2025-02-17",{"date":227,"type":21},"2026-04-30",{"name":229,"class":41},"Centre Hospitalier Intercommunal Creteil",31,{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":238,"targetDuration":4,"studyType":22,"phases":240,"briefSummary":241,"conditions":242,"keywords":245,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":4},"100617887","one-hour-positive-pressure-ventilation-after-a-pressure-support-spontaneous-breathing-trial-100617887","NCT07324460","One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial","One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients aged \\> 18 years.\n* Admitted to the intensive care unit (surgical or medical).\n* With endotracheal intubation.\n* Mechanical ventilation for more than 72 hours.\n* Who underwent successful spontaneous breathing trial (according to the study protocol) and is considered able to be extubated.\n\nExclusion Criteria:\n\n* Patients unable to obey commands.\n* With non-planned extubation.\n* Neuromuscular disease and cervical spinal cord injury.\n* Tracheostomy.\n* Contraindication for cardiopulmonary resuscitation or reintubation.\n* Terminal extubation.\n* Lack of informed consent.\n* Previously included in the trial.",{"count":239,"type":21},4000,[24],"This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to intensive care units, with more than 72 hours of mechanical ventilation and with a successful spontaneous breathing trial on pressure support. Immediately after a successful spontaneous breathing trial, eligible patients will be randomized into 2 groups that will be treated according to one of the following interventions:1) One-hour positive pressure ventilation: as soon as the success of the spontaneous breathing trial is confirmed, the patient is submitted to mechanical ventilation for 1 hour using the previous ventilatory parameters and, afterwards, extubated.2) Immediate extubation: the patient is extubated immediately after the success of the spontaneous breathing trial.",[243,244,27],"Airway Extubation","Weaning Mechanical Ventilation",[246,244,114],"Airway extubation","2026-02-11",{"date":249,"type":34},"2026-02-12",{"date":251,"type":21},"2026-02",{"date":253,"type":21},"2030-02",{"name":255,"class":41},"Hospital do Coracao",{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":262,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":263,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":267,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":268,"startDateStruct":269,"completionDateStruct":270,"leadSponsor":271,"locationsCount":4},"100617881","one-hour-positive-pressure-ventilation-after-a-t-piece-spontaneous-breathing-trial-100617881","NCT07324382","One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial","One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial: A Randomized Clinical Trial","GS-Wean Tpiece",{"count":239,"type":21},[24],"This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to intensive care units, with more than 72 hours of mechanical ventilation and with a successful spontaneous breathing trial on T-piece. Immediately after a successful spontaneous breathing trial, eligible patients will be randomized into 2 groups that will be treated according to one of the following interventions:\n\n1. One-hour positive pressure ventilation: as soon as the success of the spontaneous breathing trial is confirmed, the patient is submitted to mechanical ventilation for 1 hour using the previous ventilatory parameters and, afterwards, extubated.\n2. Immediate extubation: the patient is extubated immediately after the success of the spontaneous breathing trial.",[243,27,244],[246,114,244],{"date":249,"type":34},{"date":251,"type":21},{"date":253,"type":21},{"name":255,"class":41},{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":11,"sex":16,"minAge":279,"maxAge":104,"enrollmentInfo":280,"targetDuration":4,"studyType":22,"phases":282,"briefSummary":283,"conditions":284,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":4},"100598131","impact-of-biphasic-cuirass-ventilation-compared-to-non-invasive-ventilation-in-high-risk-extubations-100598131","NCT07067502","Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations","Impact of Biphasic Cuirass Ventilation Compared to Non-Invasive Ventilation in High Risk Extubations","Inclusion Criteria:\n\n* High risk extubation patients in the Medical Intensive care units who are being thought to be placed on non invasive ventilator post extubation.