[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"failureventricular\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:failureventricular":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":24,"studyType":25,"phases":4,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100305417","dynamics-of-platelet-activation-in-patients-with-ventricular-assist-device-vad-100305417",false,"NCT03255928","Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD)","Analysis of the Platelet Activity State in Patients Implanted With Ventricular Assist Device (VAD)","PASVAD","Inclusion Criteria:\n\n* All consenting patients candidates for short-term (Impella, ECMO) or durable (LVAD) mechanical circulatory support device implantation\n* All consenting patients that are implanted with short-term (Impella, ECMO) or durable (LVAD) mechanical circulatory support device\n\nExclusion Criteria:\n\n\\- Patients \\\u003C 18-years old",true,"ALL","18 Years","75 Years",{"count":22,"type":23},60,"ESTIMATED","2 Years","OBSERVATIONAL","Consenting patients with end-stage heart failure that are implanted with\u002Fcandidates for implant of a short-term\u002Fdurable mechanical circulatory support device (e.g.: percutaneous microaxial pumps (Impella), extracorporeal membrane oxygenator (ECMO), Ventricular Assist Device (VAD) will be enrolled in the study.\n\nAim of the study is to evaluate the patients' haemostatic and coagulation profile, how it interacts with the support device as well as the effect of antithrombotic drugs. From these data, it will be possible to derive the mechanisms triggering post-implant thromboembolic\u002Fhemorrhagic complications and to identify potential therapeutic targets.",[28,29,30,31,32],"Thrombosis","Blood Coagulation Disorder","Platelet Thrombus","Platelet Dysfunction Due to Aspirin","Failure;Ventricular",[34,35,28,36,37,38],"Platelet activation","Ventricular Assist Device","Bleeding","Antithrombotic Pharmacological Therapy","Mechanical Circulatory Support","RECRUITING","2025-05-12",{"date":42,"type":43},"2025-05-15","ACTUAL",{"date":45,"type":43},"2017-06-29",{"date":47,"type":23},"2026-12-31",{"name":49,"class":50},"Scientific Institute San Raffaele","OTHER"]