[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"extubation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:extubation":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,39,65,97,123,146,179,202,224,249,279],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100550119","extubation-related-complications---the-extube-study-extube-100550119",false,"NCT06442930","EXtubation Related Complications - the EXTUBE Study (EXTUBE)","EXtubation Related Complications - an International Observational Study To Understand the Impact and BEst Practices in the Operating Room and Intensive Care Unit - the EXTUBE Study","EXTUBE","Inclusion Criteria:\n\n* Adult patients (≥18 years old)\n* Undergoing extubation of an endotracheal tube (including index extubation and re-extubations) after general anesthesia in the OR, out of OR anesthesia location or ICU\n* Undergoing extubation during the specified enrollment window\n\nExclusion Criteria:\n\n* Patients will be excluded if the extubation is performed in the context of withdrawal of life support measures,\n* Patients will be excluded if the extubation is performed for tracheostomy decannulation\n\nFor each patient who is not included, reasons for exclusion will be reported.","ALL","18 Years",{"count":20,"type":21},3000,"ESTIMATED","OBSERVATIONAL","EXTUBE is an international, multicentre, prospective cohort study evaluating the incidence, risk factors, and outcomes of extubation-related complications and describing clinical practices related to extubation after general anesthesia or after critical illness in the operating room (OR), out of OR anesthesia location or intensive care unit (ICU).",[25],"Extubation","RECRUITING","2026-06-30",{"date":29,"type":30},"2026-07-02","ACTUAL",{"date":32,"type":30},"2025-04-14",{"date":34,"type":21},"2027-12",{"name":36,"class":37},"University Health Network, Toronto","OTHER",32,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":60,"leadSponsor":62,"locationsCount":64},"100635584","clinical-practices-of-extubation-after-invasive-mechanical-ventilation-100635584","NCT07554586","Clinical Practices of Extubation After Invasive Mechanical Ventilation","Clinical Practices of Extubation After Invasive Mechanical Ventilation in Anesthesia and Intensive Care","EPP\u002FEPP = 1","Inclusion Criteria:\n\n* Physicians and students in anesthesiology and critical care,\n* Critical care physicians,\n* State-certified nurse anesthetists (IADE),\n* State-certified nurses (IDE) working in an anesthesia or intensive care team\n* Students (medical or nurse anesthetist) with at least 1 year of extubation experience.\n\nExclusion Criteria:\n\n* Healthcare professionals with no experience in extubation (less than one year of practice) Refusal to participate",true,{"count":49,"type":21},200,"Extubation is a delicate and complex phase of airway management in anesthesia and critical care. A variety of complications are of concern, ranging from transient hypoxemia to the need for reintubation, which can then become life-threatening for the patient.\n\nFor this procedure, it may be recommended to use the positive end-expiratory pressure (PEEP) extubation technique to reduce the risks of hypoxemia, atelectasis, and aspiration. However, no specific technique is preferred given the diversity of described procedures (spontaneous ventilation on an auxiliary circuit, PEEP-assisted spontaneous ventilation, adjustment of the APL valve). However, results may vary depending on the patient population (children, adults) and the setting (operating room, intensive care unit).\n\nGiven the lack of a preferred technique for performing extubation under positive end-expiratory pressure, the aim of this study is to describe the techniques used by healthcare professionals (physicians, nurse anesthetists, nurses) during the extubation of a surgical or intensive care patient.",[52,25,53,54],"Mechanical Ventilation","Anesthesia","Critical Care, Intensive Care","NOT_YET_RECRUITING","2026-04-28",{"date":58,"type":30},"2026-05-04",{"date":56,"type":21},{"date":61,"type":21},"2026-10",{"name":63,"class":37},"Centre Hospitalier Universitaire de Nīmes",1,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":84,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":64},"100602946","endotracheal-suctionning-during-positive-pressure-extubation-in-icu-100602946","NCT07130123","Endotracheal Suctionning During Positive Pressure Extubation in ICU","Removal of the Intubation Tube Under Positive Pressure With or Without Endotracheal Suctioning During Extubation in Intensive Care: a Prospective Randomised Controlled Trial","INTENTION","Inclusion Criteria:\n\n* Adult patient\n* Intubated for more than 48 hours\n* Patient for whom extubation is prescribed by the patient's physician\n\nExclusion Criteria:\n\n* Headboard restriction\\>30°.