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>80\n* Pregnant\n* Inmate\u002FPrisoner\n* Chest wall defects\n* BMI \\>50\n* History of Diaphragmatic paralysis\n* History of Neuromuscular disease\n* Contraindication to study device (open chest wound, flail chest, complex thoracic surgeries in the past)","19 Years",{"count":281,"type":21},50,[24],"subjects on mechanical ventilator who are about to be extubated to Non invasive ventilation because the physician thinks they are high risk for failure will be approached and consented for our study. Once randomized they will either be on the standard of care Non invasive arm or the intervention arm which would mean they are placed on the Biphasic cuirass ventilation.",[146,27],"2026-02-10",{"date":287,"type":34},"2026-02-13",{"date":289,"type":21},"2026-03-01",{"date":291,"type":21},"2026-10-30",{"name":293,"class":41},"University of Missouri-Columbia",{"id":295,"slug":296,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":301,"targetDuration":4,"studyType":22,"phases":303,"briefSummary":304,"conditions":305,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":316},"100509833","postextubation-use-of-noninvasive-respiratory-support-in-severely-obese-patients-100509833","NCT05918575","Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients","A Randomized Controlled Trial of Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients","Inclusion Criteria:\n\n1. Adult, age ≥ 18 years old\n2. Receiving invasive mechanical ventilation for ≥24 hours\n3. BMI ≥40 kg\u002Fm2\n4. Undergoing planned extubation per treating team\n5. Arterial pH ≥7.35 or venous pH ≥ 7.31 within 30 mins of spontaneous breathing trial (SBT)\n\nExclusion Criteria:\n\n1. Pregnant\n2. Use of extra-corporeal membrane oxygenation\n3. Chronic tracheostomy in place\n4. Unplanned or accidental extubation\n5. Terminal\u002Fcompassionate extubation\n6. Contraindication to NIV use\n7. Intubated because of an acute exacerbation of COPD\n8. Underlying neuromuscular disease\n9. No reintubation requested by patient\u002Ffamily\n10. Documented\u002Fknown history of chronic hypercapnic respiratory failure on home NIV (including bilevel PAP).\n11. Enrolled in any other outcome study\n12. Treating clinician feels that HFNC or NIV are either mandatory or contraindicated for a given patient",{"count":302,"type":21},250,[24],"Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.",[306,27],"Obesity, Morbid","2025-10-16",{"date":309,"type":34},"2025-10-20",{"date":311,"type":34},"2023-07-10",{"date":313,"type":21},"2026-12-01",{"name":315,"class":41},"Rush University Medical Center",5,{"id":318,"slug":319,"hasResults":11,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":4,"eligibilityCriteria":323,"healthyVolunteers":11,"sex":16,"minAge":324,"maxAge":49,"enrollmentInfo":325,"targetDuration":324,"studyType":52,"phases":4,"briefSummary":326,"conditions":327,"keywords":328,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":72},"100558962","risk-factors-of-extubation-failure-in-picu-patients-100558962","NCT06557941","Risk Factors of Extubation Failure in PICU Patients","The Risk Factors of Extubation Failure in Pediatric Intensive Unite Patients at Sohag University Hospitals","Inclusion Criteria:\n\n* All patient at PICU \\\u003C 18 years subjected to MV through an endotracheal tube at least \\>12 hours.\n* Patients eligible for weaning from MV according to the weaning criteria (Evidence for some reversal of the underlying cause following for respiratory failure, Adequate oxygenation\" PaO2\u002FFIO2 ratio ≥ 200, FIO2 ≤ 0.40, PaO2 ≥ 60, PaCO2 ≤ 60 and PEEP ≤ 5 cmH2O.\", PH ≥ 7.25, Respiratory rate (RR) ≤ 45 bpm, Heart rate (HR) ≤ 140 bpm,(rapid shallow breathing index = tidal volume \u002F RR) RSBI ≤ 8 breaths\u002Fmin\u002Fml\u002Fkg body weight, Hemodynamic stable, no or minimal vasopressor or inotropes\"\\[1,12\\],.\n* Appropriate level of consciousness, No continuous sedation infusion nor neuromuscular blocking agents, afebrile, adequate hemoglobin ≥ 7.5 g\u002Fdl and\u002For no evidence of hemorrhage.\n\nExclusion Criteria:\n\n* Patients less than 30 days.\n* Tracheostomized patients.\n* Death on mv ≤ 12 hours.\n* Unplanned extubation.","30 Days",{"count":213,"type":21},"Up to 20% of MV patients experience EF \\[10\\]. EF is defined as the need to reinsert the endotracheal tube to resume MV in patients extubated for less than 48 hours. It has high rates of morbidity and mortality, prolongs the duration of MV and thus causes a longer stay in the PICU and risk of complications such as the need for tracheostomy, the incidence of pneumonia and pulmonary damage, and finally, costs increase as well and death \\[10, 11\\] .",[27],[329,152,330],"extubation failure","PICU","2024-08-14",{"date":333,"type":34},"2024-08-16",{"date":335,"type":34},"2024-05-01",{"date":337,"type":21},"2025-05",{"name":339,"class":41},"Sohag University"]