[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"eye-movements\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:eye-movements":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,60,89,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":36,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100639366","investigating-the-effect-of-caffeine-and-alcohol-on-pupil-dynamics-100639366",false,"NCT07625358","Investigating the Effect of Caffeine and Alcohol on Pupil Dynamics","Investigating the Effect of Caffeine and Alcohol on Pupil Dynamics (PAC)","PAC","Participants must meet the inclusion criteria, as shown below, to participate in this study\n\nInclusion Criteria\n\n1. Age: 30 to 50 years of age\n2. Visual Acuity: Best Corrected Visual Acuity (BCVA) of 0.20 LogMAR or better in both eyes\n3. Ability to provide informed consent: Participants must be able to understand and sign the informed consent form\n4. Ability to consume both caffeine and alcohol: Participants must be willing and able to consume caffeine and alcohol as part of the study\n\nParticipants meeting any of the exclusion criteria, as shown in the table below, will be excluded from participation.\n\nExclusion Criteria\n\n1. Diagnosed ocular conditions: Participants with ocular or ocular movement diseases such as glaucoma, age-related macular degeneration, diabetic retinopathy, amblyopia, severe ptosis, or conditions relating to pupils: anisocoria, irregular pupil, Adie tonic, Horner's syndrome, Argyll Robertson pupil, etc. These exclude cataracts, refractive errors, and any ocular condition not affecting vision or ocular movement or obstructing the pupil.\n2. Diagnosed and unresolved neurological conditions:Stroke, unresolved traumatic brain injury, space-occupying lesions in the brain, neuropathies, demyelinating conditions, nerve palsies, etc.\n3. Diagnosed systemic conditions that may restrict the participant from drinking caffeine or alcohol: Hypertension, cardiovascular disease, liver disease, kidney disease, etc.\n4. Medications: Participants taking any medications that may interact with caffeine or alcohol, affect alertness, or cause drowsiness\n5. Previous complex intraocular eye surgery: Participants who have undergone any eye surgery other than uncomplicated refractive surgery.\n6. Pregnancy or breastfeeding: Pregnant or breastfeeding women will be excluded from the study, as caffeine and alcohol can affect the fetus or baby\n7. History of substance abuse: Participants with a history of substance abuse\n8. Allergies or sensitivities: Participants with allergies or sensitivities to caffeine or alcohol\n9. Shift work or having travelled across 2 time zones over the past 2 weeks: This is essential to avoid any impact of sleep deprivation on our outcome measures\n10. Non-consumers or light-consumers of caffeine and alcohol Participants who are light consumers of caffeine or alcohol will be excluded due to higher sensitivity to side effects.\n\nCaffeine: If less than 100 mg of caffeine per week from all sources (including coffee, soft drinks, energy drinks, chocolate, and medications) based on the CCQ\\* Alcohol: If AUDIT-C\\*\\* score less than 1\n\n11- Extremely frequent consumers Participants who are extremely frequent consumers of caffeine or alcohol will be excluded due to potential withdrawal symptoms during the required 18-hour abstinence and possible reduced sensitivity to administered doses.\n\nCaffeine: If more than 400mg of caffeine (e.g., 5 espressos) per day from all sources (including coffee, soft drinks, energy drinks, chocolate, and medications) based on the CCQ\\* Alcohol: If AUDIT-C\\*\\* scores more than 4 for men and more than 3 for women\n\nNote: Participants will complete a history update questionnaire at each laboratory visit to report any changes relevant to the exclusion criteria. If a participant no longer meets the eligibility criteria at any visit after the baseline assessment, the visit will either be rescheduled, if appropriate, or the participant will be withdrawn from the study. Reimbursement will be provided on a prorated basis.\n\n\\*CCQ: Caffeine Consumption Questionnaire\n\n\\*\\*AUDIT-C: Alcohol Use Disorders Identification Test-C",true,"ALL","30 Years","50 Years",{"count":22,"type":23},100,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this study is to understand how caffeine and alcohol affect the ocular and physiological systems, especially how the pupil (the aperture in the colored part of the eye) responds to light. It will also test whether these changes can be used to detect recent caffeine or alcohol intake using a portable eye device.