\n* Decision to limit active treatment in advance of reintubation\n* Protected person (under guardianship or curatorship)\n* Person under court protection\n* Persons deprived of liberty\n* Persons not affiliated to a social security scheme\n* Pregnant or breast-feeding woman\n* No co-inclusion with a study whose period of interest is follow-up within 3 hours of extubation.",{"count":74,"type":21},120,"INTERVENTIONAL",[77],"NA","The aim of this clinical trial is to evaluate endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients (over 18 years old) in the intensive care unit (ICU). The main question it aims to answer is whether the intervention improves the respiratory oxygenation index (ROX) three hours after extubation compared to no endotracheal suction during positive pressure extubation.\n\nParticipants will only need to be extubated by the nursing team in the ICU. Follow-up will consist of evaluating respiratory rate, pulse oximetry and inspired oxygen fraction for three hours following extubation.",[80,81,82,83,25],"Mechanical Ventilation With Oral Intubation","Weaning Invasive Mechanical Ventilation","Oxygen Saturation Measurement","Rox Index",[85,86,87],"rox index","extubation","Suctionning","2025-12-12",{"date":90,"type":30},"2025-12-19",{"date":92,"type":30},"2025-10-03",{"date":94,"type":21},"2027-10",{"name":96,"class":37},"Centre Hospitalier Régional d'Orléans",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":107,"conditions":108,"keywords":109,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":122},"100503644","total-intravenous-anesthesia-tivasevoflurane-initiated-intravenous-anesthesia-siiva-in-pediatric-patients-100503644","NCT05837936","Total Intravenous Anesthesia (TIVA)\u002FSevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients","A Prospective Observational Study Evaluating Extubation Criteria in Children Less 10 Years of Age and Younger Undergoing Intravenous Anesthesia","Inclusion Criteria:\n\n* Pediatric patients \\\u003C10 years of age\n* Undergoing elective or emergency surgery with planned airway instrumentation with an endotracheal tube (ETT)\n* Patients having general anesthesia with a planned SIIVA or TIVA technique\n* Patients with an end tidal agent concentration of Sevoflurane\\\u003C0.1% at the time of emergence and extubation\n* following sevoflurane induction to place IV\n\nExclusion Criteria:\n\n* History of home oxygen use or ventilator dependence\n* Patients with cyanotic congenital heart disease\n* Patients undergoing anesthesia for imaging procedures alone\n* Patients intended to be managed with supraglottic airway\n* Patients having an anesthesia time \\\u003C 30 minutes\n* Monitored Anesthesia Care (not general anesthesia)\n* Patients with contraindication to receiving Propofol (i.e. mitochondrial myopathy)","9 Years",{"count":106,"type":21},600,"Because Propofol is the primary \"anesthetic agent,\" and inhalational agents remain in trace quantities at the end of the procedure Sevoflurane initiated intravenous anesthesia (SIIVA) or not present at all Total intravenous anesthesia (TIVA) it is likely that different criteria may be predictive of extubation success in these patients compared to inhalational anesthesia.",[25],[110,111,112],"anesthesia","Propofol","inhalational agents","2025-12-10",{"date":115,"type":30},"2025-12-18",{"date":117,"type":30},"2023-03-28",{"date":119,"type":21},"2028-03",{"name":121,"class":37},"Wake Forest University Health Sciences",2,{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":75,"phases":132,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":64},"100601730","spontaneous-breathing-trials-using-pressure-support-or-t-piece-in-overweight-and-obese-patients-100601730","NCT07114289","Spontaneous Breathing Trials Using Pressure Support or T-Piece in Overweight and Obese Patients","Comparison of Pressure Support Ventilation and T-Piece as Spontaneous Breathing Trials Before Extubation Among Obese and Overweight Patients","Inclusion Criteria:\n\n1\\. Patients had undergone intubation and mechanical ventilation for more than 24 hours prior to the first spontaneous breathing trial.\n\n2\\. Adult patients aged ≥ 18 years. 3. BMI ≥ 25 kg\u002Fm². 4. Meeting all the Inter national Consensus Conference on weaning criteria:\n\n1. Stable vital signs: heart rate \\\u003C 140 beats\u002Fmin, systolic blood pressure: 90-160 mmHg, and no use of vasopressors or use of minimal doses (\\\u003C0.2 µg\u002Fkg per min).\n2. Respiratory rate ≤ 35 breaths\u002Fmin.