[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fear-of-needles\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fear-of-needles":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100582581","phase-4-pain-perception-during-intra-articular-knee-joint-injection-what-is-the-effect-of-needle-gauge-and-the-use-of-ethyl-chloride-100582581",false,"NCT06865170","Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?","Inclusion Criteria:\n\n1. age ≥ 40 years\n2. fulfillment of the American College of Rheumatology criteria for knee OA\n3. confirmation of knee-related pain and\u002For functional loss by clinical examination.\n4. Patients with either\n\n   1. bilateral knee OA\u002Finjections, or\n   2. unilateral knee OA\u002Finjections.\n5. Agreed to an intra-articular knee joint injection with steroids\n6. Naive to use of ethyl chloride\n\nExclusion Criteria:\n\n1. Arthroscopy of the index knee(s) within the prior 6 months\n2. Steroid injection of the knee(s) within the prior 3 months\n3. Hyaluronic acid or platelet-rich plasma injection of the knee within the prior 6 months\n4. Patient reported prior injection of any type with ethyl chloride spray\n5. Knee effusion requiring aspiration at the time of the procedure\n6. Cognitively impaired individuals",true,"ALL","40 Years","89 Years",{"count":20,"type":21},88,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence or absence of topical ethyl chloride spray. Additionally, this study will investigate the effects of other various factors on patients' pain associated with the injection. Lastly, this study aims to determine the effect of patients' subjective pain from the injection on long-term clinical outcomes.\n\nSpecific aims are as follows:\n\nAim 1): Determine the effect of needle gauge size on patient reported pain associated with an ultrasound-guided intra-articular knee injection.\n\nAim 2): Determine the effect of ethyl chloride spray on patient reported pain associated with an ultrasound-guided intra-articular knee injection.\n\nAim 3): Determine the effect of sex, age, BMI, thigh size, severity of OA, and fear of needles on patient pain associated with an ultrasound-guided intra-articular knee injection.\n\nAim 4) Determine the effect of patient pain from the procedure on longer term clinical outcomes after an ultrasound-guided intra-articular knee steroid injection.\n\nResearchers will obtain data at various time points, including pre-procedural data, immediately after the procedure, 24-48 hours after, and 6 weeks post-procedure.\n\nParticipants will:\n\nConsent to receiving an intra-articular knee joint injection with steroids if indicated.\n\nScore their \"procedural\" pain immediately following the procedure, score their post-procedural \"soreness\" 24-48 hours after via telephone call, and score their overall knee pain about 6 weeks after the procedure via telephone call.",[27,28],"Osteoarthritis (OA) of the Knee","Fear of Needles",[30,31,32,33,34,35],"pain perception","fear of needles","needle gauge","ethyl chloride","corticosteroid injection","25G versus 22G","NOT_YET_RECRUITING","2026-06-26",{"date":39,"type":40},"2026-06-29","ACTUAL",{"date":42,"type":21},"2026-08",{"date":44,"type":21},"2026-12",{"name":46,"class":47},"University of California, Davis","OTHER"]