[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"eye-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:eye-disease":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,80,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100272102","natural-history-pathogenesis-and-outcome-of-ocular-disorders-100272102",false,"NCT02821767","Natural History, Pathogenesis, and Outcome of Ocular Disorders","Studies of the Natural History, Pathogenesis and Outcome of Ocular Disorders","* INCLUSION CRITERIA:\n\nTo be eligible, the following inclusion criteria must be met, where applicable.\n\n1. Have a diagnosed, undiagnosed or suspected eye disease.\n2. Have the ability to understand and sign an informed consent or have a parent\u002Flegal guardian do so if they are minor children or a legally authorized representative to provide consent for adults without consent capacity.\n\nEXCLUSION CRITERIA:\n\nA participant is not eligible if any of the following exclusion criteria are present.\n\n1. Are unwilling to give informed consent or assent when applicable.\n2. Are unwilling or unable to be followed as clinically indicated.\n3. Have a systemic disease that compromises the ability of NEI clinicians to provide adequate ophthalmologic examination or treatment.","ALL","1 Month","100 Years",{"count":20,"type":21},1000,"ESTIMATED","OBSERVATIONAL","Background:\n\nThe National Eye Institute (NEI) wants to evaluate and provide standard treatment to people with eye diseases.\n\nObjective:\n\nTo examine and treat people with eye diseases and learn more about eye diseases and how they are inherited.\n\nEligibility:\n\nPeople with eye diseases who can give consent or have a guardian who can consent for them. Asymptomatic first-degree relatives willing to provide a blood sample may also be enrolled for the purpose of genetic testing.\n\nDesign:\n\nParticipants will be screened with an eye exam.\n\nParticipants will have 1-12 visits per year depending on their eye disease for up to 5 years. Visits last about 4 hours and could include:\n\nMedical and family history\n\nPhysical exam\n\nEye exam and photography.\n\nOculography: They put on contact lenses or goggles. They watch spots on a computer\n\nscreen for 20-30 minutes.\n\nElectrooculography: Small metal disks are placed on the skin next to both eyes. They look left\n\nand right in the dark and light for about 30 minutes.\n\nElectroretinography: They sit in the dark with their eyes patched. A small metal disk is taped\n\nto the forehead. After 30 minutes, the patches are removed and contact lenses put in. They\n\nwatch flashing lights.\n\nFluorescein angiography: A needle guides a thin plastic tube into an arm vein. A dye is\n\ninjected through the tube and travels up the blood vessels in the eyes. Pictures are taken of the\n\neyes.\n\nImmunosuppressive treatment\n\nEye cell sample: Samples are obtained from swabbing, pressing paper on, or taking a small\n\nbiopsy sample from the surface of the eye.\n\nBlood tests\n\nSkin, tear, urine, saliva, stool, or hair sample\n\nExam under anesthesia for some children\n\nAt each visit participants could get medications, eye drops, eye injections, laser treatments, or surgery.",[25],"Eye Disease",[25,27],"Natural History","RECRUITING","2026-05-28",{"date":31,"type":32},"2026-05-29","ACTUAL",{"date":34,"type":32},"2016-08-03",{"date":36,"type":21},"2026-07-01",{"name":38,"class":39},"National Eye Institute (NEI)","NIH",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":40},"100623809","a-multimodal-ai-agent-for-ophthalmic-clinical-decision-support-100623809","NCT07401459","A Multimodal AI Agent for Ophthalmic Clinical Decision Support","Multicenter Randomized Controlled Trial of a Multimodal AI Agent for Ophthalmology Clinical Decision Support","Inclusion Criteria:\n\n1. Outpatient participants aged 6 to 75 years.\n2. Participants who undergo ophthalmic examinations for medical purposes during the study period.\n3. Participants who can produce clear ophthalmic images in both eyes.\n4. Agree to participate in this study with written informed consent:\n\n   1. Participants aged 18 years or older provide their own consent.\n   2. Participants aged 6-17 years require consent from a parent or legal guardian.\n\nExclusion Criteria:\n\n1. Participants who are reluctant to participate in this study.\n2. Participants presenting with acute or emergency ocular conditions requiring immediate intervention.\n3. Participants with poor quality of ophthalmic images, including blurriness, artifacts, underexposure, or overexposure.\n4. Other unsuitable reasons determined by the evaluators.",true,"6 Years","75 Years",{"count":52,"type":21},300,"INTERVENTIONAL",[55],"NA","This study is a multicenter randomized controlled trial evaluating the effectiveness and safety of EyeAgent, a multimodal artificial intelligence (AI) agent designed to assist ophthalmologists in clinical decision-making. Participants will be recruited from ophthalmology clinics and hospitals in Hong Kong and mainland China. The AI agent acts as a digital co-pilot, analyzing patient images and clinical history to provide diagnostic and management recommendations. The trial aims to determine whether the use of the AI agent improves diagnostic accuracy, treatment decision-making performance, report generation, workflow efficiency, and user satisfaction compared to standard clinical practice.",[58,59,60,25,61],"Ophthalmology","Large Language Models","AI Agent","Retinal Disease",[63,64,65,66,67,68],"medical AI agent","large language model","ophthalmology","tool integration","clinical decision support","real world study","NOT_YET_RECRUITING","2026-02-19",{"date":72,"type":32},"2026-02-23",{"date":74,"type":21},"2026-03-01",{"date":76,"type":21},"2026-12-31",{"name":78,"class":79},"The Hong Kong Polytechnic University","OTHER",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":53,"phases":88,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100579263","virtual-reality-and-its-use-in-reducing-perioperative-stress-in-cataract-surgery-100579263","NCT06822023","Virtual Reality and Its Use in Reducing Perioperative Stress in Cataract Surgery","Inclusion Criteria:\n\n1. Patients listed for cataract surgery under local anaesthetic (topical or regional) with sedation planned.