\n3. Adequate oxygenation, defined as either SpO2 \\> 90% with FiO2 ≤ 0.4, or PaO2\u002FFiO2 \\> 150 mmHg with positive end-expiratory pressure (PEEP) ≤ 8 cmH2O.\n4. Adequate cough strength (MIP \\\u003C -20 cmH2O).\n5. An awake state, defined as a score of Richmond Agitation-Sedation Scale between +1 and -2, or Glasgow Coma Scale \\> 8.\n6. No continuous sedation. 5. Informed consent provided by the patient or their relatives.\n\nExclusion Criteria:\n\n1. Patients with tracheostomy.\n2. Patients who had been admitted for traumatic brain injury.\n3. Patients who had preexisting peripheral neuromuscular disease (underlying myopathy or myasthenia gravis).\n4. Patients who had a do-not-reintubate order at the time of the initial spontaneous breathing trial were excluded\n5. Patients who have already undergone a first spontaneous breathing trial.\n6. Patients who had undergone extubation without an SBT\n7. Protected populations: pregnant or breastfeeding women, individuals under guardianship, or those under legal protection.\n8. Patients who refused to participate during the study.",{"count":131,"type":21},100,[77],"This study aims to find out which method of spontaneous breathing trial (SBT) better helps overweight and obese ICU patients prepare for extubation, which is the removal of the breathing tube. The two methods being compared are pressure support ventilation (PSV) and the T-piece.\n\nParticipants are adults with a body mass index (BMI) of 25 or higher who have been on a breathing machine (invasive mechanical ventilation) for more than 24 hours. Before removing the breathing tube, participants will be randomly assigned to receive either a PSV or a T-piece trial for 1 hour. After that, doctors will decide if they are ready for extubation.\n\nThe main question this study wants to answer is: Which method leads to a higher rate of successful extubation-defined as not needing to be reintubated within 72 hours?",[52,25,135,136],"Obesity &Amp; Overweight","Respiratory Failure","2025-11-13",{"date":139,"type":30},"2025-11-17",{"date":141,"type":30},"2025-09-29",{"date":143,"type":21},"2027-07-31",{"name":145,"class":37},"Taipei Medical University Hospital",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":17,"minAge":153,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":75,"phases":157,"briefSummary":158,"conditions":159,"keywords":162,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":64},"100601672","post-extubation-use-ram-cannula-versus-short-binasal-prong-interfaces-in-preterm-infants-100601672","NCT07113535","Post-extubation Use RAM Cannula Versus Short Binasal Prong Interfaces in Preterm Infants","RAM Cannula Versus Short Binasal Prong Interfaces of Non- Invasive Ventilation for Prevention of Extubating Failure in Preterm Infants: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Inborn preterm neonates ≤ 32 weeks of gestational and\u002For birth weight ≤1500 g with respiratory distress syndrome requiring initial invasive ventilation support for at least 24 hours.\n\nExclusion Criteria:\n\n* Outborn preterm neonates\n* Major congenital malformations.","24 Hours","28 Days",{"count":156,"type":21},90,[77],"Nowadays, the use of non-invasive ventilation for preterm infants in the NICU has increased to avoid complications associated with prolonged endotracheal intubation. Adequate pressure delivery through non-invasive ventilation is essential, as it enhances the growth and development of premature lungs. Various interfaces have been used to ensure proper sealing. The RAM cannula, used as an interface for non-invasive respiratory support in preterm neonates, is associated with reduced nasal trauma compared to short binasal prongs (SBPs), due to its softer material, making it a safer option. However, the RAM cannula has been shown to deliver lower pharyngeal pressure and, therefore, may not maintain airway pressure as consistently as nasal prongs. Currently, limited data is available regarding the efficacy of nasal prongs compared to the RAM cannula as a post-extubation interface for non-invasive ventilation support in preterm infants. Additionally, we have observed that the use of the RAM cannula for non-invasive ventilation in preterm infants is associated with a longer duration of oxygen therapy compared to SBPs.\n\nThe investigators hypothesize that the RAM cannula provides a lower level of positive end-expiratory pressure compared to SBPs during non-invasive ventilation.