\n\nThe main questions it aims to answer are:\n\n1. How does caffeine change pupil responses, eye movements, and other ocular and physiological measurements?\n2. How does alcohol change these same ocular and physiological responses?\n3. Are the effects of caffeine and alcohol different from each other?\n4. Can these changes be used to accurately identify whether someone has consumed caffeine or alcohol?\n\nResearchers will compare caffeine, alcohol, and a placebo (a look-alike drink with no active substance) to see how each affects the ocular and physiological outcomes.\n\nParticipants will:\n\n1. Attend three separate sessions where they will consume caffeine, alcohol, or a placebo (in random order)\n2. Undergo pupillary response evaluation using a handheld device that measures responses to different colored light stimuli\n3. Have their eye movements analyzed\n4. Have retinal and choroidal thickness, blood perfusion, and ocular oxygen levels measured\n5. Have basic body measurements recorded (such as pulse rate and blood pressure)\n6. Complete tests at multiple time points over 2 hours after consumption\n\nThe results of this study may help develop a quick and non-invasive way to detect recent caffeine or alcohol use for clinical and safety purposes.",[29,30,31,32,33,34,35],"Caffeine","Alcohol","Pupillary Response","Eye Movements","Optical Coherence Tomography","Optical Coherence Tomography Angiography","Physiological Responses",[29,30,37,38,39,40,41,42,43,44,45,46],"Pupillary light reflex","Pupillometry","Chromatic pupillometry","Eye movements","Oculomotor function","Optical coherence tomography","Optical coherence tomography angiography","Physiological responses","Machine learning","Non-invasive monitoring","RECRUITING","2026-05-28",{"date":50,"type":51},"2026-06-04","ACTUAL",{"date":53,"type":23},"2026-06-01",{"date":55,"type":23},"2027-11-05",{"name":57,"class":58},"National University of Singapore","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":4,"eligibilityCriteria":66,"healthyVolunteers":17,"sex":18,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":4,"studyType":24,"phases":71,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":59},"100561204","an-investigation-of-attentional-and-inhibitory-processes-during-active-visual-search-in-humans-100561204","NCT06587113","An Investigation of Attentional and Inhibitory Processes During Active Visual Search in Humans","Contributions of Attentional and Inhibitory Functioning to Saccadic Decisions","Inclusion Criteria:\n\n* 18-65 years old\n\nExclusion Criteria:\n\n* Self-reported history of neurological illness\n* Uncorrected vision problems","18 Years","65 Years",{"count":70,"type":23},225,[26],"The goal of this study is to investigate the finding that there are large individual differences in how participants move their eyes during active visual search. For example, some individuals tend to fixate, that is point their eyes steadily at a single location, for longer than other individuals before moving to another location. This experiment will use behavioral tasks to measure an individual's attentional and inhibitory functioning, and then see how each of these contributes to between-participant variability in eye movement behavior during visual search.",[32,74,75],"Attention","Executive Function",[77,40,78,74,79],"Individual differences","Perception","Inhibition","2026-02-17",{"date":82,"type":51},"2026-02-20",{"date":84,"type":51},"2024-09-15",{"date":86,"type":23},"2026-05-15",{"name":88,"class":58},"University of Colorado, Denver",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":17,"sex":18,"minAge":67,"maxAge":68,"enrollmentInfo":96,"targetDuration":4,"studyType":98,"phases":4,"briefSummary":99,"conditions":100,"keywords":103,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":4},"100608245","neuro-mimic-indicators-of-anesthesia-depth-during-general-anesthesia-100608245","NCT07199049","Neuro-Mimic Indicators of Anesthesia Depth During General Anesthesia","Monitoring Eyelid Reflex, Eye Movements, and Pupil Responses in Patients Undergoing General Anesthesia: Neuro-Mimic Indicators of Anesthesia Depth","Inclusion Criteria:\n\n* The study will include patients aged 18-65 who will undergo elective abdominal surgery (e.g., cholecystectomy\u002Fgastrectomy\u002Fcolorectal surgery\u002Fprostatectomy\u002Fhysterectomy, etc.) under general anesthesia, with a planned duration of 1-3 hours.