[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fatigue-mental\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fatigue-mental":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,84,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100634918","single-arm-monocentric-pilot-feasibility-study-on-an-interactive-virtual-reality-program-in-20-complex-in-clinic-palliative-care-patients-100634918",false,"NCT07545928","Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care Patients","ZENCTUARY_VR+","Inclusion Criteria:\n\n* Patient ≥ 18 years old, hospitalized at the USP - HUS\n* Estimated life expectancy ≥ 1 month (Pronopall score based on clinical data).\n* Montreal Cognitive Assessment (MoCA) scale score ≥ 26.\n* Able to understand the objective and risks of the study\n* VRISE score ≤ 25 after the VR familiarization procedure\n* Affiliation with the Social Security system or beneficiary of such social protection.\n* Signed consent from, able to understand and complete the questionnaires in French.\n\nExclusion Criteria:\n\n* Patients with psychiatric disease\n* Patients under court protection\n* Uncontrolled epilepsy\n* Visual impairments (lack of binocular vision, blindness) and\u002For hearing impairments (deafness) preventing the use of virtual reality","ALL","18 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","Palliative care patients frequently face a \"symptom cluster\" of pain (up to 96%), fatigue (up to 90%), and anxiety (up to 79%), which severely degrades their quality of life in their final months.The study is built on the concept of passive exposure therapy (VREP), which engages multiple senses to distract the brain from pain signals. By creating an \"immersive distraction\" or a \"flow state,\" VR can activate the brain's reward networks and reduce activity in areas associated with pain perception. Unlike most existing VR research in palliative care which uses \"passive\" VR (like watching a 360-degree video), this study uses interactive VR. Patients can perform simple actions-like grabbing or dropping virtual objects-within a calming natural environment, which may better support their sense of autonomy and dignity. Because this is a pilot study, the \"Go\u002FNo-Go\" decision for future larger trials depends on a strict composite of three factors:\n\n* Adherence: The patient must complete at least 11 out of 14 planned daily sessions.\n* Duration: Each session must average at least 7.5 minutes of usable VR exposure.\n* Tolerance: The patient must experience no device-related serious adverse events and maintain a high average tolerance score (VRISE score ≥ 25).",[26,27,28,29,30,31],"Palliative Care","Refractory Pain","Anxiety","Depression Disorders","Fatigue, Mental","Psychological Distress",[33,34,35,36,37,38,39],"palliative care","end-of-life care","refractory pain","Interactive Virtual Reality","Immersive Technology","Virtual Reality Exposure Therapy (VRET)","Cybersickness in Palliative Care","NOT_YET_RECRUITING","2026-04-15",{"date":43,"type":44},"2026-04-22","ACTUAL",{"date":46,"type":20},"2026-09-01",{"date":48,"type":20},"2027-03-01",{"name":50,"class":51},"University Hospital, Strasbourg, France","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":16,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":21,"phases":65,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":4},"100606664","sleep-hygiene-plus-physiotherapy-for-sleep-and-disability-in-chronic-neck-pain-100606664","NCT07178496","Sleep Hygiene Plus Physiotherapy for Sleep and Disability in Chronic Neck Pain","Effect of Integrating Sleep Hygiene Techniques With Physiotherapy Exercise in Improving Sleep Quality and Disability in Patients With Chronic Neck Pain","Inclusion Criteria\n\nParticipants will be eligible for the study if they meet the following conditions:\n\n1. Adults aged 20-55 years.\n2. Clinical diagnosis of chronic neck pain, defined as symptoms persisting for more than 3 months.\n3. Poor sleep quality, indicated by a Pittsburgh Sleep Quality Index (PSQI) score \\>5.\n4. Willingness to participate and comply with both the physiotherapy and sleep hygiene intervention program.\n5. Ability to provide informed consent.\n\nExclusion Criteria\n\nParticipants will be excluded if any of the following conditions are present:\n\n1. History of cervical spine trauma, surgery, or fracture within the past 6 months.\n2. Severe depression or anxiety, defined by scores above the severe threshold on the Hospital Anxiety and Depression Scale (HADS).\n3. Neurological disorders affecting neck function (e.g., cervical radiculopathy, myelopathy).\n4. Other musculoskeletal disorders causing significant neck or shoulder pain.