[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"facet-joint-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:facet-joint-syndrome":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100613931","phase-4-percutaneous-electrical-nerve-stimulation-as-alternative-to-nerve-blocks-in-anesthesia-pain-medicine-and-rehabilitation-of-nonspecific-chronic-pain-100613931",false,"NCT07273006","Percutaneous Electrical Nerve Stimulation As Alternative To Nerve Blocks In Anesthesia, Pain Medicine And Rehabilitation Of Nonspecific Chronic Pain","PENSAR","Inclusion Criteria:\n\n* Participants with chronic LBP lasting at least three months and clinical suspicion of facet joint pain.\n* A balanced sex distribution and a wide range of body mass index (BMI) will be promoted to allow subgroup analyses and to explore potential associations between obesity and procedural complications, thus strengthening the external validity of the study. This demographic selection is justified by prevalence patterns reported in the literature and by the need to capture clinically relevant effect modifiers in real clinical environments.\n* The suspicion of facet joint pain will be based on a compatible axial clinical pattern and the absence of objective neurological deficit, considering that neither physical examination nor imaging tests provide sufficient specificity. Therefore, diagnostic confirmation will be performed functionally through ultrasound-guided medial branch diagnostic blocks, which are the most reliable tool for attributing pain to the facet joint. The dual innervation of each lumbar facet joint will be considered; thus, two adjacent levels will be blocked per joint (the medial branch at the affected level and the one immediately above).\n* Eligible patients will be those with a positive functional screening in two independent medial branch diagnostic blocks performed with anesthetics of different duration, in separate sessions, to reduce false positives.\n* The diagnosis will be confirmed in cases reporting clinically relevant pain relief within the expected pharmacological window.\n\nExclusion Criteria:\n\n* Exclusion criteria will include red flags or specific etiologies such as infection, neoplasm, fracture, or cauda equina syndrome, as well as patients with progressive motor radiculopathy or another demonstrated neuropathic pain source other than facet origin.\n* Individuals who have undergone prior procedures that could compromise response interpretation such as recent radiofrequency denervation, cryoneurolysis or intra-articular corticosteroid injections within a period that could extend analgesic effects.","ALL","18 Years","80 Years",{"count":20,"type":21},82,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Chronic musculoskeletal pain of non-specific origin affects approximately 30% of the global population. Beyond its prevalence, it represents a serious health and socioeconomic problem. It is considered the leading cause of years lived with disability and is characterized by persistent functional limitation, deterioration of quality of life, and poorer mental health, with a high comorbidity of depression, anxiety, and sleep disorders, as well as a greater risk of suicidal ideation and behavior.\n\nFrom a socioeconomic perspective, chronic pain entails an impact of up to USD 635 billion annually just in United States (USA). In fact, spinal pain alone represents the condition with the highest direct costs (around USD 134.5 billion in USA) and additional indirect costs due to absenteeism and presenteeism, which impair productivity and work performance. These figures are expected to be substantially higher when considered at a global scale.\n\nOne of the main aggravating factors of this condition is that in up to 90% of patients experiencing pain there is no identifiable anatomopathological substrate that reliably explains the symptoms (non-specific pain). Radiological findings are extremely common in asymptomatic populations, and making diagnostic or therapeutic decisions based on such findings, promotes overdiagnosis and low-value clinical cascades. It is estimated that up to 50% of imaging requests and 60% of spinal surgeries6 are unnecessary or unjustified. For this reason, Clinical Practice Guidelines recommend prioritizing interventional diagnostic techniques based on functional criteria over the interpretation of radiological findings, as they allow for more sensitive and specific identification of nociceptive sources (with a recommendation grade I-II).