[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"extubation-readiness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:extubation-readiness":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,86,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100600524","a-new-tool-for-extubation-readiness-in-mechanically-ventilated-patients-readiness-for-extubation-score-100600524",false,"NCT07098611","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score (REXs STUDY)","REXs","Inclusion Criteria:\n\n\\- Patients who are in the weaning process from mechanical ventilation after being connected to invasive mechanical ventilation in the intensive care unit.\n\nExclusion Criteria:\n\n* Patients without legal guardian consent.\n* Tracheostomized patients.\n* Patients enrolled in other studies.\n* Individuals with diaphragmatic pacers.\n* Pregnant patients.","ALL","18 Years","89 Years",{"count":21,"type":22},470,"ESTIMATED","6 Weeks","OBSERVATIONAL","Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability, and adequate respiratory effort. Successful extubation is defined as not requiring invasive support within 48 hours. Due to the complexity of ICU patients, various clinical parameters and multi-component scores have been developed to predict extubation success. This study aims to develop and evaluate a multi-component score, the Readiness for EXtubation score (REXs), to predict extubation readiness in ICU patients under invasive mechanical ventilation.",[27,28,29,30,31,32,33,34],"Ventilator Weaning","Respiration, Artificial","Respiratory Failure","Extubation Readiness","Extubation Failure","Extubation Succeeded","Intensive Care Patients Invasively Ventilated","Weaning Invasive Mechanical Ventilation",[36,37,38,39,40,41],"mechanical ventilation","extubation","weaning","readiness","prediction","score","RECRUITING","2026-04-29",{"date":45,"type":46},"2026-05-05","ACTUAL",{"date":48,"type":46},"2025-06-15",{"date":50,"type":22},"2026-12-30",{"name":52,"class":53},"Medipol University","OTHER",7,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100578261","prospective-multicentre-mixed-methods-study-to-explore-extubation-practices-and-respiratory-outcomes-in-extremely-preterm-neonates-100578261","NCT06808997","Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates.","Criteria and Reasons for Extubation and Non-extubation in Preterm Infants: A Mixed Methods Study Prospectively Exploring Extubation and Reintubation Practices in Extremely Preterm Infants, and Associated Respiratory Outcomes.","CERAINE","Inclusion Criteria:\n\n* Gestational age \\\u003C 28 weeks of gestation\n* Age at admission to the participating unit \\\u003C24 hours\n\nExclusion Criteria:\n\n* Parental opposition to their infant's clinical data collection\n* Participation in a research protocol with potential impact on extubation and\u002For duration of mechanical ventilation","1 Minute","5 Months",{"count":66,"type":22},100,"The purpose of this observational study is to learn about neonatologists' perceptions of extubation readiness and extubation and reintubation practices in extremely preterm infants in the first 2 weeks of life using prospective qualitative and quantitative data. Actual extubation readiness is defined as successful extubation, defined as no reintubation in the 7 days following extubation.\n\nKey research questions are: How do clinicians assess extubation readiness in this population? Does this assessment correlate with actual extubation success? What factors (reasons, clinical status, ventilatory parameters) are associated with extubation readiness? Patients born before 28 weeks gestational age and admitted to the neonatal intensive care unit (NICU) within the first 24 hours are be included. The attending physician will complete a prospectively administered questionnaire with open-ended and multiple-choice questions to daily assess the decision and rationale for extubation or non-extubation of patients mechanically ventilated during the first 15 days of life.\n\nPatient characteristics, respiratory outcomes, and mortality will be recorded until the end of hospitalisation and\u002For definitive weaning from any ventilatory support or supplemental oxygen.",[69,30,31,70,71,72],"PreTerm Neonate","Respiratory Morbidity","Bronchopulmonary Dysplasia","Mechanical Ventilation",[74,37,36,75],"extremely preterm infants","bronchopulmonary dysplasia","2026-03-11",{"date":78,"type":46},"2026-03-12",{"date":80,"type":46},"2025-02-17",{"date":82,"type":22},"2026-04-30",{"name":84,"class":53},"Centre Hospitalier Intercommunal Creteil",31,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":110,"leadSponsor":112,"locationsCount":114},"100593536","identifying-the-best-flow-setting-strategy-for-high-flow-nasal-cannula-100593536","NCT07007715","Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula","Optimizing High-flow Nasal Cannula Settings: Comparing Different Flow Approaches and Exploring Physiological Phenotyping With End-expiratory Lung Volume, Peak Tidal Inspiratory Flow and Oxygen Demand","Inclusion Criteria:\n\n* Intubated and receiving mechanical