\n5. Sleep disorders unrelated to neck pain (e.g., obstructive sleep apnea, restless legs syndrome, narcolepsy), whether diagnosed or suspected.\n6. Ongoing pharmacological treatments that may significantly affect sleep (e.g., sedatives, hypnotics), unless the patient has been on a stable dose for \\>3 months.\n\n6 Uncontrolled systemic illnesses such as diabetes, cardiovascular disease, or cancer.\n\n7 Pregnancy.\n\n8 Participation in any recent physiotherapy program targeting neck pain within the last 3 months.",true,"25 Years","55 Years",{"count":64,"type":20},120,[23],"This study investigates the effectiveness of a combined intervention that integrates sleep hygiene education with physiotherapy exercises in patients suffering from chronic neck pain. Chronic neck pain is often associated with both musculoskeletal dysfunction and secondary sleep disturbances, which in turn may exacerbate pain perception, fatigue, and disability. Traditional physiotherapy exercise programs focus primarily on improving cervical mobility, muscle strength, and postural control, but they do not typically address sleep-related problems that can hinder recovery.\n\nThe intervention in this study consists of two main components:\n\nPhysiotherapy Exercise Program - A structured regimen targeting cervical spine mobility, deep cervical flexor strengthening, scapular stabilization, and postural correction. These exercises aim to reduce pain, restore function, and improve overall physical performance.\n\nSleep Hygiene Education - A structured educational module covering principles of healthy sleep habits, including maintaining consistent sleep-wake schedules, creating an optimal sleep environment, limiting stimulants before bedtime, and adopting relaxation strategies to promote better sleep initiation and maintenance.\n\nBy combining these approaches, the intervention addresses not only the physical impairments associated with chronic neck pain but also the psychosocial and behavioral factors contributing to poor sleep quality.\n\nOutcome Measures:\n\nPrimary Outcomes: Sleep quality, assessed using validated tools such as the Pittsburgh Sleep Quality Index (PSQI).\n\nSecondary Outcomes: Disability and functional limitations, measured by the Neck Disability Index (NDI), along with pain intensity assessed using a Visual Analog Scale (VAS).\n\nFatigue will be assessed by fatigue inventory index\n\nStudy Hypothesis: The combined intervention of sleep hygiene education and physiotherapy exercise will lead to greater improvements in sleep quality and reductions in disability and fatigue compared to physiotherapy exercise alone.\n\nClinical Significance: If effective, this integrative approach may provide a cost-effective, non-pharmacological management strategy for patients with chronic neck pain, targeting both physical and behavioral contributors to their condition.",[68,69,70,30],"Neck Pain","Neck Pain Musculoskeletal","Sleep Disturbances",[72,73,74],"sleep quaity","sleep hygiene","neck pain","2025-09-16",{"date":77,"type":44},"2025-09-17",{"date":79,"type":20},"2025-10-15",{"date":81,"type":20},"2026-05-02",{"name":83,"class":51},"Al-Azhar University",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":60,"sex":16,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":95,"conditions":96,"keywords":102,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":52},"100603382","monitoring-fatigue-in-daily-life-in-adults-with-cerebral-palsy-or-acquired-brain-injury-100603382","NCT07135791","Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain Injury","Real-Time Monitoring of Fatigue In Daily Life Among Adults With Cerebral Palsy or Acquired Brain Injury: An Observational Study","Inclusion Criteria:\n\n* Score of minimum 4 on the 7-item Fatigue Severity Scale (CP and ABI only)\n* Speak, read, and write Danish\n* Living in a private residence (i.e., not in institutional care or facilities providing 24-hour assistance)\n* Able to walk independently or with assistive devices over short distances\n* Able to operate a smartphone independently\n\nAdditional inclusion criteria for CP specifically:\n\n* Self-reported diagnosis of CP\n* Gross Motor Function Classification System (GMFCS) level ≤ II\n* Communication Function Classification System level ≤ II\n\nAdditional inclusion criteria for ABI specifically:\n\n* Self-reported diagnosis of ABI, including stroke, traumatic brain injury, brain infections, toxins, anoxia, or encephalopathy (transient ischemic attack, concussion or post-concussion syndrome, intracranial tumors, or progressive brain diseases are not included)\n* Between three months and two years post-injury\n* modified Rankin Scale (mRS) score ≤ 3\n\nExclusion Criteria:\n\n* History of other neurological disorders or chronic fatigue syndrome requiring treatment\n* Current substance or alcohol abuse\n* Night shift work or travel across time zones (1 to 3 zones within the last week or 4 to 6 zones within the last two weeks or at least 7 zones within the last 4 weeks)","30 Years","65 Years",{"count":64,"type":20},"OBSERVATIONAL","The goal of this observational study is to learn about levels and patterns of fatigue in adults with cerebral palsy (CP) and acquired brain injury (ABI) in daily life.