\n\nIn this context, the motivation of the project is to study PENS as a non-pharmacological, safe, and transferable alternative to nerve blocks, reducing the risk of complications associated with the use of local anesthetics\u002Fcorticosteroids and large-gauge needles. According to recent systematic reviews and meta-analyses confirming immediate analgesic responses, PENS could be a feasible alternative that maintains functional diagnostic and therapeutic value with a generally mild adverse-event profile and lower cost.",[27,28],"Non-specific Low Back Pain (NSLBP)","Facet Joint Syndrome",[30,31,32,33,34,35,36,37,38],"musculoskeletal ultrasound imaging","health care cost-utility","safety and adverse events","randomized clinical trial","pain neuromodulation","diagnostic nerve blocks","percutaneous electrical nerve stimulation","facet joint syndrome","non-specific low back pain","NOT_YET_RECRUITING","2026-01-09",{"date":42,"type":43},"2026-01-13","ACTUAL",{"date":45,"type":21},"2026-09-01",{"date":47,"type":21},"2029-08-31",{"name":49,"class":50},"Universidad Complutense de Madrid","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":51},"100298727","mrgfus-and-rfa-for-treatment-of-facet-joint-osteoarthritis-low-back-pain-100298727","NCT03168802","MRgFUS and RFA for Treatment of Facet-joint Osteoarthritis Low Back Pain","Comparative Study of Magnetic Resonance-guided Focused Ultrasound and Radiofrequency Ablation for Treatment of Facet-joint Osteoarthritis Low Back Pain","Inclusion Criteria:\n\n1. Men and women age 20 to 79 years old\n2. Suffering from lumbar vertebral facet joint syndrome.\n3. Lower back pain at least six months (NRS≥4).\n4. Conventional treatment of pain includes NSAIDs, opioids, muscle relaxants, oral steroids, physical therapy or chiropractic therapy.\n5. Imaging of the spine have facet osteoarthritis.\n6. Referred pain is no more below the knee.\n7. At least once when local anesthesia or diagnostic medial nerve branch injection, pain reduction\\> 75% (0.5ml of 2% lidocaine).\n\nExclusion Criteria:\n\n1. Patients with evidence of lumbosacral radiculopathy on MRI, CT or physical exam findings, including radicular leg pain.\n2. Patients with motor deficit or any other indication for surgical intervention.\n3. Patients with MRgFUS or RF treatment for LBP within the last 6 months.\n4. Patients with previous low back surgery.\n5. Patients who are pregnant.\n6. Patients with existing malignancy.\n7. Patients with allergies to relevant contrast, anesthetics, sedation drugs.\n8. Patients with contraindications for MRI.\n9. Patients with an acute medical condition (e.g., pneumonia, sepsis) that is expected to hinder them from completing this study.\n10. Patients with unstable cardiac status including:\n\n    * Unstable angina pectoris on medication\n    * Patients with documented myocardial infarction less than 40 days prior to protocol enrolment\n    * Patients with Severe Congestive Heart Failure, NYHA class 4.\n    * Patients on anti-arrhythmic drugs or with uncontrolled and\u002For untreated arrhythmia status\n    * Patients with pacemaker\n11. Patients with severe cerebrovascular disease (CVA within last 6 months)\n12. Patients with severe hypertension (diastolic BP \\> 100 on medication)\n13. Patients with an active infection or severe hematological, neurological, or other uncontrolled disease.\n14. Patients unable to communicate with the investigator and staff.\n15. Patients who are not able or willing to tolerate the required prolonged stationary position during treatment (approximately 2 hrs.)\n16. Coagulation disorders or other bleeding disorders, use of anticoagulants or antiplatelet drugs within 5 days before treatment.\n17. When local anesthesia or diagnostic medial nerve branch injection, the pain does not reach 75% (0.5 mL of 2% lidocaine).","20 Years","79 Years",{"count":62,"type":21},100,[64],"NA","This is a prospective, randomized, two-arm, phase II study.\n\nThe purpose of this study is:\n\n* To evaluate and compare the efficacy and safety of magnetic resonance-guided focused ultrasound (MRgFUS) and radiofrequency ablation (RFA) for treatment of facet-joint osteoarthritis low back pain.\n* Determining the effect of the MRgFUS System and RFA for improving functional disabilities and in reducing pain resulting from facet-joint osteoarthritis low back pain. Efficacy will be determined by the level of pain relief (as measured by the Numerical Rating Scale, NRS), decrease in analgesics\u002Fopiate, improved quality of life (as measured by the Oswestry Disability Questionnaire, ODQ, and core outcome measures index questionnaire, COMI), pain interference with function (as measured by the Brief Pain Inventory-Interference scale, BPI-QoL), general health status (as measured by the EQ5D), physical exam, X-ray and MRI studies from baseline up to 12-Months post- MRgFUS and radiofrequency treatment.\n* Evaluate incidence and severity of adverse events associated with the MRgFUS system and RFA used for the treatment of pain resulting from facet-joint osteoarthritis low back pain.",[67,28],"Chronic Low Back Pain",[69,70,71,72],"Focused ultrasound Ablation","Radiofrequency Ablation","Facet joint syndrome","Chronic low back pain","RECRUITING","2024-12-03",{"date":76,"type":43},"2024-12-05",{"date":78,"type":43},"2018-08-24",{"date":80,"type":21},"2025-11-25",{"name":82,"class":50},"Taipei Medical University Hospital"]