\n\nThe investigators aim to assess the efficacy and safety of the RAM cannula versus SBPs as nasal interfaces for post-extubation non-invasive respiratory support in preterm infants.",[160,161,25],"Premature","Respiratory Distress Syndrome",[163,164,165,166,167,168],"nasal interface","noninvasive respiratory support","premature","RAM cannula","Chest ultrasound","Diaphragm","2025-08-04",{"date":171,"type":30},"2025-08-08",{"date":173,"type":21},"2025-08",{"date":175,"type":21},"2027-12-31",{"name":177,"class":178},"Ministry of Health, Saudi Arabia","OTHER_GOV",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":186,"targetDuration":4,"studyType":75,"phases":188,"briefSummary":183,"conditions":189,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":64},"100597530","high-flow-nasal-cannula-vs-niv-after-extubation-in-children-undergoing-heart-surgery-100597530","NCT07059689","High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery","High Flow Nasal Cannula vs. Non-Invasive Ventilation in Post-Extubation Pediatric Cardiac Surgery Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients under 18 years of age.\n* Post-cardiac surgery patients in the CICU of Cipto Mangunkusumo National General Hospital\n* Patients at high risk of extubation failure (e.g., young age, open sternotomy, mechanical ventilation \\>48 hours).\n* Patients who pass the extubation readiness test and spontaneous breathing trial.\n\nExclusion Criteria:\n\n* Diaphragmatic paralysis.\n* Decreased consciousness.\n* Neuromuscular disease.\n* Pneumothorax without drainage.\n* Airway obstruction.\n* Patients with a tracheostomy.\n* Unplanned extubation.\n* Patient received PEEP (Positive End-Expiratory Pressure) \\>7 prior to extubation",{"count":187,"type":21},114,[77],[190,191,192,25],"Heart Defects, Congenital","Intensive Care Units, Pediatric","Respiration, Artificial","2025-07-07",{"date":195,"type":30},"2025-07-11",{"date":197,"type":30},"2025-06-05",{"date":199,"type":21},"2025-12",{"name":201,"class":37},"Indonesia University",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":75,"phases":212,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":64},"100540582","modified-deep-extubation-vs-standard-awake-extubation-100540582","NCT06318715","Modified Deep Extubation vs. Standard Awake Extubation","A Comparison of a Modified Deep Extubation to Standard Awake Extubation for Decreasing Operating Room Time: a Randomized Controlled Trial","mDE","Inclusion Criteria:\n\n* ASA I-III\n* laparoscopic surgery under general anesthesia\n\nExclusion Criteria:\n\n* High-risk patients:\n\n  * Documented difficult airway during intubation or developed intraoperatively.\n  * Full stomach\n  * Pregnant women\n  * Emergency surgery\n  * BMI\\>30\n  * Intraoperative bleeding leading to transfusion\n* Use of remifentanil during extubation\n* Requirement for prone position for surgical approach (i.e., spine surgery, anal fistulectomy, tumor resection of the back, etc)\n* Absolute indication for awake or deep extubation\n* Use of opioids in chronic pain patients",{"count":211,"type":21},60,[77],"The proposed study is to compare a modified DE technique, which is regularly used for low-risk patients by staff anesthesiologists at our institution, to a standard awake extubation. This modified deep extubation (mDE) occurs while the patient is still anaesthetized but at a lower dose of anaesthetic gas than previously described, and balanced with long acting opioids to attenuate the airway reaction. As previously stated, the literature shows that the risks of DE are equivalent to those of regular AE practice. Our hypothesis is that mDE will shorten the time from the end of the surgery (completion of last stitch) to the moment the patient is ready to leave the OR by at least 5 minutes when compared to standard AE practice.",[25],"2025-07-03",{"date":217,"type":30},"2025-07-09",{"date":219,"type":30},"2024-04-08",{"date":221,"type":21},"2026-12-30",{"name":223,"class":37},"Samuel Lunenfeld Research Institute, Mount Sinai Hospital",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":47,"sex":17,"minAge":18,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":75,"phases":234,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":122},"100575490","effect-of-percutaneous-electrical-acupoint-stimulation-on-the-improvement-of-incidence-of-adverse-respiratory-events-100575490","NCT06772961","Effect of Percutaneous Electrical Acupoint Stimulation on the Improvement of Incidence of Adverse Respiratory Events","Effect of Percutaneous Electrical Acupoint Stimulation on the Improvement of Incidence of Adverse Respiratory Events in the Emergence Period From General Anesthesia After Tracheal Extubation: A Single-center Randomized Controlled Study","Inclusion Criteria:\n\n* 1: Age \\>18 years old.