[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fatigue-in-multiple-sclerosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fatigue-in-multiple-sclerosis":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":37,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":4},"100631702","the-effect-of-remotely-delivered-pilates-on-physical--and-psychological-outcomes-in-individuals-with-multiple-sclerosis-100631702",false,"NCT07504120","The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis","Does Remotely Delivered Pilates Influence Physical and Psychological Outcomes in Individuals With Multiple Sclerosis?","MS","Inclusion Criteria:\n\n* Age 18 years or older\n* Self-reported diagnosis of multiple sclerosis by a neurologist\n* Relapse-free for the past 30 days before screening\n* Able to speak and read English as the primary language\n* Access to the internet and e-mail,\n* Ability to use Zoom, and willingness to complete testing sessions and questionnaires\n* Ambulatory without an assistive device (for example, cane)\n* Low to moderate disability, defined as a score of 0-4 on the Patient-Determined Disease Steps (PDDS)\n* Insufficiently active, defined as a score \\\u003C 14 on the Godin Leisure-Time Exercise Questionnaire-Health Contribution Score (GLTEQ-HCS)\n* Adequate visual ability and literacy to read materials printed in 14-point font\n* Currently treated with a disease-modifying therapy\n\nExclusion Criteria:\n\n* Pregnant\n* Elevated risk for strenuous or maximal exercise, defined as more than one \"Yes\" response on the Physical Activity Readiness Questionnaire (PAR-Q) during screening","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","Objectives Objective 1: To determine the effects of a 16-week remotely delivered Pilates intervention on walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS.\n\nObjective 2: To examine the impact of a 16-week remotely delivered Pilates intervention on depression \\& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.\n\nAim Aim 1: To assess whether the 16-week remotely delivered Pilates intervention significantly improves walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS Aim 2: To investigate whether the 16-week remotely delivered Pilates intervention significantly improves depression \\& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.\n\nHypothesis Hypothesis 1: The 16-week remotely delivered Pilates intervention will significantly improve walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS.\n\nHypothesis 2: Participants receiving the 16-week remotely delivered Pilates intervention will demonstrate significantly greater improvements in depression \\& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.",[27,28,29,30,31,32,33,34,35,36],"Multiple Sclerosis","Pilates Exercise","Walking","Balance","Fatigue in Multiple Sclerosis","Pain Management","Quality of Life","Depression","Cognition","Fatigue",[38,39,36,35,40,29,34,30,41],"multiple sclerosis","Pilates","Quality of life","Pain","NOT_YET_RECRUITING","2026-03-25",{"date":45,"type":46},"2026-03-31","ACTUAL",{"date":48,"type":21},"2026-06-01",{"date":50,"type":21},"2027-12-01",{"name":52,"class":53},"University of Illinois at Chicago","OTHER",{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":67,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100626694","non-invasive-brain-stimulation-in-multiple-sclerosis-fatigue-100626694","NCT07438964","Non-invasive Brain Stimulation in Multiple Sclerosis Fatigue","Non-invasive Brain Stimulation for Altering Neuro-inflammatory Mediators of Central Fatigue in Multiple Sclerosis","Inclusion Criteria:\n\n* Men and women\n\n  * 18 - 70 years\n  * Established MS diagnosis (relapsing-remitting MS; RRMS) prior to study inclusion\n  * Maximal EDSS of 4\n  * Maximal disease duration 10 years\n  * Existing health insurance\n  * Stable or no treatment with disease modifying treatment (DMT) in last six months prior to study onset\n  * Persons with RRMS and FSMC score ≥ 22 will be included in group \"RRMS with fatigue\"\n  * Persons with RRMS and FSMC score \\\u003C 22 will be included in group \"RRMS without fatigue\"\n\nExclusion Criteria:\n\n* • MRI contraindications\n\n  * Known endocrine, immunologic, psychiatric, and neurologic disease (other than RRMS and Major Depressive Diosorder)\n  * Current treatment