\n\nThe main question it aims to answer is: How do adults with CP and ABI experience fatigue in daily life?\n\nResearchers will compare data from CP and ABI with healthy volunteers to see if they experience fatigue differently.\n\nParticipants will:\n\n* Monitor their symptoms, mood, and behavior in real-time by completing a brief survey on their mobile phone 10 times a day for seven consecutive days.\n* Attend a briefing session the day prior to the seven-day period of real-time monitoring.\n* Wear an accelerometer for the seven-day period.\n* Complete a daily sleep diary for the seven-day period.\n* Receive feedback on their real-time monitoring data, sleep and activity data.",[97,98,99,100,30,101],"Fatigue Symptom","Fatigue Intensity","Cerebral Palsy (CP)","Acquired Brain Injury Including Stroke","Fatigue",[103,104,105,106,107,101,108],"Cerebral palsy","Acquired brain injury","ecological momentary assessment","experience sampling method","real-time monitoring","Real-time fatigue","RECRUITING","2025-08-15",{"date":112,"type":44},"2025-08-22",{"date":114,"type":44},"2025-03-26",{"date":116,"type":20},"2026-10-31",{"name":118,"class":51},"Rigshospitalet, Denmark",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":60,"sex":16,"minAge":127,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":21,"phases":131,"briefSummary":132,"conditions":133,"keywords":137,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":52},"100537743","neuromodulation-of-the-autonomic-nervous-system-in-athletes-100537743","NCT06281795","Neuromodulation of the Autonomic Nervous System in Athletes","Neuromodulation of the Autonomic Nervous System in Athletes (NANSA Trial)","NANSA","Inclusion Criteria:\n\n* Professional athletes over the age of 15 and under the age of 35;\n* Cyclic sports (swimming, modern pentathlon, athletics, triathlon);\n* Difficult coordination sports (dance sports, rhythmic gymnastics);\n* Sports category: no lower than candidate for master of sports;\n* Voluntary informed consent.\n\nExclusion Criteria:\n\n* Atypical and unrelated to physical exertion changes on the ECG (T wave inversion, st-segment depression, pathological Q waves, signs of left atrial enlargement, signs of right ventricular hypertrophy, ventricular pre-excitation, complete right or left bundle branch block, prolonged or shortened Q-T interval, Brugada-like early repolarization);\n* Heart rhythm and conduction disorders (frequent ventricular and supraventricular extrasystoles, first-degree atrioventricular block (P-Q \\> 0.21 s, not shortened during hyperventilation or physical exertion), second or third degree);\n* Expressed sinus bradycardia with resting heart rate \\\u003C 40 bpm;\n* Taking glucocorticosteroids in the last 1 month;\n* Taking any antiarrhythmic drugs, including beta-blockers.","15 Years","35 Years",{"count":130,"type":20},125,[23],"There are few studies in the literature that have evaluated the effects of using percutaneous stimulation of the auricular branch of the vagus nerve for sports purposes (to accelerate recovery after physical exertion). It has been demonstrated that tVNS in athletes improved the rate of heart rate recovery, reduced lactic acid levels in blood plasma, reduced pain, reduced overtraining syndrome and fatigue levels.",[134,135,30,136],"Efficacy, Self","Fatigue; Muscle, Heart","Fatigue; Combat",[138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154],"auricular stimulation","auricular vagus nerve stimulation","transcutaneous vagus nerve stimulation (tVNS)","vagus nerve stimulation (VNS)","heart rate","heart rate variability","power of high-frequency oscillations (HF)","power of low-frequency oscillations (LF)","LF\u002FHF","index centralization (IC)","index of vegetative balance (IVB)","athletes","sport","maximum oxygen consumption (VO2max)","treadmill speed","anaerobic threshold of metabolism.","aerobic metabolism threshold of metabolism","2025-06-23",{"date":157,"type":44},"2025-06-26",{"date":159,"type":44},"2024-04-01",{"date":161,"type":20},"2026-01-31",{"name":163,"class":164},"Bakulev Scientific Center of Cardiovascular Surgery","OTHER_GOV"]