\n\n  2: ASA I-III\n\n  3: Patients undergoing elective general anesthesia surgery who are extubated upon arrival to the PACU\n\nExclusion Criteria:\n\n* 1: Preoperative comorbidities include severe cardiovascular or respiratory diseases\n\n  2: Serious reflux aspiration during the perioperative period\n\n  3: Concurrent psychiatric disorders\n\n  4: Local skin infections or nerve damage at the upper limb Taiyuan and Hegu acupoints","100 Years",{"count":233,"type":21},236,[77],"The goal of this study is to investigate the effect of combined acupoint electrical stimulation at Taiyuan (LU9) and Hegu (LI4) on improving the incidence of respiratory adverse events after extubation in patients during the recovery period from general anesthesia.\n\nThe main content of this study involves selecting patients who have undergone general anesthesia and are admitted to the Post Anesthesia Care Unit (PACU), with an expected 236 participants. The researchers will randomly assign participants to either the TEAS group or the control group using a random number table. In the TEAS group, electrodes will be applied to the upper limbs at the Taiyuan and Hegu acupoints, without intravenous infusion, and connected to a stimulation device. The stimulation will use a frequency of 2\u002F100 Hz with sparse-dense waves, and the intensity will be adjusted to the maximum current that the patient can tolerate, starting at the time of extubation and continuing for 30 minutes. The control group will receive routine care. Throughout the process, no invasive procedures will be performed.\n\nIn the PACU, the participants will:\n\nBe positioned in a 30° head-up tilt position, with continuous ECG monitoring. The SpO2 alarm on the monitor will be set to 95%.\n\nThe same anesthesiologist will perform extubation according to the extubation criteria.\n\nAfter extubation, participants will receive routine oxygen therapy via a nasal cannula at 3L\u002Fmin with a CO2 end-expiratory monitoring module attached to the other end of the cannula. Simultaneously, the TEAS group will undergo transcutaneous electrical stimulation for 30 minutes, or the control group will receive routine care.\n\nParticipants will be observed in the PACU for at least 30 minutes. If no adverse events occur and the Steward score is ≥4, the patient will be deemed ready for discharge and escorted back to the ward. If there is any significant change in the patient's condition, they will be transferred to the ICU .\n\nIf any respiratory-related adverse events occur, measures such as awakening the patient, supporting the jaw, increasing oxygen flow, or administering mask oxygen will be taken to ensure patient safety, and these events will be recorded in the \"PACU Postoperative General Anesthesia Patient Condition Observation and Nursing Record.\"",[25,237,238,239],"Respiratory Depression","Acupuncture Points","Hypoxia","2025-02-06",{"date":242,"type":30},"2025-02-10",{"date":244,"type":30},"2025-01-25",{"date":246,"type":21},"2025-12-25",{"name":248,"class":37},"Nanjing First Hospital, Nanjing Medical University",{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":255,"eligibilityCriteria":256,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":257,"targetDuration":4,"studyType":75,"phases":259,"briefSummary":260,"conditions":261,"keywords":264,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":278},"100568995","postoperative-extubation-in-hypoxemic-patients-100568995","NCT06688487","Postoperative Extubation in Hypoxemic Patients","Early Postoperative Extubation in Hypoxemic ICU Patients: a Multicenter, Randomized Controlled Trial","EPHYRE","Inclusion Criteria:\n\n* Francophone patient affiliated to a health insurance plan;\n* Patient having granted free, informed and written consent to participate in the study;\n* Patient with hypoxemia defined as SpO2 ≤ 90% under 6 L\u002Fmin or FiO2 40% during spontaneous breathing trial.\n\nExclusion Criteria:\n\n* Presence of hypercapnia at the end of SBT (PaCO2 above 50 mmHg);\n* Presence of severe hypoxemia during SBT defined by SpO2 below 86% under 9 L\u002Fmin or FiO2 = 50%;\n* Presence of poor clinical tolerance of SBT defined by polypnoea above 30\u002Fmin, agitation, sweating, hypertension (PAS above 180 mmHg), tachycardia (HR above 140 bpm) or arrhythmia;\n* Presence of an ineffective cough or major bronchial congestion;\n* Patient already included in a type 1 interventional research protocol (RIPH1), modifying the procedure for ventilatory weaning and\u002For ventilatory support after extubation;\n* Anatomical factors precluding the use of NIV or high-flow oxygen therapy, notably facial or cervico-facial malformations;\n* Tracheostomized patient;\n* History of obstructive ventilatory disorders with indication for NIV post-extubation, chronic obstructive