[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"facial-swelling\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:facial-swelling":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100641187","comparing-obturation-using-bioceramic-nano-coated-gutta-percha-with-bioceramic-sealer-versus-traditional-gutta-percha-with-resin-sealer-for-reducing-postoperative-pain-and-swelling-after-root-canal-treatment-in-necrotic-single-rooted-teeth-100641187",false,"NCT07600099","Comparing Obturation Using Bioceramic Nano-coated Gutta-percha With Bioceramic Sealer Versus Traditional Gutta-percha With Resin Sealer for Reducing Postoperative Pain and Swelling After Root Canal Treatment in Necrotic Single-rooted Teeth.","Comparative Evaluation of Obturation Using Bioceramic Nano-coated Gutta-percha and Bioceramic-based Sealer Versus Gutta-percha and Resin-based Sealer on Postoperative Pain and Swelling: A Randomized Clinical Trial.","Inclusion Criteria:\n\nPatients aged 20-55 years. Patients with good oral hygiene, free of calculus, and with a probing depth not exceeding 2-3 mm.\n\nNecrotic single-rooted, single-canal permanent teeth with or without periapical lesions. If lesion is present, ranging from 2-5 mm in size.\n\nAbsence of swelling. Medically free patients.\n\nExclusion Criteria:\n\nPatients with poor oral hygiene. Vital teeth. Necrotic teeth without periapical lesions. Primary teeth. Complex root morphology other than Type I. Internal or external root resorption. Vertical root fractures. Cracked teeth. Intraoral or extraoral swelling.",true,"ALL","20 Years","55 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","A randomized clinical trial will compare two root canal filling approaches in necrotic single-rooted teeth. The test group will receive bioceramic mono-block obturation using bioceramic nano-coated gutta-percha with a bioceramic sealer, while the control group will receive traditional gutta-percha with a resin-based sealer. The main aim is to determine whether the bioceramic system can reduce postoperative pain and swelling within 48 hours after treatment compared with the conventional method. Patients aged 20-55 years who have necrotic single-rooted teeth and meet specific clinical and radiographic criteria will be recruited from the outpatient clinics of the Faculty of Dentistry, Cairo University.\n\nPostoperative pain will be measured using a visual analogue scale, and swelling will be assessed using a standardized swelling score at 24 and 48 hours. The study hypothesizes that the bioceramic mono-block technique, due to its improved sealing ability and bioactivity, may lead to less postoperative discomfort and better early clinical outcomes than the gold-standard resin-sealer technique. The findings are expected to provide evidence to guide clinicians on whether adopting bioceramic nano-enhanced obturation can improve patient-centered outcomes after root canal treatment.",[28,29],"Dental Pain","Facial Swelling",[31,32],"bioceramic","monoblock","NOT_YET_RECRUITING","2026-05-18",{"date":36,"type":37},"2026-05-20","ACTUAL",{"date":39,"type":22},"2026-09-01",{"date":41,"type":22},"2027-09-30",{"name":43,"class":44},"Cairo University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":45},"100611703","aescin-based-herbal-extract-reparil-for-postoperative-sequelae-after-mandibular-third-molar-surgery-100611703","NCT07244029","Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar Surgery","Evaluation of Aescin-Based Herbal Extracts for Managing Postoperative Sequelae Following Impacted Mandibular Third Molar Surgery: A Randomized, Single-Blind, Controlled Trial","Reparil","Inclusion Criteria:\n\n* Patients indicated for surgical removal of impacted mandibular third molars according to National Institute for Health and Care Excellence (NICE) guidelines.\n\nAge between 18 and 40 years.\n\nImpacted mandibular third molars with similar anatomical position and difficulty level as classified by Pell and Gregory and Pederson scoring.\n\nHealthy individuals (ASA I-II) with no significant systemic illness.\n\nWilling to provide written informed consent and attend all follow-up visits (Day 2 and Day 7 post-surgery).\n\nExclusion Criteria:\n\n* Recent use (within three weeks preoperatively) of anti-inflammatories, corticosteroids, or antibiotics.\n\nKnown allergies or hypersensitivity to Aescin, Ibuprofen, rescue medications, or local anesthetics.\n\nPregnant or lactating women.\n\nPatients with contraindications to NSAIDs (e.g., asthma, bleeding disorders, chronic kidney disease, active peptic ulcer, or cardiovascular disease).\n\nRecent use of substances that may affect surgery or interact with study drugs (e.g., contraceptives, alcohol, or tobacco).\n\nSurgical time exceeding 30 minutes or cases with intraoperative complications requiring non-study medications.","18 Years","40 Years",{"count":57,"type":22},100,[25],"This randomized, single-blind, controlled clinical trial aims to evaluate the efficacy and safety of Aescin-based herbal extract (Reparil®) compared with Ibuprofen in managing postoperative sequelae following surgical removal of impacted mandibular third molars. A total of 100 participants aged 18-40 years will be enrolled at the Dental Center, Medical City Hospital for Military and Security Services (MCMSS), Al Khoud, Oman. Participants will be randomly assigned to receive either Reparil® (Aescin 20 mg, three times daily for five days) or Ibuprofen (400 mg, three times daily for five days) following standardized third molar extraction procedures. Postoperative outcomes including pain (VAS), facial swelling (3D facial scanner), and mouth opening (digital caliper) will be assessed preoperatively, on day 2, and day 7 post-surgery. The study aims to determine whether Aescin offers comparable analgesic and anti-edematous effects to Ibuprofen with fewer adverse events.",[61,29,62],"Postoperative Pain","Trismus",[64,65,52,66,67,68,69,70,71,72],"Aescin","Escin","Ibuprofen","Herbal anti-inflammatory","Postoperative sequelae","Third molar extraction","Oral surgery","Phytotherapeutic agents","Pain management","RECRUITING","2026-01-13",{"date":76,"type":37},"2026-01-15",{"date":78,"type":37},"2026-01-01",{"date":80,"type":22},"2026-09-30",{"name":82,"class":83},"Oman Medical Speciality Board","OTHER_GOV",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":16,"sex":17,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":97,"conditions":98,"keywords":104,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":45},"100575923","comparison-of-piezoelectric-and-conventional-surgery-for-germectomy-of-the-lower-third-molar-100575923","NCT06778590","Comparison of Piezoelectric and Conventional Surgery for Germectomy of the Lower Third Molar","Comparison of Piezoelectric and Conventional Surgery for Germectomy of the Lower Third Molar: Assessment of Post-operative Sequelae","Germectomy","Inclusion Criteria:\n\n* Patients aged between 14 and 24 years, with both lower third molars in the developmental stage (with incompletely formed roots) and requiring extraction of both for prophylactic, therapeutic or strategic reasons\n* Good quality of radiographic investigations (CBCT)\n* Good health status","14 Years","24 Years",{"count":95,"type":22},22,[25],"The main objective of the study is to compare the effects of the piezoelectric surgery and the traditional technique on soft tissue edema in patients undergoing bilateral germectomy of mandibular third molars",[99,100,101,102,103,29,90],"Tooth Disease","Piezoelectric Technique","Tooth Impacted","Tooth Extraction Status Nos","Tooth Avulsion",[105,106,107,108,109,110,111],"third molar surgery","facial swelling","3D facial swelling evaluation","Piezoelectric technique","tooth impacted","piezosurgery","germectomy","2025-01-15",{"date":114,"type":37},"2025-01-16",{"date":116,"type":37},"2024-08-01",{"date":118,"type":22},"2025-10-31",{"name":120,"class":44},"Amerigo Giudice"]