with pharmaceuticals affecting monoaminergic functioning such as Levodopa, Amantadin, Fluoxetin, Paroxetin or antipsychotics\n  * Relapse or treatment with steroids in last four weeks window prior to study onset\n  * DMT other than B-cell depleting monoclonal antibodies or fumarates\n  * Sleep disorder as assessed with Pittsburgh Sleep Quality Index","70 Years",{"count":63,"type":21},84,[24],"The neurobiological basis of central fatigue in multiple sclerosis remained unclear so far. This study investigates reward-related brain mechanisms, inflammation, and their modulation by non-invasive brain stimulation using fMRI, proteomics, and clinical measures to improve future treatment of central fatigue in MS. In the study, persons suffering from relapsing-remitting MS (RRMS) with vs. without comorbid central fatigue will be included.\n\nThe study comprises five experimental visits conducted at Charité University Medicine on five consecutive days (i.e., V1 - V5) and two follow-up visits two (V6) and four (V7) weeks after V5. True or sham anodal transcranial Direct Current Stimulation (tDCS) is applied to the left dorsolateral prefrontal cortex (dlPFC) at the five visits V1 to V5. All primary and secondary outcomes are assessed at V1 and V5.\n\nAt V6 and V7, measures of central fatigue are additionally assessed via questionnaires which are send to and back from the patients via mail.\n\nParticipants of all groups will participate in all visits.",[27,31],[68,36,27],"Transcranial direct current stimulation","RECRUITING","2026-02-23",{"date":72,"type":46},"2026-02-27",{"date":74,"type":21},"2026-03-02",{"date":76,"type":21},"2028-06",{"name":78,"class":53},"Charite University, Berlin, Germany",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":15,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":93,"conditions":94,"keywords":100,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":79},"100607843","sexual-dysfunction-in-women-with-multiple-sclerosis-ms-100607843","NCT07193823","Sexual Dysfunction in Women With Multiple Sclerosis (MS)","Sexual Dysfunction Prevalence and Its Relationship With Various Factors in Women With Multiple Sclerosis","Inclusion Criteria:\n\n* Female patients aged 25-50 years\n* Literate and able to comprehend written and spoken instructions\n* Diagnosed with relapsing-remitting form of multiple sclerosis\n* Having a continuous\u002Fregular sexual partner\n* Expanded Disability Status Scale (EDSS) score ≤ 5\n* At least 3 months since the last relapse\n* Sexually active within the past 3 months\n* Spasticity level \\\u003C grade 2 according to the Modified Ashworth Scale\n\nExclusion Criteria:\n\n* Pregnancy\n* Illiteracy or inability to understand spoken or written instructions\n* Absence of a continuous\u002Fregular sexual partner\n* Expanded Disability Status Scale (EDSS) score \\> 5\n* Not sexually active within the past 3 months\n* Spasticity level ≥ grade 2 according to the Modified Ashworth Scale","FEMALE","25 Years","50 Years",{"count":91,"type":21},140,"OBSERVATIONAL","Sexual dysfunction in women with multiple sclerosis (MS) is an important yet often overlooked problem. The primary objective of this study is to investigate the prevalence of sexual dysfunction in female patients diagnosed with MS. The secondary objective is to evaluate the relationship between sexual dysfunction and fatigue, depression, anxiety, overactive bladder symptoms, and cognitive dysfunction.\n\nFor this purpose, the following validated instruments will be used: the Female Sexual Function Index (FSFI) to assess sexual dysfunction, the Brief International Cognitive Assessment for MS (BICAMS) to evaluate cognitive function, the Hospital Anxiety and Depression Scale (HADS) to assess depression and anxiety, the Fatigue Severity Scale (FSS) to measure fatigue, and the Overactive Bladder Questionnaire (OAB-V8) to evaluate overactive bladder symptoms.",[27,95,31,96,97,34,98,99,36],"Multiple Sclerosis (MS) - Relapsing-remitting","Sexual Disfunction","Cognitive Dysfunction","Anxiety","Overactive Bladder",[38,101,102,103,104,105,106],"sexual dysfunction","cognitive dysfunction","depression","anxiety","overactive bladder","fatigue","2025-09-22",{"date":109,"type":46},"2025-09-26",{"date":111,"type":46},"2024-07-16",{"date":113,"type":21},"2025-11",{"name":115,"class":53},"Ege University"]