ventilation for more than 24 hours\n* Ready for planned extubation after passing a spontaneous breathing trial\n* PaO2\u002FFiO2 \\\u003C350 mmHg on the day of extubation\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* On do-not-reintubate code\n* Pregnant women\n* Having tracheostomies\n* Infeasibility of using HFNC\n* Planning to use preventive NIV after extubation by the primary care team\n* Life expectancy less than one month",{"count":94,"type":22},480,"INTERVENTIONAL",[97],"NA","The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC). Selecting the appropriate flow rate when initiating HFNC oxygen therapy is both crucial and challenging for clinicians, as the physiological benefits of HFNC depend significantly on the flow rate. To date, there are no guidelines or consensus on flow-rate setting and weaning for HFNC oxygen therapy.\n\nThe investigators hypothesized that physiological marker-guided flow setting using peak tidal inspiratory flow (PTIF) or PaO₂\u002FFiO₂ ratios lead to better extubation outcomes as compared to empirical flow setting of 40 L\u002Fmin or 60 L\u002Fmin.\n\nParticipants will be randomly assigned to one of four study groups with different flow setting strategies summarized as follows: (1) Setting flow at 40 L\u002Fmin, (2) Setting flow at 5 L\u002Fmin above the peak tidal inspiratory flow, up to a maximum of 60 L\u002Fmin. (3) Setting flow according to P\u002FF ratio prior to extubation. Flow will be set at 60, 50 40 L\u002Fmin if P\u002FF ratio \\\u003C250 mmHg, 250-300 mmHg and \\>300 mmHg, respectively. (4) Setting flow at 60 L\u002Fmin.",[30,100],"Respiratory Failure With Hypoxia",[102,103,104,105],"flow rate","high flow nasal cannula","peak inspiratory flow","reintubation","2025-06-05",{"date":108,"type":46},"2025-06-06",{"date":106,"type":46},{"date":111,"type":22},"2028-06-30",{"name":113,"class":53},"National Taiwan University Hospital",1,{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":122,"maxAge":18,"enrollmentInfo":123,"targetDuration":4,"studyType":95,"phases":125,"briefSummary":126,"conditions":127,"keywords":131,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":114},"100561678","trial-of-spontaneous-breathing-test-100561678","NCT06593288","Trial of Spontaneous Breathing Test","Randomized Clinical Trial of Spontaneous Breathing Test","Inclusion Criteria:\n\n* Patients admitted to the PICU on MV for more than 24 hours\n* Patients over 1 month old (corrected gestational age \\> 38 weeks) and \\< 18 years old on the day of screening for ERT\n\nExclusion Criteria:\n\n* Perinatal-related lung disease\n* Congenital diaphragmatic hernia or congenital\u002Facquired paralysis of the diaphragm\n* Children with heart disease\n* Primary pulmonary hypertension\n* Bronchiolitis obliterans\n* Post-hematopoietic stem cell transplant; specifically, patients receiving continuous supplemental oxygen for three or more days prior to intubation; receiving noninvasive ventilation for more than 24 hours prior to intubation; receiving more than one vasoactive medication at the time of meeting the inclusion criteria; spending more than four days in the PICU prior to intubation; supported by or with immediate plans for renal replacement therapy; with two or more allogeneic transplants; who relapsed after transplant; or with diffuse alveolar hemorrhage\n* Post-lung transplantation\n* Home ventilator dependence with baseline Oxygen Saturation Index (OSI) \\>6 (baseline is defined as a stable period prior to the present illness)\n* Neuromuscular respiratory failure\n* Critical airway obstruction (e.g., post-laryngotracheal surgery or new tracheostomy) or anatomical lower airway obstruction (e.g., mediastinal mass)\n* Facial surgery or trauma in the past two weeks\n* Intracranial bleeding\n* Morbid obesity (2w-24mo: WHO weight-for-length z-score\u002Fheight z-score ≥+3; ≥2y: WHO body mass index (BMI)-for-age z-score ≥+3)\n* Family\u002Fmedical team unsupportive total (patient treatment considered futile)\n* Previously enrolled in a current study\n* Enrolled in any other clinical trial with intervention not approved for concomitant enrollment\n* Pregnancy","1 Month",{"count":124,"type":22},170,[97],"The hypothesis is that the Spontaneous Breathing Test (SBT) without pressure support (PS) is not inferior to the SBT with pressure support in relation to the following outcomes: a) extubation failure; b) time on MV.\n\nThe main objective of this study is to determine whether SBT without PS is non-inferior to SBT with PS in relation to the primary outcome: a) extubation failure; and secondary outcomes: b) length of stay in the PICU and c) days free of MV.\n\nPacients will be randomized to 2 arms:\n\n1. SBT with PS\n2. SBT without PS (with PEEP only)",[72,128,30,129,130],"Spontaneous Breathing Trial","Extubation Failures","Pediatrics",[132,133,36,134],"spontaneous breathing trial","extubation readiness test","pediatric intensive care","NOT_YET_RECRUITING","2024-12-03",{"date":138,"type":46},"2024-12-06",{"date":140,"type":22},"2025-03-10",{"date":142,"type":22},"2026-04",{"name":144,"class":53},"University of Sao Paulo"]