\n2. First eye cataract procedures will only be included.\n3. Capacity to give informed consent, cognitive and linguistic ability sufficient to understand and fill out questionnaire\n\nExclusion Criteria:\n\n1. Epilepsy\n2. severe vertigo\n3. poor visual acuity (below 6\u002F60 best corrected in the best seeing eye)\n4. significant hearing impairment\n5. recent facial injury\u002Fburn.",{"count":87,"type":21},75,[55],"This project is to evaluate the benefits of utilising virtual reality (VR) headsets with the aim of reducing peri-operative anxiety in cataract surgery and hence reducing the need for sedation in patients with significant stress levels noted during preassessment. This is a novel study, and with the increased use of VR technology throughout medicine, we may be able to offer our patients alternative management modalities to reduce stress and reduce need for medications with their subsequent potential side effects. It may also improve the quality of care provided and patients' experience with the cataract extraction procedure and might reduce the social care burden associated with standard sedation procedures. All patients will need to fill a quick preoperative anxiety and information scale questionnaire to assess their level of anxiety utilising The Amsterdam Preoperative Anxiety and Information Score.\n\nPatients will be randomised into 2 groups:\n\n1. Conventional group: patients will be prepared as per the standard routine clinical and further explanation of the procedure will be given. Before proceeding to the anaesthetic room, the patients will complete the anxiety score questionnaire again and given the option to proceed with sedation or opt out.\n2. Interventional Group: patients will be prepared as per the standard routine clinical care; they will then be wearing the VR mask for 10 minutes. Before proceeding to the anaesthetic room, patients will complete the anxiety score questionnaire again and given the option to proceed with sedation or opt out.\n\nPost operation, a record will be taken of the surgeon's decision on whether they want the second eye cataract surgery to be done under sedation (this is already standard practice at our centre). Finally, the patient will be asked to fill in one final grading score on whether they are happy with their decision to take\u002Fnot take sedation.",[91,25,92,93],"Virtual Reality","Cataract Surgery Anesthesia","Cataract Surgery",[95],"cataract surgery, sedation, anxiety, virtual reality","2025-02-06",{"date":98,"type":32},"2025-02-12",{"date":98,"type":21},{"date":101,"type":21},"2025-12-01",{"name":103,"class":79},"South Tyneside and Sunderland NHS Foundation Trust",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":40},"100575409","the-role-of-hexamidine-diisethionate-zamidine-1mgml-06ml-eye-drops-in-the-prophylaxis-of-surgery-oftalmic-100575409","NCT06771908","THE ROLE OF HEXAMIDINE DIISETHIONATE (ZAMIDINE®) 1MG\u002FML 0.6ML EYE DROPS IN THE PROPHYLAXIS OF SURGERY OFTALMIC","ZAMI-PRO","Inclusion Criteria:\n\n1. Age 18 years or older, male and female;\n2. Patient requiring ophthalmic surgery (intravitreal injections, glaucoma surgery, cataract surgery, vitrectomy, combined cataract and vitrectomy, corneal transplantation) and in need of antiseptic surgical prophylaxis (e.g., Zamidine®)\n3. Positive history of recurrent conjunctivitis in the eye requiring surgery.\n4. Written informed consent.\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years;\n2. Refusal to give informed consent.","18 Years","90 Years",{"count":114,"type":21},56,"Data will be gathered from patients who report having any kind of recurrent conjunctivitis and who, in accordance with clinical practice, are scheduled to have intravitreal injections, glaucoma surgery, cataract surgery, vitrectomy, combined cataract and vitrectomy, or corneal transplantation.\n\nThe data will be obtained using pseudonyms from the patients' medical records and will include the outcomes of swabs and surgeries performed in accordance with clinical practice for the patient's condition.\n\nThe following swabs will be taken into consideration for data analysis:\n\nFour days before to surgery, a conjunctival swab is used to check for the presence and load of species that do not make up the typical conjunctival flora (Baseline-T0).\n\nOn the day of operation, a conjunctival swab is taken before to entering the recovery room (T1).\n\nFollowing three minutes of 5% iodopovidone instillation in the eye to be operated on, a conjunctival swab (T2) was used.\n\nAdditionally, we will gather follow-up data from the medical record 24 and 30 hours after surgery (at day 34 +\u002F- 7 days).",[25,117],"Conjunctivitis",[119,120,121],"Ophthalmic prophylaxis","Surgery","Ophthalmic Swab","2025-01-08",{"date":124,"type":32},"2025-01-13",{"date":126,"type":21},"2025-02-01",{"date":128,"type":21},"2026-02-01",{"name":130,"class":79},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS"]