[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"facet-joint-degeneration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:facet-joint-degeneration":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100644645","degenerative-changes-after-treatment-of-thoracolumbar-junction-fractures-100644645",false,"NCT07672184","Degenerative Changes After Treatment of Thoracolumbar Junction Fractures","Degenerative Changes in Injured and Adjacent Spinal Motion Segments After Conservative and Surgical Treatment of AOSpine Type A2, A3, and A4 Thoracolumbar Junction Fractures","Inclusion Criteria:\n\nConservative Treatment Cohort:\n\n* Age 18 to 50 years.\n* Acute or subacute traumatic fracture of the thoracolumbar junction at the start of treatment.\n* AOSpine type A2, A3, or A4 fracture.\n* No clinical evidence of nerve root or spinal cord compression at the injured level.\n* Conservative treatment of the thoracolumbar junction fracture.\n* Minimum follow-up period of 1 year.\n* Written informed consent for prospective follow-up or additional study procedures, when applicable.\n\nSurgical Treatment Cohort:\n\n* Age 18 to 50 years.\n* Acute or subacute traumatic fracture of the thoracolumbar junction at the start of treatment.\n* AOSpine type A2, A3, or A4 fracture.\n* No clinical evidence of nerve root or spinal cord compression at the injured level.\n* Surgical treatment performed without disruption of the posterior supporting column.\n* Surgical treatment may include anterior fusion, transpedicular fixation, or combined surgery without direct posterior decompression.\n* Minimum follow-up period of 1 year.\n* Written informed consent for prospective follow-up or additional study procedures, when applicable.\n\nControl Cohort:\n\n* Age 18 to 50 years.\n* At least two computed tomography examinations covering the Th9-L4 vertebral levels.\n* Interval of at least 1 year between computed tomography examinations.\n* Computed tomography performed for reasons unrelated to traumatic or degenerative thoracolumbar junction disease.\n* No imaging artifacts at the spinal levels included in the study assessment.\n\nExclusion Criteria:\n\nConservative Treatment Cohort:\n\n* Severe combined trauma.\n* Severe concomitant disease.\n* Systemic bone or joint disease associated with changes in facet joints or intervertebral discs, including diffuse idiopathic skeletal hyperostosis, ankylosing spondylitis, rheumatoid arthritis, or similar disorders.\n* Verified osteoporosis.\n* Bone density of thoracolumbar vertebrae less than 100 Hounsfield units.\n* Previous spine surgery.\n* American Society of Anesthesiologists physical status class 4 or 5.\n* Participation in another clinical study related to treatment of spinal disease or spinal trauma.\n* Withdrawal of informed consent, when applicable.\n\nSurgical Treatment Cohort:\n\n* Severe combined trauma.\n* Severe concomitant disease.\n* Systemic bone or joint disease associated with changes in facet joints or intervertebral discs, including diffuse idiopathic skeletal hyperostosis, ankylosing spondylitis, rheumatoid arthritis, or similar disorders.\n* Verified osteoporosis.\n* Bone density of thoracolumbar vertebrae less than 100 Hounsfield units.\n* Previous spine surgery.\n* Direct posterior decompression or other surgery disrupting the posterior supporting column.\n* American Society of Anesthesiologists physical status class 4 or 5.\n* Participation in another clinical study related to treatment of spinal disease or spinal trauma.\n* Withdrawal of informed consent, when applicable.\n\nControl Cohort:\n\n* Complicated fracture of any spinal region.\n* Combined trauma or severe concomitant disease limiting patient mobility.\n* Systemic bone or joint disease associated with changes in facet joints or intervertebral discs, including diffuse idiopathic skeletal hyperostosis, ankylosing spondylitis, rheumatoid arthritis, or similar disorders.\n* Grade 4 facet joint degeneration according to the Pathria classification at the studied levels.\n* Bone density of thoracolumbar vertebrae less than 100 Hounsfield units.\n* Previous spine surgery, including surgery without implants.\n* Spinal fracture with injury to the posterior supporting column.\n* Participation in another clinical study related to treatment of spinal disease or spinal trauma.",true,"ALL","18 Years","50 Years",{"count":21,"type":22},150,"ESTIMATED","OBSERVATIONAL","This observational study will evaluate how degenerative changes in the facet joints and intervertebral discs develop over time after treatment of AOSpine type A2, A3, and A4 fractures of the thoracolumbar junction. Patients treated conservatively and patients treated surgically will be compared with each other and with a control group of patients who underwent repeated computed tomography examinations for reasons unrelated to traumatic or degenerative spinal disease.\n\nThe study will assess computed tomography findings at the injured spinal motion segment and adjacent segments, including facet joint degeneration, intervertebral disc degeneration, signs of ankylosis, facet joint space parameters, and facet joint angle. Clinical outcomes in the fracture cohort will be evaluated using pain scores and validated questionnaires. The purpose of the study is to identify factors associated with progression of degenerative changes after thoracolumbar junction fractures and to clarify whether treatment method is associated with long-term degeneration of the injured and adjacent spinal motion segments.",[26,27,28],"Thoracolumbar Spine Fracture","Facet Joint Degeneration","Intervertebral Disc Degeneration",[30,31,32,33,34,27,28,35,36,37],"Thoracolumbar Junction Fracture","AOSpine Classification","AOSpine Type A2 Fracture","AOSpine Type A3 Fracture","AOSpine Type A4 Fracture","Adjacent Segment Degeneration","Spinal Motion Segment","Computed Tomography","NOT_YET_RECRUITING","2026-06-27",{"date":41,"type":42},"2026-07-01","ACTUAL",{"date":44,"type":22},"2026-11-01",{"date":46,"type":22},"2027-12-31",{"name":48,"class":49},"Sklifosovsky Institute of Emergency Care","OTHER_GOV"]