\n* Patients whose eye area is left uncovered and who are in a position suitable for observation\n* Patients who have signed the informed consent form\n* Patients with an ASA score of I-III\n\nExclusion Criteria:\n\n* Patients undergoing surgical procedures in the head, neck, or face region (e.g., ENT, eye, jaw surgery, neurosurgery, thyroid\u002Fparathyroid)\n* Patients whose eye area must be completely covered with a sterile drape\n* Patients with an ASA score of IV or higher\n* Individuals with neurological disorders and impaired pupil response, patients who have previously undergone eye trauma or surgery and cannot undergo pupil evaluation\n* Patients who are unable to communicate and cannot provide informed consent\n* Emergency surgeries (e.g., appendectomy\u002Fileus\u002Fgastrointestinal perforation\u002Fcesarean section\u002Fgunshot wounds\u002Fstab wounds\u002Fmultiple trauma\u002Ftraffic accidents, etc.)\n* Individuals who have previously been included in this study (to prevent repeated inclusion)",{"count":97,"type":23},60,"OBSERVATIONAL","This prospective observational study will evaluate neuro-mimic indicators of anesthesia depth, including eyelid reflex, eyeball movements, and pupil responses, in patients undergoing elective surgery under general anesthesia. Sixty adult patients will be observed at three standardized time points: after induction, during skin incision, and mid-surgery. All parameters will be recorded alongside bispectral index (BIS) monitoring. The study aims to determine whether these observable signs correlate with anesthesia depth, contribute to early detection of intraoperative awareness, and provide a basis for developing non-invasive depth monitoring systems.",[101,102,32],"General Anesthesia","Intraoperative Awareness",[104,105,106,32,107],"Anesthesia, General","Awareness, Intraoperative","Pupillary Reflex","Reflex, Blink (Eyelid Reflex)","NOT_YET_RECRUITING","2026-02-04",{"date":111,"type":51},"2026-02-05",{"date":113,"type":23},"2026-02-03",{"date":115,"type":23},"2026-07-28",{"name":117,"class":118},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":18,"minAge":126,"maxAge":67,"enrollmentInfo":127,"targetDuration":4,"studyType":24,"phases":129,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":59},"100502309","characterization-of-mentalization-profiles-related-to-emotional-regulation-among-teenagers-with-behavioral-disorders-100502309","NCT05820581","Characterization of Mentalization Profiles Related to Emotional Regulation Among Teenagers With Behavioral Disorders","CARMEN","Inclusion Criteria:\n\n* Teenage girls or boys aged 12 to 17\n* Adolescent(s) with externalized behavioral disorder(s):\n\nrunning away, suicide attempts, self-aggression (scarification, self-mutilation), taking drugs, hetero-aggressive behavior, theft, conduct disorders sexual, oppositional behavior, lies, clastic anger.\n\n* Non-objection of the adolescent to participate in the study.\n* Written consent of the two holders of parental authority\n\nExclusion Criteria:\n\n* Intellectually disabled\n* Autism Spectrum Disorder\n* Psychotic disorder","12 Years",{"count":128,"type":23},65,[26],"Behavioral disorders in adolescents are defined by a set of diverse behaviors (such as aggressiveness, agitation, clastic crisis, running away and endangerment) whose common characteristic is the predominance of action\u002F mentalization. These disorders are associated with significant morbidity and high mortality linked to a high rate of suicide or attempted suicide. Behavioral disorders are also associated with an alteration of mentalizing capacities, that is the psychic process by which the adolescent imagines and interprets his behavior and that of others on the basis of mental states such as needs, desires, beliefs or feelings. The disorders are also associated with emotional dysregulation. To date, the psychopathological processes underlying behavioral disorders in adolescents are unknown and prevent from offering appropriate psychological care. Thus, it seems essential to characterize this clinical population by integrating both its intrapsychic representations and the physiological parameters of emotional regulation associated with it.\n\nThis project is a first step towards a larger-scale research project aimed at evaluating treatment by TBM (therapies based on mentalization) in adolescents with behavioral disorders.",[132,32],"Adolescent Behavior Disorder",[134,135,136,137],"Mentalisation","Emotion regulation","Adolescents","Neurophysiological parameters","2024-09-05",{"date":140,"type":51},"2024-09-19",{"date":142,"type":51},"2023-06-26",{"date":144,"type":23},"2026-06",{"name":146,"class":58},"Centre Hospitalier Universitaire de Besancon"]