[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"familiar-hypercholesterolemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:familiar-hypercholesterolemia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100580180","high-intensity-interval-training-in-the-treatment-of-familial-hypercholesterolemia-uppa-fh-100580180",false,"NCT06833944","High Intensity Interval Training in the Treatment of Familial Hypercholesterolemia (UPPA-FH)","Unraveling the Potential of Physical Activity in the Treatment of Familial Hypercholesterolemia: Impact of Exercise on Cardiorespiratory Fitness, Atherosclerosis Progression, and Underlying Mechanisms","UPPA-FH","Inclusion criteria:\n\n* Individuals with a diagnosis of genetic FH.\n* \\> 18 years old.\n* Minimum follow-up of 1 year in the Vascular Risk Clinic of the Virgen de las Nieves University Hospital (HUVN).\n* Clinical and treatment stability.\n* Non-pathological angio-TAC of coronary arteries in the 5 years prior to the study (for participants \\>45 years old).\n\nExclusion criteria:\n\n* Inability to read, understand and sign the informed consent.\n* Contraindications to exercise.\n* History of clinical CVD (ischemic heart disease, stroke, and\u002For peripheral arterial disease).","ALL","18 Years",{"count":20,"type":21},75,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study has one main objective:\n\na) To assess the impact of two different supervised exercise interventions on cardiorespiratory fitness and markers of subclinical atherosclerosis in patients with Familiar Hipercolesterolemia (FH), and to unravel the underlying mechanisms behind these effects.\n\nThe starting hypothesis of the UPPA-FH project anticipates that both exercise interventions will produce a large increase in cardiorespiratory fitness and will improve significant markers of atherosclerosis in patients with FH, with high-intensity interval training program (HIIT) being more efficient than the moderate-intensity continuous training (MICT) modality. The main effects will be mediated by a significant change in the metabolomic signature of the participants. In addition, higher physical activity will be associated with more favorable markers of atherosclerosis progression, as shown through blood and image technique",[27],"Familiar Hypercholesterolemia",[29,30,31,32,33,34],"Inflamation markers","Cardiovascular risk","Physical fitness","Exercise","Cardiovascular disease","LDL cholesterol","NOT_YET_RECRUITING","2025-02-13",{"date":38,"type":39},"2025-02-19","ACTUAL",{"date":41,"type":21},"2025-02-15",{"date":43,"type":21},"2026-07-31",{"name":45,"class":46},"Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental","OTHER"]