pulmonary disease (COPD) GOLD score III\u002FIV;\n* History of obstructive sleep apnea syndrome with equipment;\n* cardiogenic pulmonary edema;\n* Patient on extracorporeal membrane oxygenation (ECMO) at the time of inclusion;\n* Patient under guardianship or curatorship;\n* Minor patients;\n* Patient deprived of liberty or under court protection;\n* Pregnant or breast-feeding women;\n* Patient in therapeutic limitation with decision not to re-intubate.",{"count":258,"type":21},152,[77],"The objective of this clinical trial is to assess whether early extubation of patients with hypoxemia during the spontaneous breathing trial (SBT) shortens the duration of ventilatory support. The trial will also evaluate the safety of this approach. The key research questions include:\n\nDoes early extubation of hypoxemic patients reduce the total duration of ventilatory support (both invasive and non-invasive) by 36 hours? Does early extubation of hypoxemic patients increase the number of ventilator-free days by day 28? Can the safety of early extubation in hypoxemic patients be ensured by confirming no significant differences in rates of reintubation, tracheostomy, or mortality? The trial will compare ventilatory outcomes between two groups: hypoxemic patients who undergo early extubation (hypoxemic extubation group) and those who remain on invasive ventilation until hypoxemia resolves (conventional extubation group).",[262,25,263],"Hypoxemia","Postoperative Respiratory Complication",[86,265,266,267,268],"hypoxemia","postoperative respiratory complication","weaning","facilitative non invasive strategy","2024-11-12",{"date":271,"type":30},"2024-11-14",{"date":273,"type":21},"2024-11-18",{"date":275,"type":21},"2027-01-31",{"name":277,"class":37},"Fondation Hôpital Saint-Joseph",12,{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":17,"minAge":286,"maxAge":287,"enrollmentInfo":288,"targetDuration":4,"studyType":75,"phases":290,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":301,"locationsCount":4},"100497004","effectiveness-on-smooth-extubation-according-to-the-administration-time-of-sugammadex-100497004","NCT05751603","Effectiveness on Smooth Extubation According to the Administration Time of Sugammadex","Comparison of Smooth Emergence During Extubation After Anesthesia When Sugammadex is Administered Before and After Extubation","Inclusion Criteria:\n\n* patients undergoing general anesthesia for thyroid surgery.\n* aged between 19 and 64 years\n* American Society of Anesthesiologists physical status I and II\n\nExclusion Criteria:\n\n* patients with malformation or tumor of the upper respiratory tract\n* patients with risk of aspiration\n* obese cases with a BMI \\> 35\n* patients in which tracheal intubation was difficult\n* refusal to participate in research","19 Years","64 Years",{"count":289,"type":21},66,[77],"After surgery is completed under general anesthesia, extubation is performed after recovery from anesthesia, and during this process, bucking, coughing, and rapid and excessive hemodynamic fluctuations occur very often. These phenomena can lead to high intrathoracic pressure, venous congestion, hematoma formation, or increased bleeding after major neck surgery. (1) They can also increase the risk of aerosol generation, which can transmit infection to health care workers. (2) For this, smooth extubation is required. Methods of administering drugs such as lidocaine, opioids, or dexmedetomidine have been proposed for smooth extubation. (3-5) As a disadvantage, the use of these drugs may be associated with deep sedation and reduced airway reflexes .\n\nRecently, Babu et al. (6) reported that bucking and coughing during extubation could be reduced by changing the timing of administering a muscle relaxant antagonist rather than using these sedative drugs, and thus complications related to extubation could be reduced. In general, in the awakening process, it was common to administer the muscle relaxant at the point of recovery of spontaneous breathing. However, Babu et al. demonstrated the possibility of safe and smooth extubation by changing the timing of administering neostigmine without the use of sedatives or narcotic analgesics, but there are few studies on sugammadex.\n\nTherefore, when recovering from general anesthesia, sugammadex was administered before and immediately after extubation to evaluate and compare smooth extubation (ie, comparison of the frequency of bucking and coughing).",[293,25,294],"Sugammadex","Smooth Emergence","2024-07-23",{"date":297,"type":30},"2024-07-25",{"date":299,"type":21},"2024-10-03",{"date":92,"type":21},{"name":302,"class":37},"Ajou University School of Medicine"]